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ANTIBACTERIAL ACTIVITY OF RAMBAI LEAF EXTRACT (Sonneratia caseolaris) CONCENTRATION 25% 50% 75% AND 100% AGAINST BACTERIA Enterococcus faecalis US Ramadilla Ramadilla; Didit Aspriyanto; Sherli Diana
Dentino : Jurnal Kedokteran Gigi Vol 8, No 1 (2023)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v8i1.16076

ABSTRACTBackground: The causative factor of failure in the treatment of the root canal is the presence of microorganisms, namely the bacterium Enterococcus faecalis. Rambai leaf extract (Sonneratia caseolaris) also contains secondary metabolite compounds, namely, triterpenoids, phenols, tannins, steroids, and flavonoids that are able to inhibit the growth of Enterococcus faecalis bacteria which have the potential to cause failure in root canal treatment. Purpose: This research has a purpose to see the antibacterial activity of Rambai leaf extract (Sonneratia caseolaris) concentrations of 25%, 50%, 75%, and 100% against Enterococcus faecalis bacteria. Method: This study is a true experimental study designed by Posttest Only with Control Group Design using six. Material and methods: Rambai leaf extract concentrations of 25%, 50%, 75%, 100%, positive control of chlorhexidine gluconate 2%, and negative control of aqua dest was repeated 4 times. Antibacterial activity can be seen from the magnitude of the inhibitory zone formed in (MHA) Mueller Hinton Agar and BHIB (Brain Heart Infusion) using the diffusion method. Results: Based on Mann Whitney's final test, there was a significant difference in the clear zones formed around the paper disk. The average clear zone of Rambai leaf extract (Sonneratia caseolaris) concentration is 25% at 10.0mm, 50% at 12.7mm, 75% at 17.0mm, and 100% at 18.3mm. Conclusion: There is activity of Rambai leaf extract (Sonneratia caseolaris) concentrations of 25%, 50%, 75%, and 100% against Enterococcus faecalis bacteria. Keywords: Antibacterial Activity, Enterococcus faecalis, Rambai Leaf Extract

Differences in Panoramic Mandibular Index value between male and female hypertension patients using panoramic radiography Novi Tiara Lestari; Norlaila Sarifah; Didit Aspriyanto; Bayu Indra Sukmana; Isyana Erlita
Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Vol 7 No 2 (2023): Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI)
Publisher : Ikatan Radiologi Kedokteran Gigi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jrdi.v7i2.1065

Objectives: This study is aimed to analyze the panoramic mandibular index value in male and female hypertensive patients using panoramic radiography. Materials and Methods: This research is a comparative analytic research with a purposive sampling technique. The study sample was hypertensive patients at Ulin Hospital, Banjarmasin from March to May 2023. Results: The results showed that there was no statistically significant difference through statistical data on the panoramic mandibular index value between men (0.27 Â± 0.07) and women (0.26 Â± 0.09), The age group that experienced a decrease in mandibular cortical thickness was most in the age group â‰¥ 65 years (0.22 Â± 0.06). Conclusion: It is known that there is no significant difference in the panoramic mandibular index value between women and men.

ANTIBACTERIAL ACTIVITY OF RAMBAI LEAF EXTRACT (Sonneratia caseolaris) CONCENTRATION 25%, 50%, 75%, AND 100% AGAINST Streptococcus sanguinis Nurul Fathanah Putri; Didit Aspriyanto; Isyana Erlita
Dentino : Jurnal Kedokteran Gigi Vol 8, No 2 (2023)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v8i2.17520

