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All Journal Jurnal e-Biomedik PHARMACON JURNAL BIOMEDIK CHEMISTRY PROGRESS Briliant: Jurnal Riset dan Konseptual Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Pharmacology and Clinical Pharmacy Research Jurnal Abdi Insani Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Vivabio : Jurnal Pengabdian Multidisiplin Jurnal Perempuan dan Anak Indonesia Jurnal Kesehatan Tambusai Indonesian Biodiversity Journal Indonesian Biodiversity Journal Pharmaceutical Science Journal Jurnal Lentera: Penelitian dan Pengabdian Masyarakat Jurnal Lentera Farma
Meilani Jayanti
Universitas Sam Ratulangi
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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KEPATUHAN PASIEN HIPERTENSI TERHADAP PENGOBATAN DI PUSKESMAS KOTA MANADO Jayanti, Meilani; Mpila, Deby Afriani; Hariyanto, Yuanita Amalia
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 7 No. 1 (2024): Volume 7, No 1, Tahun 2024
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v7i1.54069

Abstract

ABSTRAK Salah satu tantangan yang dihadapi klinisi dalam penatalaksanaan penyakit hipertensi adalah kepatuhan pasien. Penyakit hipertensi yang membutuhkan pengelolaan jangka panjang, menempatkan kepatuhan sebagai salah satu faktor utama dalam pencapaian target terapi pasien. Penelitian ini bertujuan mengetahui tingkat kepatuhan pasien hipertensi terhadap pengobatan di Puskesmas Kota Manado. Penelitian ini merupakan penelitian observasional analitik dengan desain penelitian cross sectional. Subjek penelitian ditentukan berdasarkan kriteria inklusi dan eksklusi. Pengambilan data pasien diperoleh dari rekam medik, buku pengobatan dan wawancara pasien menggunakan kuesioner MMAS-8. Hasil penelitian menunjukkan bahwa sebanyak 81 (46,3%) responden memiliki tingkat kepatuhan sedang, dimana skor rata-rata tingkat kepatuhan dari seluruh responden adalah 6,1 (kepatuhan sedang). Selain itu, tidak terdapat hubungan yang signifikan antara karakteristik pasien dengan kepatuhan pengobatan. Berdasarkan hasil tersebut dapat disimpulkan bahwa kepatuhan pasien hipertensi terhadap pengobatan di Puskesmas Kota Manado masih termasuk dalam tingkat kepatuhan sedang, dimana hal ini menjadi tugas tenaga kesehatan untuk terus meningkatkan kesadaran masyarakat terkait hipertensi, khususnya terkait kepatuhan pengobatan, mengingat penyakit hipertensi merupakan salah satu penyakit terbanyak di Indonesia. Kata kunci: tingkat kepatuhan, hipertensi, pengobatan, MMAS-8, puskesmas ABSTRACT Clinicians face a challenge in managing hypertensive disease due to poor patient compliance. Compliance plays a crucial role in achieving long-term therapy goals for patients with hypertensive disease. To determine the level of compliance of hypertensive patients with treatment at the Manado City Health Center, an analytic observational study was conducted with a cross-sectional research design. The research subjects were selected based on inclusion and exclusion criteria. Patient data were collected through medical records, treatment books, and MMAS-8 questionnaire-based interviews. The study found that 81 (46.3%) respondents had a moderate level of compliance, with an average score of 6.1 (moderate compliance) across all respondents. Furthermore, the study concluded that there was no significant relationship between patient characteristics and medication adherence. These results indicate that hypertension patients' compliance with treatment at the Manado City Health Center is still moderate. Therefore, health workers must continue to raise public awareness of hypertension, particularly in terms of treatment compliance since hypertension is one of the most common diseases in Indonesia. Keywords: adherence, hypertension, medication, MMAS-8, community health center
Tempe Drink Making Training, Physical Activity Education and Optimization of Madrasah Health Units for Madrasah Teachers in Manado Lestari, Utami Sasmita; Angmalisang, Elvin Clara; Jayanti, Meilani
Abdimas Galuh Vol 6, No 2 (2024): September 2024
Publisher : Universitas Galuh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25157/ag.v6i2.16113

