Article Per Year (5 Year)
p-Index From 2020 - 2025
6.036
P-Index
This Author published in this journals
All Journal ODONTO Dental Journal Majalah Obat Tradisional Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Dentin Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Odonto dental journal Jurnal Bioteknologi & Biosains Indonesia (JBBI)
Aspriyanto, Didit
Department Of Dentomaxillofacial Radiology, Faculty Of Dentistry, Universitas Lambung Mangkurat, Banjarmasin, Indonesia, 70236
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Energy Environmental Science Health Professions Medicine & Pharmacology Physics Public Health

Published : 48 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 48 Documents
Search

 1   2   3   4   5 
UJI TOKSISITAS EKSTRAK DAUN KARAMUNTING (Rhodomyrtus tomentosa (Aiton) Hassk.) TERHADAP HATI TIKUS WISTAR Fitri Siregar, Eka Dwita Natasya; Oktiani, Beta Widya; Dwi Kurniawan, Fajar Kusuma; Aspriyanto, Didit; Wardani, Ika Kusuma
Dentin Vol 8, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v8i2.13117

Abstract

ABSTRACTBackground: Medicinal plants are types of plants that can ability to effectively treat illnesses. One such plant is caramunting leaves (Rhodomyrtus tomentosa (Aiton) Hassk). The substance in caramunting leaves includes an antibiotic that can counteract infections in the body. To determine the safe dosage of a drug, it is necessary to conduct toxicity tests in vivo on the liver of Wistar rats based on SGOT and SGPT levels. Objective: To analyze the toxic effects of administering caramunting leaf extract (Rhodomyrtus tomentosa (Aiton) Hassk.) in doses of 600 mg/kgBW, 1,200 mg/kgBW, and 2,400 mg/kgBW orally on rat liver based on SGOT and SPGT levels. Method: This study employed a true experimental posttest-only control group design to test the toxicity of caramunting leaf extract on SGOT and SGPT levels in the liver of Wistar rats given orally. Results: Following a 28-day experimental period on research animals, SGPT levels were observed to range from 34.9 to 218.1 U/L, while SGOT levels ranged from 56.1 to 201.9 U/L. These findings remain within the normal range, indicating that the extract does not have a toxic effect on SGPT and SGOT. Conclusion: Karamunting leaf extract at doses of 600 mg/kgBW, 1,200 mg/kgBW, and 2,400 mg/kgBW did not exhibit a toxic effect on SGPT and SGOT levels in Wistar rats.Keywords :     Karamunting, Toxicity, SGOT, SGPT, Antibiotic. ABSTRAK Latar Belakang: Tanaman obat adalah tanaman yang mempunyai khasiat menyembuhkan suatu penyakit. Tanaman yang memiliki potensi tersebut adalah daun karamunting (Rhodomyrtus tomentosa (Aiton) Hassk). Kandungan yang terdapat pada daun karamunting bersifat sebagai antibiotik yang mampu mengatasi infeksi dalam tubuh. Untuk mengetahui batas rasional suatu obat, maka diperlukan penelitian uji toksisitas secara in vivo pada hati tikus wistar berdasarkan kadar SGOT dan SGPT. Tujuan: menganalisis efek toksik pemberian ekstrak daun karamunting (Rhodomyrtus tomentosa (Aiton) Hassk.) dosis 600 mg/kgBB, 1.200 mg/kgBB, dan 2.400 mg/kgBB per oral pada hati tikus berdasarkan kadar SGOT dan SPGT. Metode: Penelitian ini menggunakan design true eksperimental dengan desain posttest-only with control design untuk menguji toksisitas ekstrak daun karamunting terhadap kadar SGOT dan SGPT pada hati tikus wistar yang diberikan secara oral. Hasil: Setelah dilakukan percobaan pada hewan penelitian selama 28 hari didapatkan kadar SGPT 34,9-218,1 U/L dan kadar SGOT 56,1–201,9 U/L. Nilai tersebut menunjukkan hasil tidak melebihi rentang normal yang mengartikan bahan penelitian tidak memiliki efek toksik pada SGPT dan SGOT. Kesimpulan: Ekstrak daun karamunting dengan dosis 600 mg/kgBB, 1.200 mg/kgBB, dan 2.400 mg/kgBB tidak memiliki efek toksik pada kadar SGPT dan SGOT tikus Wistar.Tidak terdapat efek toksik dari pemberian ekstrak daun karamunting dosis 600 mg/kgBB, 1.200 mg/kgBB, dan 2.400 mg/kgBB secara per oral terhadap kadar SGOT dan SGPT tikus Wistar. Kata kunci :  Antibiotik, Karamunting, SGOT, SGPT, Toksisitas
ANTIBACTERIAL ACTIVITY OF PAPUYU FISH SCALE CHITOSAN (Anabas testudineus) AGAINST Staphylococcus aureus At-Thoyyar, Aila; Ichrom Nahzi, Muhammad Yanuar; Puspitasari, Dewi; Aspriyanto, Didit; Utami, Juliyatin Putri
Dentino: Jurnal Kedokteran Gigi Vol 9, No 2 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i2.20399