Background: Dental plaque is a soft layer formed by collection of bacteria that is firmly attached to the tooth surface which if left unchecked can cause tooth decay, periodontal disease and dental caries. Streptococcus sanguinis is the first bacteria to form colonization in plaque formation. Plaque can be diminished by using chlorhexidine gluconate 0,2% mouthwash, but in long-term use it can cause side effects, so an alternative herbal-based mouthwash that has minimal side effects is needed. Rambai leaf extract can be used as an alternative mouthwash because it contains antibacterial compounds, namely, flavonoids, tannins, phenols, triterpenoids, and steroids. Purpose: The purpose of this study was to determine the antibacterial activity of rambai leaf extract at concentrations of 25%, 50%, 75% and 100% against Streptococcus sanguinis bacteria. Methods: This study used true experimental research with post-test only with a control group design using rambai leaf extract 25%, 50%, 75%, 100%, chlorhexidine gluconate 0.2%, and aquadest. The study used 6 groups with 4 repetitions with a total of 24 samples. Each group was incubated for 24 hours at 37°C, then the diameter of the inhibition zone was measured using a calliper. Results: The results of the Mann Whitney test showed that there was a significant difference between each treatment group and there was no significant difference between 100% rambai leaf extract and chlorhexidine gluconate 0.2%. The average diameter of the inhibition zone of rambai leaf extract was 25% by 9.75 mm, 50% by 13.37 mm, 75% by 16.12 mm, 100% by 19.5 mm, chlorhexidine gluconate 0.2% by 19.12 mm and aquadest 0 mm. Conclusion: Rambai leaf extract with concentrations of 25%, 50%, 75%, and 100% had antibacterial activity against Streptococcus sanguinis. Keywords : Antibacterial Activities, chlorhexidine gluconate 0,2%, rambai leaves extracts, Streptococcus sanguinis

UJI TOKSISITAS EKSTRAK DAUN GALAM (Melaleuca cajuputi subsp. Cumingiana Barlow) PADA BHK-21 SEL FIBROBLAS Brachmedio Barito Syech Erlangga; Sherli Diana; Debby Saputera; Didit Aspriyanto; Beta Widya Oktiani
Dentin Vol 7, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v7i3.10743

Latar Belakang: Karies gigi merupakan penyakit rongga mulut yang salah satu faktor penyebabnya adalah bakteri. Salah satu bahan alam yang berpotensi sebagai antibiotik dan hidup di lingkungan lahan basah adalah tanaman galam (Melaleuca cajuputi subsp. Cumingiana Barlow). Fungsi uji toksisitas adalah untuk mengetahui efek toksik dan batas dosis aman suatu senyawa kimia dalam penelitian ini pengujian ekstrak daun galam. Tujuan: Menganalisis efek toksik setelah pemberian ekstrak daun galam (Melaleuca cajuputi subsp. Cumingiana Barlow) terhadap sel fibroblas BHK-21. Metode: Penelitian ini adalah penelitian eksperimental murni (true experimental) dengan rancangan posttest-only with control group design untuk menganalisis toksisitas ekstrak daun galam terhadap sel fibroblas Baby Hamster Kidney-21 (BHK-21) dengan metode Microculture Tetrazolium Technique (MTT) assay secara in vitro. Hasil: Hasil penelitian menunjukkan bahwa ekstrak daun galam tidak toksik karena viabilitas sel pada semua konsentrasi >100% dan nilai IC50 yang tidak mungkin tercapai. Hasil uji post hoc Games-Howell menyimpulkan bahwa konsentrasi 50%, 75%, dan 100% lebih efektif daripada konsentrasi 0,125%, 0,2%, 0,25%, dan 0,4%. Kesimpulan: Tidak ada efek toksik ekstrak daun galam dengan uji MTT terhadap sel fibroblas BHK-21.Kata kunci: ekstrak daun galam, sel fibroblas BHK-21, toksisitas

PENGARUH EKSTRAK DAUN KARAMUNTING (Rhodomytrus tomentosa) TERHADAP KADAR TROMBOSIT SETELAH PAPARAN SINAR-X RADIOGRAFI PERIAPIKAL Ahda Ahda Annisa; Didit Aspriyanto; Nurdiana Dewi; I Wayan Arya Krishnawan Firdaus; Debby Saputera
Dentin Vol 7, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v7i3.10748

