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ANTIFUNGAL ACTIVITY TEST OF THE COMBINATION OF PAPAYA LEAF (Carica papaya L.) AND BASIL LEAF (Ocimum x africanum Lour) EXTRACTS AGAINST THE GROWTH OF Candida albicans Pratama, Dimas Feriza Pratama; Suswidiantoro, Vicko; Daskar, Annajim; Safutri, Wina
JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Vol. 4 No. 2 (2025): JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/js.v4i2.4214

Abstract

Fungal infections are common health problems, one of which is caused by Candida albicans. The use of synthetic antifungal agents in treatment can lead to side effects and resistance risks, thus necessitating safer natural alternatives. Papaya leaves (Carica papaya L.) and basil leaves (Ocimum x africanum Lour) are known to contain active compounds such as flavonoids, alkaloids, saponins, steroids, and tannins, which have potential as antifungal agents. The combination of these two plant extracts was used to enhance antifungal effectiveness through possible synergistic effects of their active compounds, with the expectation of yielding a more optimal inhibitory effect against Candida albicans. This study aimed to determine the effectiveness of a combination of papaya and basil leaf extracts in inhibiting the growth of Candida albicans. The research was conducted experimentally using a Completely Randomized Design (CRD) with five treatment groups and four replications. The antifungal activity was tested using the disc diffusion method with extract combinations formulated in 96% ethanol at concentrations of (18.75% : 18.75%), (37.5% : 12.5%), and (56.25% : 6.25%), as well as a negative control (aquadest) and a positive control (ketoconazole 15 μL). One-Way ANOVA analysis showed a significant difference between treatments (p < 0.05). Further analysis using Tukey HSD revealed no statistically significant differences between the three extract combination groups. However, P3 exhibited the highest inhibition zone (4.73 ± 0.91 mm), while P1 showed the lowest (3.45 ± 0.65 mm), and P2 was intermediate (3.98 ± 0.65 mm). All three combinations showed statistically significant differences compared to the negative control (0 mm) and the positive control (6.50 ± 0.83 mm). Thus, although no significant difference was observed between the combination groups, all combinations demonstrated statistically significant antifungal activity against Candida albicans compared to the negative control. In conclusion, the combination of papaya and basil leaf extracts possesses antifungal activity against Candida albicans, although the effectiveness is not yet optimal. Further research is recommended with increased extract concentrations and development into pharmaceutical dosage forms such as gels or ointments as alternative topical antifungal treatments.
An Ethnomedicinal Study of Medicinal Plants from the Zingiberaceae Family Used by the Community in Nunggalrejo Village, Punggur Subdistrict, Central Lampung Regency Malahatu Zalfa, Aisyah; Dwiningrum, Riza; Kartika Putri, Diah; Safutri, Wina
JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Vol. 4 No. 2 (2025): JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/js.v4i2.4248

Abstract

Ethnomedicine is a traditional treatment method that emphasizes local cultural practices and does not involve modern medical treatment. The community in Nunggalrejo frequently uses medicinal plants from the Zingiberaceae family to treat various ailments. Additionally, plants from this family are used in traditional medicine. The aim of this study is to analyze the species, plant parts used, preparation methods, and medicinal benefits of Zingiberaceae plants utilized in traditional medicine. This research employs a qualitative descriptive method with a snowball sampling technique and structured interviews. The research targets include herbal medicine makers, the oldest community members, and people who use traditional medicine. Based on interviews with 12 informants, the data revealed nine dominant species of Zingiberaceae, with the most frequently used being Curcuma xanthorrhiza (temulawak), Zingiber officinale (ginger), Curcuma longa (turmeric), and Kaempferia galanga (kencur), each accounting for 19%. The part most commonly used is the rhizome (100%), with boiling being the most common preparation method (50%). The most frequently treated ailment is acid reflux (29%). In conclusion, there are nine species of Zingiberaceae used to treat ten types of illnesses in Nunggalrejo Village.
FORMULATION OF VARIATIONS IN THE COMBINATION CONCENTRATIONS OF ROBUSTA COFFEE (Coffea canephora) POWDER AND TURMERIC RHIZOME EXTRACT (Curcuma longa L.) ON THE QUALITY OF BODY SCRUB PREPARATIONS Sumiyati; Rosanti, Afi Sania; Dwiningrum, Riza; Safutri, Wina
JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Vol. 4 No. 2 (2025): JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/js.v4i2.4265

