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PHYTOCHEMICAL SCREENING AND ANALYSIS POLYPHENOLIC ANTIOXIDANT ACTIVITY OF METHANOLIC EXTRACT OF WHITE DRAGON FRUIT (Hylocereus undatus) VH, Elfi Susanti; Utomo, Suryadi Budi; Syukri, Yandi; Redjeki, Tri
Indonesian Journal of Pharmacy Vol 23 No 1, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (233.544 KB) | DOI: 10.14499/indonesianjpharm23iss1pp60-64

Abstract

White dragon fruit  is  a well  known  and  widely  used  herbal medicine,  especially  in  Asia,  which  contains  several  interesting bioactive constituents and possesses health promoting properties. The  aim  of  this  study  was  to  analyze  for  the  bioactive compounds,  evaluate  total  phenolic  contents  and  antioxidant capacities  of  methanolic  extract  of  white  dragon  fruit.  The antioxidant  activity  was  determined  by  the  1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity assay. Total phenolic  content  were  determined  by  Folin-Ciocalteu  method. Phytochemical  screening  of  the  white  dragon  fruit  showed the  presence  of  triterpenoid,  alkaloid,  flavonoid  and  saponin. The  extract  exhibited  strong  antioxidant  activity  with  IC50 of 193 μg/mL, and total phenolic content of 246 μg/mL in 1 Kg dry extract.Key words: antioxidant activity, total phenolic, DPPH, white dragon fruit
The implementation of PBL integrated with STEM in the material of Temperature and Its Changes to the Improvement of Students’ Creative Thinking Skills and Learning Results Ida Madyani; Sri Yamtinah; Suryadi Budi Utomo
Journal of Educational Science and Technology (EST) Volume 5 Number 3 December 2019
Publisher : Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26858/est.v5i3.10899

Abstract

This study aims to determine the effect of implementing PBL integrated with STEM in the materials of temperature and its changes in creative thinking skills and learning outcomes. The research method was a quasi-experimental research design with non-equivalent pretest and posttest control group. Samples were selected by purposive sampling technique. Data collection instruments were creative thinking skills and knowledge tests. The analysis technique was a different test (t-test) to determine differences in the ability to think creatively and learning outcomes aspects of knowledge, and the N-gain test to determine the effectiveness of the learning method applied. The results of this study indicate that: (1) there were differences in learning outcomes and creative thinking abilities between the control and the experimental classes (2) the effectiveness test identified that the science learning using PBL integrated with STEM is quite effective in increasing the ability to think creatively.
Profile of Creative Thinking Skills on Junior High School Students in Science Learning by Gender Ida Madyani; Sri Yamtinah; Suryadi Budi Utomo
Scientiae Educatia: Jurnal Pendidikan Sains Vol 8, No 2 (2019): December 2019
Publisher : Tadris Biologi Fakultas Ilmu Tarbiyah dan Keguruan IAIN SYEKH NURJATI CIREBON

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24235/sc.educatia.v8i2.5315

Abstract

Creative thinking is one of the essential skills in science learning. Creative thinking skills become a source of strength in the development, invention, and investigation to face the obstacles in the 21st century. This study aimed to determine the creative thinking skills of junior high school students in science learning by gender. This study used descriptive analysis with quantitative data. Data collection by tests, interviews, and observation sheets. The participants of this study were 94 students from three different schools consisting of 35 male and 59 female students. The sampling technique uses purposive sampling. Indicators of critical thinking are fluency, flexibility, originality, and elaboration. Creative thinking skills in this study divided into three categories: high, medium, and low. The result of this study showed that the male students have a high percentage of flexibility, the average percentage in both originality and fluency, and a low percentage in elaboration. Female students have a high percentage in fluency, the medium percentage in elaboration, and a low percentage in both originality and flexibility.
SYNTHESIS OF TETRAKIS-N,N,N-TRIMETHYLAMMONIUMMETHYL-C-3,4-DIMETHOXYPHENYLCALIX[4]RESORCINARENE IODIDE BASED VANILLIN AND ITS ANTIDOTE ACTIVITY FOR CHROMIUM(VI) INTOXICATION Suryadi Budi Utomo; Jumina Jumina; Dwi Siswanta; Mustofa Mustofa
Indonesian Journal of Chemistry Vol 13, No 2 (2013)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (247.122 KB) | DOI: 10.22146/ijc.21299

