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Wilson’s Disease: A Review Amie Vidyani; Fauziah Diayu Retnaningtyas; Ulfa Kholili; Titong Sugihartono; Iswan Abbas Nusi; Poernomo Boedi Setiawan; Ummi Maimunah; Budi Widodo; Husin Thamrin; Muhammad Miftahussurur; Herry Purbayu
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 1 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i1.36428

Abstract

Wilson’s disease is a disease that results from a genetic disorder that causes copper accumulation. Wilson’s disease has presented challenges for physicians during the last century, but it can be diagnosed and treated over time. Diagnosing Wilson’s disease is challenging for doctors because of its wide range of clinical manifestations and complexity. Studies that can help diagnose Wilson’s disease include a 24-hour copper urine examination and neurological tests, such as a CT scan or MRI, and liver function tests. There is also a scoring system to help medical personnel diagnose this disease. Correct diagnosis and adequate therapy can be provided, such as penicillamine, trientine, zinc, and, most rarely, liver transplantation. It is also necessary to monitor the side effects of treatment and its effectiveness of treatment. When receiving therapy, Wilson’s disease has a better prognosis than if it is not treated.
Exhaled Breath Analysis for COVID-19 Investigation: Clinical instruments or Scientific Toys? Isna Mahmudah; Naufali Rizkiawan; Husin Thamrin; Brian Eka Rahman; Hasan Maulahela; Yudith Annisa Ayu Rezkitha; Yoshio Yamaoka; Muhammad Miftahussurur
ABDIMAS: Jurnal Pengabdian Masyarakat Vol. 6 No. 1 (2023): ABDIMAS UMTAS: Jurnal Pengabdian Kepada Masyarakat
Publisher : LPPM Universitas Muhammadiyah Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35568/abdimas.v6i1.2910

Abstract

The COVID-19 pandemic was crucial worldwide. Ongoing COVID-19 disease investigation methods were primarily based on molecular and serological detection. These instruments are invasive and necessarily require the use of trained personnel. Non-invasive COVID-19 investi-gation methods could help diagnose and monitor the outbreak. Because the SARS-CoV-2 virus is non-living, it lacks its metabolism. Different infectious diseases can release volatile organic compounds (VOCs), resulting in specific VOCs. All of these are metabolic products primarily produced locally in the respiratory system and systemically via blood circulation. We overview the clinical applications in the COVID-19 investigation and summarize the methodological is-sues. Numerous VOCs in the exhaled breath have the prospects to distinguish patients from healthy people and people infected with COVID-19. It is hard to define COVID-19 using VOCs from exhaled breath. Due to a lack of standardization in data collecting and processing proce-dures, their use in clinical practice is hampered. There are insufficient studies and external vali-dation to determine whether exhaled breath analysis adds value to the diagnostic and follow-up processes for COVID-19 infection. In conclusion, the use of VOCs in exhaled breath as a marker for COVID-19 infection has not been validated for clinical use.
ANXIETY LEVEL OF MIDWIFERY CLINICAL STUDENTS DURING COVID-19 PANDEMIC Nadia Sherli Syafira; Muhammad Miftahussurur; Endyka Erye Frety
Indonesian Midwifery and Health Sciences Journal Vol. 6 No. 4 (2022): Indonesian Midwifery and Health Sciences Journal, October 2022
Publisher : UNIVERSITAS AIRLANGGA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/imhsj.v6i4.2022.329-340