Latar Belakang : Paparan radiasi sinar-X radiografi periapikal dapat merusak sel darah salah satunya yaitu trombosit dengan cara membentuk radikal bebas sehingga dapat terjadinya penurunan pada sel darah. Kandungan oleh ekstrak daun karamunting dapat menangkal radikal bebas dan meningkatkan sel darah dari paparan radiasi sinar-X radiografi periapikal. Senyawa metabolit sekunder pada daun karamunting memiliki tiga kandungan senyawa tertinggi yaitu flavonoid, phenol dan tanin. Tujuan: Menganalisis pengaruh ekstrak daun karamunting terhadap kadar trombosit mencit jantan setelah paparan sinar-X radiografi periapikal. Metode : Penelitian ini menggunakan metode true experimental dengan rancangan post test only with control group design menggunakan 30 ekor mencit dibagi menjadi 5 kelompok. Kelompok K- adalah diberikan ekstrak daun karamunting tetapi tidak diberikan paparan radiasi sinar-X, kelompok K+ adalah diberikan radiasi sinar-X radiografi periapikal tanpa diberikan ekstrak daun karamunting, kelompok P1 adalah diberikan ekstrak daun karamunting dan paparan radiasi sinar-X radiografi periapikal pengulangan 1 kali, kelompok P2 adalah diberikan ekstrak daun karamunting dan paparan radiasi sinar-X radiografi periapikal pengulangan 7 kali dan kelompok P3 adalah diberikan ekstrak daun karamunting dan paparan radiasi sinar-X radiografi periapikal pengulangan 10 kali. Hasil : Hasil uji Post Hoc Bonferoni menunjukan perbedaan bermakna antar kelompok kontrol dan kelompok perlakuan. Kesimpulan : Terdapat pengaruh kadar trombosit pada mencit jantan (Mus musculus) pemberian ekstrak daun karamunting setelah paparan sinar-X radiografi periapikal. Kata kunci : Ekstrak daun karamunting, Radiografi periapikal, trombosit

PERBANDINGAN PENGETAHUAN KESEHATAN GIGI DAN MULUT ANTARA PENGGUNAAN APLIKASI HI BOGI DAN SIMANGGIS CELEBES Muhammad Yunanda Anhar; R. Harry Dharmawan Setyawardhana; Nurdiana Dewi; Aulia Azizah; Didit Aspriyanto
Dentin Vol 7, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v7i3.10741

Latar Belakang: Pentingnya menjaga kebersihan gigi dan mulut dapat ditingkatkan dengan menambah pengetahuan dalam menjaga kesehatan gigi dan mulut. Salah satu cara meningkatkan pengetahuan kesehatan gigi dan mulut yaitu dengan mengakses aplikasi HI BOGI dan SIMANGGIS CELEBES sebagai aplikasi digital yang memberikan informasi mengenai pentingnya menjaga kesehatan gigi dan mulut. Tujuan : Menganalisis perbandingan penggunaan aplikasi HI BOGI dan SIMANGGIS CELEBES terhadap pengetahuan Kesehatan gigi dan mulut pada siswa kelas III SDN Kuripan 2 Banjarmasin. Metode : Penelitian ini menggunakan metode Quasi Experimental dengan rancanga pretest dan posttest design, teknik pengambilan sampel Total sampling. Penelitian dilaksanakan di SDN Kuripan 2 Banjarmasin dengan sampel berjumlah 58 siswa. Hasil : Hasil uji wilcoxon pengetahuan pada kelompok HI BOGI didapatkan 0,000 <0,05. Hasil uji wilcoxon pengetahuan pada kelompok SIMANGGIS CELEBES didapatkan 0,000 <0,05. Hasil uji Mann Whitney pada aplikasi HI BOGI dan SIMANGGIS CELEBES didapat 0,033 <0,05. Kesimpulan : terdapat perbedaan peningkatan pengetahuan kesehatan gigi dan mulut antara aplikasi HI BOGI dan SIMANGGIS CELEBES pada siswa kelas III SDN Kuripan 2 Banjarmasin usia 8-9 Tahun. Kesimpulan: Terdapat perbedaan peningkatan pengetahuan kesehatan gigi dan mulut antara aplikasi HI BOGI dan SIMANGGIS CELEBES. Kata kunci : Aplikasi HI BOGI, Aplikasi SIMANGGIS CELEBES, Kesehatan Gigi dan Mulut, Teledentistry

