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All Journal Health Science Journal of Indonesia Jurnal Kebijakan Kesehatan Indonesia Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Kesehatan Andalas Berkala Kedokteran MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Penelitian Kesehatan Suara Forikes Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Pengabdian Pada Masyarakat Jurnal Kesehatan Komunitas BIOEDUSCIENCE Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Window of Health : Jurnal Kesehatan Media Keperawatan Indonesia IKRA-ITH ABDIMAS Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education INTEGRITAS : Jurnal Pengabdian Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Journal of Applied Data Sciences SEGARA : Jurnal Pengabdian Kepada Masyarakat Journal of Research in Pharmacy and Pharmaceutical Sciences Jurnal Kedokteran Meditek The Health Researchers Journal Journal of Religion and Public Health Journal of Diverse Medical Research: Medicosphere
Makkiyah, Feda Anisah
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : The Health Researchers Journal

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OPTIMIZATION OF EXTRACTION WITH SOLVENT VARIATION BASED ON TOTAL FLAVONOID CONTENT IN WUNGU LEAVES (Graptophyllum pictum (L.) Griff): A LITERATURE REVIEW Subeno, Setia; Makkiyah, Feda
The Health Researcher's Journal Vol. 1 No. 03 (2024): The Health Researchers Journal
Publisher : The SDGS Forum Communication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.00000/2zdv1d13

Abstract

There are many studies analyzing the flavonoid content based on the total flavonoid content (TFC) of wungu leaves through the extraction process with different extraction solvents. So, this review using literature review methodology is aimed to find out the type of extraction solvent that has the most optimum condition based on the highest TFC. The databases for collecting data involved PubMed, Scopus, and Google Scholar. Temporary, the results based on some previous studies vary greatly. Two of four selected articles showed that the highest TFC was found in semi-polar solvents; ethyl acetate and acetone. It is suspected that the samples contain more aglycones (a subtype of flavonoids) that can be soluble in semi-polar solvents. Whereas, the two others showed that the nonpolar solvent (hexane) had the highest TFC. It is suspected that the samples contain more subtypes of flavonoids called isoflavones, flavanones, flavones, and flavonols that can be soluble in nonpolar solvents. To get the appropriate and best standardized extract of wungu leaves, re-examination of this optimization based on the highest TFC in further research is necessary by using different extraction solvents that are equally polar like water, methanol, and ethanol; because the flavonoids as secondary metabolites in plants are basically polar.
Analysis of Mortality Risk Factors in Children with Epidural Hematoma (EDH) Nafira, Amodya Dahayu; Makkiyah, Feda Anisah
The Health Researcher's Journal Vol. 1 No. 03 (2024): The Health Researchers Journal
Publisher : The SDGS Forum Communication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.00000/zjdx6d05

Abstract

Head injuries hold the third position among all injury categories in Indonesia, with the highest number of cases occurring in children. Approximately 2% of all head injury cases are epidural hematomas (EDH). The majority of these epidural hematoma cases are caused by head trauma such as accidents, falls, collisions, or other physical assaults leading to traumatic mechanisms. Additionally, EDH can also be caused by non-traumatic processes such as infection/abscess, vascular malformations, tumors, and coagulopathy disorders. Epidural hematoma has a relatively favorable prognosis, yet there are several factors that contribute to a worsened prognosis. This study aims to examine of several research articles outlining the factors contributing to mortality in pediatric EDH cases. The method used is a literature review technique utilizing scholarly databases meeting specific inclusion criteria. The study found that the preoperative GCS, preoperative treatment time interval, operative treatment, and pupillary abnormalities are some of the factors that can impact patient outcomes, including mortality rates, in pediatric EDH cases. Subsequent research is expected to delve deeper on the outcomes of patients undergoing surgical and conservative interventions to address mortality incidents in pediatric EDH.
Developing Adaptive Bra Design For Woman With Hemiplegia: A Literature Review Juliana, Dian; Feda Anisah Makkiyah
The Health Researcher's Journal Vol. 1 No. 03 (2024): The Health Researchers Journal
Publisher : The SDGS Forum Communication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.00000/yxvkwg56

