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All Journal PROSIDING SEMINAR NASIONAL Biology, Medicine, & Natural Product Chemistry Biomedika Pharmacon Majalah Obat Tradisional Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Medfarm: Jurnal Farmasi dan Kesehatan BEMAS: Jurnal Bermasyarakat Indonesian Community Journal Abdi Geomedisains Jurnal Pengabdian Masyarakat Medika Journal of Pharmaceutical and Sciences. Usadha Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Edubiotik : Jurnal Pendidikan, Biologi dan Terapan Indonesian Journal of Global Health Research
Rima Munawaroh
Universitas Muhammadiyah Surakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PENYULUHAN TENTANG INFEKSI SIFILIS MELALUI WEBINAR “SIFILIS : PENYEBAB, GEJALA, DAN PENGOBATANNYA”: Counselling on Syphilis Infection Through Webinar "Syphilis: Causes, Symptoms and Treatment" Ramona, Flora; Munawaroh, Rima; Maharani, Annisa Rizki; Santi, Tika Melandya; Ekayanti, Septi Rismala; Amalia, Shafira Nurul
Jurnal Pengabdian Masyarakat Medika Vol 3. No. 2, September 2023
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v3i2.459

Abstract

ABSTRAK Infeksi menular seksual (IMS) merupakan masalah yang cukup serius di dunia karena jumlah morbiditas dan mortalitasnya yang terus meningkat setiap tahunnya. Berdasarkan World Health Organization (WHO), lebih dari 1 juta orang terkena Penyakit Menular Seksual (PMS) setiap hari dimana terdapat sekitar 500 juta orang terdiagnosis salah satu dari 4 PMS yaitu Klamidia, Gonore, Trikomoniasis, dan Sifilis. Faktor yang menyebabkan peningkatan angka kejadian PMS seperti pertumbuhan jumlah penduduk yang sangat tinggi, masalah sosial ekonomi, penderita yang tidak merasakan gejala, dan kurangnya pendidikan kesehatan dan pendidikan seks kepada masyarakat. Diperlukan penyuluhan tentang sifilis secara menyeluruh kepada masyarakat sebagai upaya preventif untuk mengurangi angka morbiditas dan mortalitas yang diakibatkan oleh IMS khususnya sifilis. Tujuan kegiatan webinar untuk mengetahui pengaruh penyuluhan kesehatan terhadap pengetahuan masyarakat tentang sifilis. Penelitian ini menggunakan metode one group pre test post test design. Total sampling sebanyak 75 peserta yang berasal darix berbagai instansi. Instrumen yang digunakan untuk pengambilan data adalah angket pertanyaan melalui google form dan analisis data menggunakan wilcoxon match paired test. Hasil penelitian menujukan skor rata-rata dari pre test sebesar 73,77%, sedangkan skor rata-rata post test meningkat menjadi sebesar 95,08%. Berdasarkan hasil analisis didapatkan bahwa nilai p= 0,000 < 0,05. Hasil ini menunjukan bahwa terdapat pengaruh penyuluhan kesehatan terhadap pengetahuan masyarakat tentang sifilis sehingga diharapkan masyarakat lebih peduli dengan kesehatan dirinya sendiri maupun lingkungannya tentang Infeksi Menular Seksual (IMS) khususnya sifilis.   ABSTRACT Sexually transmitted infections (STIs) are a fairly serious problem in the world because the number of morbidity and mortality continues to increase every year. Based on the World Health Organization (WHO), more than 1 million people are affected by Sexually Transmitted Diseases (STDs) every day, of which around 500 million people are diagnosed with one of 4 STDs, namely Chlamydia, Gonorrhea, Trichomoniasis, and Syphilis. Factors that cause an increase in the incidence of STDs include very high population growth, socioeconomic problems, sufferers who do not feel symptoms, and lack of health education and sex education in the community. Therefore, it is necessary to provide comprehensive education about syphilis to the community as a preventive effort to reduce morbidity and mortality rates caused by STIs, especially syphilis. The purpose of the webinar is to determine the effect of health education on public knowledge about syphilis. This study uses the one-group pre test post-test design method. The total sampling was 75 participants from various agencies. The instrument used for data collection is a question questionnaire via google form and data analysis using the Wilcoxon match paired test. The results showed that the average score of the pre-test was 73.77%, while the average post-test score increased to 95.08%. Based on the results of the analysis, it was found that the value of p = 0.000 <0.05. These results indicate that there is an effect of health education on public knowledge about syphilis so that people are expected to be more concerned with their own health and their environment about Sexually Transmitted Infections (STIs), especially syphilis
PERAN FARMASIS SEBAGAI KONSELOR TERAPI HIV Munawaroh, Rima; Prakoeswa, Flora Ramona Sigit; Kurniawati, Pipit Melyana; Hazimah, Jihan Naufa; Husna, Az zahra Miftahul; Kharisma, Annisa Nur; Rahmawati, Dita
Jurnal Pengabdian Masyarakat Medika Vol 2. No. 1, Maret 2022
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (588.302 KB) | DOI: 10.23917/jpmmedika.v2i1.461

