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All Journal Biomedical Journal of Indonesia Jurnal Penelitian Pertanian Terapan Jurnal Kesehatan Jurnal Aisyah : Jurnal Ilmu Kesehatan Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Kepada Masyarakat Ungu ( Abdi Ke Ungu) Jurnal Maternitas Aisyah (JAMAN AISYAH) JIFI (Jurnal Ilmiah Farmasi Imelda) JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) International Journal of Health, Engineering and Technology Journal of Innovative and Creativity International Journal of Contemporary Sciences (IJCS) Cermin Dunia Kedokteran Pesona Nusantara
Wina Safutri
Universitas Aisyah Pringsewu
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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LITERATURE REVIEW: PHARMACOLOGICAL AND TOXICOLOGICAL EFFECTS OF PLANTS FROM THE SOLANACEAE FAMILY Damayanti Abdul Karim, Dewi; Safutri, Wina; Hammami, Akmal; Ayu Chandra, Ananda
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 3: September 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v8i3.2417

Abstract

Solanaceae is a family of flowering plants with 83 genera and 2,925 species spread throughout the world. People reuse natural medicines that have been passed down from generation to generation because medical medicines have a big tendency to cause many side effects. This research aims to examine the pharmacological effects and toxicity of plants in the Solanaceae family. This research used 10 plant species, including potatoes (Solanum tuberosum L.), golden berries (Physalis angulata L.), tomatoes (Solanum lycopersicum L.), red chilies (Capsicum annuum L.), cayenne peppers (Capsicum frutescens L.), tobacco (Nicotiana tabacum L.), paprika (Capsicum annuum var. grossum), amethyst (Datura stramonium L.), Turkey berry (Solanum torvum Sw.), and black nightshades (Solanum nigrum L.). The journal search method used in this research is the Boolean System method (AND and OR) using the Google Scholar and Sinta databases. The results obtained from this research were that among the 10 plant species of the Solanaceae family studied, there were 3 pharmacological effects with the most data modes, including antimicrobial, anti-inflammatory, and anti-oxidant effects.
Antibacterial Activity Test of the Combination of Citronella Leaf Extract (Cymbopogon nardus L.) and Lime Leaf Extract (Citrus aurantifolia Swingle) Against the Growth of Streptococcus mutans Aini, Sarifatul; Safutri, Wina; Suswidiantoro, Vicko
JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Vol. 4 No. 2 (2025): JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/js.v4i2.4213

Abstract

Dental caries infection is one of the most common dental health problems caused by Streptococcus mutans bacteria. The use of synthetic antibiotics in the treatment of infection risks causing bacterial resistance, so a safer alternative, natural treatment, is needed. Citronella leaves (Cymbopogon Nardus L.) and lime leaves (Citrus aurantifolia Swingle) contain active compounds such as alkaloids, flavonoids, saponins, and tannins that have antibacterial activity. This study aims to determine the effectiveness of the combination of extracts of the two plants against the growth of Streptococcus mutans. The type of research used is laboratory experimental with Completely Randomized Design, consisting of 5 treatments and 4 repetitions. The antibacterial test was carried out by disc diffusion method using a combination concentration of extracts P1 (2.5%: 7.5%), P2 (12.5%: 5%), and P3 18.75%: 2.5%), negative control (distilled water), and positive control (tetracycline). The test results showed that the P3 produced the best inhibition against Streptococcus mutans with an average inhibition zone of (6.02 ± 0.46) mm and fell into the moderate category. Data analysis using the ANOVA test resulted in a significance value of p = 0.000 (p < 0.05), which indicated there were significant differences between treatments. Further tests using Tukey HSD showed that the P3 was significantly different compared to the other treatments. Thus, the combination of citronella and lime leaf extracts is proven to have potential as a natural antibacterial against the growth of Streptococcus mutans bacteria.
ANTIFUNGAL ACTIVITY TEST OF THE COMBINATION OF PAPAYA LEAF (Carica papaya L.) AND BASIL LEAF (Ocimum x africanum Lour) EXTRACTS AGAINST THE GROWTH OF Candida albicans Pratama, Dimas Feriza Pratama; Suswidiantoro, Vicko; Daskar, Annajim; Safutri, Wina
JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Vol. 4 No. 2 (2025): JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/js.v4i2.4214

