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All Journal Pharmasipha Indonesian Journal of Global Health research Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Kesehatan Tambusai Jurnal Ilmiah Wahana Pendidikan Jurnal Buana Farma Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium JURNAL JAMU KUSUMA Duta Pharma Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Cerdika: Jurnal Ilmiah Indonesia Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Journal of Educational Innovation and Public Health Jurnal Ilmiah Kesehatan JURNAL FARMASI DAN KESEHATAN INDONESIA The International Science of Health Journal Jurnal Riset Ilmu Kesehatan Umum dan Farmasi CERATA Usadha Journal of Pharmacy Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan International Journal of Health and Medicine Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Danang Raharjo
Pogram Studi Farmasi, Fakultas Kesehatan, Universitas Duta Bangsa, Surakarta
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan

 1 
Formulasi Dan Uji Aktivitas Antibakteri Sediaan Krim Ekstrak Etanol Kulit Buah Manggis (Garcinia Mangostana Linn.) Terhadap Bakteri Propionibacterium Acnes ATCC 1335 Lydia Fitriana; Tiara Ajeng L; Anita Dwi Septiarini S; Danang Raharjo
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 1 (2024): Januari : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i2.197

Abstract

The skin is the widest organ that makes up the human body which is the outermost and covers the entire surface of the body. The outermost location causes the skin to receive stimulation for the first time such as touch stimulation, pain, or bad influences from outside. This causes the skin to stretch due to disease. One of the most common skin diseases suffered by people is acne. Acne occurs generally triggered by the bacterium Propionibacterium acnes (gram positive bacteria). Effective acne treatment can use antibiotics, but inappropriate use of antibiotics can lead to resistance. Therefore it is necessary to have alternative therapies from plants that have the potential as antibacterial. One of the natural ingredients from plants that have antibacterial properties is mangosteen (Garcinia mangostana Linn.)This research was conducted using a descriptive experimental method with the aim of knowing the presence of antibacterial activity in cream preparations of ethanol extract of mangosteen rind (Garcinia mangostana Linn.) against Propionibacterium acnes bacteria as seen from the inhibition of bacteria with varying concentrations of 10%, 15% and 25% by using paper disc diffusion method and solid liquid dilution method. The positive control used clindamycin cream and the negative control used 1% DMSO. Analysis of the diameter of the inhibition data was carried out using the One Way ANOVA test. The preparation formulation that has the largest diameter in the diffusion test is F3 with a concentration of 25% with an average inhibition of 6.36 in the medium category. The MIC and KBM values in the dilution method were at a concentration of 12.5%. The results of a normally distributed One Way ANOVA are measured with a value (P> 0.05). Mangosteen peel extract (Garcinia mangostana Linn.) has antibacterial activity against Propionibacterium acnes bacteria.
Aktivitas Penghambatan Enzim α-Amilase Ekstrak Etanol dan Fraksi Buah Belimbing Wuluh (Averrhoa bilimbi L.) Diana Nurrah Ashari; Tiara Ajeng L.; Danang Raharjo
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 6 (2024): November : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i6.813

Abstract

The enzyme α-amylase is one of the enzymes that plays a role in the process of degrading starch into maltose and glucose. Organic compounds such as polyphenols and flavonoids are inhibitors of α-amylase. The star fruit plant (Averrhoa bilimbi L.) has α-amylase enzyme inhibition activity and has the potential to be used in the therapy of type 2 diabetes mellitus. This study aims to determine whether ethanol extract and the fraction of star fruit (Averrhoa bilimbi L.) have α-amylase enzyme inhibition activity, inhibition against α-amylase enzyme and better inhibition activity. The test of α-amylase enzyme inhibition activity was carried out using 3 test groups, namely negative control, positive control (acarbose) and samples (ethanol extract and star fruit fraction) with concentrations of 12.5 ppm, 25 ppm, 50 ppm, 100 ppm and 200 ppm. The results of testing the inhibitory activity of α-amylase enzyme of ethanol extract and the fraction of star fruit (Averrhoa bilimbi L.) obtained IC50 values of 5.581 μg/mL, 76.725 μg/mL, 43.152 μg/mL and 55.447 μg/mL, respectively. Based on these results, it can be concluded that the ethanol extract of star fruit (Averrhoa bilimbi L.) at a concentration of 200 ppm has a very strong activity in inhibiting the α-amylase enzyme with an inhibition percentage of 85.217% and an IC50 value of 5.581 μg/mL.
Optimasi Metode Microwave-Assisted Extraction (MAE) untuk Menentukan Kadar Flavonoid Total Ekstrak Etanol Kulit Pisang Kepok (Musa Paradisiaca.L) Salsabila Khoerunniyssa; Danang Raharjo; Bagas Ardiyantoro
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 6 (2024): November : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i6.814