Abstract

ABSTRAK Peran farmasis dalam terapi HIV bukan hanya sekedar drug supplier melainkan juga sebagai konselor. Hal ini didasarkan pada kurangnya tingkat kepatuhan pasien menjalani terapi antiretroviral (ARV) sehingga banyak yang mengalami resistensi obat. Upaya farmasis sebagai konselor ini dilakukan dalam upaya mencapai keberhasilan terapi HIV dan menyadarkan pentingnya peran farmasis sebagai konselor dalam terapi HIV mulai dari tingkat remaja hingga dewasa. Tujuan program ini adalah meningkatkan pengetahuan dan pemahaman masyarakat mengenai pentingnya peran farmasis dalam terapi HIV sebagai konselor utama. Metode pelaksanaan dengan dilaksanakan secara online zoom meeting. Agenda kegiatan berupa penyampaian materi beserta tanya jawab disertai dengan pretest dan posttest. Peserta mendaftarkan diri melalui link pendaftaran online. Sebelum penyampaian materi setiap peserta diberikan pre-test dan diakhir kembali diberikan post-test. Hasil dianalisis dengan uji paired sample t test. Dari 72 peserta yang hadir, nilai rata-rata pre-test adalah 81,40 dan post-test 96,49. Hasil uji-t didapatkan nilai p< 0,05 yang menunjukkan perbedaan yang signifikan antara hasil pre-test sebelum webinar dan hasil post-test setelah webinar. Hal ini berarti terdapat peningkatan pengetahuan peserta webinar mengenai peran farmasis sebagai konselor terapi HIV.   ABSTRACT In HIV therapy, pharmacists is not only as a drug supplier but also as a counselor. This is based on the lack of adherence of patients undergoing antiretroviral therapy (ARV) so that many experience drug resistance. The pharmacist's efforts as counselors are carried out in an effort to achieve the success of HIV therapy. The aim of this program is to increase public knowledge and understanding of the important role of pharmacists in HIV therapy as primary counselors. This activity was held online by zoom meeting, including material delivery, discussion session, and pretest and posttest session. Participants register themselves via the online registration link. Before delivering the material, each participant was given a pre-test and at the end was given a post-test. The results were analyzed by paired sample t test. From the 72 participants who attended, the mean score of the pre-test was 81.40 and the post-test was 96.49. The results of the t-test obtained p value <0.05 which indicates a significant difference between the results of the pre-test before the webinar and the results of the post-test after the webinar. This means that there is an increase in the knowledge of webinar participants regarding the role of pharmacists as HIV therapy counselors
Edukasi Pencegahan Diabetes dan Pemanfaatan Bahan Alam sebagai Antidiabetes bagi Masyarakat Pengunjung Car Free Day Colomadu, Karanganyar Sujono, Tanti Azizah; Kusumowati, Ika Trisharyanti Dian; Munawaroh, Rima; Utami, Wahyu; Sari, Asti Arum; Nurwaini, Setyo; Isnaniyah, Dhevi Zahra Latifatul; Anindya, Talitha Ahnaf; Firdaus, Farhand Ahmad; Harindasari, Amorita Azzah; Balqis, Moetia Rahman; Anjati, Yasinta Widia
Abdi Geomedisains Vol. 6, No. 1, June 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/abdigeomedisains.v6i1.10545

