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Muslem Muslem, Muslem
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Journal : Narra J

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Characterization of red algae (Gracilaria verrucosa) on potential application for topical treatment of oral mucosa wounds in Rattus norvegicus Hakim, Rachmi F.; Idroes, Rinaldi; Hanafiah, Olivia A.; Ginting, Binawati; Kemala, Pati; Fakhrurrazi, Fakhrurrazi; Putra, Noviandi I.; Shafira, Ghina A.; Romadhoni, Yenni; Destiana, Khaerunisa; Muslem, Muslem
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.422

Abstract

Wound healing in the mouth has its challenges due to masticatory movements and the presence of bacteria that can inhibit its process. The aim of this study was to analyze the contents of red algae (Gracilaria verrucosa) from Indonesia, and its potential as a wound-healing agent for oral wounds using animal model. Red algae content was determined by phytochemical tests and gas chromatography-mass spectroscopy (GC-MS). The wound was made by making an incision on the gingival mucosa of Rattus norvegicus and the parameters assessed were bleeding time, number of fibroblast cells, and time of wound closure. Three doses of G. verrucosa gel were used (2.5%, 5%, and 10%) and the gels were applied twice a day, at 6:00 and 18:00. Application was carried out topically by applying 0.1 ml of gel to the incision wound using a 1 mL syringe. Our phytochemical test indicated that the G. verrucosa contained alkaloids, steroids, flavonoids, and phenols. The dominant contains of the G. verrucosa were glycerol (36.81%), hexadecenoic acid (20.74%), and cholesterol (7.4%). The hemostasis test showed that the 2.5% G. verrucosa extract gel had the shortest bleeding time, 33.98±5.33 seconds. On the seventh day of the initial proliferation phase, the number of fibroblasts was not significantly different among groups. On day 14, the number of fibroblasts was only significantly different between 10% G. verrucosa and untreated group (p=0.007). On day 28, however, both 5% and 10% G. verrucosa were significantly higher compared to untreated group, both had p=0.010. Daily clinical examination showed that animals that were given 2.5% and 5% of G. verrucosa extract gel experienced wound closure on day 10. Animals treated with 10% of extract gel, all wounds healed on day 9. This study suggested that G. verrucosa extract could accelerate wound closure and wound healing.
Co-Authors - Fakhrurrazi . Azmeri, . ahmad yani Ainal Mardhiah Aisy, Rishazatul Akbar, Zulhiddin Alberto Noviano Patty Alfiady, Teuku Aminuyati Asbudi Asbudi Asna, Saifal Azwar Thaib Bhayu Gita Bhernama Binawati Ginting Dahlan Abdullah Depita Kardiati Destiana, Khaerunisa Dewi. M, Nur Sari Dwitawati, Ima Efilda, Adila Putri Fahrizal Fahrizal Faisal Syahputra, Faisal Fajrina, Salina Ahdia Ghazi Mauer Idroes Hakim, Rachmi F. Hanafiah, Olivia A. Hanan, Dafif Hayatina, Maulida Hayatun Nufus Heri Fajri, Heri Husna, Zahrotul Husni Mubarrak Ikhwan, Hady Inanta, Nora Silva Irvanizam, Irvanizam Isfanda, Isfanda Iskandar Iskandar Jafaruddin Jafaruddin, Jafaruddin Joshi, Jaghdish S. Junaidi Arsyad, Junaidi Kemala, Pati Kiflah, Marzatul Lala, Andi Lia Handayani, Lia Listia, Ayu Marlina Marlina Matsum, Hasan Maulana, Aga Maulydia, Nur Balqis Miftahul Jannah Muammar Yulian MUH. FICHRIYADI HASTIRA Muhammad Azis Muhammad Farid Muhammad Wali, Muhammad Muhammad Yusuf Mujiburrahman -, Mujiburrahman Muliyani, Tri Mulyadi Mulyadi Munira, Widia Muryali, Muryali N. Nazaruddin Nasution, Salmah Nazila, Dara Ningsih, Indah Putri Nisah , Khairun Nurhayati Nurhayati Putra, Noviandi I. Raudhatul Jannah Razief Perucha Fauzie Afidh Reni Silvia Nasution Reza Muttaqin, Reza Muttaqin Rinaldi Idroes Rivansyah Suhendra Romadhoni, Yenni Safira, Maulida Salsabila, Athaya Saputra, Feri Sari, Suci Indah Sasmita, Novi Reandy Shafira, Ghina A. Shafrida Wati, Shafrida Sofyan Sofyan Suhendra, Rivansyah Suryana, Nina Syamsidik, Syamsidik Teuku Rizky Noviandy Ulhaq, Muhammad Zia Yukadhirza, Vitra Yuli Santri Isma Zahriah, Zahriah