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All Journal Dentika Dental Journal Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Journal of Indonesian Dental Association Padjadjaran Journal of Dental Researchers and Students Interdental Jurnal Kedokteran Gigi (IJKG) Jurnal EduHealth
Sri Tjahajawati
Department Of Oral Biology, Faculty Of Dentistry, Padjadjaran University, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Veterinary

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Saliva secretion difference before and after rinsing with baking soda on menopause women Anggraeni, Dewi; Tjahajawati, Sri; Wihardja, Rosiliwati
Padjadjaran Journal of Dentistry Vol 19, No 1 (2007): March 2007
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (351.85 KB) | DOI: 10.24198/pjd.vol19no1.14178

Abstract

Menopause women can experience a decrease in saliva secretion (decrease). To understand the clear picture about saliva secretion, the volume, flow rate, pH and viscosity were then measured. The aim of this research was to obtain a picture about the difference of saliva secretion before and after rinsing with baking soda on menopause women. The type of the research used was a laboratory quasi-experiment with comparative descriptive form. The technique used in this research is the survey method, and samples were taken using the multistage cluster random sampling method, and t-student statistical analysis. This research was conducted with the saliva collected with spitting method on 45 menopause women. The results show that the average volume, flow rate, pH and viscosity before rinsing with baking soda was 1.79 ml, 0.18 ml/minute, 7.40 and 0.81 mm2/second. The average volume, flow rate, pH and viscosity after rinsing with baking soda were 2.66 ml; 0.27 ml/minute; 8.67 and 0.78 mm2/second. Statistical analysis t-student on α = 0.05 shows volume changes, flow rate, pH and saliva viscosity before and after rinsing with baking soda was 0.873; 0.086; 1.273 and 0.037 respectively. The conclusion shows a significant difference between saliva secretion before and after rinsing with baking soda, and saliva secretion after rinsing with baking soda on menopause women.
DIFFERENCES IN SALIVARY VOLUME, PH, AND ORAL CONDITIONS OF DIABETES MELLITUS AND NON-DIABETES MELLITUS PATIENTS Farhani, Dahlia Salsa; Tjahajawati, Sri; Rafisa, Anggun
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22215

Abstract

Background: The Prevalence of diabetes mellitus (DM) has been increasing over the past decades. DM is a chronic metabolic disease characterized by persistent hyperglycemia, which impacts various body systems, including the oral cavity. It affects salivary volume, salivary pH, and oral health, leading to conditions such as xerostomia, gingivitis, dental caries, and ulceration. Purpose: This study aimed to determine the differences in salivary volume, salivary pH, and oral conditions in DM patients and non-DM. Methods: This study was an analytic comparative using secondary data from the result of Unpad Lecturer Competency Research (RKDU) by a consecutive sampling of 22 DM women and 22 non-DM women. The numerical data were analyzed using t test or Mann-Whitney test and the categorical data were analyzed using z proportion test with a significance level of p<0,05. Results: The results showed that there were significant differences in salivary volume (p=0,0001), salivary pH (p=2,54E-05), xerostomia (p=0,01), and dental caries (p=0,007), and there were no significant differences in gingivitis (p=0,216) and ulceration (p=0,154) in DM group and non-DM group. Conclusion: There are differences in salivary volume, salivary pH, and the conditions of xerostomia and dental caries, but there are no differences in the conditions of gingivitis and ulceration in DM patients and non-DM. The differences in saliva and oral conditions are caused by autonomy neuropathy, dehydration, alteration in vascularization and immune response, increasing salivary glucose level, and drug consumption.
The Effectiveness of Omega-3 Fatty Acid Supplementation in the Management of Periodontal Disease in Patients with Type 2 Diabetes Mellitus Rafisa, Anggun; Dewi Marhaeni Diah Herawati; Tjahajawati, Sri; Sarilita, Erli
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Abstract