Abstract

A research has been conducted to synthesize tetrakis-N,N,N-trimethylammoniummethyl-C-3,4-dimethoxyphenylcalix[4]resorcinarene iodide from vanillin and investigate its antidote capability for Cr(VI) intoxication. The synthesis was carried out in four steps i.e. (1) O-alkylation of 4-hydroxy-3-methoxybenzaldehyde, (2) HCl-catalyzed condensation of 3,4-dimethoxybenzaldehyde with resorcinol, (3) Mannich reaction of C-3,4-dimethoxyphenylcalix[4]resorcinarene with formaldehyde and dimethylamine in the presence of HCl to yield tetrakis-N,N-dimethylaminomethyl-C-3,4-dimethoxyphenylcalix[4]resorcinarene, and (4) treatment the Mannich base with methyl iodide to produce the quaternary ammonium salt of tetrakis-N,N,N-trimethylammoniummethyl-C-3,4-dimethoxyphenylcalix[4]resorcinarene iodide. According to the analysis of 1H-NMR spectrometer, the targeted compounds tend to exist in the chair (C2h) conformation. The capability of resorcinarene for Cr(VI) antidote was examined by orally injection method on mice groups. Based on LD50 determination, the resorcinarene was classified as non toxic compound according to Loomis criteria. Therapeutic using quaternary ammonium-modified resorcinarene was able to reduce metal concentrations of Cr(VI) in liver, kidney, and serum in the magnitude of 78.30; 85.72, and 88.79%, respectively. The higher dose of drug administered the greater decrease in the level of heavy metal. Judging from the amount of milligrams of reduced chromium per gram of organ, kidney is the organ having highest decreasing metal concentrations.
KINETICS AND EQUILIBRIUM MODEL OF Pb(II) AND Cd(II) ADSORPTION ONTO TETRAKIS-THIOMETHYL-C-4-METHOXYPHENYLCALIX[4]RESORCINARENE Suryadi Budi Utomo; Jumina Jumina; Dwi Siswanta; Mustofa Mustofa
Indonesian Journal of Chemistry Vol 12, No 1 (2012)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (370.022 KB) | DOI: 10.22146/ijc.21371

Abstract

The ability of tetrakis-thiomethyl-C-4-methoxyphenylcalix[4]resorcinarene for trapping Pb(II) and Cd(II) from aqueous solution at different pH, contact times, and initial metal concentration was investigated. Concentration of metal ions before and after interaction was analyzed by Atomic Absorption Spectrophotometer (AAS). The result indicated that tetrakis-thiomethyl-C-4-methoxyphenylcalix[4]resorcinarene is a good host for metal ions, where Cd(II) sorption capacity was higher than that of Pb(II). Effect of pH on batch experiments for the mentioned ions indicated that the optimum pH for metal binding were 5 for both of lead(II) and cadmium(II). In order to investigate the mechanism of adsorption, the 1st-order, pseudo 1st-order, and pseudo 2nd-order kinetic models were used. The adsorption model of metal ions on the resorcinarene followed pseudo second order of Ho & McKay expression. The equilibrium adsorption isotherm has been analyzed by Langmuir and Freundlich equations. Langmuir model had the higher correlation coefficient than that of Freundlich model.
SYNTHESIS OF THIOMETHYLATED CALIX[4]RESORCINARENE BASED ON FENNEL OIL VIA CHLOROMETHYLATION Suryadi Budi Utomo; Jumina Jumina; Dwi Siswanta; Mustofa Mustofa; Naresh Kumar
Indonesian Journal of Chemistry Vol 11, No 1 (2011)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (435.978 KB) | DOI: 10.22146/ijc.21411