Abstract

Backgrounds: Pulp disease due to caries can be treated through endodontic treatment, which aims to eliminate bacteria in the root canal so microorganisms cannot multiply. Staphylococcus aureus is a resistant microorganism causing root canal treatment failure. Chlorhexidine as a gold standard cannot remove biofilm and other organic debris. Utilization of nature, chitosan of papuyu fish scales (Anabas testudineus) has antibacterial properties that can be an alternative root canal irrigation material. Purpose: Analyze the antibacterial activity of chitosan of papuyu fish scales against Staphylococcus aureus based on the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Methods: This research is a true experimental design with posttest only with control group design. The research groups were chitosan of Papuyu fish scales with concentrations of 25%, 50%, 75%, 100%, chlorhexidine gluconate 2% (positive control), and aquadest (negative control) with 6 repetitions. Results: The MIC value in the One-Way ANOVA test showed a significant difference (p<0.05). Data analysis followed by Post Hoc Games-Howell test showed all treatment groups had significant differences between each other (p<0.05). The MBC value in the Kruskal Wallis test shows that there is a significant difference (p<0.05). Data analysis followed by MannWhitney test showed significant differences between each other (p<0.05) except for the group of papuyu fish scale chitosan 25% concentration against papuyu fish scale chitosan 50% concentration, papuyu fish scale chitosan 100% concentration against chlorhexidine gluconate 2% (p>0.05). Conclusion: There is a difference in the antibacterial activity of chitosan of Papuyu fish scales concentrations of 25%, 50%, 75%, 100%, chlorhexidine gluconate 2% (positive control) and aquadest (negative control) against Staphylococcus aureus bacteria.
THE EFFECT OF KASTURI (Mangifera Casturi) BARK EXTRACTS AT CONCENTRATION OF 12.7% ON THE NUMBER OF MACROPHAGES AFTER TOOTH EXTRACTION Rosdayatri, Nadhira Agnia; Aspriyanto, Didit; Taufiqurrahman, Irham
Dentino: Jurnal Kedokteran Gigi Vol 9, No 1 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i1.18854

