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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Agroindustri Jurnal Fitofarmaka Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Window of Health : Jurnal Kesehatan Media Farmasi Media Kesehatan Politeknik Kesehatan Makassar PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Journal of Pharmaceutical and Medicinal Sciences ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal farmasi UIN Alauddin Makassar Devotion: Journal of Research and Community Service Narra J Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Kefarmasian Media Farmasi Jurnal Tumbuhan Obat Indonesia Media Penelitian dan Pengembangan Kesehatan
Maulita Indrisari, Maulita
Sekolah Tinggi Ilmu Farmasi Makassar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Journal : Media Farmasi

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Potensi Peningkatan Daya Ingat Pada Tikus Putih (Rattus norvegicus) Menggunakan Ekstrak Daun Kelor (Moringa oleifera) Dengan Metode Labirin Y Maze Indrisari, Maulita; Nurkhairi, Nurkhairi; Dewingsky, Lyevy; Muslimin, Lukman; Rumata, Rahma
Media Farmasi Vol 19 No 2 (2023): Media Farmasi Edisi Oktober 2023
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v19i2.208

Abstract

Potential for Improving Memory in White Rats (Rattus norvegicus) Using Moringa Leaf Extract (Moringa oleifera) Using the Y Maze Method Memory decline is a disease of impaired brain function and cognitive decline characterized by changes in behavior, decreased memory, and difficulty in communicating. One of the causative factors is oxidative stress where the imbalance between the production of Reactive Oxygen Species (ROS) and the body's antioxidant defense system, causes lipid peroxidation, protein oxidation, and changes in ROS that cause the death of brain neurons. Moringa leaf (Moringa oleifera) is a plant that contains high antioxidants, namely flavonoids. These compounds provide neuroprotective effects on the brain due to oxidative stress that causes memory decline. The purpose of this study was to determine the activity of Moringa leaf extract on memory improvement in white rats (Rattus norvegicus) using the Y-Maze Labyrinth method. Experimental animals were divided into 5 groups, namely negative control (Na-CMC), Gingko Biloba, and treatment groups given moringa leaf extract at a dose of 50 mg / kgBB, 100 mg / kgBB and 200 mg / kgBB. The rats were first induced with Hyosin-Butylbrimide at a dose of 1.5 mg/KgBB in ip for 10 days. The administration of the extract was carried out for 18 days with the observed parameters including the time required for rats to find food in the Y-maze maze tool.  The observation data obtained were then analyzed using the Mann Whitney test. The results showed that the ethanol extract of moringa leaves has a memory enhancing activity. Memory enhancing activity was shown at a dose of 200 mg/kgBB. ABSTRAK Penurunan daya ingat merupakan penyakit gangguan fungsi otak dan penurunan kognitif yang ditandai dengan perubahan perilaku, penurunan memori, serta kesulitan dalam berkomunikasi. Salah satu faktor penyebabnya adalah stress oksidatif dimana ketidakseimbangan antara produksi Reactive Oxygen Species (ROS) dengan sistem pertahanan antioksidan tubuh, sehingga menyebabkan peroksidasi lipid, oksidasi protein, perubahan ROS yang menyebabkan kematian neuron otak. Daun Kelor (Moringa oleifera) merupakan tanaman yang mengandung antioksidan tinggi yaitu flavonoid. Senyawa tersebut memberikan efek neuroprotektif pada otak akibat stres oksidatif yang menyebabkan penurunan daya ingat. Tujuan penelitian ini untuk mengetahui aktivitas ekstrak Daun Kelor terhadap peningkatan daya ingat pada tikus putih (Rattus norvegicus) menggunakan metode Labirin Y-Maze. Hewan coba dibagi menjadi 5 kelompok yaitu kontrol negatif (Na-CMC), Gingko Biloba, kelompok perlakuan yang diberikan ekstrak Daun Kelor dengan dosis 50 mg/KgBB, 100 mg/KgBB dan 200 mg/KgBB. Terlebih dahulu tikus diinduksi dengan Hyosin-Butylbrimide dengan dosis 1,5 mg/KgBB secara ip selama 10 hari. Pemberian ekstrak dilakukan selama 18 hari dengan parameter yang diamati meliputi waktu yang dibutuhkan tikus untuk menemukan makanan pada alat labirin Y-maze.  Data hasil pengamatan yang diperoleh kemudian dianalisis menggunakan uji Mann Whitney. Hasil penelitian menunjukkan bahwa ekstrak etanol Daun Kelor mempunyai aktivitas peningkat daya ingat. Aktivitas peningkat daya ingat ditunjukkan pada dosis 200 mg/kgBB.
Formulasi Sampo Antiketombe Liofilisat Buah Mengkudu (Morinda citrifolia): Aktivitas Antijamur, Uji Stabilitas Dan Keamanan Melalui HET-CAM Khairi, Nur; Yasir, Budiman; Indrisari, Maulita
Media Farmasi Vol 22 No 1 (2026): Media Farmasi Edisi April 2026
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v22i1.1898