Abstract

A research has been conducted to synthesize thiomethylated-C-4-methoxyphenylcalix[4]resorcinarene using fennel oil as a starting material. The synthesis was carried out in four steps i.e. (1) oxidation of anethole to yield p-anisaldehyde, (2) HCl-catalyzed condensation of p-anisaldehyde with resorcinol, (3) chloromethylation of C-4-methoxyphenylcalix[4]resorcinarene with paraformaldehyde and HCl in the presence of ZnCl2 to yield tetrakis-chloromethyl-C-4-methoxyphenylcalix[4]resorcinarene, and (4) reaction of tetrakis-chloromethyl-C-4-methoxyphenylcalix[4]resorcinarene with thiourea followed by hydrolysis with sodium hydroxide solution to yield tetrakis-thiomethyl-C-4-methoxyphenylcalix[4]resorcinarene. The prepared compounds were characterized based on melting point, FT-IR, and NMR spectrometers. According to the analysis of 1H-NMR spectrometer, C-4-methoxyphenylcalix[4]resorcinarene and tetrakis-chloromethyl-C-4-methoxyphenylcalix[4]resorcinarene were observed in the chair or flattened partial cone conformation, while tetrakis-thiomethyl-C-4-methoxyphenylcalix[4]resorcinarene tend to exist in the crown or cone conformation.
THE ADSORPTION OF Pb(II) AND Cr(III) BY POLYPROPYLCALIX[4]ARENE POLYMER Suryadi Budi Utomo; Jumina Jumina; Tutik Dwi Wahyuningsih
Indonesian Journal of Chemistry Vol 9, No 3 (2009)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.538 KB) | DOI: 10.22146/ijc.21512

Abstract

A research has been conducted to investigate the adsorption behavior of Pb(II) and Cr(III) onto polypropylcalix[4]arene polymer. The polypropylcalix[4]arene polymer was synthesized in the presence of H2SO4 catalyst and chloroform under N2 condition for 5 h using 25-allyloxy-26,27,28-trihydroxycalyx[4]arene as the precursor. The Polymer was obtained as yellow crystal with melting point of  288-290 °C and its relative molecular weight was 44.810 g.mol-1. The application of polypropylcalix[4]arene for trapping heavy metal cations and its adsorption model were examined by stirring the suspension of the calixarene in the sample solutions for various pH, time, and concentration of Pb(II) and Cr(III) solution. Effect of pH on batch experiments for the mentioned ions indicated that the optimum pH for metal binding were 5 for lead(II) and chromium(III). The adsorption model of metal ions on polypropylcalix[4]arene followed both the pseudo second order adsorption of Ho's and Langmuir isotherm adsorption kinetics models with rate constant (k) were 6.81 x 101 min-1 for Pb(II) and 2.64 x 10-2 min-1 for Cr(III). The adsorption equilibrium constant, K, were 5.84 x 105 L.mol-1 for Pb(II) and 4.66 x 105 L.mol-1 for Cr(III). The maximum adsorption capacity of polypropylcalix[4]arene to Pb(II) and Cr(III) were 16.31 and 18.14 mg.g-1 with adsorption energy of 32.90 and 32.34 kJ.mol-1, respectively.
Development of Reasoning Multiple Choice Questions (RMCQs) to Analyze Higher Order Thinking Skills Diah Ayu Saputri; Mohammad Masykuri; Suryadi Budi Utomo
EduChemia (Jurnal Kimia dan Pendidikan) Vol 7, No 1 (2022)
Publisher : Department of Chemical Education Faculty of Teacher Training and Education Universitas Su

