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All Journal International Journal of Public Health Science (IJPHS) Farmaka Indonesian Journal of Applied Sciences Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia JURNAL PHARMASCIENCE Indonesian Journal of Science and Technology Pharmascience The Indonesian Biomedical Journal Chimica et Natura Acta Pharmacology and Clinical Pharmacy Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) FITOFARMAKA: Jurnal Ilmiah Farmasi JFIOnline Current Research on Biosciences and Biotechnology Indonesian Journal of Biological Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis Medical Sains : Jurnal Ilmiah Kefarmasian
Ajeng Diantini, Ajeng
Fakultas Farmasi Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : The Indonesian Biomedical Journal

 1 
Nutritional Biomarkers for Predicting Pancreatic Beta Cell Failure in Central Obesity Miftakh Nur Rahman; Ajeng Diantini; Miswar Fattah; Melisa Intan Barliana
The Indonesian Biomedical Journal Vol 13, No 1 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i1.1440

Abstract

BACKGROUND: There is a continuous rise in the prevalence of central obesity and become a pressing health problem in the world. Central obesity followed by many metabolic disorders especially Type 2 Diabetes Mellitus (T2DM). The pathogenesis started from overnutrition signal that force pancreatic beta cells to produce a large number of insulin. Low-grade chronic inflammation that occurred also affects the organs sensitivity against insulin and caused beta cells to compensated this situation and at the end become exhausted and loss its function.CONTENT: Along compensation mechanism, certain nutrients were support the beta cells to maintain their mass and function to produce insulin. Short chain fatty acids (SCFAs) are gut microbiota fermentation product that act as nutrient and give an advantage to the proliferation and survivability of the beta cells. Zinc (Zn) also plays an important role in every step of insulin production. Moreover, these nutrients protecting pancreas against inflammation and oxidative stress through certain mechanism. Most of patients with central obesity are unaware of the presence of this disturbance at early stage. Whereas, at molecular level there is a magnitude of SCFAs and Zn level in the blood that would become an early signal and predict the damage of beta cells.SUMMARY: Quantification of these two nutrients in the blood expected to provide an early warning tool to maintain insulin adequacy and predict the possibility of beta cell failure in central obesity with promising performance.KEYWORDS: central obesity, T2DM, SCFAs, Zinc, beta cell failure 
Co-Authors Adit Taufik Aditya Seiza Wibisono Adryan Fristiohady Agung W.M. Yodha Ahmad Faried ALAMANDA - PUSPITA ALIA RESTI AZURA ALMIRA TSANIYA GITA Amalia, Riezki Anas Subarnas Andini Sundowo Angga Geganaputra Anggraeni, Sra R. Angliana Chouw Anjabtsawa, Daffa Asti Y. Rindarwati Bayu W. Putera Bryan J. Siagian Budhi Prihartanto Cynthia R. Sartika Cynthia R. Sartika Destiani, Dika P. Dika P. Destiani Dika P. Destiani Dina Mulyana Syafitri Dwi A. P. Dewi Dyah Pradnyaparmita Duarsa Effendi, M. Fariz Euis Julaeha Euis Julaeha Euis Julaeha Fattah, Miswar Fauzia Azzahra, Fauzia Febrianti, Raden M. Febriyanti, Maya Felia Rizka Sudrajat Fitri N. Ramadhani Fransiska Silalahi Hadad, Nur Diana HANIFAH, SYIFA I Sahidin I. Sahidin Ibrahim, Susannia Ida Musfiroh Ida Musfiroh -, Ida Musfiroh Intania, Ruri Irma M. Puspitasari Irma M. Puspitasari Irma M. Puspitasari, Irma M. Julia Riswandani Jutti Levita Keri Lestari Komang Suma Triyasa Listiani, Nita Maya Febriyanti Mega Juliana Melisa I. Barliana Melisa Intan Barliana Miftakh Nur Rahman Mirdayani, Eli Miswar Fattah Miswar Fattah Moelyono Moektiwardoyo Moelyono Moektiwardoyo, Moelyono Moelyono, M W Moelyono, M W Mohammad Ghozali Muchtaridi Muchtaridi Muhammad F. Effendi Muhammad Ilyas Y Mutakin Mutakin Nadiya N. Afifah Nadiya Nurul Afifah NADYA NURUL ZAMAN Ni Nyoman Sri Budayanti Nur Rahayuningsih, Nur Pande Putu Januraga Putri, Norisca A. Putri, Norisca A. Putri, Refitha Nurul Putu Dian Putu Dian, Putu Raden Maya Febrianti Raden Maya Febriyanti Rahmayanti, Annisa N. Rano K. Sinuraya Riezki Amalia Rindarwati, Asti Y. Rini Daud Supu Riza Yulisar Rizky Abdulah Rochjana, Anna Uswatun Hasanah Rudi Supriyadi Ruri Intania Sahidin Sahidin Sahidin, Idin Shelly Iskandar Shinta Marpaung Siagian, Bryan J. Sinuraya, Rano K. Sinuraya, Rano K. Sitepu, Rini Daud Sofa D. Alfian Sofa D. Alfian, Sofa D. Sofa Fajriah Sra R. Anggraeni Sri Adi Sumiwi Susannia Ibrahim Suwantika, Auliya A. Taofik Rusdiana Tati Herlina Tati Herlina Taufik, Adit Tono Djuwantono Tri Mayanti Tri Mayanti W. Wahyuni Wa Ode Nurfinti Wahyuni Wahyuni Wibisono, Aditya Seiza Widowati, I Gusti Ayu Rai - Yanni Dirgantara Yasmiwar Susilawati Yoppi Iskandar Yulisar, Riza Yuni Elsa Hadisaputri