Abstract

Female stroke patients with hemiplegia will experience difficulties to not be able to use bras independently are due to weakness in the upper extremities. Meanwhile, the use of bras is very important for women because bras have a major function in maintaining breast shape by lifting the breasts. Therefore, this study aims to review developing adaptive bra design for woman with hemiplegia. The method of this study was a literature review. After screening stages, two studies are included in this review. Adaptive bra design for woman with hemiplegia is the development of a bra with modifications of material, design, and additional features, especially in the fasteners section by paying attention to good and comfortable materials for users. Some additional features can also be used either to monitor the physiological body of the user or in order to assist the use of the bra. A good adaptive bra design is a design that can help wear and remove the bra with one hand while still paying attention to comfort and aesthetic value.
ANTI-INFLAMMATORY EFFECTS OF Graptophyllum pictum (L.) GRIFF EXTRACT IN PRECLINICAL RATS HIND-PAW EDEMA MODELS: A LITERATURE REVIEW Shofiy, Alifya Rayyani; Makiyyah, Feda Anisah
The Health Researcher's Journal Vol. 2 No. 01 (2025): The Health Researchers Journal
Publisher : The SDGS Forum Communication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.00000/37a33t66

Abstract

Graptophyllum pictum (L.) Griff or daun ungu is a common medical plant in Indonesia that possesses many promising medical properties, including anti-inflammation. This review aims to discuss the anti-inflammatory effects of Graptophyllum pictum (L.) Griff extract in preclinical hind-paw edema animal models. Through literature search and analyze based on keywords, PICO, inclusion, and exclusion criteria, a total of four studies were included in this review. As a result, ethanol extract of Graptophyllum pictum (L.) Griff shows anti-inflammatory effects significantly reducing the volume of edema and having high anti-inflammatory power by inhibition of the arachidonic inflammatory pathway. Therefore, these preclinical test studies confirmed the anti-inflammatory effects of Graptophyllum pictum (L.) Griff. However, further studies and human trials are required to confirm the efficacy and develop a  standardized formula for Graptophyllum pictum (L.) Griff.
COMPARATIVE ANALYSIS OF INFARCT VOLUMES IN PERMANENT AND TRANSIENT MCAO MODELS USING TTC STAINING: A REVIEW OF CURRENT RESEARCH AND FUTURE DIRECTIONS Buana, Gherriandi Raja; Makkiyah, Feda Anisah; Wahyudi, Dhyani Paramita
The Health Researcher's Journal Vol. 2 No. 01 (2025): The Health Researchers Journal
Publisher : The SDGS Forum Communication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.00000/js818616

Abstract

Ischemic stroke research often relies on animal models to understand the pathological processes underlying brain injury. Among the most widely used models are permanent middle cerebral artery occlusion (pMCAO) and transient middle cerebral artery occlusion (tMCAO), both of which simulate ischemic events in the brain. However, while existing studies have compared the effects of pMCAO and tMCAO on infarct volumes, many have been limited by short observation periods (e.g., 4 hours) or have focused only on non-occlusion models. This literature review aims to evaluate the comparative effectiveness of these two models in generating infarct sizes, specifically utilizing triphenyltetrazolium chloride (TTC) staining to measure infarct volumes. Our analysis highlights the variability in infarct volumes between the two models and emphasizes further research incorporating longer observation intervals (e.g., 6, 18, and 24 hours). This gap in research is crucial for refining experimental stroke models and improving the clinical relevance of findings, particularly regarding therapeutic strategies for ischemic stroke. The review also suggests potential research pathways to enhance model standardization and consistency in future studies, aiming for more accurate and reproducible results that will inform the development of effective stroke treatments.
PURPLE LEAVES (Graptophyllum pictum L. Griff) AND PINEAPPLE (Ananas comosus L. Merr.) FOR THE PRODUCTION OF HERBAL TEA TO SUPPORT NERVOUS SYSTEM HEALTH Aritonang, Hosianna Stephany; Makkiyah, Feda Anisah
The Health Researcher's Journal Vol. 2 No. 01 (2025): The Health Researchers Journal
Publisher : The SDGS Forum Communication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.00000/fadfe331