Abstract

Adolescence is a transition period from childhood to adulthood. Adolescence can be an indicator of health in adulthood. Consumption patterns and low physical activity in adolescents trigger obesity which is a risk factor for dyslipidemia. Tempe contains protein that affects the improvement of lipid profiles. Modifying tempe into tempe drinks makes the serving is more practical and preferred by adolescents. This activity aimed to improve the role of madrasah teachers in preventing dyslipidemia among adolescent girls through training in making tempe drinks, physical activity education and optimization of UKM. Teachers are figures who directly deal with adolescents who are students to transfer knowledge and skills in healthy living behaviors. The process of providing health education also needs to be supported by qualified facilities and infrastructure, through optimization of madrasah health units functions and programs. A total of 26 madrasah teachers participated in this activity. This activity was carried out with several stages of activities. They were counseling on dyslipidemia and the potential of tempe drinks as an effort to prevent dyslipidemia in adolescent girls and continued with training on making tempe drinks. Furthermore, counseling on physical activity and training on optimizing the function of UKM and developing health promotion media. The results of this community service activity were expected to improve the quality of adolescent health and could be implemented in the form of sustainable programs by academicians at the madrasah.
TINGKAT KEPATUHAN PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN HIPERTENSI DI PUSKESMAS KEMA KABUPATEN MINAHASA UTARA Debora Gebby Tumundo; Weny Indayany Wiyono; Meilani Jayanti
PHARMACON Vol. 10 No. 4 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.37409

Abstract

ABSTRACTHypertension or high blood pressure is an increase in systolic blood pressure of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg. Hypertension is a chronic disease with life-long treatment. Adherence to treatment of hypertensive patients is important because hypertension is a disease that must always be controlled so that complications do not occur which can lead to death. This study aimed to identify the level of adherence of hypertensive patients at Puskesmas Kema, North Minahasa regency in taking antihypertensive drugs using the Modified Morisky Adherence Scales-8 (MMAS-8) method and the data was collected on 40 patients. The results showed that patients with a high level of adherence were 22.5%, a moderate level of adherence was 20%, and a low level of adherence was 57.5%. Therefore, could be concluded that the level of adherence with the use of antihypertensive drugs in hypertensive patients at Kema Health Center was in the low category. Key words: Hypertension, Adherence level in taking medication.  ABSTRAKHipertensi atau tekanan darah tinggi adalah peningkatan tekanan darah sistolik lebih dari 140 mmHg dan tekanan darah diastolik lebih dari 90 mmHg. Hipertensi merupakan penyakit kronis dengan pengobatan yang dilakukan seumur hidup. Kepatuhan pengobatan pasien hipertensi merupakan hal penting karena hipertensi merupakan penyakit yang harus selalu dikontrol atau dikendalikan agar tidak terjadi komplikasi yang dapat berujung pada kematian. Penelitian ini bertujuan untuk mengidentifikasi tingkat kepatuhan pasien hipertensi di Puskesmas Kema Kabupaten Minahasa Utara dalam mengonsumsi obat antihipertensi dengan menggunakan metode Modified Morisky Adherence Scales-8 (MMAS-8) dengan pengambilan data terhadap 40 pasien. Hasil penelitian menunjukan bahwa pasien dengan tingkat kepatuhan tinggi sebesar 22,5%, tingkat kepatuhan sedang sebesar 20%, dan tingkat kepatuhan rendah sebesar 57,5%. Dengan demikian dapat disimpulkan bahwa tingkat kepatuhan penggunaan obat antihipertensi pada pasien hipertensi di Puskesmas Kema termasuk dalam kategori rendah. Kata kunci : Hipertensi, Kepatuhan minum obat.
TINGKAT PENGETAHUAN DAN PERILAKU PENGGUNAAN ANTIBIOTIK SECARA SWAMEDIKASI PADA MASYARAKAT YANG BERKUNJUNG DI APOTEK KABUPATEN BOLAANG MONGONDOW I Dewa Ayu M. Melaniawati; Weny I. Wiyono; Meilani Jayanti
PHARMACON Vol. 10 No. 4 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.37410