Abstract

Fungal infections are common health problems, one of which is caused by Candida albicans. The use of synthetic antifungal agents in treatment can lead to side effects and resistance risks, thus necessitating safer natural alternatives. Papaya leaves (Carica papaya L.) and basil leaves (Ocimum x africanum Lour) are known to contain active compounds such as flavonoids, alkaloids, saponins, steroids, and tannins, which have potential as antifungal agents. The combination of these two plant extracts was used to enhance antifungal effectiveness through possible synergistic effects of their active compounds, with the expectation of yielding a more optimal inhibitory effect against Candida albicans. This study aimed to determine the effectiveness of a combination of papaya and basil leaf extracts in inhibiting the growth of Candida albicans. The research was conducted experimentally using a Completely Randomized Design (CRD) with five treatment groups and four replications. The antifungal activity was tested using the disc diffusion method with extract combinations formulated in 96% ethanol at concentrations of (18.75% : 18.75%), (37.5% : 12.5%), and (56.25% : 6.25%), as well as a negative control (aquadest) and a positive control (ketoconazole 15 μL). One-Way ANOVA analysis showed a significant difference between treatments (p < 0.05). Further analysis using Tukey HSD revealed no statistically significant differences between the three extract combination groups. However, P3 exhibited the highest inhibition zone (4.73 ± 0.91 mm), while P1 showed the lowest (3.45 ± 0.65 mm), and P2 was intermediate (3.98 ± 0.65 mm). All three combinations showed statistically significant differences compared to the negative control (0 mm) and the positive control (6.50 ± 0.83 mm). Thus, although no significant difference was observed between the combination groups, all combinations demonstrated statistically significant antifungal activity against Candida albicans compared to the negative control. In conclusion, the combination of papaya and basil leaf extracts possesses antifungal activity against Candida albicans, although the effectiveness is not yet optimal. Further research is recommended with increased extract concentrations and development into pharmaceutical dosage forms such as gels or ointments as alternative topical antifungal treatments.
An Ethnomedicinal Study of Medicinal Plants from the Zingiberaceae Family Used by the Community in Nunggalrejo Village, Punggur Subdistrict, Central Lampung Regency Malahatu Zalfa, Aisyah; Dwiningrum, Riza; Kartika Putri, Diah; Safutri, Wina
JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Vol. 4 No. 2 (2025): JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/js.v4i2.4248

Abstract

Ethnomedicine is a traditional treatment method that emphasizes local cultural practices and does not involve modern medical treatment. The community in Nunggalrejo frequently uses medicinal plants from the Zingiberaceae family to treat various ailments. Additionally, plants from this family are used in traditional medicine. The aim of this study is to analyze the species, plant parts used, preparation methods, and medicinal benefits of Zingiberaceae plants utilized in traditional medicine. This research employs a qualitative descriptive method with a snowball sampling technique and structured interviews. The research targets include herbal medicine makers, the oldest community members, and people who use traditional medicine. Based on interviews with 12 informants, the data revealed nine dominant species of Zingiberaceae, with the most frequently used being Curcuma xanthorrhiza (temulawak), Zingiber officinale (ginger), Curcuma longa (turmeric), and Kaempferia galanga (kencur), each accounting for 19%. The part most commonly used is the rhizome (100%), with boiling being the most common preparation method (50%). The most frequently treated ailment is acid reflux (29%). In conclusion, there are nine species of Zingiberaceae used to treat ten types of illnesses in Nunggalrejo Village.
FORMULATION OF VARIATIONS IN THE COMBINATION CONCENTRATIONS OF ROBUSTA COFFEE (Coffea canephora) POWDER AND TURMERIC RHIZOME EXTRACT (Curcuma longa L.) ON THE QUALITY OF BODY SCRUB PREPARATIONS Sumiyati; Rosanti, Afi Sania; Dwiningrum, Riza; Safutri, Wina
JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Vol. 4 No. 2 (2025): JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/js.v4i2.4265

