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Journal : Science and Technology Indonesia

Surfactant Variations in Capsanthin-loaded Nanostructured Lipid Carrier: Formulation, Characterization, and Stability Study Efiana, Nuri Ari; Shofa-ulhusna, Fatihah; Paramita, Lathifah Aurora; Heavena, Indana Azza; Masyfiyah, Salsabila Fariha; Muhamed, Farahidah; Permadi, Adi; Wahyuningsih, Iis
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.335-344

Abstract

The stability of drugs and nanocarriers is a crucial factor in guaranteeing their efficacy and quality. Nanostructured lipid carriers (NLCs) as lipid-based nanocarriers provide benefits in overcoming the stability and other issues associated with the drug. Surfactants play a crucial role in imparting the desired characteristics of lipid based systems, including stability, particle size, size distribution, and zeta potential. This study aimed to develop a capsanthin-loaded NLC formulation with an optimal surfactant combination that exhibits the required properties and stability. Three formulations were prepared applying Tween 20 and Span 80 in ratios of 5:1, 2:1, and 1:1 for F1, F2, and F3, respectively. Capsanthin, as an active ingredient, originates from paprika powder. NLC properties regarding transmittance, particle size, polydispersity index (PI), zeta potential, loading capacity (LC), and loading efficiency (LE) were characterized. Furthermore, stability studies were also conducted in this research. The results showed that F1 exhibited desirable characteristics, including transmittance percentage, particle size, PI, zeta potential, LC, and LE of 87.22±2.64%, 255.4±46.88 nm, 0.54±0.13, -39.51±3.02 mV, 12.59±0.35%, and 35.40±3.07%, respectively. Moreover, the physical stability studies exhibited that F1 provided a more stable system compared to other formulations. Additionally, the chemical stability indicated that degradation occurred in the paprika powder, not in the NLC. In conclusion, NLC can protect capsanthin, as evidenced by the stable capsanthin levels in NLC compared to those in paprika powder.
Co-Authors Abdul Aziz Afwiyah, Fadhilah Agung Kurniawan Al Haq, Permata Aulia Alamsyah, Tegar Ali, Fitra Mara Andi Rifki Rosandy Aprilla, Annisa Hera Aprillia Syahputri, Arina Ardina Fitri Sugianti Arwini, Arwini Astarudin, Tatang Azhar, Sella Angelina Baswara, Ahmad Raditya Cahya Budiastuti, Pramudita Chang, Jia-Yaw Chasanah, Alfi Dewi, Kartika Tunggal Dimas, Doni Djamaluddin Perawironegoro Efiana, Nuri Ari Endah Sulistiawati Fadilah, Haqi Miftah Fatma Nuraisyah, Fatma Fausta, Ahnaf Zaki Febian, Muhammad Izzul Firdaus, Stradivary Firdaus, Stradivary Maulida Gulo, Herbert Alessandro Panias Hadi, Mulyono Halimathusyakhdyah, Halimathusyakhdyah Hapsari, Intan Tri Hasnaeni hasnaeni, Hasnaeni Hayuningtyas, Ratih Heavena, Indana Azza Hendry Pangestu Husni, Asep Iis Wahyuningsih Iqbal Ramadhan, Iqbal Irawan, Ichsanul Fikri Umar Iswahyudi Hidayat Joko Pitoyo Khairi, Amalya Nurul Khasanah, Fitri Nur Latifatunnajib, Sukma Lubnah, Ifa Lukhi Mulia Shitophyta Lupi, Ahmad Maema, Nadin Okta Mahendra, Abang Muhammad Wahyu Mariska, Novia Maryudi Maryudi Masila, Maya Laffayza Daeng Masyfiyah, Salsabila Fariha Maulana, Iqbal Taufik Ma’arif, Sandhy Aulia Mufti Khakim, Mufti Muhamed, Farahidah Muhammad Ali Akbar, Muhammad Ali Munawaroh, Annisa Luthfiana Mustaqim, Luthfi Mutiara Wilson Putri Nafi’, Zahrotun Nazzal, Sami Novitasari, Putri Rachma Nur Halimah NURUL HIDAYAH Oemardy, Zalfadhia Luthfia Paramita, Lathifah Aurora Pariz, Ananda Rizky Al Pawenang, Denta Kesdik Pranotoputera, Faris Makarim Prastiwi, Salma Maulidya Pratiwi Apridamayanti, Pratiwi Pratiwi, Margaretha Herlin Pratomo, Zaki PURWANTI PURWANTI Putri, Aninda Cahaya Putri, Mutiara Wilson Rahayu, Wahidah Mahanani Rahman, Zulfan Hanif Rahmawati, Daniar Ramadan, Deden Faldi Ramadani, Noorpani Ramadhan, M. Kaisar Sutomo Ramadhan, Muhammad Kaisar Sutomo Ramadhan, Rafli Rosyidah, Ummy Rullyansyach, Mochammad Rumaisha, Sanda Safitri, Harminah Sapsuha, Nurkhalisah Sapto Yuliani Saputri, Rully Indah Satar, Ibdal Satria, Rizky Adi Sembada, Radja Haehta Septiyani, Retnosyari Setyanto, Barry Nur Shahibul Hikam, Muhammad Athaillah Shofa-ulhusna, Fatihah Sholihah, Laila Melati Nur Sinaga, Alexander Maruli Tua Sinaga, Alexander MT Sirajuddin, Muhammad Mar’ie Siti Jamilatun Siti Nur Azizah, Siti Nur Sofiana, Nurani Sofyan Hadi Sumardani, Wahyu Bintoro Suyadi Suyitno Suyitno Syamsuddin, Arief Syaputri, Dhayu Carista Totok Eka Suharto Totok Eka Suharto Trianik Widyaningrum W, Hamizagha Nur Abid Wahyuni, Denik Putri Wantini Wardana, Mikael Dia Wibisono, Ilham Kukuh Widyasmoko, Hamizagha Nur Abid Wilson, Mutiara Winarni Winarni Wulandana, Rachmadian Wulandari, Annisa Desna Yanti, Dinda Putri Dwi Zahrul Mufrodi, Zahrul