Abstract

This study explores the potential of purple leaves and pineapple as raw materials for producing herbal tea. It examines the availability of these plants in Indonesia, analyzes their bioactive compounds, investigates the tea production process, and evaluates food safety through toxicity and microbiological testing. The research employs an experimental approach, integrating literature reviews, phytochemical analysis, and laboratory testing. The study involves identifying key bioactive compounds in purple leaves and pineapple, formulating an optimal tea blend, and conducting toxicity and microbial safety evaluations.The study finds that purple leaves contains flavonoids, alkaloids, and tannins, which possess neuroprotective and anti-inflammatory. Pineapple contains bromelain and vitamin C, which are known for their antioxidative and anti-inflammatory. This research provides a novel contribution by introducing a herbal tea formulation combining purple leaves and pineapple. It offers valuable insights into the potential of Indonesian herbal resources for functional food development and phytopharmacology.
A COMPARATIVE ANALYSIS OF TRANSCARDIAL PERFUSION TECHNIQUES FOR BRAIN FIXATION IN RODENTS: A CALL FOR STANDARDIZATION OF TRANSCARDIAL PERFUSION Wahyudi, Dhyani Paramita; Makkiyah, Feda Anisah; Buana, Gherriandi Raja
The Health Researcher's Journal Vol. 2 No. 01 (2025): The Health Researchers Journal
Publisher : The SDGS Forum Communication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.00000/6nrjth51

Abstract

Transcardial perfusion is a crucial technique in rodent research for tissue fixation and preservation. The process typically involves flushing the vascular system with saline to remove blood, followed by fixation with 4% paraformaldehyde (PFA) or formalin. However, differences in species, procedural techniques, and fluid volumes can influence perfusion efficiency and tissue quality. This literature review compares six transcardial perfusion protocols used in mice and rats, focusing on procedural variations and fluid volume requirements. Data were collected from published protocols detailing perfusion techniques, obtaining evidence that substantial variability is observed in the protocols, including differences in anesthesia regimens, surgical approaches, perfusion techniques, fluid compositions, and fixation outcomes. Future research should focus on standardizing perfusion protocols to improve consistency in fixation quality, minimize tissue degradation, and preserve structural and molecular integrity.
CASE REPORT: PROGRESSIVE HEADACHE IN A RARE CASE OF MENINGIOMA Saragih, Nia Citama; Makkiyah, Feda Anisah; Syahrin, Rosita Alfi; Sihotang, Theodora Caroline
The Health Researcher's Journal Vol. 3 No. 1 (2026): The Health Researchers Journal
Publisher : The SDGS Forum Communication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.00000/dv7q3e86

Abstract

The most prevalent primary tumour of the central nervous system is meningioma, and the incidence increases with age. This tumour can be detected through radiological examination and classified based on the results of anatomical pathology examination. A 48-year-old woman presented to the hospital with complaints of a left-sided progressive headache for several years without any other complaints. Imaging examination showed a lesion in the falx cerebri of the sinistra aspect that suggested typical meningioma. The woman decided to undergo craniotomy resection surgery and histopathological analysis. Based on the WHO classification, the histopathology results revealed a microcystic and chordoidal meningioma. The patient had significant improvement in her symptoms postoperatively, and the tumour size decreased on follow-up imaging. This case report aims to highlight the diagnostic challenges and clinical relevance of identifying progressive headaches as one manifestation of atypical meningioma. 
A CASE REPORT OF 41-YEAR-OLD MALE WITH POST TRAUMATIC ENCEPHALOMALACIA Kharitano, Fathia; Makkiyah, Feda Anisah
The Health Researcher's Journal Vol. 3 No. 2 (2026): The Health Researchers Journal
Publisher : The SDGS Forum Communication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.00000/azy3vr10

