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All Journal Dentika Dental Journal Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Dentino: Jurnal Kedokteran Gigi Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Journal of Indonesian Dental Association Padjadjaran Journal of Dental Researchers and Students Jurnal EduHealth
Sri Tjahajawati
Department Of Oral Biology, Faculty Of Dentistry, Padjadjaran University, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Veterinary

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Salivary Flow Rates in Various Occlusal Support Zones in Elderly Individuals Kartika Indah Sari; Askani Maulida; Sri Tjahajawati
Journal of Indonesian Dental Association Vol. 4 No. 1 (2021): April
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jida.v4i1.628

Abstract

Introduction: Elderly individuals experience many changes in the oral cavity, one of which is tooth loss. Tooth loss disrupts the relationships between the maxillary and mandibular occlusions, which is detrimental to mastication. Mastication influences salivary secretion due to the salivary-masticatory reflex. Pressure on the teeth during mastication activates mechanoreceptors in the periodontal ligament, which can also stimulate salivary secretion. Objective: This study aimed to describe the salivary flow rates in various occlusal support zones in the elderly based on the Eichner Index. Methods: The study was cross-sectional and used a descriptive research method. The sample population comprised 36 elderly subjects residing in the village of Lebak Gede, Indonesia. Occlusal support zones were classified using the Eichner Index and stimulated salivary flow rates were measured using the Saxon test. Results: The sample population’s mean salivary flow rate was 1.35 ± 0.65 mL/min. The mean salivary flow rates for Eichner classifications A, B1, B2, and B3, were 1.56 ± 0.78 mL/min, 1.52 ± 0.56 mL/min, 1.18 ± 0.45 mL/min, and 0.95 ± 0.86 mL/min, respectively. Conclusion: The mean stimulated salivary flow rate tended to decrease as occlusal support zones decreased in Eichner classifications A, B1, B2, and B3.
The Effectiveness of Omega-3 Fatty Acid Supplementation in the Management of Periodontal Disease in Patients with Type 2 Diabetes Mellitus Anggun Rafisa; Dewi Marhaeni Diah Herawati; Sri Tjahajawati; Erli Sarilita
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Abstract

Type 2 diabetes mellitus is closely associated with periodontitis through chronic inflammation and impaired tissue healing, resulting in a bidirectional relationship that adversely affects both metabolic control and periodontal health. Omega-3 fatty acids possess anti-inflammatory and pro-resolving properties and have been proposed as adjunctive host-modulatory agents in periodontal therapy for patients with diabates. This systematic review aimed to evaluate the effectiveness of omega-3 fatty acid supplementation, alone or in combination with other adjunctive therapies, on periodontal and systemic outcomes in patients with periodontitis and type 2 diabetes mellitus. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive literature search was conducted in PubMed and Scopus databases for randomized controlled trials published between 2015 and 2025. Eligible studies investigated omega-3 fatty acid supplementation as an adjunct to nonsurgical periodontal therapy in patients with periodontitis and diabetes mellitus. Data were extracted and synthesized descriptively. Six randomized controlled trials met the inclusion criteria. Adjunctive omega-3 fatty acid supplementation consistently demonstrated greater improvements in periodontal parameters, including probing depth, clinical attachment level, and gingival inflammation, compared with nonsurgical periodontal therapy alone. Omega-3–based interventions were associated with significant reductions in inflammatory and cardiometabolic biomarkers, such as interleukins, pentraxin, chemerin, malondialdehyde, and glycated hemoglobin. Combined interventions, particularly omega-3 with low-dose aspirin or omega-3–enriched cranberry juice, yielded the most pronounced periodontal and metabolic benefits. Omega-3 fatty acids appear to be a promising adjunctive therapy for improving periodontal and systemic outcomes in patients with type 2 diabetes mellitus.
DIFFERENCES IN SALIVARY VOLUME, PH, AND ORAL CONDITIONS OF DIABETES MELLITUS AND NON-DIABETES MELLITUS PATIENTS Dahlia Salsa Farhani; Sri Tjahajawati; Anggun Rafisa
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22215