Abstract

Diabetes mellitus (DM) is a chronic (non-communicable) disease whose prevalence is currently increasing. Public awareness of the importance of early detection and prevention of diabetes is still relatively low, because this disease is sometimes asymptomatic. Various efforts to prevent and treat DM continue to be developed, including through public education. This activity aims to increase public knowledge about diabetes and the use of natural ingredients as antidiabetics. Car-free day Colomadu was chosen as a strategic location to reach the community by providing accessible health education. This activity is a collaboration between the UMS Faculty of Pharmacy and the Aisyiyah Colomadu Branch Management. The method used is to detect diabetes through blood sugar level checks and education about diabetes, which is done by providing leaflets. The level of knowledge is measured by comparing the pretest and posttest. A total of 19 respondents met the inclusion criteria: visitors to the Colomadu car-free day, had had a blood sugar level check, were willing to fill out a questionnaire, and had a history of education/work not in the health sector. Based on the results of statistical tests, there was a significant increase in knowledge about diabetes (p<0.001) with a pretest value (72.11) in the sufficient category and a posttest value (78.95) in the good category. Based on this, education using this leaflet can increase public knowledge about diabetes. Still, it is recommended that other educational methods, such as counseling accompanied by questions and answers, be used to optimize the results.
Peningkatan Pemasaran Produk pada Kelompok Wanita Tani Sri Rejeki di Desa Cabeyan Sukoharjo Nugraheni, Ambar Yunita; Purbasari, Heppy; Utami, Wahyu; Cholisoh, Zakky; Nurwaini, Setyo; Kusumowati, Ika Trisharyanti Dian; Wikantyasning, Erindyah Retno; Munawaroh, Rima; Hanwar, Dedi; Larasati, Arindra; Ramdani, Tasya Eka
Abdi Geomedisains Vol. 6, No. 1, June 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/abdigeomedisains.v6i1.10989

Abstract

Kelompok Wanita Tani (KWT) Sri Rejeki in Cabeyan Village, Sukoharjo, is a community of women actively engaged in plant cultivation and the production of instant herbal products such as ginger and temulawak (curcuma). However, their product marketing activities are still limited to conventional methods and have not yet reached digital marketing platforms. This community service activity aimed to enhance the knowledge and skills of KWT members in digital product marketing through educational sessions and practical training. The methods used included interactive lectures, group discussions, and hands-on practice related to the use of social media and e-commerce platforms. The educational materials covered product marketing and basic understanding of Break Even Point (BEP) calculation. A total of 18 active KWT members and 5 teenagers participated in this activity. The participants' knowledge test results before (pre-test) and after (post-test) the educational session showed an increase in the average knowledge level, from the fair category (63.77%) to the good category (97.10%). KWT members began to understand the importance of market segmentation, slogan development, and the use of digital platforms such as WhatsApp Business, Instagram, and Shopee. This activity demonstrated that participatory training could equip participants with practical skills to improve their product marketing strategies. It is recommended that an internal marketing team be formed and continuous mentoring provided to optimize digital marketing efforts and product legality aspects such as PIRT (Home Industry Food Permit) and halal certification.
Active Antibacterial Fraction from Ethanolic Extract of Johar Leaves (Cassia siamea Lam.) against Staphylococcus epidermidis and Its Bioautography Munawaroh, Rima; Khoirunnisa, Khoirunnisa
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 2 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i2.23298

