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Immunological Profile of Patients with Controlled and Uncontrolled Type 2 Diabetes Melitus in Mataram City, West Nusa Tenggara Arjita, I Putu Dedy; Adnyana , I Gede Angga; Anulus, Ayu; Saputra, I Putu Bayu Agus; Diarti, Maruni Wiwin
JURNAL INFO KESEHATAN Vol 21 No 2 (2023): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol21.Iss2.933

Abstract

The prevalence of DM disease in West Nusa Tenggara Province is not much different from that in Indonesia. DM cases in NTB are included in the ten most non-communicable illnesses suffered by the community and the incidence continues to increase from year to year. An increase in the levels of pro-inflammatory cytokines in the body is one of the causes of insulin resistance in cells which can further develop into type 2 diabetes. This study involved diabetic patients at the Mataram Community Health Center, who were assigned into 2 groups, namely the controlled diabetes group and the uncontrolled diabetes group and involved a standard group which was a group consisted of healthy people. Each group was examined for Fasting Blood Glucose (FBG) and HbA1c levels. The results of the examination in the standard group, controlled diabetes group and uncontrolled diabetes group obtained the FBG levels of 89.22 mg/dl, 110.0 mg/dl, and 245.80 mg/dl, respectively. Furthermore, the results of the HbA1c test in the standard group, controlled diabetes group and uncontrolled diabetes group were 5.44%, 6.03%, and 10.49%, respectively. The results of the examination of IL-6 levels in the standard group, controlled diabetes group and uncontrolled diabetes were 329.36 pg/ml, 331.52 pg/ml, and 320.33 pg/ml, respectively. The results of the IL-10 test in the standard group, controlled diabetes group and uncontrolled diabetes were 71.80 pg/ml, 116.60 pg/ml, and 128.10 pg/ml, respectively. Based on the results of the study, there was no significant difference in the levels of interleukin 6 and interleukin 10 between respondents with diabetes mellitus and healthy respondents (p>0.05). It can be concluded that there were no differences in interleukin 6 and 10 levels between healthy people with patients with controlled and uncontrolled diabetes.
Hubungan Lama Sakit, Tingkat Pendidikan, Motivasi Pasien, dan Dukungan Keluarga dengan Kepatuhan Diet Pasien Diabetes Melitus Tipe II di Rumah Sakit Daerah (RSD) Mangusada Kabupaten Badung Bali Manutama, Putu Agi Abhimana; Arjita, I Putu Dedy; Saputra, I Putu Bayu Agus; Bagiansah, Mamang
MAHESA : Malahayati Health Student Journal Vol 4, No 6 (2024): Volume 4 Nomor 6 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i6.14470

Abstract

ABSTRACT Diabetes mellitus is a non-infectious disease that has become one of the health threats worldwide. Dietary adherence has a very important function in the management of DM. factors that can affect the dietary adherence of DM patients, namely education, knowledge, motivation, family support, and length of suffering. To analyze the relationship of length of illness, education level, patient motivation, and family support with dietary compliance of Type II DM patients at RSD Mangusada Badung Regency Bali. Observational analytic quantitative research with simple random sampling research design with a sample size of 92 respondents. Data were analyzed by Chi-Square test and Spearman Rank test with a significance value limit (p-value) <0.05. The results showed that the majority of respondents were 51-60 years old 44 (47.8%), the majority of respondents were male 48 (52.2%), 78 (84.8%) complied with the diet, the length of illness without complications 42 (45.7%), higher education 35 (38%), good patient motivation 75 (81.5%), good family support 71 (77.2%). Bivariate analysis showed that there was a significant relationship between length of illness with dietary compliance (p=0.048), education level with dietary compliance (p=0.015), patient motivation with dietary compliance (p=0.001), and family support with dietary compliance (p=0.009). Length of illness, education level, patient motivation, and family support are associated with dietary adherence of Type II DM patients at Mangusada Hospital, Badung Regency, Bali. Keywords: Diabetes Melitus, Dietary Compliance, Long Illness, Level Of Education, Patient Motivation, Family Support  ABSTRAK Diabetes melitus merupakan penyakit non-infeksi yang menjadi salah satu ancaman kesehatan di seluruh dunia. Kepatuhan diet memiliki fungsi yang sangat penting dalam pengelolaan DM. faktor-faktor yang dapat mempengaruhi kepatuhan diet pasien DM, yaitu pendidikan, pengetahuan, motivasi, dukungan keluarga, dan lama menderita. Menganalisis hubungan lama sakit, tingkat pendidikan, motivasi pasien, dan dukungan keluarga dengan kepatuhan diet pasien DM Tipe II di RSD Mangusada Kabupaten Badung Bali. Penelitian kuantitatif analitik observasional dengan desain penelitian simple random sampling dengan besar sampel 92 responden. Data di analisis dengan uji Chi-Square dan uji Rank Spearman dengan batas nilai signifikansi (p-value) <0,05. Hasil penelitian menunjukkan mayoritas responden berusia 51-60 tahun 44 (47,8%), responden mayoritas berjenis kelamin laki-laki 48 (52,2%), patuh menjalani diet 78 (84,8%), lama sakit tanpa komplikasi 42 (45,7%), pendidikan tinggi 35 (38%), motivasi pasien baik 75 (81,5%), dukungan keluarga baik 71 (77,2%). Analisis bivariat menunjukkan terdapat hubungan yang signifikan antara lama sakit dengan kepatuhan diet (p=0,048), tingkat pendidikan dengan kepatuhan diet (p=0,015), motivasi pasien dengan kepatuhan diet (p=0,001), dan dukungan keluarga dengan kepatuhan diet (p=0,009). Lama sakit, tingkat pendidikan, motivasi pasien, dan dukungan keluarga berhubungan dengan kepatuhan diet pasien DM Tipe II di RSD Mangusada Kabupaten Badung Bali. Kata Kunci: Diabetes Melitus, Kepatuhan Diet, Lama Sakit, Tingkat Pendidikan, Motivasi Pasien, Dukungan Keluarga
Noni (Morinda Citrifolia) Ethanol Extract Lowered Blood Glucose Levels, Increased Glutathione Peroxidase Activity, And Decreased Malondialdehyde in White Rats Model of Diabetes Arjita, I Putu Dedy; Saputra, I Putu Bayu Agus; Sukmana, Dhika Juliana
Jurnal Penelitian Pendidikan IPA Vol 9 No 12 (2023): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i12.6076