Anti-inflammatory Effects of Channa micropeltes Extract through NF-κB and TNF-α in Diabetic Rat Carabelly, Amy Nindia; Aspriyanto, Didit; Sari, Milka Widya; Norfitriyah, Erika; Utami, Juliyatin Putri
Majalah Obat Tradisional Vol 29, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.87104

Diabetes mellitus (DM) is a disorder of carbohydrate, fat, and protein metabolism caused by impaired insulin secretion, insulin action, or both characterized by hyperglycemia. Hyperglycemic condition is associated with inflammation process leading to complications. Food supplements play an important role in controlling protein metabolism and have anti-inflammatory properties such as Channa micropeltes (CM). This study aimed to analyze the effect of CM extract on the levels of molecular markers Nuclear factor kappa beta (NF-κB) and Tumor Necrosis Factor alfa (TNF-α) in normal and diabetic rats. The experimental design of this investigation was a post-test-only control group design and the samples were the diabetic model group given CM extract at 16 mL/kgBB dose, and negative control group for 14 days, respectively. Serum concentrations of NF-κB and TNF-α were measured by ELISA. DM-CM group showed decreasing levels of NF-κB. TNF- α was detected with the lowest level in the N-CM group. The levels of TNF- α declined close to normal levels in the DM-CM group. Hence, the conclusion was the CM at a dose of 16 mL/kg BW for 14 days in Wistar rats can reduce Nf-κB and TNF-α in groups of normal and diabetic rats.

PHARMACOLOGICAL INVESTIGATION OF THE ORAL WOUND HEALING ACTIVITY OF Stachytarpheta jamaicensis ROOT EXTRACT GEL IN WISTAR RATS Utami, Juliyatin Putri; Wasiaturrahmah, Yusrinie; Carabelly, Amy Nindia; Aspriyanto, Didit; Nahzi, Yanuar Ichrom; Arifin, Rahmad; Ramadhaniyah, Nur; Jatmiko, Habibi Naufal
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.9390

The Stachytarpheta jamaicensis (L) Vahl root contains bioactive compounds like saponins, alkaloids, flavonoids, tannins, phenols, and terpenoids, which have antibacterial and anti-inflammatory properties. This study investigates the wound healing effects of Stachytarpheta jamaicensis (L) Vahl root extract gel in oral mucosa. The experiment involved 28 male Wistar rats, divided into four groups: a positive control treated with povidone iodine 10%, a negative control treated with gel base, and two experimental groups treated with 6% and 10% S. jamaicensis root extract gels. The gel was applied twice daily, and wound healing was assessed by epithelial thickness, inflammation cell and hydroxyproline content. Both concentrations of S. jamaicensis root extract gel significantly enhanced wound healing, as shown by increased epithelial thickness, inflammation cell and hydroxyproline content levels compared to the negative control. These findings suggest that S. jamaicensis root extract gel effectively promotes wound healing in the excision wound model.

PHARMACOLOGICAL INVESTIGATION OF THE ORAL WOUND HEALING ACTIVITY OF Stachytarpheta jamaicensis ROOT EXTRACT GEL IN WISTAR RATS Utami, Juliyatin Putri; Wasiaturrahmah, Yusrinie; Carabelly, Amy Nindia; Aspriyanto, Didit; Nahzi, Yanuar Ichrom; Arifin, Rahmad; Ramadhaniyah, Nur; Jatmiko, Habibi Naufal
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.9390

The Stachytarpheta jamaicensis (L) Vahl root contains bioactive compounds like saponins, alkaloids, flavonoids, tannins, phenols, and terpenoids, which have antibacterial and anti-inflammatory properties. This study investigates the wound healing effects of Stachytarpheta jamaicensis (L) Vahl root extract gel in oral mucosa. The experiment involved 28 male Wistar rats, divided into four groups: a positive control treated with povidone iodine 10%, a negative control treated with gel base, and two experimental groups treated with 6% and 10% S. jamaicensis root extract gels. The gel was applied twice daily, and wound healing was assessed by epithelial thickness, inflammation cell and hydroxyproline content. Both concentrations of S. jamaicensis root extract gel significantly enhanced wound healing, as shown by increased epithelial thickness, inflammation cell and hydroxyproline content levels compared to the negative control. These findings suggest that S. jamaicensis root extract gel effectively promotes wound healing in the excision wound model.