Abstract

Johar leaves (Cassia siamea Lam.) have been traditionally used to treat pruritus due to their antibacterial properties. This study aims to identify the active fraction of an ethanolic extract of Johar leaves against Staphylococcus epidermidis, as well as the active chemical class. The extraction process involved maceration with 96% ethanol. The liquid-liquid extraction method was used to separate the n-hexane, ethyl acetate, and water fractions. The resulting extract and fraction were assessed for antibacterial activity using the well diffusion method. Sample loadings of 4 mg, 2 mg and 1 mg per well were used, with DMSO as a negative control and 6 mg chloramphenicol as a positive control. The test results indicate that the ethyl acetate fraction is more effective than the extract. Specifically, the fraction produced an inhibition zone of 13.5 ± 0.5 mm at a loading of 4 mg/well, while the extract only produced an inhibition zone of 9.3 ± 1.2 mm at the same loading. Additionally, there was a significant difference in the diameter of the inhibitory zone between treatment groups at p 0.05. The TLC results indicate that the ethyl acetate fraction of Johar leaves contains alkaloid, phenolic, flavonoid, and steroid compounds when using silica gel 60 F254 stationary phase and chloroform:ethyl acetate:ethanol (7:2:1 v/v/v) mobile phase. Bioautography results showed that the phenolic and alkaloid compounds at Rf 0.22 and phenolic compound at Rf 0.42 are responsible for the antibacterial activity against Staphylococcus epidermidis.
AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum) DAN PERASAN JERUK NIPIS (Citrus aurantifolia) TERHADAP BAKTERI Escherichia coli dan Shigella flexneri Febriani, Rizkina Elistya; Munawaroh, Rima
Usadha Journal of Pharmacy Vol. 1 No. 4 (2022): November
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v1i4.134

Abstract

Infeksi termasuk dalam masalah kesehatan yang umum di negara maju ataupun negara berkembang seperti di Indonesia karena jumlah penyakit dan kematian yang relatif tinggi. Bakteri merupakan penyebab utama infeksi, bakteri dibedakan menjadi bakteri gram positif dan gram negatif, salah satu bakteri gram negatif yaitu bakteri Escherichia coli dan Shigella flexneri. Daun sirih merah dan jeruk nipis diketahui memiliki aktivitas antibakteri. Penelitian ini bertujuan untuk melihat potensi kombinasi kedua ekstrak tanaman tersebut sebagai agen antibakteri pada bakteri Escherichia coli dan Shigella flexneri. Daun sirih merah diekstraksi secara maserasi menggunakan etanol 96% sedangkan buah jeruk nipis diperas dan diuji aktivitas antibakterinya terhadap bakteri Escherichia coli dan Shigella flexneri dengan loading ekstrak 10, 5, 2,5, dan 1,25 mg/disk. Antibiotik ciprofloxacin digunakan sebagai kontrol positif dan DMSO 100% digunakan sebagai kontrol negatif. Ekstrak daun sirih merah dan perasan jeruk nipis dapat menghambat kedua bakteri tersebut. Kombinasi ekstrak daun sirih merah dan ekstrak perasan jeruk nipis dengan perbandingan konsentrasi 5: 1,25, 2,5:2,5, dan 1,25:5 mg/disk menghasilkan diameter zona hambat terhadap bakteri Escherichia coli dan Shigella flexneri lebih kecil dibandingkan dengan penambahan uji ekstrak tunggal. Hasil KLT Bioautografi menunjukkan senyawa aktif dalam sirih merah adalah flavonoid dan flavonol sedangkan yang dari jeruk nipis adalah flavonoid dan flavonol.
AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN DAN BATANG KEMANGI (Ocimum basilicum) SERTA FRAKSI AKTIFNYA TERHADAP Staphylococcus epidermidis Utari, Berlian; Munawaroh, Rima
Usadha Journal of Pharmacy Vol. 2 No. 1 (2023): Februari
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v2i1.141