Abstract

Background: Tooth extraction is a surgical procedure to take part of the tooth that exposes the bone and soft tissues of the oral cavity. The wound will occur in the soft tissue, and hard tissue around the extraction area after the tooth extraction. Wound healing after tooth extraction begins with the inflammatory phase, in which the movement of leukocytes occurs, such as neutrophil cells. If the wound is chronic, it will be replaced by macrophages. Macrophages are the dominant cells in chronic inflammation and have a role in phagocytizing bacteria and clean damaged tissue. However, if the disturbance occurs during the wound-healing phase, it can cause bleeding, swelling, and infection, so that a safe alternative medicine is required, which is from an herbal plant of Kasturi bark extracts at a concentration of 12.7%. Objective: To prove the effect of the administration of Kasturi (Mangifera casturi) bark extracts at a concentration of 12.7% applied topically to the number of macrophage cells in the tooth extraction wound of Wistar rats (Rattus novergicus). Methods: This study was an Experimental Laboratories research with Post Test with Control Group Design. This study was performed on 24 Wistar rats that had been adapted ±2 weeks with a simple random sampling technique. The calculation of macrophage cells was conducted through direct observation with a light microscope and 3 visual fields. Results: The results of the study showed that Kasturi bark extracts had more effect on the number of macrophage cells than control groups. The results of One Way ANOVA showed that there is a significant relationship between each group (p<0.05). Conclusion: Kasturi bark extracts at a concentration of 12.7% can help the number of macrophage cells increase on the 3rd day and decrease on the 5th day after tooth extraction of Wistar rats. Keywords: Kasturi Bark Extract, Macrophage, Tooth Extraction.
ANTIBACTERIAL EFFECTIVENESS OF RAMBAI (Sonneratia Caseolaris) LEAVES EXTRACT AGAINST STREPTOCOCCUS MUTANS Nor Rahmatika, Aniqah; Aspriyanto, Didit; Ichrom Nahzi, Muhammad Yanuar
Dentino: Jurnal Kedokteran Gigi Vol 9, No 1 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i1.18859

Abstract

Background: The 2018 Riskesdas data stated that dental caries prevalence in Indonesia was 88.8%. Dental caries is a multifactorial disease characterized by hard tissue damage to the enamel, dentin, and cementum of the teeth. One of the causes of caries is the presence of a microorganism called Streptococcus mutans. Rambai leaf extract (Sonneratia caseolaris) is a typical plant of South Kalimantan with content flavonoids, tripernoids, tannins, phenols, steroids that have antibacterial properties against the growth of Streptococcus mutans which can prevent caries. Purpose: To determine the difference in the effectiveness of the antibacterial extract of rambai leaves (Sonneratia caseolaris) against bacteria Streptococcus mutans in vitro. Methods: This research was a true experimental with a post-test-only design and a control group, using six treatment groups, namely 20%, 40%, 60%, 80%, positive control (povidone iodine 1%), and negative control (aquadest) respectively. Each treatment got 3 repetitions. The antibacterial test method used in this study was the liquid dilution method to determine the Minimun Inhibitory Concentration (MIC) by using Spectrophotometer and solid dilution to determine the Minimum Bactericidal Concentration (MBC) by using tools Colony Counter. Results: Based on the results and data analysis, it can be seen that the rambai leaf extract has a MIC of 20% and a MBC of 60%. Conclusion: Rambai leaf extract (Sonneratia caseolaris) can inhibit and have antibacterial activity against the growth of Streptococcus mutans. Keywords: Antibacterial, Rambai leaf extract, Streptococcus mutans
Anti-inflammatory Effects of Channa micropeltes Extract through NF-κB and TNF-α in Diabetic Rat Carabelly, Amy Nindia; Aspriyanto, Didit; Sari, Milka Widya; Norfitriyah, Erika; Utami, Juliyatin Putri
Majalah Obat Tradisional Vol 29, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.87104

Abstract

Diabetes mellitus (DM) is a disorder of carbohydrate, fat, and protein metabolism caused by impaired insulin secretion, insulin action, or both characterized by hyperglycemia. Hyperglycemic condition is associated with inflammation process leading to complications. Food supplements play an important role in controlling protein metabolism and have anti-inflammatory properties such as Channa micropeltes (CM). This study aimed to analyze the effect of CM extract on the levels of molecular markers Nuclear factor kappa beta (NF-κB) and Tumor Necrosis Factor alfa (TNF-α) in normal and diabetic rats. The experimental design of this investigation was a post-test-only control group design and the samples were the diabetic model group given CM extract at 16 mL/kgBB dose, and negative control group for 14 days, respectively. Serum concentrations of    NF-κB and TNF-α were measured by ELISA. DM-CM group showed decreasing levels of NF-κB. TNF- α was detected with the lowest level in the N-CM group. The levels of TNF- α declined close to normal levels in the DM-CM group. Hence, the conclusion was the CM at a dose of 16 mL/kg BW for 14 days in Wistar rats can reduce Nf-κB and TNF-α in groups of normal and diabetic rats.
TOXICITY TEST OF Eusideroxylon zwageri BARK EXTRACT ON LIVER HISTOPATHOLOGY PARENCHYMATOUS DEGENERATION AND FATTY DEGENERATION A'idah, Nurul; Aspriyanto, Didit; Krishnawan Firdaus, I Wayan Arya; Sukmana, Bayu Indra; Wydiamala, Erida
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22203