Abstract

Body scrub is a skincare product used to exfoliate dead skin cells and accelerate skin regeneration. Natural ingredients such as robusta coffee powder (Coffea canephora), which contains caffeine, act as a natural exfoliant, while turmeric rhizome extract (Curcuma longa L.), which contains curcuminoids, functions as an antioxidant and skin brightener. This study aimed to formulate a body scrub using varying concentrations of robusta coffee powder and turmeric extract, and to evaluate its physical properties, stability, and consumer preference. An experimental method was used with five formulations: F1 (10% coffee), F2 (10% turmeric), F3 (7%:3%), F4 (8%:2%), and F5 (9%:1%). Evaluations included organoleptic testing, homogeneity, pH, spreadability, adhesion, cream type, viscosity, stability, and hedonic testing. Results showed that all formulations met the criteria for good physical quality. Based on hedonic tests, F1 was the most preferred in terms of color, while F4 was most favored for aroma and texture, making it the best formulation with no significant difference (p>0.05). This study supports the development of natural body scrubs using local ingredients that are safe and effective.
The Relationship between Compliance with Antihypertensive Drugs and the Life Quality of the Elderly in the Kresnomulyo Village Public Health Center, Pringsewu, Lampung Hotimah, Etika Khusnul; Wina Safutri; Mida Pratiwi; Diah Kartika Putri
JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Vol. 4 No. 2 (2025): JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/js.v4i2.4291

Abstract

One major issue in worldwide public health is hypertension. The third-highest rate of hypertension in Ambarawa District is seen in Kresnomulyo Village. In addition to making patients' conditions worse, noncompliance with antihypertensive treatment can result in problems such as heart enlargement, stroke, and kidney failure. Patients' quality of life is affected by their compliance with antihypertensive treatment, which includes both medication and lifestyle changes. The research objective was to analyze the correlation between compliance with antihypertensive medication use and the quality of life of patients at the Kresnomulyo Public Health Center. This research is a non-experimental quantitative analytical study. Data collection was conducted by distributing questionnaires to 146 respondents. Data were analyzed using the Chi-Square test. The results showed that 69% of respondents were non-compliant with their medication regimen, while 31% were compliant. Regarding quality of life, 20% of respondents reported no problems, 22% reported mild problems, 24% moderate, 19% severe, and 15% very severe. In conclusion, there is a significant correlation between the level of compliance to antihypertensive medication use and the quality of life of elderly hypertensive patients at the Kresnomulyo Public Health Center, Pringsewu, with a significance level of 0.000 (p < 0.05).
Formulation and Evaluation of Face Mist Preparation from Ethanol Extract of Agarwood Leaves (Aquilaria malaccensis L) as an Antioxidant trijayanti, mesi; Pratiwi, Mida; Daskar, Annajim; Safutri, Wina
JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Vol. 4 No. 2 (2025): JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/js.v4i2.4311

Abstract

Skin damage due to UV exposure and pollution can trigger the formation of free radicals that accelerate the process of premature aging. The use of natural antioxidants in cosmetic products to combat free radicals serves as an alternative to synthetic antioxidants, which often cause side effects. Agarwood leaves (Aquilaria malaccensis L.) are known to contain groups of active compounds such as flavonoids, tannins, alkaloids, saponins, and terpenoids that have potential as antioxidants. This study aims to formulate and evaluate the face mist preparation of ethanol extract from agarwood leaves in three different concentration variations: FI (5%), FII (6%), and FIII (7%). The research was conducted experimentally in the laboratory, covering the stages of plant determination, maceration with 96% ethanol, phytochemical screening, formulation of preparations, physical evaluation (organoleptic, homogeneity, pH, specific gravity, spreadability, spray condition, drying time, protection, and stability through cycling tests), as well as antioxidant activity testing using the DPPH method with UV-Vis spectrophotometry. The results showed that all formulations had good physical characteristics and were stable using the cycling test method, except for FII which was unstable in the specific gravity test. The IC₅₀ values of each formulation were FI at 28.138 mg/L, FII at 21.871 mg/L, and FIII at 19.387 mg/L, categorized as very strong antioxidants and the three formulations had significant differences with a p-value of ˂0.05. The conclusion of this research is that the FIII formula (7%) is the best formula because it has high antioxidant activity, is stable physically and chemically, and has the potential as a natural cosmetic product that protects the skin from free radicals.
Synergistic Antihyperglycemic Effects of Soursop Leaves and Garlic in Alloxan-Induced Rats Suswidiantoro, Vicko; Safutri, Wina; Pratiwi, Mida; Putri, Diah Karika; Dwiningrum, Riza; Lestari, Fina Aulika
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 12 (2024): October 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v1i12.12038

