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All Journal Majalah Obat Tradisional Acta Pharmaciae Indonesia : Acta Pharm Indo Jurnal Kreativitas PKM JFM (Jurnal Farmasi Malahayati) Jurnal Inovasi Teknik Kimia Jurnal Ilmiah Medicamento Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Pengabdian Dharma Wacana Indonesian Community Journal Pharmacy Reports Jurnal Abdimas Dosma Jurnal Pengabdian Masyarakat Bangsa Amal Ilmiah: Jurnal Pengabdian Kepada Masyarakat JPEMAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Abdimas Dosma
Tantri Liris Nareswari
Department Of Pharmacy, Faculty Of Science, Institut Teknologi Sumatera, South Lampung 25365, Lampung, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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In silico screening of cucurbitacin variants identifies 11-deoxycucurbitacin I as a candidate ligand for the NACHT domain of NLRP3 Sarmoko; Ahmad Zammi Autadan Hakim; Nisa Yulianti Suprahman; Refsya Azanti Putri; Muhammad Yogi Saputra; Tantri Liris Nareswari; Manami Toriyama
Pharmacy Reports Vol. 6 No. 2 (2026): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.125

Abstract

Chronic inflammation contributes to a wide range of diseases, driving the need for novel anti-inflammatory agents with minimal side effects. The NACHT domain of NLRP3 mediates ATP-dependent inflammasome assembly and represents a validated target for anti-inflammatory therapy. This study aimed to predict and compare the binding interactions of twenty-two cucurbitacin variants against the NACHT domain using molecular docking, following geometry optimization with Density Functional Theory (B3LYP/6-31G(d)). Docking validation reproduced the native ligand pose with an RMSD of 0.87 angstrom. Among all variants tested, 11-deoxycucurbitacin I showed the most favorable predicted binding energy (-7.38 kcal/mol), sharing several interacting residues with the native ligand RM5, including Ala227, Ala228, Pro352, Ile411, Phe575, and Met661, although its predicted affinity remained weaker than that of RM5 (-10.35 kcal/mol). These shared contacts suggest that 11-deoxycucurbitacin I may engage a similar region of the NACHT inhibitor-binding pocket as RM5. In conclusion, 11-deoxycucurbitacin I is identified as the most favorable predicted binder among the cucurbitacin variants tested toward the NACHT domain, representing a candidate warranting further experimental validation.
Network pharmacology and molecular docking of cucurbitane-type triterpenoids from Momordica charantia against psoriasis-associated targets Ahmad Bayu Satriawan; Sarmoko; Tantri Liris Nareswari; Nisa Yulianti Suprahman; Muh Fajar Fauzi; I Gede Raditya Purwanata
Pharmacy Reports Vol. 6 No. 3 (2026): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.127

Abstract

Psoriasis is a chronic immune-mediated inflammatory skin disorder characterized by keratinocyte hyperproliferation, persistent inflammation, dysregulated apoptosis, and tissue remodeling. Momordica charantia has attracted attention as a potential anti-psoriatic herbal candidate; however, the molecular basis of its bioactive metabolites remains insufficiently understood. This study investigated the anti-psoriatic potential of cucurbitane-type triterpenoids from M. charantia using integrated network pharmacology and molecular docking. Of 192 secondary metabolites, 50 passed pharmacokinetic and toxicity screening, yielding 347 predicted human targets, of which 159 overlapped with 3,383 psoriasis-associated genes. Key hub genes identified by protein-protein interaction and topological analyses included AKT1, TNF, EGFR, STAT3, IL1B, CASP3, MMP9, HIF1A, and ESR1, with enriched biological processes related to oxidative stress, lipid and hormonal responses, and intracellular receptor signaling. Molecular docking of five cucurbitane-type triterpenoids against four validated hub proteins demonstrated consistently favorable predicted binding affinities for AKT1 via its allosteric pocket, as well as for EGFR and IL1B. Karavilagenin A showed the most favorable binding energy against AKT1, momordicin I against EGFR and IL1B, and cucurbitacin B demonstrated favorable profiles across multiple targets. These findings suggest that M. charantia may influence psoriasis-related biology through multi-target mechanisms, providing a basis for further experimental validation.
Transfersome nanocarriers of green arabica coffee (Coffea arabica L.) bean extract: physicochemical characterization and in vitro antioxidant activity Nur Adliani; Amelya Lukita; Yasinda Oktariza; Tantri Liris Nareswari
Pharmacy Reports Vol. 6 No. 2 (2026): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.129