Abstract

ABSTRACTAntibiotics are drugs used for infectious diseases. Irrational use of antibiotics can lead to resistance. In self-medication, inappropriate use of antibiotics often occurs. This is due to the lack of public knowledge about the proper and correct use of antibiotics. This study aims to determine the level of knowledge and behavior of using self-medicated antibiotics in the community who visit the Bolaang Mongondow District Pharmacy. This study was a descriptive observational study with a cross-sectional approach to 195 respondents who met the inclusion criteria. Based on the results of the study, it is known that the level of public knowledge about antibiotics is still low (54%) and the level of behavior in using antibiotics is sufficient (61%).. Keywords: Antibiotics, self-medication, knowledge, use  ABSTRAKAntibiotik merupakan obat yang digunakan untuk penyakit infeksi. Penggunaan antibiotik yang tidak rasional dapat mengakibatkan resistensi. Dalam swamedikasi penggunaan antibiotik yang tidak tepat sering terjadi. Hal ini disebabkan karena kurangnya pengetahuan masyarakat tentang penggunaan antibiotik yang baik dan benar. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan dan perilaku penggunaan antibiotik secara swamedikasi pada masyarakat yang berkunjung di Apotek Kabupaten Bolaang Mongondow. Penelitian ini merupakan penelitian deskriptif yang bersifat observasional dengan pendekatan cross-sectional terhadap 195 responden yang memenuhi kriteria inklusi. Berdasarkan hasil penelitian, diketahui bahwa tingkat pengetahuan masyarakat tentang antibiotik masih tergolong kurang (54%) dan tingkat perilaku penggunaan antibiotik tergolong cukup (61%). Kata kunci: Antibiotik, swamedikasi, pengetahuan, penggunaan
TINGKAT PENGETAHUAN DAN PERILAKU PENGGUNAAN ANTIBIOTIK SECARA SWAMEDIKASI PADA MASYARAKAT YANG BERKUNJUNG DI APOTEK KECAMATAN TUMINTING Dian Suryanita Sari; Weny I. Wiyono; Meilani Jayanti
PHARMACON Vol. 10 No. 4 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.37411

Abstract

ABSTRACTAntibiotics are important drugs used in the treatment of bacterial infections. Inappropriate use of antibiotics is often encountered in people who carry out self-medication. This study aims to determine the level of knowledge of antibiotics and antibiotics use behavior in the community visiting the Tuminting district pharmacy. This study is a descriptive observational study with a cross-sectional approach to 200 respondens who fit the inclusion criteria. The result showed that the level of knowledge of antibiotics in the community who visited the Pharmacy in Tuminting district was in the good category (16%), (10%) enough, and less (74%). Meanwhile, the level of antibiotics use in the community who visited the Pharmacy in Tuminting district was in the good categorized (15%), (53,5%) moderate, and (31,5%) less. This study concluded that the level of knowledge of antibiotics in the community in who visited the Pharmacy in Tuminting sub-district was still relatively low (74%) and the level of antibiotics use was sufficient (53,5%)..Keywords: Antibiotics, Self-Medication, Knowledge, Use.  ABSTRAKAntibiotik merupakan obat yang penting digunakan dalam pengobatan infeksi bakteri. Penggunaan antibiotik yang tidak tepat sering ditemui pada masyarakat yang melakukan swamedikasi. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan antibiotik dan perilaku penggunaan antibiotik pada masyarakat yang berkunjung di apotek Kecamatan Tuminting. Penelitian ini merupakan penelitian deskriptif yang bersifat observasional dengan pendekatan cross-sectional terhadap 200 responden yang sesuai dengan kriteria inklusi. Hasil penelitian menunjukkan bahwa tingkat pengetahuan antibiotik pada masyarakat yang berkunjung di apotek Kecamatan Tuminting yang termasuk kategori baik 16%, cukup 10%, dan kurang 74%. Sedangkan, tingkat penggunaan antibiotik pada masyarakat yang berkunjung di apotek Kecamatan Tuminting yang termasuk kategori baik 15%, cukup 53,5%, dan kurang 31,5%. Penelitian ini menyimpulkan bahwa tingkat pengetahuan antibiotik pada masyarakat yang berkunjung di apotek Kecamatan Tuminting masih tergolong kurang (74%) dan tingkat penggunaan antibiotik tergolong cukup (53,5%). Kata kunci: Antibiotik, Swamedikasi, Pengetahuan, Penggunaan.
TOXICITY TEST OF THE COMBINATION Eleutherine americana Merr. AND Areca vestiaria EXTRACTS AGAINST THE INTESTINAL ORGANS OF Rattus norvegicus Sarai Raehilda Febriansi Korban; Herny Simbala; Meilani Jayanti
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.41911