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated blood glucose levels due to impaired insulin production. Natural remedies, such as soursop leaves (Annona muricata) (SL) and garlic (Allium sativum) (GAR), are known for their antihyperglycemic properties. This study aimed to investigate the effects of SL and GAR extracts, individually and in combination, on reducing blood glucose levels in alloxan-induced diabetic rats. A total of 24 male Wistar rats were divided into six groups, receiving treatments of either metformin, SL, GAR, or their combination for seven days following alloxan administration to induce hyperglycemia. Blood glucose levels were measured before and after induction, and post-treatment on day 15. The results showed that the combined extracts exhibited better antihyperglycemic activity compared to individual treatments, with the most effective dose being 26.3 mg/kg BW SL + 31.5 mg/kg BW GAR.
UJI AKTIVITAS ANTIFUNGI KOMBINASI EKSTRAK UMBI BAWANG PUTIH (Allium sativum L) DAN DAUN SIRIH MERAH (Piper ornatum N.E.Br) TERHADAP PERTUMBUHAN Candida albicans Artadevy, Nadhila Fahira; Daskar, Annajim; Suswidiantoro, Vicko; Safutri, Wina
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 1 (2025): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i1.2001

Abstract

Candida infection caused by Candida albicans is a common health problem, especially in the skin and female reproductive organs. In Indonesia, the prevalence of candidiasis is around 20–25%, with a predominance in the hair, skin, mucous membranes, mouth, and esophagus. In Lampung Province, candidiasis incidents include severe intertrigo (56%), mild intertrigo (44%), axillary candidiasis (52%), and breast candidiasis (20%). This study aimed to evaluate the antifungal activity of a combination of garlic bulb (Allium sativum L.) and red betel leaf (Piper ornatum N.E.Br) extracts against the growth of Candida albicans. This study used a laboratory experimental method with a Completely Randomized Design (CRD), consisting of a negative control (distilled water), a positive control (fluconazole), and a combination of extracts with a ratio of 20%:20%, 20%:40%, and 40%:40%. The extract was obtained through maceration method, and antifungal activity was measured based on the inhibition zone. Phytochemical tests showed the presence of active compounds such as saponins, flavonoids, alkaloids, tannins, and steroids that act as antifungals. The results of the disc diffusion test showed the average diameter of the inhibition zone as follows: 0 mm (negative control), 6.49 ± 1.05 mm (positive control), 2.9 ± 0.26 mm (P1, weak), 4.15 ± 1.57 mm (P2, weak), 5.68 ± 2.73 mm (P3, moderate), and 6.81 ± 1.92 mm (P4, moderate). Statistical tests showed significant differences between negative and positive controls and treatments 2 and 3. In conclusion, the combination of garlic and red betel leaf extract, especially P4, has antifungal potential against Candida albicans.
Uji Aktivitas Antibakteri Kombinasi Ekstrak Daun Binahong (Anredera cordifolia (Ten.) Steenis) dan Daun Kelor (Moringa oleifera Lam.) terhadap Bakteri Penyebab Jerawat Propionibacterium acnes: Penelitian Agustina, Mela; Anggista Putri, Nopi; Safutri, Wina; Mayola Pisacha, Iga
Cermin Dunia Kedokteran Vol 52 No 12 (2025): Desember 2025
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i12.1427