Abstract

Jerawat merupakan penyakit kulit yang secara keseluruhan banyak dijumpai di usia remaja dan dewasa muda dan memiliki kejadian dengan perkiraan 75% pada remaja di dunia dan hampir 80% dari semua kalangan pernah menderita penyakit ini. Beberapa penyebab jerawat yaitu peningkatan produksi sebum dan inflamasi akibat Staphylococcus epidermidis. Penyakit ini dapat diatasi salah satunya menggunakan kemangi karena penelitian sebelumnya menemukan ekstrak etanol 96% herba kemangi mengandung senyawa alkaloid, flavonoid, polifenol/tannin, saponin dan steroid/triterpenoid. Penelitian ini bertujuan membandingkan aktivitas antibakteri ekstrak dan fraksi dari daun dan batang kemangi (Ocimum basilicum) terhadap Staphylococcus epidermidis. Daun dan batang kemangi diekstraksi secara maserasi menggunakan etanol 96%, ekstrak yang aktif antibakterinya kemudian difraksinasi menggunakan metode partisi cair-cair menjadi fraksi n-heksan, etil asetat dan air. Metode uji aktivitas antibakteri yang digunakan pada penelitian ini yaitu metode difusi sumuran dan KLT-bioautografi. Hasil berdasarkan penelitian ini yaitu ekstrak daun kemangi memiliki diameter zona hambat sebesar 18,67 ± 0,29 mm pada loading ekstrak 25 mg/sumuran dan 17,83 ± 0,29 mm pada loading ekstrak 12,5 mg/sumuran sedangkan ekstrak batang kemangi tidak memiliki aktivitas antibakteri. Fraksi air merupakan fraksi aktif dari ekstrak etanol daun kemangi dengan diameter zona hambat 17 ± 0,5 mm pada loading fraksi 25 mg/sumuran. Hasil KLT-bioautografi dari fraksi air ekstrak etanol 96% daun kemangi yaitu terdapat zona hambat pada semua hasil elusi fraksi pada kromatogram meliputi Rf 0,14; 0,16; 0,2; 0,26; 0,3 dan 0,4 yang pada analisis KLT menunjukkan kandungan senyawa flavonoid, tannin, alkaloid, saponin.
AKTIVITAS ANTIBAKTERI DAN BIOAUTOGRAFI EKSTRAK ETANOL DAUN MAYANA JANTAN (Coleus atropurpureus Benth.) TERHADAP Pseudomonas aeruginosa DAN Klebsiella pneumoniae Azzahra, Shafanisa Alivia; Mardiyaningsih, Ana; Munawaroh, Rima
Usadha Journal of Pharmacy Vol. 3 No. 1 (2024): Februari
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v3i1.309