Abstract

Green Arabica coffee beans contain high concentrations of phenolic antioxidants, including chlorogenic acid and gallic acid, with demonstrated potential for topical skin protection. To enhance skin penetration and bioavailability of these active compounds, a transfersome delivery system was developed using ethanolic extract of green Arabica coffee beans from Aceh, Indonesia. Five formulations (F1–F5) were prepared by the thin-film hydration method with varying soybean lecithin:Tween 80 ratios (90:10 to 50:50), maintaining a total lipid mass of 500 mg and a fixed extract load of 50 mg. Physicochemical evaluation showed no significant differences in pH (5.41–5.46) across formulations, while viscosity of F1 was significantly higher than F2–F5 (p<0.05). Gallic acid content, determined by HPLC-UV, was highest in F4 at 45.370 mg/L. F4 also exhibited optimal particle characteristics (mean size 10.595 nm, zeta potential −30.5 mV, PDI < 0.3) and the strongest DPPH radical scavenging activity (IC50 = 2.652 ± 0.083 µg/mL). The 60:40 lecithin:Tween 80 ratio of F4 provided optimal bilayer flexibility without compromising vesicular integrity. These results support F4 as a promising topical antioxidant candidate; skin permeation and stability studies are required for further development.
Molecular Docking Study of Pongamia pinnata Phytochemicals as Phosphodiesterase-4 Inhibitors for Atopic Dermatitis Adinda Salsabila; Riska Arini; Tantri Liris Nareswari; Naura Nurnahari
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 15 No 1 (2026): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v15i1.815

Abstract

Atopic dermatitis is a chronic inflammatory skin disease characterized by recurrent itching, eczematous lesions, and associated with significant impairment in quality of life. Current therapies for AD, including corticosteroids and calcineurin inhibitors, are often associated with adverse effects, highlighting the need for safer alternatives. Pongamia pinnata is widely used in traditional medicine and has demonstrated anti-inflammatory and antioxidant properties. Therefore, this study aimed to explore the potential of P. pinnata phytochemicals as phosphodiesterase-4 inhibitors for atopic dermatitis through molecular docking analysis. Molecular docking analysis was conducted against phosphodiesterase-4 to evaluate their binding affinities and key amino acid residues compared to the native ligand and roflumilast as the reference drug. Subsequently, Lipinski’s Rule of Five was applied to assess the oral drug-likeness properties of the selected compounds. Karanjachromene exhibited the highest binding affinity toward PDE4 (ΔG = −8.17 kcal/mol), exceeding both the reference drug roflumilast (ΔG = −6.47 kcal/mol) and the native ligand (ΔG = −7.81 kcal/mol). Interaction analysis demonstrated that karanjachromene shared several key amino acid residues with the native ligand, indicating similar binding interactions with phosphodiesterase-4. In addition, karanjachromene fulfilled Lipinski’s Rule of Five and favorable ADMET properties, suggesting oral administration potential. However, further in vitro and in vivo evaluations are required to validate its pharmacokinetics, bioavailability, and pharmacological activity against phosphodiesterase-4.
Co-Authors A.L, Ihza Adzkiya Mubarak Abdul Muhyi Adinda Salsabila Ahmad Bayu Satriawan Ahmad Bayu Satriawan Ahmad Bayu Satriawan Ahmad Zammi Autadan Hakim Amelya Lukita Anandar, Salsabila Fauziah Anjar Hermadi Saputro Annisa Maulidia Rahayyu Annisa Nofriani Arrafi, Muhammad Zhafran Ayda Nuraniza Ayuwulanda, Aditya Azra Afifah Cahyadi, Dzaky Raihan Cresentia Aurora Mizuki Dina Putri Agustina Dzaki Arrafif Evi Kurniawaty Fahmi, Achmad Gus Firjatullah, Aiman Firly Shalsha Billa Gayatri Simanullang Hidayaturahmah, Rizky I Gede Raditya Purwanata intan kusuma wardani Irfanianta Arif Setyawan Isnina, Isnina Iwan Syahjoko Saputra Keisya Aurora Natasha Chairunisa Kiki Yuli Handayani Lulu Zaqia Lusi Meliyana Nur Indah Sari Manami Toriyama Meiriska Maharani Surya Nugroho Misbahudin Alhanif Muh Fajar Fauzi Muh Fajar Fauzi Muhammad Yogi Saputra Muhammad Yogi Saputra Muhyi, Abdul Murni Sari N.S, Yonatan Adi Nabila Ahlika Ulya Nabila, Novrilia Atika Nadia Nur Syakilla Natasya Armelia Putri Naura Nurnahari Nisa Yulianti Suprahman Nisa Yulianti Suprahman Nisa Yulianti Suprahman Novrilia Atika Nabila Nur Adliani Nur Adliani Nur Adliani Nurjannah, Okta Okta Nurjannah Oktosa, Megi Putra, Okta Nama Putri Amelia Rooswita Rahayyu, Annisa Maulidia Refsya Azanti Putri Refsya Azanti Putri Reny Haryani Rifqi Sufra Riska Arini Rooswita, Putri Amelia Saeli, Pinka Mustika Salsabila Fauziah Saputri, Desi Riana Sari, Untia Kartika Sarmoko Sarmoko Sarmoko Sarmoko Sarmoko Sarmoko Setyawan, Irfanianta Arif Shabira, Cika Amalia Sheldian, Rizki Shindy Martha Rahayu Shofiyah Arruwaidah Simanullang, Gayatri Siti Zulaicha, Annisaa Sudewi Mukaromah Khoirunnisa Suri, Faradila Azzahra Suyadi Suyadi Syaadatun Nadiah Syafitri, Erga Syaikhul Aziz Tamba, Evasus Triana Hertiani Untia Kartika Sari Ramadhani Vina Alfionita, Vina Winda Septiani Winda Septiani Windari, Nurul Irna Winni Nur Auli Yasinda Oktariza Yusron Darojat Yusupandi, Fauzi Zada Agna Talitha Zuyyina Dea Nabila