Abstract

Introduction: Clinical midwifery students experience higher anxiety than the general population during COVID-19 pandemic. The higher level of anxiety is due to pressure in their clinical learning environment. This study will explore the effect of the clinical learning environment on the increased anxiety in midwifery students during the COVID-19 pandemic. Method: This prospective cross-sectional study was conducted on 82 clinical midwifery students at Airlangga University using an online survey. We excluded students who had not started clinical studies and students with pre-existing medical or comorbid psychiatric conditions that could explain the pain. Information from participants included  socio-demographic, clinical learning environment questionnaire, and Hamilton Rating Scale for Anxiety (HRS-A). Results: The study showed that most of the respondents aged 20-27 years (73.2%), in the second semester (76.8%), living in boarding houses/contracts (74.4%), unmarried status (75.6%), the level of family income is very high (68.3%), and the perception of a poor clinical learning environment (51.2%). Participants experienced no anxiety the most (52.4%) and significantly correlated with the age p=0.047, domicile status p=0.076, and clinical learning environment p=0.008. But not their semester p=0.991, marital status p = 0.406, and family income p=0.872. Conclusion: These data indicate that age, domicile status, and clinical learning environment contribute to the incidence of anxiety in midwifery clinic students during the COVID-19 pandemic. 
Puasa Selama Kebuntingan terhadap jumlah sel neuron Cereberum dan Cerebellum Rattus norvegicus Baru Lahir Ucik Nurul Hidayati; Hermanto Tri Joewono; Muhammad Miftahussurur; Agus Sulistyono; Martono Tri Utomo; Sulistiawati Sulistiawati
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (270.623 KB) | DOI: 10.30742/jikw.v9i1.634

Abstract

Fasting by pregnant women causes increasing neurons in the brain. An increasing number of neuron cells will speed up information processing, so it is expected to increasing intelligence. The purpose of this study was to analyze the effect of fasting during pregnancy on the number of new cells of the cerebrum neuron and the newly born Rattus norvegicus cerebellum. The research design was true experimental laboratory posttest only with control group design. Pregnant Rattus norvegicus samples consisted of 3 groups and 1 control group with a total sample of 32 divided by 4; Xo control group without fast treatment, fasting X1 group in 1st trimester (2 days), fasting X2 group in 2nd trimester (2 days), fasting group X3 at TM 3 (2 days). Data analysis using Shapiro – Wilk normality test, followed by ANOVA test and using SPSS for Windows 23 software. The results of statistical analysis showed no significant difference in the number of cerebrum neuron cells in the four groups P = 0.210 (p> 0.05) and there were significant differences in the number of cerebrum neuron cells in the four groups P = 0.032 (p <0.05). The conclusion of this study is there was no difference in the number of neuron cells in cerebrum and cerebellum of Rattus norvegicus newborn in the fasting mother 2 days during trimester I, II dan III of pregnancy. There was a difference in the number of neuron cells in the new cerebellum of Rattus norvegicus fasting for 2 days during trimester III of pregnancy, and there were differences the effect of the number of neuron cell in cerebellum of Rattus norvegicus in all groups.
Perbedaan Jumlah Sel Neuron Cerebrum dan Cerebellum Mus musculus pada Kehamilan Remaja dan Dewasa Tri Purwanti; Widjiati Widjiati; Muhammad Miftahussurur
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (410.515 KB) | DOI: 10.30742/jikw.v9i1.639

Abstract

Teenage pregnancy contributes to emotional stress higher than adult women Pregnancy in adolescents will trigger negative thoughts and feelings of fear that become the root cause of stress reactions. The onset of stress will trigger the occurrence of Axis HPA activity and the release of corticotrophin releasing hormone (CRH) by the paraventricular nucleus of the hypothalamus, then stimulate the production of adrenencorticotropic hormone (ACTH) by the anterior pituitary gland. ACTH will stimulate glucocorticoids (cortisol) from the adrenal gland cortex to increase the production of CRH in the placenta and give an effect of increasing cortisol in the maternal, as well as the amount of cortisol in the fetus will also increase because it follows the blood placenta barrier. This affects the growth and development of the fetal brain, so that the process of proliferation and differentiation, migration, organization and synaptogenesis and myelination in brain cells. The growth of the brain decreases which affects the number of neuron cells. This study aims to analyze the differences in the number of neuron cells in the cerebrum and cerebellum Mus musculus newly born in adolescent and adult pregnancy. The division of the study group consisted of two groups, namely the adolescent and adult pregnancy groups each of 16 individuals. Taking the examination sample is by taking each of the 3 children from the parent with the heaviest, medium and lowest weights. Then the Mus musculus children were sacrificed by anesthesia and decapitation, then Hematoxilin-Eosin preparations were made from the child's brain. The next step is to examine Hematoxilin-Eosin to calculate the number of neuron cells in the cerebrum and cerebellum with the analysis of the Independent T test showing significant differences between the control and treatment groups with a value of p = 0,000 (p <0.05). Then the analysis of the number of brain neuron cells using the Mann Whitney test showed a difference that the control group was higher than the adolescent group.
Analysis of Caesarean Section Rates and Source of Payment Using the Robson Classification System Nurhayati, Fitasari Nidia; Prasetyo, Budi; Miftahussurur, Muhammad
Journal of Maternal and Child Health Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (34.546 KB) | DOI: 10.26911/thejmch.2023.08.01.01

