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All Journal Indonesian Journal of Tropical and Infectious Disease Jurnal Ilmiah Kedokteran Wijaya Kusuma Health Notions Jurnal Ilmiah Universitas Batanghari Jambi Journal of Maternal and Child Health INTERNATIONAL JOURNAL OF NURSING AND MIDWIFERY SCIENCE (IJNMS) Care : Jurnal Ilmiah Ilmu Kesehatan Abdimas Umtas : Jurnal Pengabdian kepada Masyarakat Biomolecular and Health Science Journal Journal of Telenursing (JOTING) Jurnal Layanan Masyarakat (Journal of Public Service) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL Narra J Journal Of Sustainability Perspectives Journal of Scientech Research and Development The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of Sustainability Perspectives Proceeding Of International Conference On Education, Society And Humanity Jurnal Greenation Sosial dan Politik
Muhammad Miftahussurur
Departemen Penyakit Dalam, Rumah Sakit Dr. Seotomo, Jl. Mayjen Prof. Dr. Moestopo No.6-8, Surabaya 60286, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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New Paradigm of Gastric Pathogenesis: The Important Role of Gastric Microbiota Miftahussurur, Muhammad; Savitri, Camilia Metadea Aji; I'tishom, Reny; Rejeki, Purwo Sri; Rezkitha, Yudith Annisa Ayu; Yamaoka, Yoshio
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 1 (2022): VOLUME 23, NUMBER 1, April 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (384.874 KB) | DOI: 10.24871/231202262-66

Abstract

Microbiota was deemed essential as it involved in energy metabolism, nutrient absorption, intestinal immune system maturation, and pathogen protection. Gastrointestinal microbiome played essential roles in human body, such as immune response regulation, pathogen colonization, and few other diseases.  The relation between gastric microbiota and host were difficult to explore for years due to unculturable microbes. Stomach with its acid production was presumed to be sterile and unfavorable for bacterial growth until the discovery of Helicobacter pylori. It dominates the stomach as it was estimated to colonize almost 50% global population. H. pylori infection was linked to the development of chronic gastritis and recognized as a definite carcinogen. There was a probability that the alteration of gastric microbiota likely influenced gastric immunobiology and possible gastric diseases. Recent studies showed that five phyla consist of Firmicutes, Bacteroidetes, Actinobacteria, Fusobacteria and Proteobacteria have been discovered in stomach mucosa which might contribute to the pathological process. In addition, genera such as Lactobacillus, Escherichia-Shigella, Lachnospiraceae, Burkholderia and Nitrospirae were considered to have a role on gastric carcinogenesis.
PUASA PADA KEBUNTINGAN TRIMESTER 1, 2 DAN 3 RELATIF AMAN DILIHAT PADA INDEKS APOPTOSIS SEL NEURON OTAK RATTUS NORVEGICUS BARU LAHIR Wati, Yunita Kholilaili Saras; Joewono, Hermanto Tri; Miftahussurur, Muhammad
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 9, No 2 (2021): EDITION JULY 2021
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v9i2.1388

