Creating a balance between human health and the environment is very important to implement. In this case, pollution caused by cigarette smoke is a disruption of the creation of a balance of human health and the environment. In several districts/cities, regional regulations on No Smoking Areas (KTR) have now been implemented. North Labuhanbatu Regency is one of the regions that has implemented this regulation, through KTR regional regulation number 33 of 2022. The local government of North Labuhanbatu Regency in this case makes no-smoking warnings in every corner of the KTR in the region as a form of optimizing PERDA no 33 of 2022. This research uses qualitative methods, the source of information from this research is obtained through activities, interviews, observations, and documentation studies. The research subjects in this study include the health department, district government, and the surrounding community. The object of research is the optimization of the application of KTR. The results showed that the North Labuhanbatu district government was still not effective in optimizing local regulation number 33 of 2022 regarding KTR. In an effort to overcome these problems, an integrated strategy is needed for the KTR PERDA.