MEASUREMENT VALUE OF BANJAR ETHNIC MANDIBULAR INCISOR POSITION USING LATERAL CEPHALOMETRIC RADIOGRAPH Nor Helma Warni; Didit Aspriyanto; Agung Satria Wardhana; Isyana Erlita; Ika Kusuma Wardani
Dentin Vol 9, No 2 (2025)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v9i2.17744

ABSTRACTBackground: Appearance is one of the most important things for everyone in this modern era. Malocclusion, also known as tooth-jaw disharmony, can lead to a decline in a person's appearance. The position and inclination of the anterior teeth must be favorable to ensure maximum facial harmony. One common effort to achieve maximum facial harmony is orthodontic treatment. To support this treatment, x-rays are needed, one of which is the cephalometric technique with Steiner analysis. Purpose: This study aims to determine the measurement value of the mandibular incisor position of Banjarese students of SMAN 12 Banjarmasin from the lateral cephalometric radiograph using Steiner analysis. Method: Cephalometric measurements were carried out using the Steiner analysis method on the dental landmarks; L1-NB. Data analysis was carried out using descriptive statistical methods. The sample in this study was secondary data from previous research and took pure Banjarese students of SMAN 12 Banjarmasin, characterized by at least two generations (father, mother, grandfather, and grandmother) who had never or were not undergoing orthodontic treatment and were willing to be subjects in the study. Results: The average value of L1-NB distance measurement was 7.18±2.31 mm and the L1-NB inclination measurement was 30.22˚±6.16˚. Conclusion: The average value of mandibular incisor position in students of SMAN 12 Banjarmasin was classified as protrusion, and the average inclination was also included in the proclination group.Keywords: banjar ethnic, cephalometry, lateral cephalometry, steiner analysis ABSTRAK Latar belakang: Penampilan menjadi salah satu hal terpenting bagi setiap orang di era modern ini. Ketidakharmonisan relasi gigi dan rahang atau yang dikenal dengan maloklusi akan menyebabkan penurunan penampilan seseorang.Posisi dan kemiringan gigi anterior ini harus menguntungkan untuk memastikan keharmonisan wajah yang maksimal. Usaha yang biasa dilakukan untuk mendapatkan keharmonisan wajah yang maksimal salah satunya melakukan perawatan ortodonti.Untuk mendukung perawatan tersebut, perlu dilakukan rontgen salah satunya teknik sefalometri dengan analisis Steiner.Tujuan: Penelitian ini bertujuan untuk mengetahui nilai pengukuran posisi insisif mandibula siswa SMAN 12 Banjarmasin yang berasal dari etnis Banjar ditinjau dari radiografi sefalometri lateral dengan menggunakan analisis Steiner. Metode: Pengukuran sefalometri dilakukan dengan menggunakan metode analisis Steiner pada landmark gigi; L1-NB. Analisis data dilakukan dengan metode statistik deskriptif. Sampel dalam penelitian ini merupakan data sekunder penelitian terdahulu dan mengambil siswa SMAN 12 Banjarmasin suku Banjar murni yang ditandai dengan minimal dua generasi (ayah, ibu, kakek, dan nenek) yang tidak pernah atau tidak sedang melakukan perawatan orthodonti dan telah bersedia menjadi subjek dalam penelitian. Hasil: Nilai rata-rata pengukuran jarak L1-NB sebesar 7.18±2.31 mm dan nilai pengukuran inklinasi L1-NB sebesar 30.22˚±6.16˚. Kesimpulan: Nilai rata-rata posisi insisif mandibula pada siswa SMAN 12 Banjarmasin tergolong protrusi, dan rata-rata inklinasi nya juga termasuk dalam golongan proklinasi. Kata kunci: analisis steiner, sefalometri, sefalometri lateral, suku banjar.

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