Abstract

Background: Ironwood bark extract can be developed into an alternative herbal medicine for wound healing because it contains phenolics, flavonoids, and proanthocyanidins which can act as an antioxidant. Before being used as an herbal medicine, it is necessary to ensure its safety through an toxicity test. Purpose: To find out whether there is no toxic effect on the orally administration of ironwood bark extract (Eusideroxylon zwageri) at the doses of 1,250 mg/kgBW, 2,750 mg/kgBW, and 4,750 mg/kgBW to the livers of Wistar rats (Rattus norvegicus) based on histopathological appearance of parenchymatous degeneration and fatty degeneration. Methods: This research is purely experimental with a posttest only with control design. The sample in this study were 16 Wistar rats which were divided into  4 groups, namely the control group which was only  administered distilled water and the treatment groups P1, P2, P3 which were administered ironwood bark extrac at the doses of 1,250 mg/kg BW, 2,750 mg/kg BW, and 4,750 mg/kgBW of 2x1 ml every 24 hours for 14 days. Results: The average percentages of histopathological appearance of parenchymatous degeneration and fatty degeneration in the K, P1, P2, and P3 groups showed a score of 0 which was categorized as normal. Data analysis showed that there were no significant differences between groups P1, P2, and P3 with the control group. Conclusion: Ironwood bark extract doses of 1,250 mg/kg BW, 2,750 mg/kg BW, and 4,750 mg/kg BW had no toxic effect on the liver of Wistar rats based on histopathological appearance of parenchymatous degeneration and fatty degeneration.
TOXICITY TEST OF KELAKAI LEAF EXTRACT (Stenochlaena palustris) TOWARD WISTAR RATS LIVER (Rattus norvegicus) Putra Ramadhani, Krisna Erlangga; Krishnawan Firdaus, I Wayan Arya; Wasiaturrahmah, Yusrinie; Aspriyanto, Didit; Wydiamala, Erida
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22200

