Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Pharmacon

Validasi Metode Analisis Matriks Patch Domperidon Maleat dengan Perbedaan Polimer Menggunakan Spektorfotometri UV-Vis Shesanthi Citrariana; Oktavia Indrati; Puspa Dwi Pratiwi; Ita Nurma Sari; Ari Wibowo
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 2 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v18i2.14576

Abstract

Uv-Vis spectrophotometry is an analytical method that can be used to determine the levels of domperidon maleate contained in transdermal patches with different polymers. The analysis method needs to be validated to prove that it can provide measurement results that match its designation. The purpose of this study is to prove that uv-vis spectrophotometry methods can provide the specificity, linearity, thoroughness, and precision that meet the requirements. In this study, linearity was known by calculating the r value on the curve of the relationship between levels and absorbance. Precision is obtained based on rsd value. Accuracy is calculated based on the return value. Selectiveity is known by means of identity confirmation that calculates the absorbance ratio at different wavelengths. The results showed that the method meets the requirements with a value of r=0.999; RSD precision results at a level of 10 ppm obtained RSD 0.236%. The accuracy values of 80%, 100%, and 120% in the matrix of transdermal domperidon maleate patches with PVA and PVP polymers respectively recovery was 99.50%, 101.15%, and 99.13%.. In the matrix of transdermal patches domperidon maleate with polymers HPMC and Na-CMC respectively recovery was 100.91%, 100.31%, and 100.67%. In the matrix of transdermal domperidon patches with HPMC and EC polymers respectively recovery was 98.00%, 98.00%, and 99.00%. The identity confirmation results on the transdermal domperidon patch matrix with PVA and PVP polymers, HPMC and Na-CMC, as well as HPMC and EC respectively have ratio value close to the standard solution with an average value of 0.800; 0,806; and 0.808. It can be concluded that the method of analyzing the levels of domperidone maleate in matrix of transdermal patches has qualified for good validity.
Co-Authors Adi, Mika Akhmad Kharis Nugroho Alfanaar, Rokiy Ardi Akbar Tanjung Ari Wibowo Arsana, Mu afa Arsana, Mu’afa Purwa Arsana, Mu’afa Purwa Awalul Fatiqin Awumistiko Awumistiko Ayu, Regina Wahyudyah Sonata Ayuchecaria, Noverda Baiq Maylinda Gemantari Bambang Hernawan Nugroho Chuchita Dea Betriksia Decenly Decenly Decenly, Decenly Defilia Anogra Riani Defilia Anograh Riani Desindria, Galang Rizdho Efriyana Oksal Efriyana Oksal Emma Ayudia Noriadita Endang Lukitaningsih Erni Dwi Puji Setyowati, Erni Dwi Puji Fatiqin, Awalul Fauziah, Anisa Rahma Gerung, Jenny Blessia Gintoro, Atilla Dian Dewanti Gunawan, Yohanes E Gunawan, Yohanes Edy Guntur Satrio Pratomo Halida Suryadini Haq, Muhammad Hasanul Ita Nurma Sari Ita Nurma Sari Jipasca, Elon Kalalinggi, Septaria Yolan Krissilvio, Eka Jonathan M Munawwarah Ma'rifah, Siti Mariasa, Joice Cleriska Melliani Melliani Muhammad Dawam Muhammad Priyadi Mu’afa Purwa Arsana Mu’afa Purwa Arsana Ngazizah, Febri Nur Nur Hidayat Oktavia Indrati, Oktavia Parametta, Vidya Puspa Dwi Pratiwi Puspa Dwi Pratiwi Rahman, Ansori Rahman, Sudarman Reny Nadya Oktari Riani, Defilia Rika Arfiana Safitri Risqika Yulia Tantri Paramawidhita Rizki Rachmad Saputra Rokiy Alfanaar Shodri, Muhammad Rifqi Simajuntak, Ruth Riama Siti Sunariyati Solikha, Sisi Sulistia, Tiya Thathit Suprayogi Tri Megawati Wahyu Nugroho Wilda, Robiatul Witari Yahya Febrianto Yahya Febrianto Yehezkiel Steven Kurniawan Yohanes Edy Gunawan Yosaeunike, Vitatani Yulita, Elia Zimon Pereiz