Abstract

Body scrub is a skincare product used to exfoliate dead skin cells and accelerate skin regeneration. Natural ingredients such as robusta coffee powder (Coffea canephora), which contains caffeine, act as a natural exfoliant, while turmeric rhizome extract (Curcuma longa L.), which contains curcuminoids, functions as an antioxidant and skin brightener. This study aimed to formulate a body scrub using varying concentrations of robusta coffee powder and turmeric extract, and to evaluate its physical properties, stability, and consumer preference. An experimental method was used with five formulations: F1 (10% coffee), F2 (10% turmeric), F3 (7%:3%), F4 (8%:2%), and F5 (9%:1%). Evaluations included organoleptic testing, homogeneity, pH, spreadability, adhesion, cream type, viscosity, stability, and hedonic testing. Results showed that all formulations met the criteria for good physical quality. Based on hedonic tests, F1 was the most preferred in terms of color, while F4 was most favored for aroma and texture, making it the best formulation with no significant difference (p>0.05). This study supports the development of natural body scrubs using local ingredients that are safe and effective.
The Relationship between Compliance with Antihypertensive Drugs and the Life Quality of the Elderly in the Kresnomulyo Village Public Health Center, Pringsewu, Lampung Hotimah, Etika Khusnul; Wina Safutri; Mida Pratiwi; Diah Kartika Putri
JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Vol. 4 No. 2 (2025): JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/js.v4i2.4291

Abstract

One major issue in worldwide public health is hypertension. The third-highest rate of hypertension in Ambarawa District is seen in Kresnomulyo Village. In addition to making patients' conditions worse, noncompliance with antihypertensive treatment can result in problems such as heart enlargement, stroke, and kidney failure. Patients' quality of life is affected by their compliance with antihypertensive treatment, which includes both medication and lifestyle changes. The research objective was to analyze the correlation between compliance with antihypertensive medication use and the quality of life of patients at the Kresnomulyo Public Health Center. This research is a non-experimental quantitative analytical study. Data collection was conducted by distributing questionnaires to 146 respondents. Data were analyzed using the Chi-Square test. The results showed that 69% of respondents were non-compliant with their medication regimen, while 31% were compliant. Regarding quality of life, 20% of respondents reported no problems, 22% reported mild problems, 24% moderate, 19% severe, and 15% very severe. In conclusion, there is a significant correlation between the level of compliance to antihypertensive medication use and the quality of life of elderly hypertensive patients at the Kresnomulyo Public Health Center, Pringsewu, with a significance level of 0.000 (p < 0.05).
Formulation and Evaluation of Face Mist Preparation from Ethanol Extract of Agarwood Leaves (Aquilaria malaccensis L) as an Antioxidant trijayanti, mesi; Pratiwi, Mida; Daskar, Annajim; Safutri, Wina
JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Vol. 4 No. 2 (2025): JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/js.v4i2.4311

Abstract

Skin damage due to UV exposure and pollution can trigger the formation of free radicals that accelerate the process of premature aging. The use of natural antioxidants in cosmetic products to combat free radicals serves as an alternative to synthetic antioxidants, which often cause side effects. Agarwood leaves (Aquilaria malaccensis L.) are known to contain groups of active compounds such as flavonoids, tannins, alkaloids, saponins, and terpenoids that have potential as antioxidants. This study aims to formulate and evaluate the face mist preparation of ethanol extract from agarwood leaves in three different concentration variations: FI (5%), FII (6%), and FIII (7%). The research was conducted experimentally in the laboratory, covering the stages of plant determination, maceration with 96% ethanol, phytochemical screening, formulation of preparations, physical evaluation (organoleptic, homogeneity, pH, specific gravity, spreadability, spray condition, drying time, protection, and stability through cycling tests), as well as antioxidant activity testing using the DPPH method with UV-Vis spectrophotometry. The results showed that all formulations had good physical characteristics and were stable using the cycling test method, except for FII which was unstable in the specific gravity test. The IC₅₀ values of each formulation were FI at 28.138 mg/L, FII at 21.871 mg/L, and FIII at 19.387 mg/L, categorized as very strong antioxidants and the three formulations had significant differences with a p-value of ˂0.05. The conclusion of this research is that the FIII formula (7%) is the best formula because it has high antioxidant activity, is stable physically and chemically, and has the potential as a natural cosmetic product that protects the skin from free radicals.
Synergistic Antihyperglycemic Effects of Soursop Leaves and Garlic in Alloxan-Induced Rats Suswidiantoro, Vicko; Safutri, Wina; Pratiwi, Mida; Putri, Diah Karika; Dwiningrum, Riza; Lestari, Fina Aulika
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 12 (2024): October 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v1i12.12038