Abstract

Background: The Prevalence of diabetes mellitus (DM) has been increasing over the past decades. DM is a chronic metabolic disease characterized by persistent hyperglycemia, which impacts various body systems, including the oral cavity. It affects salivary volume, salivary pH, and oral health, leading to conditions such as xerostomia, gingivitis, dental caries, and ulceration. Purpose: This study aimed to determine the differences in salivary volume, salivary pH, and oral conditions in DM patients and non-DM. Methods: This study was an analytic comparative using secondary data from the result of Unpad Lecturer Competency Research (RKDU) by a consecutive sampling of 22 DM women and 22 non-DM women. The numerical data were analyzed using t test or Mann-Whitney test and the categorical data were analyzed using z proportion test with a significance level of p<0,05. Results: The results showed that there were significant differences in salivary volume (p=0,0001), salivary pH (p=2,54E-05), xerostomia (p=0,01), and dental caries (p=0,007), and there were no significant differences in gingivitis (p=0,216) and ulceration (p=0,154) in DM group and non-DM group. Conclusion: There are differences in salivary volume, salivary pH, and the conditions of xerostomia and dental caries, but there are no differences in the conditions of gingivitis and ulceration in DM patients and non-DM. The differences in saliva and oral conditions are caused by autonomy neuropathy, dehydration, alteration in vascularization and immune response, increasing salivary glucose level, and drug consumption.
Physicochemical characteristics evaluation of commercial artificial saliva based on hydroxyethyl cellulose Pratiwi, Wening; Tjahajawati, Sri; Kuswandani, Faisal; Budiman, Arif; Malinda, Yuti
Padjadjaran Journal of Dental Researchers and Students Vol 10, No 2 (2026): June 2026
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v10i2.70045