Type 2 diabetes mellitus is closely associated with periodontitis through chronic inflammation and impaired tissue healing, resulting in a bidirectional relationship that adversely affects both metabolic control and periodontal health. Omega-3 fatty acids possess anti-inflammatory and pro-resolving properties and have been proposed as adjunctive host-modulatory agents in periodontal therapy for patients with diabates. This systematic review aimed to evaluate the effectiveness of omega-3 fatty acid supplementation, alone or in combination with other adjunctive therapies, on periodontal and systemic outcomes in patients with periodontitis and type 2 diabetes mellitus. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive literature search was conducted in PubMed and Scopus databases for randomized controlled trials published between 2015 and 2025. Eligible studies investigated omega-3 fatty acid supplementation as an adjunct to nonsurgical periodontal therapy in patients with periodontitis and diabetes mellitus. Data were extracted and synthesized descriptively. Six randomized controlled trials met the inclusion criteria. Adjunctive omega-3 fatty acid supplementation consistently demonstrated greater improvements in periodontal parameters, including probing depth, clinical attachment level, and gingival inflammation, compared with nonsurgical periodontal therapy alone. Omega-3–based interventions were associated with significant reductions in inflammatory and cardiometabolic biomarkers, such as interleukins, pentraxin, chemerin, malondialdehyde, and glycated hemoglobin. Combined interventions, particularly omega-3 with low-dose aspirin or omega-3–enriched cranberry juice, yielded the most pronounced periodontal and metabolic benefits. Omega-3 fatty acids appear to be a promising adjunctive therapy for improving periodontal and systemic outcomes in patients with type 2 diabetes mellitus.
Determination of MIC and MBC of Peperomia pellucida Extract Against Aggregatibacter actinomy-cetemcomitans Using Serial Dilution and Colony Count Assay Nasution, Dewi Lidya Ichwana; Tjahajawati, Sri; Indriyanti, Ratna; Amaliya, Amaliya; Permadi, Muhammad Ammar
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 22 No. 1 (2026): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v22i1.12376

Abstract

Introduction: Periodontitis is an infectious disease that damages periodontal tissues and may lead to tooth loss. Aggregatibacter actinomycetemcomitans is one of the main pathogenic bacteria associated with periodontitis. Peperomia pellucida (L.) Kunth contains flavonoids, alkaloids, and tannins with antibacterial potential. This study evaluated its effectiveness against A. actinomycetemcomitans and determined its Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Materials and Methods: This laboratory experimental study used a post-test-only control group design. Antibacterial testing was performed using the serial dilution method in eight groups: extract concentrations of 3.125%, 6.25%, 12.5%, 25%, 50%, and 100%, 0.2% chlorhexidine as the positive control, and distilled water as the negative control. MIC was assessed by bacterial growth on Mueller–Hinton Agar, while MBC was determined by colony counts (CFU/mL). Data were analyzed using Kruskal–Wallis and Mann–Whitney tests. Results: Peperomia pellucida extract showed antibacterial activity against A. actinomycetemcomitans. MIC was achieved at 6.25% concentration with 92.5% inhibition, while MBC was achieved at 12.5% concentration with 100% bactericidal effect. Conclusion: Peperomia pellucida extract effectively inhibited and killed A. actinomycetemcomitans, with greater antibacterial activity at higher concentrations.
Co-Authors Alia Intan Kusuma Ramadhani Amaliya Amaliya Ame Suciati Setiawan Amida, Aya An Nisaa Mardhatillah Anggun Rafisa Ayu Trisna Hayati Ayu Vidya Putri Cahyanto, Arief Chandra, Angievel Cucu Zubaedah De Hersa, Sarah Cinthia Richy Artha Dewi ANGGRAENI Dewi Marhaeni Diah Herawati Diani Prisinda Dudi Aripin Edeh Roletta Haroen Erli Sarilita Fairuz, Anargya Alfa Farhani, Dahlia Salsa Fatimah, Aulia Fitriana, Elizabeth Fourier Dzar Eljabbar Latief Franklin, Martin Hadiputri, Felicia Hening Tjaturina Pramesti Indra Hadikrishna Irna Sufiawati Islami, Mutiara Indah Permata Sari Kosterman Usri Kusumaningrum, Dias Mareta Lesmana, Dian Lubis, Vita Tarawan Lusi Epsilawati Marry Siti Mariam Maulida, Askani Md Ismail, Nur Adlina Diyana Merry Annisa Mochammad Rodian Muhammad Farhan Mutiara, Rahman Nabila Anisha Nabillah Handika Nani Murniati Nasution, Dewi Lidya Ichwana Nina Djustiana Permadi, Muhammad Ammar Popy Rufaidah Rasmi Rikmasari Ratna Indriyanti Razali, Ervin Rina Putri Noer Fadilah, Rina Putri Noer Ririn Ariyanti, Ririn Rizali, Ervin Rosiliwati Wihardja, Rosiliwati Rosita Aisyah Sari, Kartika Indah Silvi Kintawati Soo Ling Fu, Soo Ling Stefani, Stacia Sunardhi Widyaputra Yetty Herdiyati, Yetty Yurika Ambar Lita Yuti Malinda