Abstract

Background: Sectio caesarea delivery is the last alternative to save the mother and fetus when normal delivery is not possible. The increase in caesarean section worldwide has become a major public health problem, so it is necessary to supervise to reduce the number of caesarean sections that are considered unnecessary, one of which is through the Robson Classification. The existence of health insurance for the people of Indonesia, including BPJS which covers the costs of sectio caesarea, makes it possible to increase the incidence of sectio caesarea. The aim of the study was to analyze the incidence of sectio caesarea and financing status based on Robson's classification at Muhammadiyah Babat Hospital. Subjects and Method: This study used a retrospective observational analytic method with a cross sectional design. The research sample was mothers giving birth at Muhammadiyah Babat Hospital who were included in the inclusion criteria and were taken through a total sampling technique of 127 mothers giving birth. The dependent variable is sectio caesarea. The independent variable is financing status. The instrument used was medical record data collected in collection sheets and analyzed using the Chi Square test. Results: A total of 87 (68.5%) subjects gave birth by sectio caesarea with the prevalence of the Robson group 2, 4, and 5 as the main contributor. A total of 64 (63.4%) subjects gave birth by sectio caesarea with BPJS financing status. The results of the chi-square analysis showed that mothers with BPJS financing status reduced the incidence of sectio caesarea, and it was statistically significant (OR= 0.23; 95% CI= 0.06 to 0.80; p= 0.026). Conclusion: The data shows that the incidence of sectio caesarea is still very high and most are in the Robson group 1-5 with BPJS financing status. Based on Robson's grouping results, there is a relationship between financing status and the incidence of sectio caesarea, BPJS financing status reduces the incidence of caesarean section. Keywords: sectio caesarea, robson classification, financing status. Correspondence: Budi Prasetyo. Department of Obstetrics and Gynecology, Facullty of Medicine, Universitas Airlangga, Indonesia, Jl. Mayjen Pro. Dr. Moestopo No. 47, Pacar Kembang, Tambaksari, Surabaya 60132, East Java, Indonesia. Email: budi-p@fk.unair.ac.id.  Mobile: +6281553019486
Konsep Kompetensi Keperawatan dalam Praktik Telenursing Nurullia Hanum Hilfida; Muhammad Miftahussurur; Hanik Endang Nihayati
Journal of Telenursing (JOTING) Vol 5 No 1 (2023): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v5i1.5908

Abstract

This study aims to describe the development of nursing competency in telenursing practice. The method used is a systematic review by collecting articles through the Scopus, Science Direct, PubMed, and Google Scholar databases with publications starting in 2020-2023. Articles were selected with PRISMA based on predetermined inclusion and exclusion criteria, using telenursing, telehealth nursing, telecommunication nurse, and nurse competency. The results showed that there were 279 articles consisting of 17 Scopus articles, 10 Science Direct articles, 16 PubMed articles, and 9 Google Scholar articles. Based on the analysis, 15 full-text articles met the inclusion criteria for review. The study's results show that nursing competence in telenursing consists of social competence, personal competence, professional and methodological competence, telenursing etiquette, and telenursing practice framework during consultations between patients and nurses. In conclusion, telenursing competence must be implemented in telenursing practice readiness to improve nursing services. Keywords: Nursing Competence, Nurse, Practice, Telenursing
Penerapan Teknologi Kesehatan pada Gaya Hidup dan Tingkat Stres Pasien Gastroesophageal Reflux Disease Ishomatul Faizah; Muhammad Miftahussurur; Eka Mishbahatul Mar'ah Has
Journal of Telenursing (JOTING) Vol 5 No 2 (2023): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v5i2.6921