Abstract

Diabetes mellitus can increase oxidative stress and damage cells. Noni fruit has antibacterial, antifungal, antitumor, analgesic, hypotensive, and anti-inflammatory benefits, can boost immunity, and has antioxidant content. Noni contains phenolic compounds (anthraquinones, acuities, asperulosides, and scopoletin), organic acids (capric and caprylic acids), and alkaloids (xeronine). The effect of noni ethanol extract can significantly reduce blood glucose (P<0.05) of the T2 group (177.00±137.78) and T3 (159.40±86.53) when compared to the C+ group (511.00±131.45). The T1 group (387.40±170.06) had no significant difference (P>0.05) when compared to the C+ group (511.00±131.45), but there was a decrease in the average yield at T1 (387.40±170.06). Serum malondialdehyde (MDA) examination showed a significant decrease (p<0.05) in T1 (1188.32±93.41), while in T2 (1385.35±38.65) and T3 (1460.32±42.51) was not significant (p<0.05). Examination of serum glutathione peroxidase (GPX) showed a significant decrease in T1 (119.97±37.45), there was a decrease in GPX levels, while in the T2 group (236.14±6.05) and T3 (185.24±43.07), there was no decrease. Noni ethanol extract can lower blood glucose levels, reduce Malondialdehyde levels, and prevent increased activity of the enzyme glutathione peroxidase. Flavonoid compounds in noni ethanol extract can avoid increased blood glucose and reduce free radicals formed due to hyperglycemia conditions.  
Potensi senyawa turunan flavonoid dalam menjadi inhibitor enzim HMG-Coa reductase kandidat obat h Saputra, I Putu Bayu Agus; Arjita, I Putu Dedy
Jurnal Penelitian Pendidikan IPA Vol 10 No 5 (2024): May
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i5.6237