Abstract

Background: Kelakai leaf extract can be used as an alternative wound healing medicine because it contains flavonoid and phenolic compounds that act as antioxidants. Before use, herbal plants must ensure the level of safety that can be obtained from toxicity tests, one of which is in vivo which can be seen from their effect on the liver of Wistar rats based on SGOT and SGPT levels. Purpose: Proving there is no toxic effect from the administration of kelakai leaf extract doses of 2,000, 2,500, and 3,000 mg/kgBW on the liver of Wistar rats based on SGOT and SGPT levels. Method: Pure laboratory experimental research with posttest-only design with control group design, consisting of 16 wistar rats divided into 4 groups with 1 negative control group given distilled water and 3 treatment groups given doses of kelakai leaf extract 2,000, 2,500 and 3,000 mg/kgBW twice a day every morning and evening for 28 days. Results: SGOT and SGPT levels after 28 days were still in the normal range. SGOT levels in treatment groups 1, 2, and 3 were 61.244 U/L, 58.953 U/L, and 53.536 U/L. SGPT levels in treatment groups 1, 2 and 3 were 25.137 U/L, 23.331 U/L, and 21.179 U/L. Based on statistical tests, there were significant differences in all treatment groups. Conclusion: There is no toxic effect from the administration of kelakai leaf extract doses of 2,000, 2,500, 3,000 mg/kgBW orally for 28 days on the liver of Wistar rats based on SGOT and SGPT levels.
PHARMACOLOGICAL INVESTIGATION OF THE ORAL WOUND HEALING ACTIVITY OF Stachytarpheta jamaicensis ROOT EXTRACT GEL IN WISTAR RATS Utami, Juliyatin Putri; Wasiaturrahmah, Yusrinie; Carabelly, Amy Nindia; Aspriyanto, Didit; Nahzi, Yanuar Ichrom; Arifin, Rahmad; Ramadhaniyah, Nur; Jatmiko, Habibi Naufal
Jurnal Bioteknologi dan Biosains Indonesia Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The Stachytarpheta jamaicensis (L) Vahl root contains bioactive compounds like saponins, alkaloids, flavonoids, tannins, phenols, and terpenoids, which have antibacterial and anti-inflammatory properties. This study investigates the wound healing effects of Stachytarpheta jamaicensis (L) Vahl root extract gel in oral mucosa. The experiment involved 28 male Wistar rats, divided into four groups: a positive control treated with povidone iodine 10%, a negative control treated with gel base, and two experimental groups treated with 6% and 10% S. jamaicensis root extract gels. The gel was applied twice daily, and wound healing was assessed by epithelial thickness, inflammation cell and hydroxyproline content. Both concentrations of S. jamaicensis root extract gel significantly enhanced wound healing, as shown by increased epithelial thickness, inflammation cell and hydroxyproline content levels compared to the negative control. These findings suggest that S. jamaicensis root extract gel effectively promotes wound healing in the excision wound model.
Co-Authors A'idah, Nurul Adhimas Rilo Pambudi Ahda Ahda Annisa Aini, Lisa Shofa’ Nur Aliffia Azizah Kawiadji Alya Royyana Amy Nindia Carabelly Arifin, Rahmad At-Thoyyar, Aila Audina, Nina Aulia Azizah Azaria, Nisa Bayu Indra Sukmana Bayu Yordha Senggara Beta Widya Oktiani Brachmedio Barito Syech Erlangga Debby Saputera, Debby Desty Ayu Dwiyanti Dewi Nurdiana Dewi Puspitasari Dewi Puspitasari Dian Dwiyanti Dita Puspita Sari Diza Afira Hutasuhut Dwi Kurniawan, Fajar Kusuma Dwiyanti, Dian Eny Febriyanti Erika Norfitriyah Firda Damayanti Fitri Siregar, Eka Dwita Natasya Helda Helda Hendrik Setia Budi I Wayan Arya Krishnawan Firdaus Ichrom Nahzi, Muhammad Yanuar Ihsan, Muhammad Fauzan Ika Kusuma Wardani Intan Nirwana, Intan Jatmiko, Habibi Naufal Khairunnisa Puspita Sari Krishnawan Firdaus, I Wayan Arya Maulana, Noval Ihza Maydina Izzatul Yazidah Milka Widya Sari Muhammad Hasanu Reksi Muhammad Yunanda Anhar Nadia Chairina Nahzi, Yanuar Ichrom Naila Khairiyah Nina Audina Nor Rahmatika, Aniqah Norfitriyah, Erika Novi Tiara Lestari Nurlailatul Rahmah Nurrahman, Tri Nurul Fathanah Putri Oktiani, Beta Widya Prilly Sonya Puteri Priyawan Rachmadi Putra Ramadhani, Krisna Erlangga Ramadhaniyah, Nur Ramadhanty, Aina Renie Kumala Dewi Rini Rahmiyati Rosdayatri, Nadhira Agnia Rosihan Adhani, Rosihan Rudie Syahrizal Akhmad Sari, Milka Widya Sarifah, Norlaila Senggara, Bayu Yordha Setyawardhana, R. Harry Dharmawan Setyawardhana, Raden Harry Dharmawan Sherli Diana Syifa Ennisa Tri Putri, Deby Kania US Ramadilla Ramadilla Utami, Juliyatin Putri Wydiamala, Erida Yusrinie Wasiaturrahmah