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Journal : Berkala Kedokteran

Clinical Analysis of Channa micropeltes for Treating Wound of Diabetes Mellitus Maharani Laillyza Apriasari; Marina Arum Syahadati; Amy Nindia Carabelly
Berkala Kedokteran Vol 16, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (439.385 KB) | DOI: 10.20527/jbk.v16i1.8096

Abstract

Abstract: Toman fish contains albumin and omega-6 fatty acid that are instrumental in the healing process of diabetes mellitus (DM) wound. People with DM usually have a prolonged wound healing process. Albumin controls the osmotic pressure, the development of granulation tissue, gives the energy to re-epithelialisation process and collagen base material. Omega-6 fatty acid interrupts phagocytosis induced by neutrophil cells. It increases the action of machropage cell, so that Toman fish can be used as an alternative in accelerating the DM wound healing process. The purpose of this research is to prove the effect of Toman fish extract at 16 mL/ KgBW rat dosage per oral on wound length and contraction on the back of wistar rat (Rattus novergiucs) with DM for 14 days. It was the experimental with a posttest only with control group design  used 12 wistar rat that were divided into 3 groups; the group of Toman fish extract with dose 16 mL/ Kg BW rat, positive control group using Haruan extract with dose 13,54 mL/ Kg BW rat and negative control group using Comfeed BR2 feed. One-way ANOVA test result for wound length and contraction (p= 0,000). The result Post-hoc Least Significant Difference test for wound length and contraction shows that there are significant differences between the group of Toman fish extract and Haruan fish extract (p= 0,000). There is also significant difference between the group of Toman fish extract and Comfeed BR2 feed (p= 0,000). There is no significant difference between the group of Haruan fish extract and Comfeed BR2 feed (p= 0,930). The research concluded that Toman fish extract at 16 mL/ Kg BW rat dosage affects the length and contraction of diabetic mellitus wound. Keywords: Channa micropeltes, clinical analysis, diabetes mellitus, wound
Analysis of Oral Chronic Kidney Disease with Hemodialysis Therapy in South Kalimantan - Indonesia Isnur Hatta; Khairunnisa Amalia Pratami; Maharani Laillyza Apriasari
Berkala Kedokteran Vol 15, No 2 (2019)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (265.555 KB) | DOI: 10.20527/jbk.v15i2.7129

Abstract

Abstract: Chronic kidney disease (CKD) is a world health problem where the incidence continues to increase, has a poor prognosis and high-level financing. Clinical manifestations of the oral cavity can occur in CKD patients with hemodialysis therapy due to a decrease in the immune system. To analyze the descriptively the clinical manifestations of oral cavity in CKD patients with hemodialysis therapy at RSUD Ulin Banjarmasin South Kalimantan, period January-March 2019. This is a descriptive analysis with a cross sectional study design, based on history and clinical examination of the oral cavity. Data was entered and analyzed using chi square test. Sampling by purposive sampling. there is a relationship between uremic odor and duration of hemodialysis (p = 0.017). There was a relationship between xerostomia and gender (p = 0.035) and there was a relationship between xerostomia and the duration of hemodialysis (p = 0.007). There is a relationship between gingival swelling and age (p = 0.010) and there is a relationship between gingival swelling and diabetes mellitus (p = 0,000). Manifestations found in the oral cavity of CKD patients with hemodialysis therapy are uremic odor, mouthache, xerostomia, mucosal lesions, candidiasis, and gingival swelling. There is a relationship between sex with xerostomia, the relationship between age with gingival swelling, the relationship between the duration of hemodialysis with uremic odor and xerostomia, the association between DM with gingival swelling. Keywords: Chronic Kidney Disease, Clinical Manifestations, Hemodialysis, Oral Cavity
Anti Inflammatory Effect Of Toman Fish (Channa micropeltes) Extract In Wound Healing Process Maharani Laillyza Apriasari; Dewi Puspitasari; Amy Nindia Carabelly
Berkala Kedokteran Vol 14, No 2 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (320.431 KB) | DOI: 10.20527/jbk.v14i2.5335

Abstract

 Abstract: One phase of wound healing is the inflammatory phase. Haruan fish extract has shown to accelerate the healing process up because it has anti-inflammatory effects. Toman fish originates from the same genus as the Haruan fish, but its anti-inflammatory effect remains unknown. It was done to analyzed anti-inflammatory effects of Toman fish extract. This study was true experimental design with posttest-only control design. Twenty-seven male mice of Balb-C strain were divided into 3 groups. Incision wound of 1 cm was made along the back of the mice. Nine mice in each group were sacrificed on 3rd days, then histopathology examination was conducted with Haematoxylin eosin. There were significant differences between treatment group given Toman fish extract and positive control group given Haruan fish extract, and also compared to the negative control group in PMN cell examination. There were significant differences between treatment group given Toman fish extract and positive control group given Haruan fish extract compared to negative controls on the number of macrophage cells. Toman fish extract could lower the number of PMN cells and was able to increase the number of macrophages on the 3rd days. Toman fish has anti-inflammatory effects on the wound healing process. Keywords: Anti-inflammatory effects, haruan fish extract, macrophages, PMN cells, toman fish extract
Acute Toxicity Test of Toman Fish Extract on Erythrocyte Number and Hemoglobin Level in Normal and Diabetic Wistar Rat Model Amy Nindia Carabelly; Beta Widya Oktiani; Nurashfia Nurashfia; Maharani Laillyza Apriasari; Dewi Puspitasari
Berkala Kedokteran Vol 19, No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i1.15703