Abstract

Fasting in pregnancy that can increase neural network activity in the brain region and produce BDNF secretions that seek survival pathways will produce pro survival / anti apoptosis in cerebral neuron cells and the cerebellum. The aim of this study to analyze the effect of fasting during pregnancy on the index of apoptosis of cerebral neuron cells and the cerebellum of the newly born Rattus norvegicus. This research was using Experimental laboratory studies that were correct with the post test study design were only the control group design using experimental animals Rattus norvegicus at the Pathology Laboratory of the Faculty of Medicine, Airlangga University Surabaya which were collected into 3 research groups (1st, 2nd, and 3rd trimesters) and 1 control group . Each group consisted of 6 Rattus norvegicus mothers. The brain dissection of the newborn Rattus norvegicus child was taken and the apoptotic index was calculated using the Immunohistochemical Tunnel method. and discuss with the Immunoreactive Score (IRS). The results of the Kruskal wallis analysis were expressed as the Cerebrum apoptosis index in all four groups (p 0.05). Most apoptosis in the cerebrum was in the first trimester (3.9) and lowest in the second trimester (1.5). The results of the cerebellar apoptosis index analysis by the Kruskall wallis test proved that the most cerebellar apoptosis in the first trimester (4.87) and the lowest in the second trimester (1.33). Conclusion there is no difference between the 1,2 th trimester and 3 in the control of the cerebrum and cerebellum
Faktor-faktor yang Mempengaruhi Pengambilan Keputusan dalam Melakukan Vaksinasi HPV pada Mahasiswa Kesehatan: Literature Review Watari, Rekno; Handayani, Samsriyaningsih; Miftahussurur, Muhammad
Jurnal Ilmiah Universitas Batanghari Jambi Vol 24, No 1 (2024): Februari
Publisher : Universitas Batanghari Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33087/jiubj.v24i1.3866

Abstract

The research aims to analyze the factors that influence the administration of HPV vaccination to health students. The research method used is a literature review. The literature search uses data for the last 5 years from electronic databases such as PubMed, Science Direct, and Google Scholar. After fulfilling the inclusion and exclusion criteria, six articles were collected and discussed in the literature review. Literature results N=106, Pubmed N=53, ScienceDirect N=12, Google Scholar N=41. Six papers can be reviewed and fulfilled based on the inclusion criteria. Based on the results of the journal review, the research concludes that several things influenced health students in carrying out the HPV vaccination, knowledge about cervical cancer and HPV vaccination, attitudes and support for getting vaccinated, and exposure to social media
Capsule Endoscopy as a Diagnostic Tool for Inflammatory Bowel Disease in a Patient with Multiple Myeloma Rizkiawan, Naufali; Mahmudah, Isna; Miftahussurur, Muhammad
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025280-286

Abstract

Capsule endoscopy is an important tool for minimally invasive evaluation of the small bowel, allowing improved diagnostic yield with low complication rates relative to traditional modalities. Here, we present the first case of inflammatory bowel disease (IBD) diagnosed by a capsule endoscopy in Surabaya. There was a case of a patient who suffered chronic diarrhea for four months. When the patient experienced persistent diarrhea, generalized weakness was then reported as a symptom. The patient then received a conventional endoscopy and was planned for a colonoscopy. However, the endoscopy was canceled due to the patient's respiratory distress. The patient underwent capsule endoscopy, where hyperemia and erosion from the small intestine to the colon were found. The diagnosis of IBD was established and the patient was given sulfasalazine 500 mg every 24 hours. In order to image the small intestine endoscopically, capsule endoscopy remains to be the preferred method. This case serves as an example of the advantages of capsule endoscopy, especially in terms of the diagnosis of inflammatory bowel disease.
Spleen Stiffness Measurement as a Predictor of Advanced Liver Fibrosis in Chronic Hepatitis B Patients Hertanto, Carisa Irene; Maimunah, Ummi; -, Aryati; Miftahussurur, Muhammad
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025237-244