Abstract

This study aims to identify the influence of technology on GERD patients. The research method used is a literature review through electronic databases and websites, namely Scopus—Science Direct, PubMed, ProQuest, and Sage. The research results showed that of the 20 articles, there were articles that reported that lifestyles such as smoking, high BMI, lack of exercise, eating at night, not eating breakfast, and lack of sleep were risk factors for GERD. Apart from that, GERD is a psychosomatic disease, namely a disease that also originates from the mind, where stress, anxiety, and depression are also closely related to the incidence of GERD. Some articles also report that technology can help patients treat and control their diseases. In conclusion, using technology on the lifestyle and stress levels of gastroesophageal reflux disease patients can help patients treat their condition. Keywords: GERD, Technology, Lifestyle, Stress
Human Norovirus Molecular Analysis and Development of Norovirus Vaccine Adinda Juwita Syakila Elizafanti; Maria Inge Lusida; Muhammad Miftahussurur; Alpha Fardah Athiyyah
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 1 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i1.32699

Abstract

The most common organism of acute viral gastroenteritis is norovirus, which accounts for roughly 20% of all occurrences of acute gastroenteritis globally. The virus kills over 200,000 children each year and is the leading cause of childhood diarrhea in the rotavirus-vaccinated population. This study aims to review available studies regarding the information on the genogroup norovirus in humans, development of norovirus vaccines, and effectiveness of norovirus vaccines. A systematic review using Science Direct, PubMed, and Scopus databases to identify eligible case studies. The search was conducted in September-October 2021. The quality of the included literature used checklists from the Critical Appraisal Skills Program (CASP). All of the six selected studies with populations given RT-PCR intervention showed positive for norovirus infection. The most predominant genogroups in humans are GI and GII. As for the research results of the two selected studies on norovirus vaccine, namely the human phase 2 trial containing two Virus-Like Particles (VLP) genotypes, one study showed efficacy at 18-49 one study at ≥ 60 years of age. This study analysis uses Takeda bivalent vaccine. The vaccine includes norovirus antigens of the GI and GII genogroups, intending to expand its protective immune potential. GI, GII, and GIV genogroups are prevalent in humans. VLP that contains GI.I and consensus GII.4c have been created as the NoV vaccine, providing signifi cant efficacy. Very likely because they contain GI dan GII antigens, which are the genogroups that infect humans the most. Patients given a placebo developed acute gastroenteritis due to norovirus GII.2, indicating a genotype cross-reactivity.
HEPATITIS B VIRUS INFECTED INDIVIDUALS' QUALITY OF LIFE AND RELATED FACTORS Ummi Maimunah; Ulfa Kholili; Amie Vidyani; Annisa Zahra Mufida; Diah Rizki Rahma Dini; Isna Mahmudah; Titong Sugiharto; Muhammad Miftahussurur
Journal of Scientech Research and Development Vol 6 No 1 (2024): JSRD, June 2024
Publisher : Ikatan Dosen Menulis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56670/jsrd.v6i1.422

