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All Journal Jurnal e-Biomedik PHARMACON JURNAL BIOMEDIK CHEMISTRY PROGRESS Briliant: Jurnal Riset dan Konseptual Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Pharmacology and Clinical Pharmacy Research Jurnal Abdi Insani Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Vivabio : Jurnal Pengabdian Multidisiplin Jurnal Perempuan dan Anak Indonesia Jurnal Kesehatan Tambusai Indonesian Biodiversity Journal Indonesian Biodiversity Journal Pharmaceutical Science Journal Jurnal Lentera: Penelitian dan Pengabdian Masyarakat Jurnal Lentera Farma
Meilani Jayanti
Universitas Sam Ratulangi
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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FORMULASI DAN EVALUASI SEDIAAN ROLL ON AROMATERAPI MINYAK CENGKEH (SYZIGIUM AROMATICUM) KHAS SULAWESI UTARA Ticoalu, Pricilia Kesia; Siampa, Jainer Pasca; Jayanti, Meilani
Jurnal Kesehatan Tambusai Vol. 5 No. 3 (2024): SEPTEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i3.32197

Abstract

Cengkeh (Syzigium aromaticum) merupakan tanaman penghasil minyak atsiri dari Sulawesi Utara yang memiliki potensi besar untuk dikembangkan sebagai minyak gosok yang alami dan efektif. Penelitian ini bertujuan untuk membuat formulasi serta menentukan efektifitas sediaan roll on aromaterapi minyak cengkeh berdasarkan karakteristik fisik sediaan. Penelitian ini menggunakan metode eksperimental laboratorium untuk mengembangkan formulasi sediaan dengan variasi konsentrasi minyak cengkeh 5%, 10% dan 15% menggunakan metode pencampuran. Kemudian diuji secara fisik meliputi  uji organoleptik, pH, homogenitas, bobot jenis, viskositas, iritasi dan hedonik. Hasil Penelitian menunjukkan bahwa sediaan roll on aromaterapi minyak cengkeh memenuhi syarat uji dengan organoleptik (cairan bening dan kekuningan berbau khas cengkeh), pH 5, homogen, bobot jenis 0,859-0,912, nilai viskositas 4,115- 4,745, tidak mengiritasi kulit dan formulasi dengan konsentrasi 15% menjadi sediaan yang paling banyak disukai. Kesimpulannya, minyak cengkeh dapat di formulasikan menjadi sediaan roll on aromaterapi yang memenuhi persyaratan karakteristik fisik sediaan dan memenuhi  uji iritasi dan uji hedonik.
Peningkatan Nilai Guna Cangkang Kepiting sebagai Kitosan untuk Raw Material pada Pasta Gigi Herbal Hariyanto, Yuanita Amalia; Antasionasti, Irma; Jayanti, Meilani
BRILIANT: Jurnal Riset dan Konseptual Vol 8 No 3 (2023): Volume 8 Nomor 3, Agustus 2023
Publisher : Universitas Nahdlatul Ulama Blitar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28926/briliant.v8i3.1574

