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Journal : Berkala Kedokteran

EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) AND CARCINOEMBRYONIC ANTIGEN (CEA) RELATIONSHIP OF LUNG ADENOKARSINOMA IN SAIFUL ANWAR HOSPITA MALANG Normawati, Normawati; Pratiwi, Suryanti Dwi; Setijowati, Nanik
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i2.4073

Abstract

Abstract: EGFR mutations is associated with sensitivity to tyrosine kinase inhibitors (TKI’s) therapy which are found in Lung Adenocarcinoma. There are some limitations in detecting EGFR mutation. CEA is also expected to predict treatment efficiency of EGFR-TKIs therapy. In this study, we investigated the relationship between serum Carcinoembryonic antigen (CEA) and Epidermal Growth Factor Receptor (EGFR) Mutations in Lung Adenocarcinoma patient. Methods : The research was conducted in Dr. Saiful Anwar General Hospital Malang. From May 2014 to November 2015, 54 lung adenocarcinoma patients who had underwent measurements of EGFR  mutation and serum CEA level were retrospectively recruited. None of them had surgery, radiotherapy, chemotherapy and  targeted therapy. EGFR mutation was detected using PCR, serum CEA levels were analyzed using electrochemical luminescence. Result: Abnormal serum levels of CEA were significantly associated with EGFR mutation (95% CI, P=0,043) with an odds ratio of 3.4 (95% CI: 1.010-11.451). The area under the ROC curve for CEA was 0.558 (95% CI, P=0.078). Conclusion: Serum CEA is associated with mutation of EGFR in lung adenocarcinoma patients.  Keywords : Lung cancer, adenocarcinoma, EGFR, CEA
Co-Authors A.A. Ketut Agung Cahyawan W Ahmad Rosandi Sakir Ahmad Syahid Ali, Israwati Mw. Almahdali, Humairah Ambariyanto Ambariyanto Amelia.Y, Riska Annisa, Siti Maisarah Bahasoan, A. Bila, Salsah Bilgais, Sukma A. Bustam Layn, Safrudin Dianti, Misbala Dody Hartanto Dwi Kristiani, Dwi Fadli, Zul Fauzia, Elsa Risty Fitriani Fitriani Hasrawi, Hasrawi Hasriana Hasriana, Hasriana Hilal, Muhammad Hitimala, Ida Husein Alaydrus, Husein Indrianto Kadeko Juadry Engko, Garry Jusuf Madubun kadir, surni Kamal, Kamal Karepesina, K.F. Asiqien Karim, Ratna D. Lasawali, Adhriansyah A LAURENS, SAMSON Layn, Safrudin Bustam Liklikwatil, Debyella Cesya LUBIS, MUKHLIS M Parinussa, Ronald Mahrani, Mahrani Mamulaty, Arjun Mansur Mansur Mansyur, Siskawati Marnianti Irnawan, Sri Masdul, Muh Rizal Masdul, Muh. Rizal Minarsih Minarsih Nanik Setijowati Nasution, Ali Napiah Nurhudaya, Nurhudaya Nurtati Nurtati, Nurtati NURUL ANNISA Olii, Putri Zharifatul Rahmadiani Patta, Suwija Pattimukai, Hengky A.V Pattimukay, Hengky Virgo Richardo Pical, Khusnul Khatimah Pratiwi, Suryanti Dwi Rahmat Rahmat Rahmawati, Rahmawati Rahmi Rahmi Rengifurwarin, Zainal Abidin Riski Amaliah, Riski Rudji, Hamdi Rusni Rusni, Rusni Sahariah, Sahariah Sahetapy, Petronela Sahman, Irawati A. Said, Colle M. Sakka Samudin Selanno, Hendry Sopamena, Ibrahim Idham Sri Utami Sulasmini Sulasmini, Sulasmini Sulkipli, Sulkipli Surni Kadir Syarif Hidayat Tahalele, Imelda Anthonia Tuanaya, Wahab Tuasikal, Nasmaun Tuasikal, Umiasalamu Ufie, J.A. Ufie, Josep A Ufie, Josep A. Wahyu Nanda Eka Saputra, Wahyu Nanda Eka WAISAPY, Jeanly WALLA, NONA Wijiasih, Bekti Seyto Windasari Windasari, Windasari Wulan, Wulan Yulianti Yulianti Yusti, Eli