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated blood glucose levels due to impaired insulin production. Natural remedies, such as soursop leaves (Annona muricata) (SL) and garlic (Allium sativum) (GAR), are known for their antihyperglycemic properties. This study aimed to investigate the effects of SL and GAR extracts, individually and in combination, on reducing blood glucose levels in alloxan-induced diabetic rats. A total of 24 male Wistar rats were divided into six groups, receiving treatments of either metformin, SL, GAR, or their combination for seven days following alloxan administration to induce hyperglycemia. Blood glucose levels were measured before and after induction, and post-treatment on day 15. The results showed that the combined extracts exhibited better antihyperglycemic activity compared to individual treatments, with the most effective dose being 26.3 mg/kg BW SL + 31.5 mg/kg BW GAR.
PENINGKATAN PENGETAHUAN DAN KETERAMPILAN WARGA DESA TANJUNG AGUNG DALAM MEMANFAATKAN KULIT KAKAO SEBAGAI ANTIDIABETES Pisacha, Iga Mayola; Karim, Dewi Damayanti Abdul; Safutri, Wina; Putri, Diah Kartika; Rismawan, Iqfan Adi; Faizal, Doni; Purwanti, Etik
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 5 No. 6 (2024): Vol. 5 No. 6 Tahun 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v5i6.40245

Abstract

Kulit kakao memiliki peran penting dalam mencegah diabetes, berfungsi sebagai pengobatan herbal yang membantu proses penurunan diabetes. Namun, di Kabupaten Pesawaran, masyarakat menghadapi tantangan dalam akses terhadap obat berkualitas dan kurangnya kemampuan mengolah tumbuhan pertanian lokal sebagai alternatif pengobatan dan penghasilan. Observasi menunjukkan banyak warga Desa Tanjung Agung kesulitan mendapatkan pengobatan efektif, dengan keterbatasan dana dan masalah dalam rantai pasokan obat. Kurangnya metode pembelajaran yang variatif membuat masyarakat kurang mengenal dan menghargai tanaman tradisional sebagai alternatif pengobatan, padahal warga memiliki kelompok tani kakao yang sangat berpotensi dimanfaatkan sebagai obat tradisional. Tanpa intervensi yang tepat, pengetahuan masyarakat mengenai pengobatan herbal menjadi sangat terbatas, berpotensi mengakibatkan hilangnya warisan budaya. Kegiatan ini bertujuan meningkatkan pengetahuan tentang diabetes dan manfaat teh kulit buah kakao dengan menggunakan metode ceramah dan pelatihan. Kegiatan ini meliputi pelatihan pembuatan dan pengecekan kesehatan. Dengan harapan dapat mengatasi permasalahan utama yang diidentifikasi termasuk rendahnya pengetahuan tentang diabetes dan manfaat kulit kakao. Antusias warga begitu besar terhadap adanya kegiatan tersebut, parameter kesuksesan program diukur dari peningkatan pengetahuan peserta saat pretest dan posttest. Hasil analisis data diperoleh terjadinya peningkatan pengetahuan warga dari 49,40% menjadi 87,80%. Dengan adanya kegiatan ini, harapannya masyarakat tidak hanya memperoleh keterampilan baru, tetapi juga meningkatkan kesadaran akan pentingnya pengobatan tradisional, sehingga dapat mengembangkan identitas dan kebanggaan terhadap budaya lokal yang melimpah.
UJI AKTIVITAS ANTIFUNGI KOMBINASI EKSTRAK UMBI BAWANG PUTIH (Allium sativum L) DAN DAUN SIRIH MERAH (Piper ornatum N.E.Br) TERHADAP PERTUMBUHAN Candida albicans Artadevy, Nadhila Fahira; Daskar, Annajim; Suswidiantoro, Vicko; Safutri, Wina
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 1 (2025): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i1.2001