Abstract

Dayak onions (Eleutherine americana Merr.) and Pinang Yaki (Areca vestiaria) have been used by the community as traditional medicine. The purpose of this study was to determine the safety level of extracts of Dayak onion and Pinang Yaki against the macroscopic appearance of the intestinal organs of Wistar male white rats. This study used an experimental method with 18 male white rats of the Wistar strain who were given ethanol extract of Dayak onion and Pinang Yaki orally at a dose of 10,8mg, 14,4mg, and 21,6mg for 14 days. The results showed that there was a decrease in body weight, in each treatment group but the largest weight loss occurred in the dose group V from 199gram to 182gram while the smallest weight loss occurred in the dose group I from 199gram to 198gram and for the macroscopic picture of the intestinal organs there was no significant difference between the test group with the control group. In conclusion, the administration of extracts of Dayak onion and Pinang Yaki does not affect the macroscopic picture of the intestinal organs.
Evaluasi Penggunaan Antibiotik pada Pasien Covid-19 di RSUP Prof. Dr. R. D. Kandou Manado Periode Januari-Maret 2021 Christian Aseng; Weny Wiyono; Meilani Jayanti
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42200

Abstract

Covid-19 adalah penyakit infeksi jenis baru yang disebabkan oleh virus Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). Penelitian ini bertujuan untuk mengetahui profil penggunaan dan kuantitas penggunaan antibiotik yang diberikan pada pasien Covid-19 di RSUP Prof. Dr. R. D. Kandou Manado periode Januari-Maret 2021. Didapatkan sebanyak 60 sampel rekam medis, kemudian dianalisis secara kuantitatif menggunakan metode ATC/DDD. Didapat 7 jenis antibiotik yang diberikan pada pasien Covid-19 yaitu  Azitromisin (51,72%), Seftriakson (22,99%), Levofloksasin (17,24%), Sefadroksil (2,30%), Meropenem (2,30%), Moksifloksasin (2,30%) dan Siprofloksasin (1,15%). Diperoleh nilai total DDD/100 pasien-hari sebesar 97,36 DDD/100 pasien-hari, antibiotik Azitromisin memiliki nilai DDD/100 hari-pasien tertinggi sebesar 44,54 DDD/100 pasien-hari, dan antibiotik yang masuk dalam segmen 90% adalah Azitromisin (45,75%), Seftriakson (29,85%) dan Levofloksasin (16,02%).
ISOLATION AND IDENTIFICATION OF FLAVONOID COMPOUNDS ETHANOL EXTRACT OF SUANGGI LEMON PEEL Citrus limon L. Rizya Marchilia Mamahit; Fatimawali Fatimawali; Meilani Jayanti
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42204

Abstract

ABSTRACTSuanggi lemon peel is a plant that is often used as a traditional health therapy. The outer skin of the lemon suanggi (Citrus Limon L.) is rich in oil glands, bright yellow in color with a distinctive and fresh citrus aroma. The purpose of this study was to isolate and identify the class of flavonoid compounds from the rind of lemon suanggi (citrus limon L.) by using the UV-Vis spectrophotometer method. The rind of the suanggi lemon was extracted by maceration method using 95% ethanol as solvent which resulted in a thick extract of suanggi lemon rind. Isolation was carried out by thin layer chromatography (TLC) method with Chloroform: n-hexane (4:2) as the eluent. The fourth spot from the result of Thin Layer Chromatography was positive for containing flavonoid compounds. From the spectrum of the UV-Vis spectrophotometer, it can be assumed that the flavonoid compound is a flavonol group, which can be seen from its wavelength range, which is between 200- 500 nm from its wavelength range of 366 nm.Keywords: lemon suanggi, flavonoids, thin layer chromatography, UV-Vis spectrophotometer.
Uji Aktivitas Antioksidan Ekstrak Etanol Spons Lamellodysidea herbacea yang Diperoleh dari Pantai Selatan Kabupaten Minahasa Christian Alexandro Lanes; Adithya Yudistira; Meilani Jayanti
PHARMACON Vol. 12 No. 3 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.49217

