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All Journal Journal of Environmental Engineering and Sustainable Technology Jurnal Kedokteran MNJ (Malang Neurology Journal) Journal of Information Technology and Computer Science Jurnal Pengembangan Teknologi Informasi dan Ilmu Komputer Journal of Islamic Medicine Journal of Pain, Vertigo and Headache Jurnal Kesehatan Masyarakat
Eko Arisetijono
Universitas Brawijaya
Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health

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Serum Clusterin Level Associated with Post-ischemic Stroke Cognitive Dysfunction Harahap, Herpan Syafii; Indriyana, Yanna; Rianawati, Sri Budhi; Arisetijono, Eko; Rivarti, Arina Windri
Jurnal Kesehatan Masyarakat Vol. 20 No. 3 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i3.4401

Abstract

The exploration of potential blood-based biomarkers that could be useful in the early detection of cognitive impairment associated with ischemic stroke is still being studied. The objective of this study was to examine the correlation between serum clusterin levels and the prevalence of cognitive impairment in individuals with ischemic stroke. A total of 86 outpatients with mild ischemic stroke within the first three months of its onset were recruited from three primary hospitals in Mataram, Indonesia. ELISA was used to measure the serum clusterin level. Patients’ sociodemographic and clinical data were also collected as covariates. The Montreal Cognitive Assessment-Indonesian version (MoCA-INA) instrument was used to evaluate cognitive status. The study used multivariate logistic regression analysis to investigate the effect of clusterin on the occurrence of cognitive impairment associated with ischemic stroke while controlling for other variables. Results: The multivariate logistic regression analysis revealed a significant correlation between elevated serum clusterin levels and a higher prevalence of cognitive impairment in ischemic stroke patients (odds ratio [OR] 3.56, 95% confidence interval [CI] 1.04-12.16, p = 0.043). Conclusion: Elevated serum clusterin levels have been associated with a higher occurrence of cognitive impairment in ischemic stroke patients.
Co-Authors Agustin, Aisyiyah Alviana Arief Andy Soebroto Asmiragani, Syaifullah Badrul Munir, Badrul Catur Ari Setianto Catur Ari Setianto, Catur Ari Chozin, Iin Noor Deby Putri Indraswari Dessika Rahmawati Didi Candradikusuma Dwi, Pratiwi Suryanti Ernanda, Shelby Amrus Haq, Nabiila Ala Qoonita Najma HARI PURNOMO Heri, Sutanto Herman Tolle Herpan Syafii Harahap Hidayat, Rudi Rakhmad Indriyana, Yanna Ismiarta Aknuranda Karmia Larissa Br Pandia Masruroh Rahayu Muhamad Rasjad Indra Nanik Setijowati Nidia Suriani Pradhana, Satwika Priana, Aan Jelli Rahmawati, Dessika Rahmawati, Dessika Raisa, Neila Rivarti, Arina Windri Rodhiyan Rakhmatiar Shahdevi Nandar Kurniawan, Shahdevi Nandar siti nurlela Sitompul, Boyke Sri Budhi Rianawati, Sri Budhi Sri Budi Rianawati Tri Wahju Astuti, Tri Wahju Widodo Mardi Santoso Widodo Mardi Santoso, Widodo Mardi Wirathmawati, Andina Yulia Damayanti Yuyun Yueniwati Zamroni Afif