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30870/educhemia.v7i1.11791

Abstract

The development of reasoning multiple choice questions (RMCQs) to analyze higher-order thinking skills is based on the need for appropriate assessment instruments to determine high-order thinking skills on learning requirements in the 21st century. The development used the model proposed by Thiagarajan, 4D-models with four process stages: (1) define; (2) design; (3) develop; (4) disseminate. The results were analyzed using the winstep application to obtain the value of validity, reliability, discriminatory power, distractor index, and difficulty level. The instrument has a good reliability coefficient, shown by the item reliability in the final test of 0.98, with the ability to distinguish three groups of samples, low, moderate, and high. 75% of the validity index and 80% of the distractor index function well, so the assessment instrument developed can be used to analyze high-order thinking skills. The assessment instrument is also applicative if used as an evaluation instrument in chemistry learning.
Pelatihan dan Pendampingan Produksi Minyak Atsiri Lempuyang Emprit (MALE) dan Hand Sanitizer Beradisi MALE serta Pemasaran Produk secara Digital pada UKM Herbal Suti Sehati di Kabupaten Sukoharjo Jawa Tengah Sri Retno Dwi Ariani; Sri Mulyani; Elfi Susanti VH; Suryadi Budi Utomo; Muhammad Hizbul Wathon; Anastasia Diaz Pramesti; Agustin Wulandari; Aufa Vib Mitsalina
Jurnal Abdi Masyarakat Indonesia Vol 3 No 4 (2023): JAMSI - Juli 2023
Publisher : CV Firmos

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54082/jamsi.802

Abstract

UKM Herbal Suti Sehati merupakan salah satu UKM di Jawa Tengah yang mampu bertahan walaupun terjadi pandemi Covid-19. Tujuan kegiatan ini adalah untuk menyelenggarakan pendampingan di bidang produksi, pengemasan, labelisasi, perhitungan analisis kelayakan usaha, dan tata cara pengurusan ijin edar produk minyak atsiri lempuyang emprit (MALE) dan hand sanitizer beradisi MALE, terhadap UKM Suti Sehati, serta pemasaran produk-produknya melalui digital marketing. Permasalahan yang dihadapi oleh UKM adalah: 1) UKM belum memiliki alat distilasi uap-air guna mengisolasi MALE, 2) UKM belum bisa memproduksi MALE dan hand sanitizer beradisi MALE, 3) UKM perlu pendampingan pemasaran produk-produknya melalui digital marketing. Solusi guna mengatasi permasalahan yang ada di UKM adalah, Tim P2M melaksanakan: 1) pemberian hibah alat distilasi uap-air, 2) pendampingan produksi, pengemasan, labelisasi, perhitungan analisis kelayakan usaha dan tata cara pengurusan perijinan usaha produk MALE dan hand sanitizer beradisi MALE, serta 3) memberikan pelatihan digital marketing. Hasil dari kegiatan pelatihan dan pendampingan produksi minyak atsiri lempuyang emprit (MALE) dan hand sanitizer beradisi MALE serta pemasaran produk secara digital terhadap UKM herbal Suti Sehati adalah terwujudnya pemanfaatan tanaman lempuyang emprit yang banyak tumbuh di lahan milik UKM, menambah jenis produk yang dihasilkan oleh UKM, dan peningkatan pendapatan UKM.
Analysis of Students Needs For Chemistry Module Based On Guided Discovery To Improve Critical Thinking Ability and Science Process Skills Jekson Obianto Babys; Ashadi Ashadi; Sulistyo Saputro; Suryadi Budi Utomo
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (114.959 KB) | DOI: 10.36418/syntax-literate.v7i9.9402