Abstract

Encephalomalacia is the softening of brain tissue resulting from hemorrhagic contusions, infarctions, or diffuse axonal injury, which can develop months or even years after head trauma. Encephalomalacia may occur in adults, albeit rarely, following acquired brain injuries such as infection, trauma, or infarction. We report a 41-year-old male who presented with headache and memory loss, symptoms that developed one year after a motorcycle accident in which he sustained a head injury. Imaging revealed hypodense lesions in the left temporoparietal lobe, consistent with encephalomalacia and associated ventriculomegaly. This case highlights the significance of detailed clinical and radiological assessments in diagnosing encephalomalacia, underscoring the importance of early intervention and management to prevent long-term neurological complications.
A CASE REPORT: POSTOPERATIVE EPIDURAL HEMATOMA AFTER MENINGIOMA RESECTION Anastasya Chanita Putri Maharani; Feda Anisah Makkiyah
The Health Researcher's Journal Vol. 3 No. 2 (2026): The Health Researchers Journal
Publisher : The SDGS Forum Communication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.00000/0pyz4087

Abstract

Postoperative Epidural Hematoma (PEDH) is a rare but potentially life-threatening complication following craniotomy for intracranial tumor resection, particularly in elderly patients. The incidence of postoperative epidural hematoma is estimated to be approximately 1-2% of intracranial surgeries, and its development is often attributed to rapid reductions in intracranial pressure, excessive cerebrospinal fluid drainage, or coagulation abnormalities. This report presents a 71-year-old female who developed PEDH following craniotomy for meningioma. The patient initially showed stable postoperative recovery but experienced sudden neurological deterioration, prompting an urgent CT scan that revealed an epidural hematoma. Immediate surgical intervention was performed to evacuate the hematoma, leading to gradual neurological improvement. This case highlights the importance of early detection, rapid intervention, and careful perioperative management to optimize outcomes in patients with PEDH
Co-Authors Abd. Rasyid Syamsuri Ahmad Aulia Ahmad Taufik Aisyah, Ammara Alifah Safira Amperatmoko Alma Putri Maulidawati Alya Roza Lisanti Anastasya Chanita Putri Maharani Anisah Anisah Antoni, Darius Apriningsih, Apriningsih Apriningsih Arfiyanti Arfiyanti Arfiyanti, Arfiyanti Aritonang, Hosianna Stephany Ayu Devania Dipta Gayatri, Gusti Ayu Magdalena Natalia Situmeang Basuki Supartono Bintang Bayu Aryandi Buana, Gherriandi Raja Budiman, Anisa Novita Dian Pertiwi Dian Pertiwi Digna, Audrey Alvura Erna Harfiani Faustine, Gracella Fitriana Fitriana Goenarjo, Roman Gracella Faustine Heni Pujiastuti Heristyorini, Ayodya Herkan, Muhamad Thariq Imam Prabowo, Imam Juliana, Dian Kamaludin, Fahmi Kharitano, Fathia Lisanti, Alya Roza Marlina Dewiastuti Marlina Dewiastuti, Marlina Masiran, Ruziana` Meiskha Bahar Melly Kristanti Muhammad Ferrel Privansyah Cader Cader Muhammad Reihan Arianda Nabila Aulia Ainaya Nafira, Amodya Dahayu Napitupulu, Partogi Natanel, Handro Steve Nia Citama Saragih Nugrahana, Raisa Yunika Nurfitri Bustamam Nurhadi Ibrahim Nurrahmah, Rahma Nida Nurrizka, Rahmah Huda Oktafiani, Devi Oktavia, Sabina Pasiak, Taufiq Fredrik Prita Maya Savitri Rachmawati, Alfira Rahayu, Melinda Dwi Rahma Hida Nurrizka Rahmah Hida Nurrizka Rahmah Huda Nurrizka Rizkyta, Bunga Mentari Rosadi, Andrea Salsabila Rosita Alfi Syahrin Sabita, Rifqi Safira, Lisa Salim Harris, Salim Saragih, Nia Citama Savitri, Prita Maya Sembiring, Rinawati Setyaningsih, Yuni Shelly Nobel Shofiy, Alifya Rayyani Sihotang, Theodora Caroline Subeno, Setia Syahrin, Rosita Alfi Taufik Jamaan Taufiq Fredrik Pasiak Theodora Caroline Sihotang Tiwuk Susantiningsih Wahyudi, Dhyani Paramita Widayani Wahyuningtyas Yani, Sri Yuni Setyaningsih Yuri Nurdiantami Zulfa , Fajriati