Abstract

Indonesia is a country that has a lot of banana diversity. One of the banana plants that is widely found in Indonesia is the Kepok banana (Musa Paradisiaca.L). Kepok banana skin has a very high content of flavonoids and phenols. Flavonoids are known as good antioxidants because they can find reactive oxygen species with the phenolic hydroxyl group that flavonoids have. The aim of this research was to determine the results of the optimization of the Microwave-Assisted Extraction (MAE) method on the total flavonoid content of kapok banana peel ethanol extract. Microwave-Assisted Extraction (MAE) was done to extraction flavonoid from ethanol extract of kepok banana peel (Musa Paradisiaca.L). The sample collected from Widoro village, Karangsambung sub-district, Kebumen regency. Optimum extraction condition was determined by the Response Surface Methodology (RSM). The Box- Behnken design (BBD) was used to evaluate the influence of 3 factors with 3 levels extraction that is power level (10%, 30%, 50%), ethanol concentration (50, 70, 96%), and extraction time (3, 5 and 7 minutes) with 15 different runs. The research showed that optimum extraction condition was at 24,14 % of power level, 66,26% ethanol concentration, and time extraction of 3,52 minutes with calculations from the Design Expert program, the total flavonoid content response was 8.491 Mg QE/g. The total flavonoid content value obtained experimentally was 8,246 Mg QE/g under condition of 30 % power level, 70% ethanol concentration, and time extraction of 5 minutes. Based on the result, total flavonoid content can be significantly increased by optimizing the MAE process use RSM.
Co-Authors Addawiyyah, Muniroh Adiyantoro, Bagas Aini, Riszki Nur Aminnulloh, Muhammad Aminnulloh, Muhhamad Aminulloh, Muhammad Anita Dwi Septiarini Anita Dwi Septiarini S Anna Fitriawati Apriliawan, Hidayah apriliyanti, laela intan Bagas Ardiyantoro Bangkit Riska P Bangkit Riska Permata Bangkit Riska Permata Chyang, Pang Jyh Desy Ayu Irma Permatasari Diana Nurrah Ashari Dwi Bagus Pambudi Dwi Bagus Pambudi Dwi Budi Santoso Dwi Nurul Khotimah Dwi S, Anita Eny Wijayanti Fadilla, Fitri Hansa Fatimah Azzahro Febriyani, Rima Fevi Indri Oktaviani Fitriwati, Anna Gusmao, Nandito Manuel Ximenes Haryoto, H Hidayat, Allif Nur Ilham Zikri kristian saputra, samuel Kusumaningtyas Siwi Artini Listyani, Tiara Ajeng Lisyani, Tiara Ajeng Luthfia Dhiyaul Amalia Luthfiyanti, Niken Lydia Fitriana M. Adam Firdausi Muhamad Farid Nurohman Krisnadi Musniati, Musniati Nafiah, Azidatun Niken Luthfiyanti Nuniek Nizmah Fajriyah Nurcahyani, Dona Agustin NURUL HIDAYAH Oktafia Nur Fatimah Pambudi, Dwi Bagus Permata, Bangkit Riska Permatasari, Desy Ayu Irma Pratama, Kharisma Jayak Rafidah Hanifah Raharjo, Oktavia Wijaya Rahmat Hidayat Ramadhani, Diza Aulia Rusmiati Rusmiati Salsabila Khoerunniyssa Sania, Sania Septian Maulid Wicahyo Setyaningrum, Fidya Siska Wardani, Tatiana Siti Fatimah Siti Fatimah Siwi Artini, Kusumaningtyas Sya'bania, Muti' Tiara Ajeng L Tiara Ajeng L. Vinkasari, Elriza Wardani , Tatiana Siska Wardani, Tatiana Siska Wulandari, Nia Isa Yuliya Rahma