Abstract

Candida infection caused by Candida albicans is a common health problem, especially in the skin and female reproductive organs. In Indonesia, the prevalence of candidiasis is around 20–25%, with a predominance in the hair, skin, mucous membranes, mouth, and esophagus. In Lampung Province, candidiasis incidents include severe intertrigo (56%), mild intertrigo (44%), axillary candidiasis (52%), and breast candidiasis (20%). This study aimed to evaluate the antifungal activity of a combination of garlic bulb (Allium sativum L.) and red betel leaf (Piper ornatum N.E.Br) extracts against the growth of Candida albicans. This study used a laboratory experimental method with a Completely Randomized Design (CRD), consisting of a negative control (distilled water), a positive control (fluconazole), and a combination of extracts with a ratio of 20%:20%, 20%:40%, and 40%:40%. The extract was obtained through maceration method, and antifungal activity was measured based on the inhibition zone. Phytochemical tests showed the presence of active compounds such as saponins, flavonoids, alkaloids, tannins, and steroids that act as antifungals. The results of the disc diffusion test showed the average diameter of the inhibition zone as follows: 0 mm (negative control), 6.49 ± 1.05 mm (positive control), 2.9 ± 0.26 mm (P1, weak), 4.15 ± 1.57 mm (P2, weak), 5.68 ± 2.73 mm (P3, moderate), and 6.81 ± 1.92 mm (P4, moderate). Statistical tests showed significant differences between negative and positive controls and treatments 2 and 3. In conclusion, the combination of garlic and red betel leaf extract, especially P4, has antifungal potential against Candida albicans.
Co-Authors Adi Saputra Adinda Shofa Hermalia Hermalia Afi Sania Rosanti Afi Sania Rosanti Agustina, Mela Ahmad Sutomo Aini, Sarifatul Amanda Tirtasena Amilia Rusda Andika Wahyu Saputra Anggista Putri, Nopi Annajim Daskar Artadevy, Nadhila Fahira Arum Vika Sari Atika Nabila, Novrillia Audya Zahra Aulika Lestari, Fina Aurelia, Tessa Aurelia Ayu Chandra, Ananda Bayu Satriawan, Ahmad Damayanti Abdul Karim, Dewi Daskar, Annajim Dela Maya Fitria Desni Sagita, Yona Dhea Amanda Firly Diah Kartika Diah Kartika Putri Dian Ratnasari Dila Cindy Reptiana Dina Rahmawati Dinda Naziah Dwi Oktarosada Elsya Azis Suryani Eva Nurul Baity Fachry Abda El Rahman Fadia Zahra, Alya Faizal, Doni Fani Rahmawati Haikal Fadhila Haikal Nur Islam Hammami, Akmal Hazballah Asy Syifa Hotimah, Etika Khusnul Iga Mayola Pisacha Indah Safitri Juliatika Kurniawati Kartika Putri, Diah Katika Putri, Diah Kiki Ariska kurniati, nova Lestari, Fina Aulika Lintang Sevira Malahatu Zalfa, Aisyah Mayola Pisacha, Iga Meiliya Areza Mela Annisa Mela Kurniasari Mida Pratiwi Mida Pratiwi Mida Pratiwi Miftah Khoirun Nissa Miftausakina, Taufiki Miko Nanda Kusuma Muji Lestari Nanggroe Logawan Nopi Anggista Putri Noventy Ratna Sari Novi Ana Nurlaili Nur Aminudin Nurazizah, Amalia Siti Nuriyanto Nuriyanto Nurul Fatonah Pisacha, Iga Mayola Pratama, Dimas Feriza Pratama Purwanti, Etik Putri, Diah Karika Putri, Diah Kartika Putri, Elsa Claudia Rahadiyanto, Kemas Ya'Kub Rahmat Rizky Prayogo Riesce Octa Verantika Riki Renaldo Rinda Agustin Rismawan, Iqfan Adi Rismayanti Carla Putri Riza Dwiningrum Riza Dwiningrum Riza Dwiningrum, Riza Riza Dwiningum Rolinia Dina Marsela Rosanti, Afi Sania Sari, Yuhana Satriawan, Ahmad Bayu Silvi Alfiani Siti Maesaroh Siti Rahmawati Sumiyati Sunariyah Suswidiantoro, Vicko Syaifurrahman, Amir Tanoehardjo, Fransisca Srioetami Taufiki Miftausakina trijayanti, mesi Tundjung Tripeni Handayani Tundjung Tripeni Handayani, Tundjung Tripeni Turisma Alfi Arizona Vanesa Dwi Cahyani Vicko Suswidiantoro Vicko Suswidiantro Winabila, Putri Windi Lestari, Nita Wulan Cahya Indah Yamsi Nurfala Yurike Elanda Zulkifli Zulkifli