Abstract

Globally, hepatitis B is a public health issue, and Indonesia is not an exception. We investigated a number of factors related to chronic hepatitis B patients' quality of life. Patients with Hepatitis B provided information to us through the WHO Quality of Life questionnaire. Data analysis conducted in this study was a chi-square test and a multivariate logistic regression model was used to calculate the odds ratios (OR). This study involved 31 people with varying quality of life. The average age range for good quality of life was 33 years, with 61.9% of patients being Javanese and 38.1% being Madurese. 70% of very good quality of life patients were Javanese, while 30% were Madurese. High school education was the most common, with 52.4% of patients having a good quality of life. Most patients worked as housewives, with 90.5% and 9.5% as factory employees. Hepatitis B control history was also a significant factor, with 57.1% of patients having never had it. Pregnancy status was 81% of patients with good quality of life, while 90% had no other diseases. Housewives with hepatitis B had a better quality of life than the others (P = 0.043). However, we could not find any association between age, ethnicity, education background, treatment, current pregnancy, and have other disease with quality of life (P = 0.645, P = 0.218, P = 0.417, P = 0.339, P = 0.133 and P = 0.419, respectively). This study reveals a significant relationship between occupation and the quality of life of hepatitis B patients, highlighting the importance of health-related quality of life in evaluating treatment and prognosis.
Co-Authors Adi Pranoto Adinda Juwita Syakila Elizafanti Agoes Soegianto Agus Sulistyono Alfaray, Ricky I. Alpha Fardah Athiyyah Alshawsh, Mohammed A. Amie Vidyani Ana, Devi Andino Maseleno Annisa Zahra Mufida Aryati -, Aryati Astri Dewayani Aswin, R. Haryanto Ayu Citra Gestari Bernadetta Jonan Brian Eka Rahman Budi Prasetyo Budi Widodo Chabib Fachry Albab Dewi, Selva R. Diah Rizki Rahma Dini Dianbudiyanto, Wahid Dita Mega Utami Djazuly Chalidyanto Dominicus Husada Dwiki Noni Armyta Dwiyanti Puspitasari, Dwiyanti Eka Mishbahatul Mar'ah Has Endyka Erye Frety Fauzia, Kartika A. Fauziah Diayu Retnaningtyas Gatut Hardianto, Gatut Gilda Hartecia Hadisuwarno, Wiharjo Hajjarianti, Permata Hamzah Hamzah Hartecia, Gilda Hasan Maulahela Heasty Oktaricha HERAWATI, LILIK Hermanto Tri Joewono Herry Purbayu Hertanto, Carisa Irene Hubur, Aa Hunowu, Ramdan I'tishom, Reny Indra Alfaray, Ricky Ishomatul Faizah Isna Mahmudah Isna Mahmudah Iswan A Nusi Iswan Abbas Nusi Izzatul Fithriyah Jonan, Bernadetta Juniastuti Juniastuti Karnaji, Karnaji Kartika Afrida Fauzia Lionardy Yodianto Mahmudah, Isna Maria Inge Lusida Martono Tri Utomo MISBAKHUL MUNIR Mohammad Anam Al-Ari Nadia Sherli Syafira Natasya Ariesta Selyardi Putri Naufali Rizkiawan Nihayati, Hanik Endang Nurhayati, Fitasari Nidia NUrina Fitriani, NUrina Nurullia Hanum Hilfida Pangestu Adi Pathak, Yashwant Poernomo Boedi Setiawan Purwo Sri Rejek Rejeki, Purwo Sri Riani Widia Parantika Rizkiawan, Naufali Samsriyaningsih Handayani Savitri, Camilia Metadea Aji Soelistijo, Soebagijo Adi Sugiyatmi, Tri A. Sulistiawati Sulistiawati Susanti Susanti Tanaya, Willa M. Thamrin, Husin Titong Sugiharto Titong Sugihartono Tri Purwanti Ucik Nurul Hidayati Ulfa Kholili Ummi Maimunah Usman Hadi Vasa Adi Wisnu Wardana Wahyul Anis Watari, Rekno Wati, Yunita Kholilaili Saras Wessels, Firda I. Widjiati Widjiati Widyaleksono, Trisnadi Willy Sandhika Woro Setia Ningtyas Yoshio Yamaoka Yoshio Yamaoka Yoshio Yamaoka, Yoshio Yudith Annisa Ayu Rezkitha Yudith Annisa Ayu Rezkitha, Yudith Annisa Ayu Zagita, Lauditta Chavia