Abstract

Spons merupakan salah satu organisme laut yang mempunyai potensi untuk menghasilkan senyawa metabolit sekunder yang mempunyai banyak manfaat. Salah satu fungsi dari metabolit sekunder adalah sebagai antioksidan. Antioksidan merupakan senyawa yang dapat menghambat proses oksidasi yang diakibatkan oleh radikal bebas. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dari spons Lamellodysidea herbacea yang diperoleh dari Pantai Selatan Kabupaten Minahasa. Penelitian ini merupakan eksperimental laboratorium dengan metode ekstraksi maserasi menggunakan pelarut etanol 95%. Pengujian antioksidan menggunakan metode DPPH (1.1-difenil-2-pikrihidrazil) dengan 4 seri konsentrasi sampel (25, 50, 75, 100 ppm) yang diukur menggunakan spektrofotometer UV-Vis dengan nilai absorbansi diukur pada panjang gelombang 517 nm. Hasil penelitian diperoleh rata-rata nilai persen inhibisi yang didapat pada konsentrasi 25, 50, 75, 100 ppm secara berturut-turut adalah 40,068%, 51,446%, 65,25%, 70,369%. Penelitian ini menyimpulkan bahwa ekstrak spons Lamellodysidea herbacea mempunyai aktivitas antioksidan pada konsentrasi 50, 75, dan 100 ppm.
GROWTH ACTIVITY TEST OF WHITE RAT HAIR COMBINATION OF CELERY (Apium Graveolens) LEAF EXTRACT AND GREEN GEDI (Abelmoschus Manihot) LEAF Kawatu, Chelsea; Lebang, Julianri Sari; Jayanti, Meilani
Indonesian Biodiversity Journal Vol. 5 No. 3 (2024): December 2024
Publisher : Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53682/ibj.v5i3.11058

Abstract

Celery and Green Gedi leaves have been long considered traditional topical supplements to support hair growth. They contain flavanoids that are efficacious to induce keratinocyte proliferation. However, the research about whether the combination of celery and green gedi leaves can still provide an effect is limited. This current study aims to determine the effect of the combination of ethanol extracts of celery leaves and green gedi leaves on white rat hair growth. This is laboratory experimental research to compare the hair growth in three different groups with normal and positive control. Animals were randomly grouped (n=3 for each group) and then given a combination of leaf extracts and carbopol with a concentration of 17.5%:10%; 27.5%:15%;37.5%:20%. A normal control group was left untreated, while another group was treated with 2% minoxidil as positive control. The results of measuring fur weight on day 21 showed that the treatment group given the combination of extracts did affect the growth of rat hair. Statistical tests using one-way ANOVA showed a p-value of <0.001 which means there is a significant difference in the average hair weight of rats treated. LSD post hoc test showed that treatment with a 17.5%:10% concentration ratio was significantly different from the other treatments. It can be concluded that the combination of celery leaf extract and gedi leaf positively affects rat hair growth.
Co-Authors Abdullah, Surya Sumantri Adithya Yudistira Andi Buanasari Andy A.N Hiola Angmalisang, Elvin Clara Antasionasti, Irma Arsyad, Aswin ASARI Asep Rahman Asep Rahman Ayu Wati Ningsih Buanasari, Andi Christian Alexandro Lanes Christian Aseng Citra Fatima Marsidi Debora Gebby Tumundo DEBY AFRIANI MPILA Defny S. Wewengkang, Defny S. Dian Suryanita Sari Eldy Sengkey Elly Suoth Essing, Jacklien Deswita Fadila Al-A’izzah Fathoni, Kristiani W. S. W. Fatimawali . Fatrini Djaber Febrianika Ayu Kusumaningtyas Frenly Wehantouw Gayatri Citraningtyas Gunawan, Lea Nathaniela Agneta Hariyanto, Yuanita A. Hariyanto, Yuanita Amalia Herny E.I. Simbala Hiola, Andy A.N Hosea Jaya Edy I Dewa Ayu M. Melaniawati Ihsan S. Tome Imam Jayanto Irma Antasionasti Jayanto, Imam Julianri Sari Lebang, Julianri Sari Kapondo, Gwendolyn L. Kawatu, Chelsea Keri Lestari Lestari, Utami Sasmita Liling, Yessi Manuel, Jennike T. Maria Efrani Tengor Olvi Datu Owu, Nadya M. Rizky Abdulah Rizya Marchilia Mamahit Sarai Raehilda Febriansi Korban Sengkey, Eldy Shabrina Wahyudi Sharon Colin Tangkere Siampa, Jainer Pasca Soleman, Puput Sri Sudewi, Sri Surya Sumantri Abdullah Tengor, Maria Efrani Ticoalu, Pricilia Kesia Tinungki, Syalomita Esther Tome, Ihsan S. Wenas, Glori Anjelina Preysi Weny I. Wiyono Weny I. Wiyono Weny Indayany Wiyono Weny Indayany Wiyono Weny Indayany Wiyono Weny Wiyono Wiyono, Wenny I. Wiyono, Weny Indayany Woran, Falinry Wori, Preicy Augenia