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All Journal Althea Medical Journal Indonesian Journal of Cancer Majalah Obstetri dan Ginekologi Majalah Kesehatan FKUB Health Notions MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Majalah Patologi Indonesia Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of Stem Cell Research and Tissue Engineering Jurnal Ners Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Jurnal Pengabdian Masyarakat dalam Kesehatan Indian Journal of Forensic Medicine & Toxicology Narra J Indonesian Journal of Cancer Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Masyarakat Bangsa Journal of Global Research in Public Health Folia Medica Indonesiana
Alphania Rahniayu
Anatomical Pathology Department, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia
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Journal : Narra J

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Correlation between interleukin-6 expression in post-mortem core liver biopsy and degree of liver injury in patients with fatal COVID-19 Maimunah, Ummi; Maharani, Andi RK.; Soegiarto, Gatot; Rahniayu, Alphania; Gunawan, Vania A.; Wiratama, Priangga A.; Djuanda, Stephanie N.; Supriadi, Supriadi; Marhana, Isnin A.; Semedi, Bambang P.; Lefi, Achmad; Kusumastuti, Etty H.; Suyanto, Edi; Lilihata, Jilientasia G.; Anggoro, Adhitri; Rinjani, Lalu GP.; Rosyid, Alfian N.; Wahyu, Dwi; Fauziah, Dyah; Rahaju, Anny S.; Kurniasari, Nila; Ariani, Grace; Nugroho, Gilang MS.; Yandi, I KR.; Nugraha, Ricardo A.
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.463

Abstract

Excessive release of interleukin-6 (IL-6) during the progression of coronavirus disease 2019 (COVID-19) induces cytokine storms, resulting in multi-organ damages including liver injury, similar in nature with mechanism of viral hepatitis. Systemic IL-6 has been associated with the incidence of liver injury among COVID-19 patients; however, studies on IL-6 expression in the liver tissue are completely lacking. The aim of this study was to measure the IL-6 expression in the liver tissues and to determine its correlation with the degree of liver injury in fatal COVID-19 patients. Through this first cross-sectional study, IL-6 expression was measured through immunohistochemical staining and the degree of liver injury was identified based on level of serum alanine aminotransferase (ALT). The Spearman correlation test was used to identify the correlation between IL-6 expression and the degree of liver injury. A total of 47 deceased COVID-19 patients were included and IL-6 expression was observed in all post-mortem liver specimens, ranging from mild to strong expression. Liver injury at various degrees (mild to severe) was found in more than half (59.5%) of the cases. The Spearman correlation analysis suggested a statistically insignificant correlation between liver IL-6 expression and the degree of liver injury (r=0.152; p=0.309). In conclusion, even IL-6 expression was observed in all post-mortem liver specimens, there was an insignificant correlation between IL-6 expression in the liver tissue with the degree of liver injury among fatal COVID-19 patients, suggesting that IL-6 was not the only main factor contributing to liver damage in COVID-19 patients.
Co-Authors , Isnin Anang Marhana Afria Arista Afria Arista, Afria Alfi Nureta Rachmani Anggoro, Adhitri Anisia Indiralia Anny Setijo Rahaju, Anny Setijo Ariadna Anggi Pasang Ariani, Grace Bilqis Inayatillah Budi Harjanto Budi Harjanto David Setyo Budi Dewi Sartika A. W. Dhamayanti, Hanifa Erlin Djuanda, Stephanie N. Dwi Murtiastutik DYAH FAUZIAH, DYAH Edi Suyanto Endang Joewarini Evy Ervianti Fatimah, Nurmawati Fetty Fatimah Fira Soraya Fitria Kusumastuti Gatot Soegiarto Gondo Mastutik Gunawan, Vania A. Harjono, Shella HERAWATI, LILIK Heriyawati, Heriyawati Heru Fajar Trianto Heru Purwanto I'tishom, Reny Ifadah, Hanna Aulia Ilmiah, Khafidhotul Imam Susilo Indiralia, Anisia INDRA YULIATI, INDRA Irwadi, Irfiansyah Isnin Anang Marhana I’tishom, Reny Khafidhotul Ilmiah Khafidhotul Ilmiah Kusumastuti , Etty Hary Kusumastuti, Etty H. Kusumastuti, Etty Hari KUSUMASTUTI, ETTY HARY Ladyna Rumapar Lefi, Achmad Lestari, Neviana Fitri Lilihata, Jilientasia G. Linda Dewanti Lutfi, Delfitri Maharani, Andi RK. Mamiek Dwi Putro Marhana, Isnin A. Meyta Riniastuti Mochamad Amin MOCHAMAD AMIN Mohammad Fathul Qorib Muhammad Alim Ananto Muhammad Alim Ananto Nabiha Missaoui Nadya Kelfinta Hanani Nila Kurniasari Nila Kurniasari Nugraha, Ricardo A. Nugroho, Gilang MS. Nurdhani Hi Djafar Priangga Adi Wiratama Qonitatillah, Ana Rahaju, Anny S. Rahmi Alia Rahmi Alia Rahmi Alia, Rahmi Ramadhani, Amelia Safitri Raniah Baswedan Renny I’tishom Ridholia Ridholia, Ridholia Rinjani, Lalu GP. Romi Alfianto Rosyid, Alfian N. Rumapar, Ladyna S.Pd. M Kes I Ketut Sudiana . Sari, Aditya Sita Sari, Eny Wulan Sawitri, Brihastami Semedi, Bambang P. Setiawan, Hayuris Kinandita Sjahjenny Mustokoweni, Sjahjenny Stella Agatha Widjaja Suhartono Taat Putra Supriadi Supriadi Tamam Jauhar Tomy Lesmana Trianto, Heru Fajar Trisniartami Setyaningrum Ummi Maimunah Vira Yasmina Ramadhani Wahyu, Dwi Willy Sandhika Wira Santoso Ongko Wiratama, Priangga A. Wiratama, Priangga Adi Yandi, I KR. Yudith Meityana Hernandita Zamzam, Ramadhani Rizki Zuhria, Ismi