Abstract

This research aims to find out students 'needs for chemistry modules based on guided discovery for thermochemical material to improve students' critical thinking skills and science process skills. Ninety students from three Senior High School in Surakarta participated in this research. The research method used is qualitative. Sources of data obtained from open questionnaires and interviews. The results of the analysis show that 90% of students state that there is a need for chemistry modules based on guided discovery for thermochemical material because the guided discovery stage can guide them to learn systematically so that what is learned is easier to understand, students stated that the chemistry module based guided discovery can help them think more critically and improve their science process skills. Learning activities with the guided discovery learning model will run well if supported by appropriate modules.
Co-Authors A.J.A.P, Ajeng Resni Agustin Wulandari Alfiah Putri Chandra Pramudya Alfina Wijayanti Amiroh, Yuli Anastasia Diaz Pramesti Antoro, Yogi Dwi Antuni Wiyarsi Apriana Indi Rigiyanita Ari Syahidul Shidiq Ariyanti, Dewi Ashadi Ashadi Ashadi Ashadi, Ashadi Aufa Vib Mitsalina Bayu Antrakusuma Bilhaq, Natiq Budi Utami Cahyanto, Muhammad Agung Safari Chayati, Nirmala Dhika Rizqi Damayanti Diah Ayu Saputri Dwi Siswanta Dwi Siswanta Dwi Siswanta Elfi Susanti V. H. Elfi Susanti V. H. Elfi Susanti Van Hayus Elfi Susanti VH Fadhilah, Nur Fajar Sanubari Fajrin, Hans Fithria Gebran, Benasir Akbar Grandis Humaira Muanas Gusbandono, Toto Hanif, Rizka Fauzia Hanifah, Kisti Makrifatul Haryono, . Haryono, Haryono Hayuni Retno Widarti Hidayah Wati, Suci Tri Huda, Zamira Zia’ul Ida Madyani Ida Madyani Iqsan Tiyas Istiqo Istiqo, Iqsan Tiyas Jekson Obianto Babys Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Kharolinasari, Rachma Kurniasari, Ayuk Widiyastuti Lailatus, Shofiana Luluk Fajri Mahardika Yuhana Bayu Putra Majid, Karima Marwanto, Muhammad Danang Maya Firda Hidayah Mita Fujiyanti Mohammad Masykuri Mohammad Masykuri Muanas, Grandis Humaira Muhammad Danang Marwanto Muhammad Hizbul Wathon Muhammad Hizbul Wathon Mulyani, Bakti Mulyani, Sri Munawarah, Sinta Al Muslikhah, Nurul Mustika Cahyaningrum Mustofa Mustofa Mustofa Mustofa Nanik Dwi Nurhayati Naresh Kumar Nazatin Nuroini Nindya Pramesthi Handayani Ningtyas, Arin Ika Nirmala Chayati Noviyanti, Berliana Nugrahani, Arumsasi Putri Nurkhasanah, Lina Nurrizqi, Adysti Eren Fattaah Paerah, Paerah Panie, Maria Yuliana Perdana, Dimas Dian Permatasari, Ika Yudita Pramanawati, Refi Indah Pramesti, Anastasia Diaz Pramudya, Alfiah Putri Chandra Purwati Purwati Putra, Mahardika Yuhana Bayu Putranto, Rizky Akbar Wahyu Putri, Ayu Aryanti Putri, Rischa Oktaviana Christy Rahmadany, Anggita Lintang Rahmadina, Salsabila Adzani Rahmawan, Arifin Aziz Rahmawati, Cici Putri Rahmawati, Jiantika Rakhmadhani, Nuzul Ramadhani, Dimas Gilang Ramadhani, Lathifah Redjeki, Tri Redjeki, Tri Retnani, Fidha Yusti Rischa Oktaviana Christy Putri Rizky Akbar Wahyu Putranto Rohmawati, Addini Rohmiyati, Nazillatur Saputro, Agung Nugroho Catur Saputro, Sulistyo Septyadini, Dita Setyapatra, Meline Setyawan, Levia Pavita Hisa Setyowati, Widiastuti Agustina Eko Setyowati, Widiastuti Agustina Eko Shofiana Lailatus Singa Murti, Mirrah Megha Siswanto, Predy Sitaresmi, Kun Sasanti Sri Mulyani Sri Mulyani Sri Mulyani Sri Retno Dwi Ariani Sri Retno Dwi Ariani Sri Retno Dwi Ariani Sri Sulystya Ningsih N.D.Tiring, Sri Sulystya Ningsih Sri Yamtinah Sucianingtyas, Rani Fathonah Sugiarto, Dwi Hari Sugiharto, . Sukardjo, J. S. Sukardjo, Jakobus Salesius Sukarmin Sulistyo Saputro Sulistyo Saputro Sulistyo Saputro Sulistyowati, Tri Susanti V.H, Elfi Susanti VH1, Elfi Tresni Setiati Tutik Dwi Wahyuningsih Umami, Muhammad Rizza Wahyuni, Nita Tri Warih Puji Lestari Wathon, Muhammad Hizbul Widha Sunarno Widianingrum, Winda Mega Widiastuti Agustina Eko Setyowati Widyawati, Riana Lilis Wijayanto, Herry Wulandari, Dyah Yandi Syukri Zai, Fila Delfia