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All Journal International Journal of Public Health Science (IJPHS) Farmaka Indonesian Journal of Applied Sciences Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia JURNAL PHARMASCIENCE Indonesian Journal of Science and Technology Pharmascience The Indonesian Biomedical Journal Chimica et Natura Acta Pharmacology and Clinical Pharmacy Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) FITOFARMAKA: Jurnal Ilmiah Farmasi JFIOnline Current Research on Biosciences and Biotechnology Indonesian Journal of Biological Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis Medical Sains : Jurnal Ilmiah Kefarmasian
Ajeng Diantini, Ajeng
Fakultas Farmasi Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Indonesian Journal of Science and Technology

 1 
In-Vitro Anticancer Activity of Chemical Constituents from Etlingera alba Poulsen against Triple Negative Breast Cancer and in silico Approaches towards Matrix metalloproteinase-1 Inhibition W. Wahyuni; Ajeng Diantini; Mohammad Ghozali; Anas Subarnas; Euis Julaeha; Riezki Amalia; Adryan Fristiohady; Andini Sundowo; Sofa Fajriah; Yuni Elsa Hadisaputri; Raden Maya Febrianti; Fauzia Azzahra; Agung W.M. Yodha; I. Sahidin
Indonesian Journal of Science and Technology Vol 7, No 2 (2022): IJOST: VOLUME 7, ISSUE 2, September 2022
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/ijost.v7i2.50547

Abstract

Etlingera alba (EA) is one of the endemic plants grown in Sulawesi. We determined the cytotoxic and anti-metastatic activity of isolates obtained from EA rhizome extract. IC50 value for 1,7-diphenyl-6-heptene-3-one, sitostenone, sinapyl alcohol diacetate, and sinapyl alcohol acetate were 134.59; 170 ; 128.11; and 161.96 μg/mL, respectively. The compounds also had anti-migration activity. 200-μg/mL Sitostenon exhibited the lowest migration rate (3.32%). The free bond energies of sitostenon, 1,7-diphenyl-6-heptene-3-one, sinapyl alcohol acetate, and sinapyl alcohol diacetate were -11.81; -8.25; -6.64; and -6.28 kcal/mol, respectively. All compounds were more effective in stabilizing the Matrix metalloproteinase 1 complex. Isolation from EA rhizomes have the potential to be developed as anti-metastatic for Triple-Negative Breast Cancer.
Co-Authors Adit Taufik Aditya Seiza Wibisono Adryan Fristiohady Agung W.M. Yodha Ahmad Faried ALAMANDA - PUSPITA ALIA RESTI AZURA ALMIRA TSANIYA GITA Amalia, Riezki Anas Subarnas Andini Sundowo Angga Geganaputra Anggraeni, Sra R. Angliana Chouw Anjabtsawa, Daffa Asti Y. Rindarwati Bayu W. Putera Bryan J. Siagian Budhi Prihartanto Cynthia R. Sartika Cynthia R. Sartika Destiani, Dika P. Dika P. Destiani Dika P. Destiani Dina Mulyana Syafitri Dwi A. P. Dewi Dyah Pradnyaparmita Duarsa Effendi, M. Fariz Euis Julaeha Euis Julaeha Euis Julaeha Fattah, Miswar Fauzia Azzahra, Fauzia Febrianti, Raden M. Febriyanti, Maya Felia Rizka Sudrajat Fitri N. Ramadhani Fransiska Silalahi Hadad, Nur Diana HANIFAH, SYIFA I Sahidin I. Sahidin Ibrahim, Susannia Ida Musfiroh Ida Musfiroh, Ida Intania, Ruri Irma M. Puspitasari Irma M. Puspitasari Irma M. Puspitasari, Irma M. Julia Riswandani Jutti Levita Keri Lestari Komang Suma Triyasa Listiani, Nita Maya Febriyanti Mega Juliana Melisa I. Barliana Melisa Intan Barliana Miftakh Nur Rahman Mirdayani, Eli Miswar Fattah Miswar Fattah Moelyono Moektiwardoyo Moelyono Moektiwardoyo, Moelyono Moelyono, M W Moelyono, M W Mohammad Ghozali Muchtaridi Muchtaridi Muhammad F. Effendi Muhammad Ilyas Y Mutakin Mutakin Nadiya N. Afifah Nadiya Nurul Afifah NADYA NURUL ZAMAN Ni Nyoman Sri Budayanti Nur Rahayuningsih, Nur Pande Putu Januraga Putri, Norisca A. Putri, Norisca A. Putri, Refitha Nurul Putu Dian Putu Dian, Putu Raden Maya Febrianti Raden Maya Febriyanti Rahmayanti, Annisa N. Rano K. Sinuraya Riezki Amalia Rindarwati, Asti Y. Rini Daud Supu Riza Yulisar Rizky Abdulah Rochjana, Anna Uswatun Hasanah Rudi Supriyadi Ruri Intania Sahidin Sahidin Sahidin, Idin Shelly Iskandar Shinta Marpaung Siagian, Bryan J. Sinuraya, Rano K. Sinuraya, Rano K. Sitepu, Rini Daud Sofa D. Alfian Sofa D. Alfian, Sofa D. Sofa Fajriah Sra R. Anggraeni Sri Adi Sumiwi Susannia Ibrahim Suwantika, Auliya A. Taofik Rusdiana Tati Herlina Tati Herlina Taufik, Adit Tono Djuwantono Tri Mayanti Tri Mayanti W. Wahyuni Wa Ode Nurfinti Wahyuni Wahyuni Wibisono, Aditya Seiza Widowati, I Gusti Ayu Rai - Yanni Dirgantara Yasmiwar Susilawati Yoppi Iskandar Yulisar, Riza Yuni Elsa Hadisaputri