Abstract

Infeksi merupakan masalah yang sulit diatasi oleh masyarakat, contoh bakteri yang dapat menginfeksi yaitu Pseudomonas aeruginosa dan Klebsiella pneumoniae. Selain pengobatan infeksi dengan antibiotik, sediaan herbal dapat menjadi alternatif pengobatan. Daun mayana jantan (Coleus atropurpureus) oleh masyarakat Halmahera Barat dimanfaatkan untuk meredakan nyeri, menyembuhkan bisul, batuk, luka, dan meningkatkan nafsu makan. Tujuan dari penelitian ini adalah untuk menguji aktivitas antibakteri ekstrak etanol 96% daun mayana jantan terhadap bakteri Pseudomonas aeruginosa dan Klebsiella pneumoniae, serta untuk mengetahui senyawa aktif yang menyebabkan aktivitas antibakteri. Dilakukan uji identifikasi bakteri dengan pengecatan Gram dan metode biokimia, serta uji sensitivitas bakteri dengan metode difusi cakram. Pengujian aktivitas antibakteri dilakukan dengan metode difusi sumuran. Uji statistik dengan Kruskal-Wallis dan Mann-Whitney, menunjukkan pada loading ekstrak 20 mg/sumuran memberikan aktivitas antibakteri terbesar untuk Pseudomonas aeruginosa dan Klebsiella pneumoniae dengan zona hambat masing-masing sebesar 12,2±0,3 mm dan 11,3±0,3 mm. Identifikasi senyawa  menggunakan metode KLT dengan fase diam silika gel 60 F254 dan fase gerak n-heksan:etil asetat (7:3 v/v), hasil uji menunjukkan ekstrak daun mayana jantan positif mengandung terpenoid, fenolik, flavonoid, dan triterpenoid. Senyawa aktif yang berperan sebagai antibakteri terhadap Pseudomonas aeruginosa adalah fenolik (Rf = 0,24) dan triterpenoid (Rf = 0,68) berdasarkan uji bioautografi dengan metode kontak sedangkan senyawa yang berpotensi sebagai antibakteri terhadap Klebsiella pneumoniae belum dapat ditentukan.
Development of primers amplifying DNA barcoding genes matK and rbcL of Legundi (Vitex trifolia) Hartanto, Nadhifah Riski; Sari , Banuwati Kartika; Rahayu, Triasuti; Munawaroh , Rima; Fawwaz , Muammar; Purwono , Bambang; Zulperi, Dzarifah; Prayitno, Trio Ageng; Sidiq, Yasir
Edubiotik : Jurnal Pendidikan, Biologi dan Terapan Vol. 10 No. 02 (2025): Edubiotik : Jurnal Pendidikan, Biologi dan Terapan
Publisher : Biology Education Department, Universitas Insan Budi Utomo, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33503/ebio.v10i02.1497

Abstract

Legundi (Vitex trifolia) is one of the crucial ethno-pharmacological plants. However, the genetic exploration of these plants in Indonesia remains limited. Moreover, a set of primers can be an initial important step to explore the genetics of V. trifolia as well as to molecularly identify the species of Legundi. This study aimed to develop the two pairs of primers of maturase-K (matK) and ribulose bisphosphate carboxylase large subunit (rbcL) genes. This type of research is exploratory research using a quantitative approach. The research sampling are the leaves of the V. trifolia species, which were collected from Makassar, Indonesia, and the purposive sampling method. The data were obtained through DNA barcoding, and the data were analyzed using bioinformatics analysis. This study found two pairs of developed primers, matK and rbcL, successfully amplified both matK and rbcL target genes of V. trifolia. The newly developed species-specific primers successfully amplified the matK and rbcL genes of V. trifolia, and sequence analysis revealed high similarity values in BLAST and BOLD databases ranging from 99.2 to 100%, with PCR amplification of the matK marker showing particularly high DNA concentration and specificity for species-level identification. This study supports the genetic exploration and identification of useful ethno-pharmacy plants, V. trifolia. The conclusion of the study shows that two primer pairs of maturase-K (matK) and ribulose bisphosphate carboxylase large subunit (rbcL) genes have been developed from V. trifolia plants. This study supports the genetic exploration and identification of ethnopharmaceutical plants of V. trifolia and the role of bioinformatics tools in molecular studies of medicinal plants.
In vitro Study of the Antibiofilm Potential of Bay Leaf Extract (Syzygium polyanthum (Wight) Walp) against Streptococcus sanguinis and Streptococcus mutans Listiana Masyita Dewi; Azka Tarisa Atmaja; Muhammad Marcelliano Rifky Aditomo Putra; Devi Usdiana Rosyidah; Nurhayani Nurhayani; Rima Munawaroh
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.1145-1152