Abstract

Introduction: Acne is a skin disease that is often found in many teenagers to young adults. Propionibacterium acnes is one of the causes of acne infection with a prevalence of 12.9%. As long-term inappropriate use of antibiotics can cause resistance, traditional medicine using natural ingredients can act as an alternative. The secondary metabolite compounds from binahong (Anredera cordifolia (Ten.) Steenis) leaves and moringa (Moringa oleifera Lam.) leaves are believed to have antibacterial activity. This study aims to determine the antibacterial activity of a combination of binahong leaves and moringa leaves in inhibiting the growth of acne-causing bacteria, Propionibacterium acnes. Methods: This quantitative experimental research study tested the antibacterial properties of binahong leaves and moringa leaves againstPropionibacterium acne with random design (RAL) of 11 treatments with 3 repetitions. Bacterial test used paper disc diffusion with a single concentration of 20%, 40%, 60% and a combination of 20%:20%, 40%:60%, and 60%:40%, with clindamycin as positive control and sterile aquadest as negative control. Results: The phytochemical screening results were that binahong leaves and moringa leaves contained alkaloids, tannins, saponins, and flavonoids while the results of the antibacterial activity test were that the 60%:40% combination was more effective in inhibiting the growth of Propionibacterium acnes with an inhibition zone diameter of 26.7 mm ± 2.0 (strong). Conclusion: Binahong leaves and Moringa leaves contain secondary metabolite compounds of tannins, alkaloids, saponins, and flavonoids, and have antibacterial activity. Binahong leaves and moringa leaves can inhibit the growth of bacterium Propionibacterium acnes with a strong inhibition zone category.
The Correlation between Knowledge Level and Gout Prevention Behavior among the Elderly in Kresnomulyo Village, Ambarawa District, Pringsewu Regency, Lampung Winabila, Putri; Safutri, Wina; Pratiwi, Mida; Dwiningrum, Riza
JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Vol. 4 No. 3 (2025): JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/js.v4i3.4307

Abstract

Gout is a purine metabolism disorder characterized by increased levels of uric acid in the blood, leading to the accumulation of uric acid crystals and joint pain, particularly among the elderly. Knowledge about gout prevention behavior in the elderly significantly affects the success of gout management. Gout management is essential to prevent long-term complications such as joint damage and kidney stones. This study aims to determine the relationship between knowledge level and gout prevention behavior among the elderly in Kresnomulyo Village, Ambarawa District, Pringsewu Regency, Lampung. This study was a descriptive quantitative study with a cross-sectional design. The sampling technique used purposive sampling based on inclusion and exclusion criteria, with a total of 110 respondents. The results showed that 31% of respondents had a moderate level of knowledge, while 79% had a low level of knowledge. In terms of behavior, 100% of respondents exhibited poor gout prevention behavior. The Chi-Square test results showed an Asymp. Sig value of 0.000 < 0.05, indicating a significant relationship between knowledge and gout prevention behavior among the elderly in Kresnomulyo Village, Ambarawa District, Pringsewu Regency, Lampung. Village administrators can actively contribute to enhancing community awareness about gout prevention by conducting educational initiatives and implementing practical programs. Furthermore, promoting sufficient water intake, regular physical activity, and a balanced diet through Posyandu or local community gatherings is essential.
Evaluation And Quality Of Hand And Body Lotion Preparations From Of Broccoli (Brasica oleracea L.) and Carrot (Daucus carota L.) Extract Combinations Aurelia, Tessa Aurelia; Rosanti, Afi Sania; Safutri, Wina; Dwiningrum, Riza
JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Vol. 4 No. 3 (2025): JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/js.v4i3.4333