Abstract

Sejauh ini inovasi raw material pasta gigi herbal yang berasal dari limbah masih jarang dikembangkan, cangkang kepiting menjadi material yang berpotensi untuk menjadi bahan baku dalam pembuatan pasta gigi herbal. Tujuan penelitian ini yaitu mengembangkan limbah cangkang kepiting menjadi material yang memiliki nilai ekonomi. Penelitian ini dilakukan dengan ekstraksi dan sintesis sederhana. Karakterisasi XRD, FTIR, dan SEM-EDX digunakan untuk menganalisis kristalinitas, gugus fungsi, dan morfologi kitosan. Hasil analisis menunjukkan struktur kitosan membentuk kristalin yang ditunjukkan dengan terkonfirmasinya tiga puncak tajam pada 2-teta 19o, 26o, dan 29o. Hasil analisis puncak serapan FTIR menunjukkan terdeteksinya 5 gugus fungsi utama kitosan pada bilangan gelombang 3458 cm-1, 2895,15 cm-1, 1654,92 cm-1, 1587,42 cm-1, dan 1386,82 cm-1 adalah OH stretching, CH(CH3) bending, C=O (-NHCOCH3) stretching amida I, NH (-NHCOCH3) bending amida II, CH (-CH2) bending sym secara berturut-turut. Morfologi kitosan yang disintesis dari cangkang kepiting berpori, bergelombang, dan bentuknya tidak teratur serta unsur yang terkandung yaitu C, O, Ca, dan Si.
Biosintesis Nanopartikel Hidroksiapatit Termodifikasi Ekstrak Daun Gedi (Abelmoschus manihot L) sebagai Agen Antibakteri Hariyanto, Yuanita Amalia; Jayanti, Meilani; Asari
BRILIANT: Jurnal Riset dan Konseptual Vol 10 No 1 (2025): Volume 10 Nomor 1, Februari 2025
Publisher : Universitas Nahdlatul Ulama Blitar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28926/briliant.v10i1.2341

Abstract

A tuna bones, particularly in the jaw region, constitute a category of food waste prevalent in North Sulawesi. Hydroxyapatite can be produced from tuna jaws. Abelmoschus manihot L (gedi) can improve the efficacy of hydroxyapatite as an antibacterial agent owing to its bioactive components. This study aimed to assess the antibacterial efficacy of hydroxyapatite treated with Abelmoschus manihot L extract. The samples were produced through multiple stages: preparation of tuna fish bones, synthesis of hydroxyapatite nanoparticles (nHA), extraction of gedi leaves and biosynthesis of nHA from gedi leaf extract. Biosynthesis was conducted via the co-precipitation technique with diverse compositions. The samples were then analyzed using FTIR and TEM, and their antibacterial activity was assessed using the well diffusion method. According to the results of the FTIR study, functional groups from the gedi leaf extract were detected at wave numbers 1731 cm-1, 1234 cm-1, and 896 cm-1, and nHA was discovered at wave numbers 576 cm-1, 608 cm-1, 964 cm-1, and 1041 cm-1, indicating the phosphate group. Furthermore, the results of the TEM investigation revealed that the samples formed spheres smaller than 100 nm. The antibacterial activity of gedi extract/nHA at concentrations of 0.5%, 1%, and 1.5% revealed the presence of inhibitory zones in the strong and very strong categories for S. aureus bacteria. Meanwhile, E. coli bacteria's inhibitory zones were moderate to strong. This suggests that gedi/nHA extract possesses antibacterial properties, making it ideal for use in biomedical applications.
GROWTH ACTIVITY TEST OF WHITE RAT HAIR COMBINATION OF CELERY (Apium Graveolens) LEAF EXTRACT AND GREEN GEDI (Abelmoschus Manihot) LEAF Kawatu, Chelsea; Lebang, Julianri Sari; Jayanti, Meilani
Indonesian Biodiversity Journal Vol. 5 No. 3 (2024): December 2024
Publisher : Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53682/ibj.v5i3.11058

Abstract

Celery and Green Gedi leaves have been long considered traditional topical supplements to support hair growth. They contain flavanoids that are efficacious to induce keratinocyte proliferation. However, the research about whether the combination of celery and green gedi leaves can still provide an effect is limited. This current study aims to determine the effect of the combination of ethanol extracts of celery leaves and green gedi leaves on white rat hair growth. This is laboratory experimental research to compare the hair growth in three different groups with normal and positive control. Animals were randomly grouped (n=3 for each group) and then given a combination of leaf extracts and carbopol with a concentration of 17.5%:10%; 27.5%:15%;37.5%:20%. A normal control group was left untreated, while another group was treated with 2% minoxidil as positive control. The results of measuring fur weight on day 21 showed that the treatment group given the combination of extracts did affect the growth of rat hair. Statistical tests using one-way ANOVA showed a p-value of <0.001 which means there is a significant difference in the average hair weight of rats treated. LSD post hoc test showed that treatment with a 17.5%:10% concentration ratio was significantly different from the other treatments. It can be concluded that the combination of celery leaf extract and gedi leaf positively affects rat hair growth.
GROWTH ACTIVITY TEST OF WHITE RAT HAIR COMBINATION OF CELERY (Apium Graveolens) LEAF EXTRACT AND GREEN GEDI (Abelmoschus Manihot) LEAF Kawatu, Chelsea; Lebang, Julianri Sari; Jayanti, Meilani
Indonesian Biodiversity Journal Vol. 5 No. 3 (2024): December 2024
Publisher : Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53682/ibj.v5i3.11058