Abstract

The ability to form biofilms is one of the characteristics of microbes that has the potential to cause antimicrobial resistance. The oral cavity environment, which is frequently exposed to external environments and has a specific histological structure, can lead to the accumulation of EPS, thereby increasing the risk of biofilm formation. Streptococcus is one of the bacterial groups known to have the ability to produce biofilms. Bay leaves (Syzygium polyanthum (Wight) Walp), a member of the Syzygium genus that has been widely used in treating infectious diseases, both traditionally and medically, due to their eugenol content, are suspected to have antibiofilm activity. This study aimed to prove the antibacterial and antibiofilm effects of ethanol extract of bay leaves against Streptococcus sanguinis and Streptococcus mutans bacteria. This study used a post-test only controlled group design, with a microtiter plate assay technique, and determination of MIC50 and MBIC50 through a probit test. The bacterial test results showed that the MIC50 values for Streptococcus sanguinis and Streptococcus mutans were 37.57% and 9.65%, respectively, while the MBIC50 values were 6.41% and 29.98%, respectively. The coefficient of determination (R2) values for both test bacteria, in both the antibacterial and antibiofilm tests, were close to 1. Thus, it can be concluded that bay leaf extract is effective as an antibacterial and antibiofilm agent against Streptococcus sanguinis and Streptococcus mutans bacteria, with a stronger antibiofilm effect than its antibacterial effect.
Co-Authors Agviolisa Kusuma Wardhani Ahwan Ahwan Amalia, Shafira Nurul Amanda Wahyu Kurniawan Ambar Yunita Nugraheni Ana Mardiyaningsih Ana Mardiyaningsih Anindya, Talitha Ahnaf Anjati, Yasinta Widia Arifah Sri Wahyuni Asti Arum Sari Audi Tahta Aurellia Azka Tarisa Atmaja Azzahra, Shafanisa Alivia Balqis, Moetia Rahman Berlian Utari Brainandiva Ade Fitria Cahya Rahma Utami Chatarina Umbul Wahyuni Dedi Hanwar Devi Usdiana Rosyidah Ekayanti, Septi Rismala Em Sutrisna Endang Nur Widiyaningsih Endang Setyaningsih Erindyah Retno Wikantyasning Erna Prawita Setyowati Fauziah, Isnaeni Nur Febriani, Rizkina Elistya Firdaus, Farhand Ahmad Flora Ramona Sigit Prakoeswa Harindasari, Amorita Azzah Hartanto, Nadhifah Riski Hazimah, Jihan Naufa Heppy Purbasari Husna, Az zahra Miftahul Ika Trisharyanti Dian Kusumowati Isnaniyah, Dhevi Zahra Latifatul Kharisma, Annisa Nur Khoirunnisa Khoirunnisa Kumalaningtyas, Martdwitanti Ajeng Kurniawati, Pipit Melyana Larasati, Arindra Listiana Masyita Dewi Luluk Ria Rakhma Maharani, Annisa Rizki Maureen, Raden Roro Nadya Muammar Fawwaz Muhammad Ikhsan Al Af Ghani Muhammad Marcelliano Rifky Aditomo Putra Muhammad Nurul Fadel Muhtadi Muhtadi N Nurhayani Nur ‘Azah Peni Indrayudha Purwono , Bambang Rahayu, Triasuti Rahmawati, Dita Ramdani, Tasya Eka Refsya Azanti Putri Retno Murwanti Rizkina Elistya Febriani Sania Nayasari Khoirunnisa Santi, Tika Melandya Sari , Banuwati Kartika Setyo Nurwaini Shafanisa Alivia Azzahra Shafira Arifah Maharani Sheila Nur Izzati Siswadi Siswadi Suprapto Suprapto . Suprapto . Tanti Azizah Sujono Tri Oktarina Triana Hertiani Trio Ageng Prayitno Utari, Berlian Wahyu Utami Yasir Sidiq Yuka Aulia Rahma Zakky Cholisoh Zulperi, Dzarifah