Abstract

Kulit kering merupakan masalah kulit umum yang disebabkan oleh berkurangnya kadar air di stratum korneum dan peningkatan Trans Epidermal Water Loss (TEWL). Prevalensinya tinggi, mencapai 50%-80% di Indonesia. Kulit kering dapat diatasi dengan hand and body lotion. Hand and body lotion merupakan sediaan kosmetik berbentuk suspensi zat padat dengan pesuspensi yang tepatatau dapat berupa minyak dalam air. Salah satu bahan alami yang kaya akan manfaat adalah brokoli (Brassica oleracea L.) dan wortel (Daucus carota L.). Tujuan penelitian ini untuk mengetahui karakteristik mutu sediaan hand and body lotion ekstrak brokoli (Brasica oleracea L.) dan wortel (Daucus carota L.). Metode penelitian yaitu kuntitatif eksperimental. Sampel yang digunakan ekstrak brokoli dan wortel dengan formulasi dibuat dalam tiga konsentrasi ekstrak (15 g, 20 g, dan 30 g). Berdasarkan hasil penelitian menunjukkan mutu sediaan, termasuk organoleptik, homogenitas, pH, daya lekat, dan daya sebar, memenuhi standar yang ditetapkan dan menunjukkan stabilitas yang baik selama penyimpanan. Namun, uji viskositas menunjukkan bahwa semua formula tidak memenuhi syarat SNI (2000-50000 cP), mengindikasikan kekentalan yang berlebih. Preferensi hedonik dengan F0 (kontrol), F1 (15 g ekstrak) dan F3 (30 g ekstrak) menunjukkan tingkat kesukaan yang baik dalam aspek aroma dan tekstur. Kesimpulan formula hand and body lotion ekstrak brokoli dan wortel menunjukkan karakteristik mutu sediaan yang telah memenuhi syarat meskipun viskositasnya melebihi standar yang disyaratkan. Berdasarkan hasil uji hedonik terdapat formula F0, F1 dan F3 paling disukai.
Co-Authors Adi Saputra Adinda Shofa Hermalia Hermalia Afi Sania Rosanti Afi Sania Rosanti Afina Rizky Ramadhani Agustina, Mela Ahmad Sutomo Aini, Sarifatul Amalia Siti Nurazizah Amanda Tirtasena Amilia Rusda Andika Wahyu Saputra Anggista Putri, Nopi Annajim Daskar Artadevy, Nadhila Fahira Arum Vika Sari Atika Nabila, Novrillia Audya Zahra Aulika Lestari, Fina Aurelia, Tessa Aurelia Ayu Chandra, Ananda Bayu Satriawan, Ahmad Damayanti Abdul Karim, Dewi Daskar, Annajim Debby Heldayani Dela Maya Fitria Desni Sagita, Yona Dhea Amanda Firly Diah Kartika Diah Kartika Putri Dian Ratnasari Dila Cindy Reptiana Dina Rahmawati Dinda Naziah Doni Faizal Dwi Oktarosada Elsya Azis Suryani Etik Purwanti Eva Nurul Baity Fachry Abda El Rahman Fadia Zahra, Alya Fani Rahmawati Ferly Ardhy Fina Aulika Lestari Haikal Fadhila Haikal Nur Islam Hammami, Akmal Hazballah Asy Syifa Hotimah, Etika Khusnul Ida Nursanti Iga Mayola Pisacha Indah Safitri Iqfan Adi Rismawan Juliatika Kurniawati Kartika Putri, Diah Katika Putri, Diah Kiki Ariska kurniati, nova Lestari, Fina Aulika Lintang Sevira Lu’lu’ Anjeli Malahatu Zalfa, Aisyah Mayola Pisacha, Iga Meiliya Areza Mela Annisa Mela Kurniasari Mellisa Haryani Mida Pratiwi Mida Pratiwi Mida Pratiwi Miftah Khoirun Nissa Miko Nanda Kusuma Mila Naura Shalsabila Muji Lestari Nanggroe Logawan Nita Windi Lestari Nopi Anggista Putri Noventy Ratna Sari Novi Ana Nurlaili Nur Aminudin Nuriyanto Nuriyanto Nurul Fatonah Pratama, Dimas Feriza Pratama Purwanti, Etik Putri, Diah Karika Putri, Elsa Claudia Rahadiyanto, Kemas Ya'Kub Rahmat Rizky Prayogo Rena Tiyarma Sari Riesce Octa Verantika Riki Renaldo Rinda Agustin Riska Nur Aeni Rismayanti Carla Putri Riza Dwiningrum Riza Dwiningrum Riza Dwiningrum, Riza Riza Dwiningum Rolinia Dina Marsela Rosanti, Afi Sania Salsabila Salsabila Sari, Yuhana Satriawan, Ahmad Bayu Silvi Alfiani Siti Maesaroh Siti Rahmawati Sumiyati Sunariyah Suswidiantoro, Vicko Syaifurrahman, Amir Tahta Herdian Andika Tanoehardjo, Fransisca Srioetami Taufiki Miftausakina Taufiki Miftausakina trijayanti, mesi Tundjung Tripeni Handayani Tundjung Tripeni Handayani, Tundjung Tripeni Turisma Alfi Arizona Vanesa Dwi Cahyani Vicko Suswidiantoro Vicko Suswidiantoro Vicko Suswidiantro Winabila, Putri Windi Lestari, Nita Wulan Cahya Indah Yamsi Nurfala Yurike Elanda Zulkifli Zulkifli