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All Journal International Journal of Public Health Science (IJPHS) Farmaka Indonesian Journal of Applied Sciences Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia JURNAL PHARMASCIENCE Indonesian Journal of Science and Technology Pharmascience The Indonesian Biomedical Journal Chimica et Natura Acta Pharmacology and Clinical Pharmacy Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) FITOFARMAKA: Jurnal Ilmiah Farmasi JFIOnline Current Research on Biosciences and Biotechnology Indonesian Journal of Biological Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis Medical Sains : Jurnal Ilmiah Kefarmasian
Ajeng Diantini, Ajeng
Fakultas Farmasi Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Current Research on Biosciences and Biotechnology

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ERCC2 rs13181 and ERCC1 rs11615 polymorphisms in non-small cell lung cancer patients in West Java: towards personalized medicine approaches Afifah, Nadiya Nurul; Effendi, M. Fariz; Diantini, Ajeng; Barliana, Melisa Intan; Intania, Ruri
Current Research on Biosciences and Biotechnology Vol. 6 No. 2 (2025)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2025.6.2/3DCBQ451

Abstract

Non-Small Cell Lung Cancer (NSCLC) is a disease with a high incidence rate, low survival due to late diagnosis and treatment delays, and varying effectiveness of platinum-based chemotherapy. Individual responses to platinum-based chemotherapy are influenced by genetic polymorphisms in genes affecting pharmacokinetic and pharmacodynamic mechanisms. This study focuses on identifying polymorphisms in the ERCC2 and ERCC1 genes, which play a role in platinum pharmacodynamics, and their effects on chemotherapy response. The study involved 23 NSCLC patients conducted at Dr. H.A. Rotinsulu Lung Hospital in Bandung. Polymorphism data were obtained through genotype analysis using sequencing methods from prospective whole blood samples of patients, while chemotherapy effectiveness was assessed by evaluating chemotherapy response using the RECIST 1.1 method, and radiological response prediction and prognostic factors were determined through CYFRA 21-1 levels. The results showed an OR of 0.964 (95% CI: 0.160 - 5.795) for ERCC2 rs13181 CC + AC vs. AA against chemotherapy response evaluation by RECIST 1.1, and 0.722 (95% CI: 0.062 - 8.464) against CYFRA 21-1 values. Meanwhile, for ERCC1 rs11615, an OR of 0.268 (95% CI: 0.046 - 1.548) CT + TT vs. CC for RECIST 1.1 and 0.3 (95% CI: 0.026 - 3.427) for CYFRA 21-1 values were obtained. In clinical interpretation, it is known that variant alleles at rs13181 and rs11615 have potential for better chemotherapy response although not statistically significant (p>0.05), these results can be considered when assessing patient response to chemotherapy within six cycles. This study provides initial data and forms the basis for future comprehensive cohort observational research.
Co-Authors Adit Taufik Aditya Seiza Wibisono Adryan Fristiohady Agung W.M. Yodha Ahmad Faried ALAMANDA - PUSPITA ALIA RESTI AZURA ALMIRA TSANIYA GITA Amalia, Riezki Anas Subarnas Andini Sundowo Angga Geganaputra Anggraeni, Sra R. Angliana Chouw Anjabtsawa, Daffa Asti Y. Rindarwati Bayu W. Putera Bryan J. Siagian Budhi Prihartanto Cynthia R. Sartika Cynthia R. Sartika Destiani, Dika P. Dika P. Destiani Dika P. Destiani Dina Mulyana Syafitri Dwi A. P. Dewi Dyah Pradnyaparmita Duarsa Effendi, M. Fariz Euis Julaeha Euis Julaeha Euis Julaeha Fattah, Miswar Fauzia Azzahra, Fauzia Febrianti, Raden M. Febriyanti, Maya Felia Rizka Sudrajat Fitri N. Ramadhani Fransiska Silalahi Hadad, Nur Diana HANIFAH, SYIFA I Sahidin I. Sahidin Ibrahim, Susannia Ida Musfiroh Ida Musfiroh -, Ida Musfiroh Intania, Ruri Irma M. Puspitasari Irma M. Puspitasari Irma M. Puspitasari, Irma M. Julia Riswandani Jutti Levita Keri Lestari Komang Suma Triyasa Listiani, Nita Maya Febriyanti Mega Juliana Melisa I. Barliana Melisa Intan Barliana Miftakh Nur Rahman Mirdayani, Eli Miswar Fattah Miswar Fattah Moelyono Moektiwardoyo Moelyono Moektiwardoyo, Moelyono Moelyono, M W Moelyono, M W Mohammad Ghozali Muchtaridi Muchtaridi Muhammad F. Effendi Muhammad Ilyas Y Mutakin Mutakin Nadiya N. Afifah Nadiya Nurul Afifah NADYA NURUL ZAMAN Ni Nyoman Sri Budayanti Nur Rahayuningsih, Nur Pande Putu Januraga Putri, Norisca A. Putri, Norisca A. Putri, Refitha Nurul Putu Dian Putu Dian, Putu Raden Maya Febrianti Raden Maya Febriyanti Rahmayanti, Annisa N. Rano K. Sinuraya Riezki Amalia Rindarwati, Asti Y. Rini Daud Supu Riza Yulisar Rizky Abdulah Rochjana, Anna Uswatun Hasanah Rudi Supriyadi Ruri Intania Sahidin Sahidin Sahidin, Idin Shelly Iskandar Shinta Marpaung Siagian, Bryan J. Sinuraya, Rano K. Sinuraya, Rano K. Sitepu, Rini Daud Sofa D. Alfian Sofa D. Alfian, Sofa D. Sofa Fajriah Sra R. Anggraeni Sri Adi Sumiwi Susannia Ibrahim Suwantika, Auliya A. Taofik Rusdiana Tati Herlina Tati Herlina Taufik, Adit Tono Djuwantono Tri Mayanti Tri Mayanti W. Wahyuni Wa Ode Nurfinti Wahyuni Wahyuni Wibisono, Aditya Seiza Widowati, I Gusti Ayu Rai - Yanni Dirgantara Yasmiwar Susilawati Yoppi Iskandar Yulisar, Riza Yuni Elsa Hadisaputri