Abstract

ABSTRACT Introduction: Artificial saliva is used to manage xerostomia, a medical disorder primarily caused by impaired salivary gland function, by serving as a substitute for natural saliva. Because of its favorable viscosity and stability, hydroxyethyl cellulose (HEC) is frequently used as a thickening agent and lubricant in artificial saliva. Artificial saliva should be evaluated for its physicochemical characteristics to ensure that the formulation closely mimics natural saliva. This study aimed to evaluate the physicochemical characteristics of HEC-based artificial saliva commercially available in Indonesia. Methods: Based on market availability, two artificial saliva products in liquid formulations were obtained and analyzed. Sample 1 was an HEC-based formulation with a combination of polyethylene glycol (PEG) and methylparaben, whereas sample 2 was an HEC-based formulation with Aloe vera and cetylpyridinium chloride (CPC). The physicochemical characteristics of the samples were evaluated based on chemical properties (pH and buffer capacity) and physical properties (viscosity, density, and surface tension). Results: The results showed that sample 1 had an average pH of 6.81±0.32, a buffer capacity of 0.288 mmol H+/L, a viscosity of 10.33 mPa.s, a density of 1.065 g/cm³, and a surface tension of 44.8 mN/m. Meanwhile, sample 2 had an average pH of 5.08±0.52, a buffer capacity of 0.158 mmol H+/L, a viscosity of 2.50 mPa.s, a density of 1.113 g/cm³, and a surface tension of 45.6 mN/m. Conclusion: This study found that sample 1 demonstrated chemical and physical characteristics more similar to natural saliva, whereas sample 2 had a lower pH, buffer capacity, and viscosity but a slightly higher density and surface tension.KEY WORDS: Hydroxyethyl cellulose, artificial saliva, saliva substitute, physicochemical characteristics.Evaluasi karakteristik fisikokimia air liur buatan komersial berbasis hidroksietil selulosa ABSTRAKPendahuluan: Air liur buatan digunakan untuk mengobati xerostomia, suatu gangguan medis yang terutama disebabkan oleh gangguan kelenjar ludah, dengan menggantikan air liur alami. Karena viskositas dan stabilitasnya yang menguntungkan, hidroksietil selulosa (HEC) sering digunakan sebagai pengental dan pelumas dalam air liur buatan. Air liur buatan perlu dievaluasi dari segi karakteristik fisikokimia untuk memastikan bahwa formulasi tersebut menyerupai air liur alami. Penelitian ini bertujuan untuk mengevaluasi karakteristik fisikokimia air liur buatan berbasis HEC yang tersedia secara komersial di Indonesia. Metode: Berdasarkan ketersediaan di pasaran, dua air liur buatan dalam formulasi cair diperoleh dan dianalisis. Sampel 1 adalah formulasi berbasis HEC dengan kombinasi polietilen glikol (PEG) dan metilparaben, sedangkan sampel 2 adalah formulasi berbasis HEC dengan lidah buaya dan setilpiridinium klorida (CPC). Karakteristik fisikokimia sampel diukur, baik sifat kimia (pH, kapasitas buffer) maupun sifat fisik (viskositas, densitas, tegangan permukaan) dievaluasi. (3) Hasil: Hasil penelitian menunjukkan bahwa sampel 1 memiliki pH rerata 6,81±0,32, kapasitas buffer 0,288 mmol H+/L, viskositas 10,33 mPa.s, densitas 1,065 g/cm³, dan tegangan permukaan 44,8 mN/m. Sementara itu, sampel 2 memiliki pH rata-rata 5,08±0,52, kapasitas buffer 0,158 mmol H+/L, viskositas 2,50 mPa.s, densitas 1,113 g/cm³, dan tegangan permukaan 45,6 mN/m. (4) Simpulan: Penelitian ini menemukan bahwa sampel 1 menunjukkan karakteristik kimia dan fisik yang lebih mirip dengan air liur alami, sedangkan sampel 2 memiliki pH, kapasitas buffer, dan viskositas yang lebih rendah tetapi densitas dan tegangan permukaan yang sedikit lebih tinggi.KATA KUNCI: Hidroksietil selulosa, air liur buatan, pengganti air liur, karakteristik fisikokimia.
Co-Authors Alia Intan Kusuma Ramadhani Amaliya Amaliya Ame Suciati Setiawan Amida, Aya An Nisaa Mardhatillah Anggun Rafisa Anggun Rafisa Arif Budiman Askani Maulida Ayu Trisna Hayati Ayu Vidya Putri Cahyanto, Arief Cucu Zubaedah Dahlia Salsa Farhani De Hersa, Sarah Cinthia Richy Artha Dewi ANGGRAENI Dewi Marhaeni Diah Herawati Diani Prisinda Dudi Aripin Edeh Roletta Haroen Erli Sarilita Fairuz, Anargya Alfa Faisal Kuswandani Fatimah, Aulia Fitriana, Elizabeth Fourier Dzar Eljabbar Latief Franklin, Martin Hadiputri, Felicia Hening Tjaturina Pramesti Indra Hadikrishna Irna Sufiawati Islami, Mutiara Indah Permata Sari Kartika Indah Sari Kosterman Usri Kusumaningrum, Dias Mareta Lesmana, Dian Lubis, Vita Tarawan Lusi Epsilawati Marry Siti Mariam Maulida, Askani Md Ismail, Nur Adlina Diyana Merry Annisa Mochammad Rodian Muhammad Farhan Mutiara, Rahman Nabila Anisha Nabillah Handika Nani Murniati Nasution, Dewi Lidya Ichwana Nina Djustiana Popy Rufaidah Pratiwi, Wening Rasmi Rikmasari Ratna Indriyanti Razali, Ervin Rina Putri Noer Fadilah, Rina Putri Noer Ririn Ariyanti, Ririn Rizali, Ervin Rosiliwati Wihardja, Rosiliwati Rosita Aisyah Sari, Kartika Indah Silvi Kintawati Soo Ling Fu, Soo Ling Stefani, Stacia Sunardhi Widyaputra Yetty Herdiyati, Yetty Yurika Ambar Lita Yuti Malinda