Abstract

Celery and Green Gedi leaves have been long considered traditional topical supplements to support hair growth. They contain flavanoids that are efficacious to induce keratinocyte proliferation. However, the research about whether the combination of celery and green gedi leaves can still provide an effect is limited. This current study aims to determine the effect of the combination of ethanol extracts of celery leaves and green gedi leaves on white rat hair growth. This is laboratory experimental research to compare the hair growth in three different groups with normal and positive control. Animals were randomly grouped (n=3 for each group) and then given a combination of leaf extracts and carbopol with a concentration of 17.5%:10%; 27.5%:15%;37.5%:20%. A normal control group was left untreated, while another group was treated with 2% minoxidil as positive control. The results of measuring fur weight on day 21 showed that the treatment group given the combination of extracts did affect the growth of rat hair. Statistical tests using one-way ANOVA showed a p-value of <0.001 which means there is a significant difference in the average hair weight of rats treated. LSD post hoc test showed that treatment with a 17.5%:10% concentration ratio was significantly different from the other treatments. It can be concluded that the combination of celery leaf extract and gedi leaf positively affects rat hair growth.
Co-Authors Abdullah, Surya Sumantri Adithya Yudistira Andi Buanasari Andy A.N Hiola Angmalisang, Elvin Clara Antasionasti, Irma Arsyad, Aswin ASARI Asep Rahman Asep Rahman Ayu Wati Ningsih Buanasari, Andi Christian Alexandro Lanes Christian Aseng Citra Fatima Marsidi Debora Gebby Tumundo DEBY AFRIANI MPILA Defny S. Wewengkang, Defny S. Dian Suryanita Sari Eldy Sengkey Elly Suoth Essing, Jacklien Deswita Fadila Al-A’izzah Fathoni, Kristiani W. S. W. Fatimawali . Fatrini Djaber Febrianika Ayu Kusumaningtyas Frenly Wehantouw Gayatri Citraningtyas Gunawan, Lea Nathaniela Agneta Hariyanto, Yuanita A. Hariyanto, Yuanita Amalia Herny E.I. Simbala Hiola, Andy A.N Hosea Jaya Edy I Dewa Ayu M. Melaniawati Ihsan S. Tome Imam Jayanto Irma Antasionasti Jayanto, Imam Julianri Sari Lebang, Julianri Sari Kapondo, Gwendolyn L. Kawatu, Chelsea Keri Lestari Lestari, Utami Sasmita Liling, Yessi Manuel, Jennike T. Maria Efrani Tengor Olvi Datu Owu, Nadya M. Rizky Abdulah Rizya Marchilia Mamahit Sarai Raehilda Febriansi Korban Sengkey, Eldy Shabrina Wahyudi Sharon Colin Tangkere Siampa, Jainer Pasca Soleman, Puput Sri Sudewi, Sri Surya Sumantri Abdullah Tengor, Maria Efrani Ticoalu, Pricilia Kesia Tinungki, Syalomita Esther Tome, Ihsan S. Wenas, Glori Anjelina Preysi Weny I. Wiyono Weny I. Wiyono Weny Indayany Wiyono Weny Indayany Wiyono Weny Indayany Wiyono Weny Wiyono Wiyono, Wenny I. Wiyono, Weny Indayany Woran, Falinry Wori, Preicy Augenia