Abstract

Abstract: Patients with diabetes mellitus (DM) may experience vascular impairment, wounds that emerged from dental practice require special attention in people who suffer from DM. Toman fish has the potential as an alternative medicine to accelerate the healing process in normal and diabetic wound. Erythrocyte and hemoglobin are two components of blood profile which can be used as the parameter to identify the effect of material toxicity. This study aims to test the acute toxicity of Toman fish extract at 16 mL/Kg BW dosage on the number of erythrocyte and the level of hemoglobin in normal and diabetic Wistar rat model after 14 days treatment. This is a true experimental study with post-test only and control group design. Samples were comprised of 21 male Wistar rats allocated to three different groups; normal rats given Toman fish extract (A), diabetic rats given Toman fish extract (B), and diabetic rats given BR2 feed only (C). The results showed that in group A, the number of erythrocytes was 8.67x106/mm3 and the level of hemoglobin was 17.30 g/dL. In group B, the number of erythrocytes was 7.39x106/mm3 and the level of hemoglobin was 16.32 g/dL. In group C, the erythrocyte number was 4.88x106/ mm3 and the hemoglobin level was 11.54 g/dL. It can be concluded that Toman fish extract at the dosage of 16 mL/Kg BW after 14 days administration is not toxic which was indicated by erythrocyte number and hemoglobin level in the blood of normal and diabetic Wistar rats models.
Co-Authors Adhiya, Geyanina Melda Agung Satria Wardhana Almadina Latanza Amy Nindia Carabelly Anita Fitriani Annisa Vara Nurdianty Aprilyani, Nur Ariska Endariantari Asphia Rahmah Astuti, Nadia Dewi Aulia Azizah Aulia Rahma Annisa Bagus Soebadi Beta Widya Oktiani Beta Widya Oktiani Cane Lukisari, Cane Debby Saputera, Debby Destri Khusnul Khotimah Dewi Nurdiana Dewi Puspitasari Dewi Puspitasari Dewi Rahayu Diah Savitri Ernawati Dita Permatasari Dita Permatasari Dwi Kurniawan, Fajar Kusuma Dwi Setyaningtyas, Dwi Eko Suhartono Eriwati, Yosi Kusuma Erni Marlina Fajriani, Nuril Firdaus, I Wayan Arya Krishnawan Fuady, Ridwan Ichshalul Hadi Waskito Hamdani, Riky Hatta, Isnur Hening Tuti Hendarti Husma, Emma Annahal I Wayan Arya K. Firdaus I Wayan Arya Khrisnawan Firdaus I Wayan Arya Krishnawan Firdaus I Wayan Arya Krisnawan Firdaus Ichrom Nahzi, Muhammad Yanuar Ika Kustiyah Oktaviyanti Khairunnisa Amalia Pratami Komarudin, Koko Krishnawan Firdaus, I Wayan Arya Kurnia Fatwati Lia Yulia Budiarti M. Jusri M. Ridhotama Wibowo Maria Tanumihardja, Maria Marina Arum Syahadati Mashud, Mustain Melisa Budipramana, Melisa Moh. Ihsan Rifasanto Monica Thiodora Limay Monita Valentine Silalahi Muhammad Ikhlasul Amal Sangadji MUHAMMAD RAYHAN Nadia Dewi Astuti Nafi’ah, Nafi’ah Nor Kamalia Novie Aprianti Novie Aprianti, Novie Nurashfia Nurashfia Nuril Fajriani Nurrahman, Tri Nurul Ikhsani Umar Pramitha, Selviana Rizky Priyawan Rachmadi Rahmadella, Afifah Renie Kumala Dewi Retno Andriati, Retno Retno Pudji Rahayu Rifasanto, Moh. Ihsan Saldy Rizky Saputra Saldy Rizky Saputra, Saldy Rizky Sari, Tiara Intan Permata Sherli Diana Silalahi, Monita Valentine Sundah, Serenada Audria Tri Putri, Deby Kania Utami, Juliyatin Putri Wenda Fitriati Noor Wenda Fitriati Noor, Wenda Fitriati Yunike Christanti Yusnida, Resha Yusrinie Wasiaturrahmah