Abstract

Dandruff is a common issue caused by the overgrowth of Malassezia furfur on the scalp. This study aims to develop a safe antidandruff shampoo formulation based on lyophilized noni fruit (Morinda citrifolia L.) and evaluate its effectiveness in combating dandruff. The lyophilized noni fruit was tested for its antifungal activity at five concentrations: 2%, 4%, 6%, 8%, and 10%, and then formulated into shampoo in three concentrations: F1 (6%), F2 (8%), and F3 (10%). The effectiveness of the shampoo formulations was tested against Malassezia furfur using the agar diffusion method. The safety of the formulations was also evaluated using the HET-CAM method to ensure their non-irritating properties. The results indicated that lyophilized noni fruit exhibited significant antifungal activity, with the largest inhibition zone observed at 10% concentration (23.16 ± 5.36 mm), which was not significantly different from the positive control (ketoconazole). Additionally, the HET-CAM test showed no irritation for all formulations, with an irritation score of 0. This study concludes that lyophilized noni fruit shampoo can serve as an effective and safe natural alternative for dandruff treatment.
Co-Authors Abd Halim Umar Abdul Halim Umar Ade Irma Sari Ade Putri Allyah Agustina Ma'tang Parinding Aisyah, Andi Nur Akbar Awaluddin Aksa, Rahmat Amriani Amriani Amriani Sapra Amriani Sapra Andi Nur Aisyah Andi Nur Aisyah Andi Nur Aisyah, Andi Nur Aisyah Arisah, Arisah Asril Burhan Astuti Amin Awaluddin, Akbar Dewingsky, Lyevy Djamaluddin, Suci F Fadhillah Maryam Fitriyanti Jumaetri Habibie Habibie Hapiwaty, Saldi Ikbal Ikbal Ikbal Indradewa, Rhian Irwana, Rina Ismah Mahmud Ismail Khairi, Nur Lukman Lukman Madinatul munawwarah Margaretha Margaretha Marliana Pasang Marliana Pasang, Marliana Marwati Marwati Marwati Marwati Marwati Marwati Maryam, Fadhillah Mar’atun Jannah, Imrawati, Muzakkir Baitz, Megawati - Megawati Megawati Michrun Nisa Mus, Suwahyuni Muslimin, Lukman Noer Fauziah Nur Rahma Rumata Nurhikma Awaluddin Nurkalbi, Nuni Rismayanti Nurkhairi, Nurkhairi Nursamsiar Nursamsiar Nurul Hikma Nurwijayanti paluseri, Andi Riska Rahayu Rosyid, Sujud Z Sami, Fitriyanti Saputra, Agil Saritani, Ayunda Tamara Barito Sembiring, Thyrister Nina Asarya Sitti Rahimah Sitti Rahimah Sitti Rahimah, Sitti Solly Aryza St. Rahimah Sukmawati Sukmawati Sukriani Kursia, Sukriani Surida Surida Surida, Surida Suryani Tawali Suwahyuni Mus Syamsu Nur Syamsu Nur, Syamsu Syamsu Nur, Syamsu Nur Utami, Novi F. Wahyu Hendrarti Wahyu Hendrarti Yasir, Budiman Zulham Zulham