Abstract

Cardiovascular disease (CVD) is a disease that causes death in the world. Behavioral risk factors are crucial in dealing with CVD disease. High levels of cholesterol in the blood are associated with hypercholesterolemia. It can increase the risk of CVD disease. The HMG-CoA reductase enzyme is an enzyme that plays a role in cholesterol synthesis. It will convert the HMG-CoA compound into the mevalonate. Inhibition of this enzyme can reduce cholesterol synthesis because it inhibits the formation of mevalonate, which is the initial stage of cholesterol synthesis. Herbal compounds are compounds produced by plants. It has good benefits for the body. Flavonoid compounds can be beneficial for health. Molecular docking is a method used to determine the binding affinity and interaction values ​​of the enzyme protein interaction with the ligand to be bound. The results of Apigenin binding affinity values is -7.7 kcal/mol, Luteolin is -8 kcal/mol, Quercetin is -8.2 kcal/mol, Kaempferol is -7.4 kcal/mol, Phloretin is -6.8 kcal/mol, Chalconaringenin is -6.9 kcal/mol, Cyanidin is -7.9 kcal/mol, Delphinidin is -7.8 kcal/mol, Hesperetin is -7.7 kcal/mol, Narigenin is -7.8 kcal/mol, Daidzein is -6.8 kcal/mol, Genistein is -7 kcal/mol, Rutin is -9.2 kcal/mol, Taxifolin is -8 kcal /mol, Diosmetin is -7.6 kcal/mol, and its native ligand Rosuvastatin is -8.5 kcal/mol. Flavonoid derivative compounds can bind to the HMG-CoA reductase enzyme. They can be candidates for antihyperlipidemia drugs.
HUBUNGAN BERAT BADAN LAHIR DAN DIABETES GESTASIONAL DENGAN KEJADIAN HIPOGLIKEMIA NEONATUS DI RSUD KOTA MATARAM Muhammad Rezki Al-Ayyubi; I Putu Dedy Arjita; Muhammad Ashhabul Kahfi Mathar; Ananta Fittonia Benvenuto
Indonesian Journal of Health Research Innovation Vol. 3 No. 1 (2026): Indonesian Journal of Health Research Innovation
Publisher : Yayasan Menawan Cerdas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64094/zejw2m96

Abstract

Hipoglikemia neonatus merupakan salah satu masalah metabolik pada bayi baru lahir yang dapat terjadi tanpa gejala dan berpotensi menimbulkan komplikasi bila tidak ditangani. Kejadian hipoglikemia neonatus dipengaruhi oleh berbagai faktor, termasuk berat badan lahir dan kondisi maternal seperti diabetes gestasional.Tujuan penelitian untuk mengetahui hubungan berat badan lahir dan diabetes gestasional dengan kejadian hipoglikemia neonatus di RSUD Kota Mataram. Penelitian kuantitatif analitik observasional dengan rancangan cross-sectional. Penelitian dilaksanakan pada Oktober 2023 di RSUD Kota Mataram menggunakan data rekam medis kelahiran hidup tahun 2022. Teknik pengambilan sampel menggunakan purposive sampling dengan jumlah sampel 103 neonatus. Analisis bivariat dilakukan untuk menilai hubungan antarvariabel dengan tingkat signifikansi 0,05. Tidak terdapat hubungan yang signifikan antara berat badan lahir dan kejadian hipoglikemia neonatus (p=0,052). Terdapat hubungan yang signifikan antara diabetes gestasional dan kejadian hipoglikemia neonatus (p=0,001). Diabetes gestasional berhubungan signifikan dengan kejadian hipoglikemia neonatus, sedangkan berat badan lahir tidak menunjukkan hubungan yang signifikan dengan hipoglikemia neonatus di RSUD Kota Mataram.
Antibacterial Effectiveness of A Combination of Binahong (Anredera cordifolia) and Soursop (Annona muricata) Leaf Extract on The Growth of Escherichia coli in Vitro Wiranty, Agna Shailla Monica; Arjita, I Putu Dedy; Setyowati, Ety Retno
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11504

Abstract

The high incidence of diarrhea and the increasing resistance of Escherichia coli to various first-line antibiotics has prompted the search for safer and more effective antibacterial alternatives. Herbal plants such as binahong leaves and soursop leaves are known to contain secondary metabolites with antibacterial potential. This study aims to determine the antibacterial effectiveness of a combination of binahong and soursop leaf extracts on the growth of Escherichia coli in vitro and to determine the most effective combination concentration. This study was a laboratory experimental study with a true experimental design, then tested against Escherichia coli using the agar diffusion method. Statistical analysis was performed using the Kruskal–Wallis test and continued with the Mann–Whitney test. The results showed that the combination of binahong and soursop leaf extracts was able to inhibit the growth of Escherichia coli at all concentrations tested. There was a statistically significant difference in the diameter of the inhibition zone between treatment groups (p < 0.05). The combination of extracts at a concentration of 50% showed more optimal inhibitory activity than other concentrations, which is thought to be influenced by the interaction of the active compounds in both extracts. In conclusion, the combination of binahong and soursop leaf extracts has antibacterial effectiveness against the growth of Escherichia coli in vitro and has the potential to be developed as a natural antibacterial alternative.
UJI DAYA HAMBAT EKSTRAK BATANG KAYU SECANG (Caesalpinia Sappan L.) TERHADAP BAKTERI Escherichia Coli Dharmayanti, Ni Made Dwi; Arjita, I Putu Dedy
JURNAL KEDOKTERAN Vol. 4 No. 1 (2018)
Publisher : Fakultas Kedokteran Universitas Islam Al-Azhar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (60.304 KB) | DOI: 10.36679/kedokteran.v4i1.60

