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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Anestesiologi Indonesia Jurnal Kedokteran Brawijaya Indonesian Journal of Urology Journal of Biomedicine and Translational Research The Indonesian Biomedical Journal Biosaintifika: Journal of Biology & Biology Education Media Medika Muda Amerta Nutrition Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Narra J Bioscientia Medicina : Journal of Biomedicine and Translational Research Berkala Penelitian Hayati Indonesian Journal of Cancer Berita Kedokteran Masyarakat
Ignatius Riwanto, Ignatius
Department Of Digestive Surgery, Faculty Of Medicine, Diponegoro University, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Association between cholesterol and blood pressure examination in Sampangan, Semarang City: a preliminary study Christyana, To Lidwina Prillya Indra; Riwanto, Ignatius; Sebong, Perigrinus H; Sutanto, Eviana Budiartanti; Ernestia, Henrita; Tjitradinata, Cynthia; Kristanti, Alberta Widya
BKM Public Health and Community Medicine Vol 39 No 12 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.v39i12.9841

Abstract

Purpose: This study aims to determine the baseline prevalence and association between blood pressure and cholesterol examination. Method: This preliminary study used a cross-sectional design to analyze the secondary blood pressure and cholesterol levels data in the Sampangan sub-district, Semarang City. The total sampling technique covered those enrolled in the metabolic syndrome screening from January to April 2023. The logistic regression test was used in data analysis. Results: 58 respondents took blood pressure checks, while only 40 had cholesterol checks. The probability of males getting changes in cholesterol levels was higher than that of females (OR = 8.69; p-value = 0.01). However, neither (female nor male) had a significant relationship, and there was no difference in the chances of changes in blood pressure (OR = 1.43; p = 0.72). Respondents above 60 years had a significant association with changes in blood pressure compared to those under 60 years (OR = 0.09; p = 0.007). Conclusion: This study revealed males of a certain age experience higher changes in cholesterol levels compared to females. People over 60 years old tend to have higher blood pressure compared to those under 60 years old. These findings propose an outreach strategy for health screening for patients with limited mobility, transportation access, and finances for routine checkups at public or government healthcare facilities.
Soursop Leaf Extract Reduces AST, ALT, Bilirubin Levels, and Liver Damage Scores in Sorafenib-treated Wistar Rats with Hepatocellular Carcinoma Susilaningsih, Neni; Prajoko, Yan Wisnu; Budijitno, Selamat; Prabowo, Erik; Istiadi, Hermawan; Muniroh, Muflihatul; Riwanto, Ignatius
The Indonesian Biomedical Journal Vol 18, No 1 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i1.3883

Abstract

BACKGROUND: Sorafenib, the standard therapeutic agent for advanced hepatocellular carcinoma (HCC), may induce hepatic dysfunction, thereby necessitating adjunctive therapy to mitigate this adverse effect. While preliminary research has suggested that Soursop (Annona muricata) leaves exhibit anti-tumor and hepatoprotective properties, their efficacy in mitigating liver damage associated with sorafenib treatment remains unexplored. This study was conducted to assess the liver-protective effects of soursop leaf extract in Wistar rats receiving sorafenib for HCC treatment.METHODS: Ethanol extract of soursop leaves was prepared using the maceration method. Twenty-nine Wistar rats were divided into five groups: healthy control (HC) group, HCC groups receiving no treatment, sorafenib only, sorafenib + 50 mg/kgBW/day soursop extract, and sorafenib + 100 mg/kgBW/day soursop extract. All groups, except the HC group, were given Diethyl Nitrosamine (DEN) to cause HCC. Following a two-week treatment period, serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were assessed using colorimetric methods, while total bilirubin was assessed using diazo with sulphanilic acid method. From histopathological specimen, relative liver weight was measured and liver damage score was assessed using Hematoxylin and Eosin.RESULTS: Administration of sorafenib resulted in a reduction of AST, ALT, total bilirubin, relative liver weight, and liver damage scores. Furthermore, the combined administration of sorafenib with soursop leaf extract at dosages of 50 and 100 mg/kgBW/day led to a dose-dependent amelioration of these indicators. The most pronounced improvement was observed with the highest dose of soursop extract, which significantly reduced AST, ALT, total bilirubin, relative liver weight, and liver damage scores compared to the sorafenib-only group.CONCLUSION: Soursop leaf extract at 100 mg/kgBW/day effectively reduced AST, ALT, bilirubin levels, and liver damage score in sorafenib-treated Wistar rats with HCC, indicating its hepatoprotective effects. These findings suggest that soursop leaf extract may be a promising adjuvant therapy for mitigating sorafenib-induced hepatotoxicity in HCC treatment.KEYWORDS: Annona muricata, hepatocellular carcinoma, sorafenib, AST, ALT, bilirubin, hepatoprotective
Co-Authors A.A. Ketut Agung Cahyawan W Abdul Mughni Agung Aji Prasetyo, Agung Aji Agung Pribadi Agung Putra Anindita Soetadji Ar, Ardiyana Azhar, Abu Bahrudin Bahrudin Banundari Rachmawati Baskoro, Adhi Gunawan Bernadus Parish Budiono Budi Mulyono Bulandari, Beatrice LA. Catharina Suharti Christyana, To Lidwina Prillya Indra Czeresna Heriawan Soejono Dody Novrial, Dody Dwi Pudjonarko Edi Dharmana Edwin Basyar Eriawan Agung Nugroho Eriawan Agung Nugroho, Eriawan Agung Ernestia, Henrita Fuadi, Ahmad F. Gasem, Muhammad Hussein Hardhono Susanto Henry Setyawan Susanto Henry Setyawan Susanto Heri Nugroho Hermawan Istiadi Ibrahim, Sugeng Indra Wijaya Irawan, Andry Iwan Vanca Saragih Kosnayani, Ai Sri Kristanti, Alberta Widya Kurniawati, Yovie Lisyani Budipardigdo Suromo Mario Sadar Bernitho Hutagalung Meita Hendrianingtyas Muniroh, Muflihatul Mupangati, Yudo Murti Neni Susilaningsih Nugrahadi, Dimas Erlangga Nugroho, Trilaksana Nur Anna Chalimah Sadyah Pambudi Utomo, Gede Parish Budiono Prabowo, Erik Prawara, Ananta Sidhi Purnomo, Hery D. Radityo Prakoso Rampengan, Derren DCH. Renata, Bella Reno Rudiman Respati, Danendra RK. Satrio Adi Wicaksono Satyagraha, Muhammad Thifan Sebong, Perigrinus H Sefri Noventi Sofia Selamat Budijitno Sigit Adi Prasetyo Sigit Adi Prasetyo, Sigit Adi Suhartono, Suhartono Suharyo Hadisaputro Sutanto, Eviana Budiartanti Sutiman B Sumitro Sutiman B. Sumitro Tjandra, Kevin C. Tjitradinata, Cynthia Tjokorda Gde Dalem Pemayun Tri Indah Winarni Trilaksana Nugroho Wardhani, Avriana Pety Wibisono, Agoes Yan Wisnu Prajoko