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Dini Suryani, Dini
JKSG Universitas Muhammadiyah Yogyakarta, Indonesia
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Journal : AKSONA

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Determinants of Executive Dysfunction: Serum NRF2 and Sociodemographic Profiles in Lombok Island’s Coastal Population Wulandari, Inayah; Nurhidayati, Nurhidayati; Hunaifi, Ilsa; Rivarti, Arina Windri; Harahap, Herpan Syafii; Saputri, Legis Octaviana; Suryani, Dini; Zubaidi, Fitriannisa Faradina; Rosyidi, Rohadi Muhammad
AKSONA Vol. 6 No. 1 (2026): JANUARY 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v6i1.74449

Abstract

Highlight: Coastal communities show high prevalence of cognitive decline. There is no correlation between NRF2 levels and executive function. Gender and education level were significantly associated with executive dysfunction.   ABSTRACT Introduction: Elderly people frequently suffer from neurodegenerative conditions that affect cognitive function. Redox homeostasis dysregulation plays a significant role in neurodegenerative diseases. Oxidative stress activates the transcription factor called nuclear factor erythroid 2-related factor 2 (NRF2), which is essential for regulating the expression of genes involved in cellular defense mechanisms. Objective: This study aimed to determine the relationship between serum NRF2 levels and executive function, as well as to identify other variables that may influence executive function among residents of coastal villages on Lombok Island. Methods: The study used a cross-sectional design with consecutive sampling. Data on sociodemographic characteristics, hypertension, diabetes mellitus, smoking status, and physical activity were collected. Statistical analyses employed Spearman's rank correlation test, Fisher's exact test, and logistic regression test. Results: A total of 39 participants were included, with an average age of 53.38 years. Most participants were female, had a low educational level, did not have hypertension or diabetes mellitus, had high physical activity levels, and were non-smokers. The average NRF2 level was 0.54 ng/mL. The correlation test showed no significant relationship between serum NRF2 levels and executive function. Fisher's exact test showed a significant relationship between gender and education with executive function. Furthermore, logistic regression analysis identified education level as a predictor of executive dysfunction. Conclusion: Serum NRF2 levels were not correlated with executive dysfunction. Educational level was identified as a predictive factor for executive dysfunction.
Co-Authors . NURHAYATI Afwa', Rafi Abdika Andhera, Athalita Anjani, Dewa Ayu Vania Novista Anugrah, M. Fardi Ariuso, Al Hafiz Arnawati, Ida Ayu Arnawati Aryasta, Ida Bagus Putra Bayu Aulia, Dian Aziz, Nyimas Latifah Letty Azizaturrahmah, Gina Aulia Bahraen, Raehanul Balqis, Ananda Amirah Damayanti, Ida Ayu Andara Diana Morika, Honesty Dilaga, Marisa Syafitri Elizar, Lale Justin Amelinda Fakar, Wina Arsylia Fitriantoro, Santo Haq, Abiyyu Didar Harahap , Herpan Syafii Herpan Syafii Harahap Heru Cahyono Hilam, Muhammad Humam, Anang Muh. Naufal Ilsa Hunaifi, Ilsa Indrayana, Yanna Ismaya, Ferium Trah Krisna , I Gusti Lanang Landapa, Raditya Rachman Linggabudi, I Gusti Bagus Widiamtara Maharani, Amelia Wahyu Mawaddah, Alfia Muttaqin, Syihabul Novera, Milya Novsyaini, Zhayyin Palna Rial Nurhidayati Nurhidayati Nurhidayati Ocktaviana Saputri, Legis Oktavianus Prayitno, Oktavianus Pandikar, Ernandia Panjaitan, Melisa Parida Djayanti Permadi, Pongki Permatasari, Lina Prawiro, Aurellia Wongso Putri, Setyawati Asih Putri, Siti Noururrifqiyati Juna Putu Aditya Wiguna R. Siti Zuhro Rahma, Elrica Nadia Riantiani, Baiq Prita Ristia, Ovia Intan Rivarti, Arina Windri Rosyidi, Rohadi Muhammad Sanjaya, I Kadek Ari Saputri, Legis Octaviana Sari AZ, Winna Kurnia Sari, Putri Minas Sari, Winna Kurnia Sari.AZ, Winna Kurnia Shafa C, Cloresta Sinaga, Maria Hotmauli Sri Budhi Rianawati, Sri Budhi Sri Mulyati Stephen, Mishael Enoch Syifa, R.R Ditya Mutiara Wardi, Baiq Prita Riantiani Wulandari, Inayah Wulandari, Rizka Yusuf Maulana, Yusuf Zubaidi, Fitriannisa Faradina