Abstract

Escherichia coli merupakan bakteri gram negatif berbentuk batang dalam sel tunggal atau berpasangan. Escherichia coli termasuk anggota flora normal dalam usus dan dapat menjadi patogen bila mencapai jaringan di luar jaringan intestinal. Mengingat obat-obatan kimiawi banyak yang menyebabkan resistensi dan efek samping, para ahli farmakologi mulai mengembangkan pengobatan dengan bahan-bahan yang tradisional seperti tanaman secang (Caesalpinia sappan L.) yang bermanfaat sebagai antibakteri (Katno, 2008).Tujuan penelitian ini adalah untuk mengetahui daya hambat ekstrak batang kayu secang (Caesalpinia sappan L.) terhadap bakteri Escherichia coli. Penelitian ini merupakan jenis penelitian True Experiment dengan rancangan Posttest dengan Kelompok Kontrol (Posttest Only Control Group Design), menggunakan Rancangan Acak Lengkap (RAL) dengan 24 unit percobaan dan 4 kali ulangan. Sampel penelitian adalah ekstrak batang kayu secang (Caesalpinia sappan L) dengan konsentrasi 10%, 20%, 30% dan 40%, 2 kelompok kontrol terdiri dari kontrol positif ciprofloxacin dan kontrol negatif aquades. Daya hambat diperoleh berdasarkan pengukuran zona hambat dan data yang diperoleh dianalisis menggunakan uji One Way Anova.Hasil penelitian zona hambatan untuk Escherichia coli pada konsentrasi 10% (0 mm); 20% (0 mm); 30% (0 mm) dan 40% (0 mm). Hasil uji Kruskal Wallis diperoleh nilai signifikan yakni 1,000 lebih besar dari p value: 0,05 sehingga dapat dinyatakan bahwa ekstrak batang kayu secang (Caesalpinia sappan L.) tidak memiliki daya hambat terhadap pertumbuhan bakteri Escherichia coli
ANALISIS KADAR HEMOGLOBIN, AKTIVITAS FISIK, DAN LAMA HEMODIALISIS TERHADAP KUALITAS HIDUP PASIEN PENYAKIT GINJAL KRONIS Hidayaturrizqi, Baiq Humairo; Utama, Lalu Buly Fatrahady; Arjita, I Putu Dedy; Mulianti, Rizki
Jambura Journal of Health Sciences and Research Vol 8, No 2 (2026): APRIL: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v8i2.36728

Abstract

Penyakit ginjal kronis (PGK) pada stadium lanjut memerlukan terapi hemodialisis yang berdampak pada kualitas hidup pasien secara multidimensional. Kebaruan penelitian ini terletak pada penguatan bukti empiris bahwa kualitas hidup pasien hemodialisis tidak selalu dipengaruhi oleh parameter klinis seperti kadar hemoglobin dan tingkat aktivitas fisik, melainkan lebih berkaitan dengan durasi menjalani terapi hemodialisis sebagai proses adaptasi jangka panjang pasien terhadap penyakit kronis. Penelitian ini bertujuan untuk menganalisis hubungan antara kadar hemoglobin, aktivitas fisik, dan lama menjalani hemodialisis dengan kualitas hidup pasien PGK yang menjalani hemodialisis. Penelitian ini menggunakan desain observasional analitik dengan pendekatan cross-sectional terhadap 62 pasien PGK di Unit Dialisis RSUD dr. Soedjono Selong yang dipilih menggunakan consecutive sampling, di mana kadar hemoglobin diperoleh dari data rekam medis, aktivitas fisik diukur menggunakan International Physical Activity Questionnaire–Short Form (IPAQ-SF), dan kualitas hidup dinilai menggunakan WHOQOL-BREF, dengan analisis bivariat menggunakan Fisher’s Exact Test. Hasil penelitian menunjukkan bahwa tidak terdapat hubungan yang signifikan antara kadar hemoglobin (p = 0,328) maupun tingkat aktivitas fisik (p = 0,882) dengan kualitas hidup, sedangkan lama menjalani hemodialisis berhubungan signifikan dengan kualitas hidup pasien PGK (p = 0,000). Kesimpulannya, kualitas hidup pasien PGK yang menjalani hemodialisis lebih dipengaruhi oleh adaptasi terhadap terapi jangka panjang, sehingga intervensi pelayanan kesehatan perlu diarahkan pada pendekatan holistik yang mendukung adaptasi fisik dan psikososial pasien.
Efektivitas Kombinasi Ekstrak Etanol Daun Kirinyuh (Chromolaena Odorata) dan Daun Talas (Colocasia Esculenta) terhadap Daya Hambat Pertumbuhan Methicillin-Resistant Staphylococcus Aureus (MRSA) Nursoleha, Dienda Rara; Arjita, I Putu Dedy; Sabariah, Sabariah; Setyowati, Ety Retno
Malahayati Nursing Journal Vol 8, No 4 (2026): Volume 8 Nomor 4 (2026)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v8i4.24121