Abstract

Background: Chronic hepatitis B is a viral infection that may progress to liver fibrosis. Progressive fibrosis increases portal pressure, leading to elevated spleen stiffness. Although inflammatory reactions and mechanical cholestasis affect liver stiffness, the effect is comparatively limited. Therefore, this study aims to analyze spleen stiffness as a noninvasive marker of liver fibrosis and evaluate the correlation between spleen and liver stiffness.Methods: A retrospective cross-sectional study was performed on chronic hepatitis B patients. Fibroscan was used to measure liver and spleen stiffness. Liver fibrosis was categorized as nonsignificant (F0–F1), significant (F2–F3), and advanced (F4). Correlations between spleen stiffness and liver fibrosis stages were assessed using Spearman’s test, with p 0.05 considered statistically significant. Results: The results showed that 127 patients were eligible for analysis, predominantly male (71.7%), with a mean age of 46.4 ± 9.8 years. The median spleen and liver stiffness were 25.5 kPa (range 5.6–100) and 9.4 kPa (range 2.4–75), respectively. Moreover, spleen stiffness had a positive correlation with liver stiffness (Spearman r = 0.503; p 0.001) and liver fibrosis stages (Spearman r = 0.479; p 0.001). The optimal cutoff for spleen stiffness in predicting advanced fibrosis was 28 kPa, with an area under the receiver operating characteristic curve(AUROC) of 0.816, sensitivity of 0.739, and specificity of 0.753.Conclusion: Spleen stiffness is significantly correlated with liver fibrosis severity. A cutoff of 28 kPa was identified for advanced fibrosis, suggesting spleen stiffness measurement serves as a promising alternative to biopsy.
Co-Authors Adi Pranoto Adinda Juwita Syakila Elizafanti Agoes Soegianto Agus Sulistyono Alfaray, Ricky I. Alpha Fardah Athiyyah Alshawsh, Mohammed A. Amie Vidyani Ana, Devi Andino Maseleno Annisa Zahra Mufida Aryati -, Aryati Astri Dewayani Aswin, R. Haryanto Ayu Citra Gestari Bernadetta Jonan Brian Eka Rahman Budi Prasetyo Budi Widodo Chabib Fachry Albab Dewi, Selva R. Diah Rizki Rahma Dini Dianbudiyanto, Wahid Dita Mega Utami Djazuly Chalidyanto Dominicus Husada Dwiki Noni Armyta Dwiyanti Puspitasari, Dwiyanti Eka Mishbahatul Mar'ah Has Endyka Erye Frety Fauzia, Kartika A. Fauziah Diayu Retnaningtyas Gatut Hardianto, Gatut Gilda Hartecia Hadisuwarno, Wiharjo Hajjarianti, Permata Hamzah Hamzah Hartecia, Gilda Hasan Maulahela Heasty Oktaricha HERAWATI, LILIK Hermanto Tri Joewono Herry Purbayu Hertanto, Carisa Irene Hubur, Aa Hunowu, Ramdan I'tishom, Reny Indra Alfaray, Ricky Ishomatul Faizah Isna Mahmudah Isna Mahmudah Iswan A Nusi Iswan Abbas Nusi Izzatul Fithriyah Jonan, Bernadetta Juniastuti Juniastuti Karnaji, Karnaji Kartika Afrida Fauzia Lionardy Yodianto Mahmudah, Isna Maria Inge Lusida Martono Tri Utomo MISBAKHUL MUNIR Mohammad Anam Al-Ari Nadia Sherli Syafira Natasya Ariesta Selyardi Putri Naufali Rizkiawan Nihayati, Hanik Endang Nurhayati, Fitasari Nidia NUrina Fitriani, NUrina Nurullia Hanum Hilfida Pangestu Adi Pathak, Yashwant Poernomo Boedi Setiawan Purwo Sri Rejek Rejeki, Purwo Sri Riani Widia Parantika Rizkiawan, Naufali Samsriyaningsih Handayani Savitri, Camilia Metadea Aji Soelistijo, Soebagijo Adi Sugiyatmi, Tri A. Sulistiawati Sulistiawati Susanti Susanti Tanaya, Willa M. Thamrin, Husin Titong Sugiharto Titong Sugihartono Tri Purwanti Ucik Nurul Hidayati Ulfa Kholili Ummi Maimunah Usman Hadi Vasa Adi Wisnu Wardana Wahyul Anis Watari, Rekno Wati, Yunita Kholilaili Saras Wessels, Firda I. Widjiati Widjiati Widyaleksono, Trisnadi Willy Sandhika Woro Setia Ningtyas Yoshio Yamaoka Yoshio Yamaoka Yoshio Yamaoka, Yoshio Yudith Annisa Ayu Rezkitha Yudith Annisa Ayu Rezkitha, Yudith Annisa Ayu Zagita, Lauditta Chavia