Abstract

ABSTRACT Methicillin-Resistant Staphylococcus aureus (MRSA) infection has resulted in an increase of the death rate due to Antimicrobial Resistance around the world, one of it is Indonesia. The treatment of MRSA infections mostly uses synthetic antibacterial drugs. However, currently many synthetic drugs are getting resistance, that allowing MRSA infections out of control. One of the attempts to solve this problem is to use natural ingredients such as Chromolaena odorata and Colocasia esculenta plants which have been proven to have antimicrobial effects against some bacteria. This research aims to test the effectiveness of the combination of Chromolaena odorata and Colocasia esculenta extract with ethanol in inhibiting the growth of MRSA. This research method uses true experimental using the Cup-plate technique/well diffusion method. The number of experimental units was 28 that divided into 7 groups with a ratio of 1:0, 1:1, 1:2, 2:1, 0:1, positive control of Vancomycin 30ug/disk, negative control of ethanol 95%. From the antibacterial test, there were results a very strong categories in combination of 1:0, 1:1, 1:2, and 2:1 ethanol extract of Chromolaena odorata and Colocasia esculenta with inhibitory zone diameters of 20 mm, 20.875 mm, 21.25 mm, and 22.125 mm. Meanwhile, the ratio of 0:1 is unable to inhibit MRSA. The results of the Mann-Whitney test showed that there was no significant difference between the ratio of 1:0, 1:1, 1:2, and 2:1 with the positive control, meanwhile the ratio of 0:1 has a significant difference. In this study, there was an effectiveness on the combination of Chromolaena odorata and Colocasia esculenta extract with ethanol in the ratio of 1:0, 1:1, 1:2, and 2:1 that inhibited the growth of MRSA.  Keywords: Antibacteria, Combination, MRSA.  ABSTRAK Infeksi Methicillin-Resistent Staphylococcus aureus (MRSA) mengakibatkan terjadinya peningkatan angka kematian akibat Antimicrobial Resistance diseluruh dunia, salah satunya di Indonesia. Pengobatan infeksi MRSA sebagian besar menggunakan obat-obatan antibakteri sintetik. Namun, saat ini obat-obatan sintetik banyak mengalami resistensi sehingga memungkinkan infeksi MRSA semakin tidak terkendali. Salah satu upaya untuk mengatasi hal tersebut adalah dengan menggunakan bahan alami seperti tanaman Chromolaena odorata dan Colocasia esculenta yang tebukti memiliki efek antimikroba terhadap beberapa bakteri. Penelitian ini bertujuan untuk menguji efektivitas kombinasi ekstrak etanol Chromolaena odorata dan Colocasia esculenta dalam menghambat pertumbuhan MRSA. Metode penelitian ini menggunakan true experimental menggunakan metode difusi Cup-plate technique/sumuran. Jumlah unit percobaan sebanyak 28 pada 7 kelompok dengan perbandingan 1:0, 1:1, 1:2, 2:1, 0:1, kontrol positif Vankomisin 30ug/disk, kontrol negatif etanol 95%. Dari uji antibakteri tersebut terdapat hasil pada kombinasi 1:0, 1:1, 1:2, dan 2:1 ekstrak etanol Chromolaena odorata dan Colocasia esculenta memiliki diameter zona hambat 20 mm, 20,875 mm, 21,25 mm, dan 22,125 mm termasuk kategori sangat kuat. Sedangkan pada perbandingan 0:1 tidak mampu menghambat MRSA. Hasil uji Mann-Whitney menunjukkan bahwa tidak terdapat perbedaan secara signifikan pada perbandingan 1:0, 1:1, 1:2, dan 2:1 terhadap kontrol positif. Sedangkan perbandingan 0:1 memiliki perbedaan secara signifikan. Pada penelitian ini terdapat efektivitas kombinasi ekstrak etanol Chromolaena odorata dan Colocasia esculenta pada perbandingan 1:0, 1:1, 1:2, dan 2:1 dalam menghambat pertumbuhan MRSA Kata Kunci: Antibakteri, Kombinasi, MRSA.