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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Biology, Medicine, & Natural Product Chemistry JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks JURNAL EKSAKTA PENDIDIKAN (JEP) Jurnal Teladan: Jurnal Ilmu Pendidikan dan Pembelajaran Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Majalah Farmasetika Cendekia Journal of Pharmacy Jurnal Pengabdian Harapan Ibu (JPHI) BioEksakta : Jurnal Ilmiah Biologi Unsoed Khazanah Intelektual Jurnal Ipteks Terapan : research of applied science and education Jurnal Abdi Panca Marga Jurnal Katalisator Riset Informasi Kesehatan Jurnal Pengabdian Harapan Ibu (JPHI) Journal of Pharmaceutical and Sciences. Journal of The Indonesian Society of Integrated Chemistry Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian
Barmi Hartesi
Universitas Jenderal Achmad Yani, Cimahi
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Isolasi dan Karakterisasi Bakteri Penghasil Enzim β-CGTase dari Tanah Perkebunan Ubi Jalar Kurniadi, Helman; Sagita, Desi; Hartesi, Barmi; Andriani, Lili; Dahlia, Dimbi
BioEksakta : Jurnal Ilmiah Biologi Unsoed Vol 6 No 3 (2024): BioEksakta
Publisher : Fakultas Biologi Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.bioe.2024.6.3.11779

Abstract

β-CGTase (β-cyclodextrin glycosyl transferase) is an enzyme that converts starch into CD (cyclodextrin). The CD is a high-value oligosaccharide used for modifying food, textiles, chemicals, medicines, cosmetics, and biotechnology. This research aims to obtain isolates of β-CGTase producing bacteria from sweet potato plantation soil. Screening is carried out using Horikoshi media which contains the color indicators phenolphthalein and methyl orange. Bacteria producing β-CGTase will give a yellow hollow zone if they grow on this media. CGTase activity was measured using a UV-Vis spectrophotometer. Three isolates producing CGTase were obtained, coded BSP6A, BSP6B, and BSP6C, which had the characteristics of being Gram-positive, shaped like bacilli, produced spores, were motile, had a positive catalase test, and could ferment acid. These three isolates were able to produce the optimum CGTase enzyme if incubated for 18 and 24 hours at a temperature of 37°C and pH 10 and were able to convert starch into CD if incubated for 30 minutes at a temperature of 37°C and pH 7.
Isolation of b-Cyclodextrin Gycosyl Transferase (b-CGTase) Producing Bacteria from Potato Plantation Soil Kurniadi, Helman; Sagita, Desi; Hartesi, Barmi
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.193-197

Abstract

Cyclodextrin glycosyltransferase (CGTase) is an extracellular enzyme produced by several microorganisms, particularly bacteria, that converts starch into cyclodextrin (CD). CD has various applications in fields such as food, textiles, pharmaceuticals, chemistry, and biotechnology. The objective of this study was to isolate b-CGTase-producing bacteria from soil in a potato plantation located in Kerinci, and to conduct their characterization. Screening was conducted using Horikoshi agar media with phenolphthalein and methyl orange color indicators. The results indicated that one isolate, coded CK-2, produced the optimum b-CGTase enzyme when incubated for 30 hours at 37 ºC and pH 10. The CGTase enzyme converted starch to CD when incubated for 60 minutes at 37 ºC and pH 7. The CK-2 isolate was identified as monobacilli Gram-positive bacteria, having spores, positive in the catalase test, and motile. The study concluded that the bacteria producing b-CGTase enzyme are found in the soil of potato plantations in Kerinci, which is believed to originate from the genus Bacillus sp.
Quantitative Analysis of Mineral in Seawater Concentrate from Pamekasan, Madura Using XRF and ICP-OES Methods Hartesi, Barmi; Wardhana, Yoga Windu; Muhaimin, Muhaimin; Sriwidodo, Sriwidodo; Khairinisa, Miski Aghnia; Dewi, Mayang Kusuma; Chaerunisaa, Anis Yohana
Journal of The Indonesian Society of Integrated Chemistry Vol. 16 No. 1 (2024): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v16i1.34656

Abstract

Seawater concentrate from Pamekasan is a product with high mineral content. The mineral content analysis of Pamekasan seawater concentrate was conducted using a comparative test of results from X-Ray Fluorescence Spectrometry (XRF) and Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES). This mineral content testing used a skin moisture device. The essential minerals found in Pamekasan seawater concentrate through analysis are Mg, Cl, K, Ca, Cr, Mn, Cu, and Zn. Statistical analysis results from XRF and ICP-OES on market products showed no significant difference in average results; however, there was a significant difference in average results in the samples. The most recommended method for analyzing seawater mineral concentrate from Pamekasan is ICP-OES due to its wider detection range and lower matrix interference.
KONSENTRASI HAMBAT MINUMUM ENZIM BROMELIN DARI KULIT DAN BONGGOL NANAS (Ananas comosus (L.) Merr) TERHADAP Staphylococcus aureus Sagita, Desi; Hartesi, Barmi; Fitri, Kurnia; Lufita, Lufita
Kartika : Jurnal Ilmiah Farmasi Vol 8 No 2 (2023)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v8i2.278

Abstract

Enzim bromelin adalah enzim proteolitik yang memiliki kemampuan menghidrolisis protein sehingga bisa berperan sebagai antibakteri. Enzim bromelin dapat diisolasi dari kulit, buah, bonggol Nanas (Ananas comosus (L.) Merr ). Tujuan penelitian ini adalah untuk mendapatkan konsentrasi enzim bromelin dari kulit dan bonggol buah Nanas dalam menghambat pertumbuhan Staphylococcus aureus. Bromelin diisolasi dengan cara ekstraksi dengan buffer pospat, dipurifikasi dengan ammonium sulfat 60%. Uji aktivitas antibakteri enzim bromelin dari kulit dan bonggol Nanas terhadap bakteri Staphylococcus aureus dilakukan secara invitro menggunakan difusi cakram dengan mengukur zona hambat.  Konsentrasi enzim bromelin yang digunakan adalah 1 %, 2%, 3% dan 4% dengan antibiotik kloramfenikol sebagai kontrol positif. Enzim bromelin dari kulit dan bonggol Nanas pada konsentrasi 4% menghambat pertumbuhan Staphylococcus aureus dengan zona hambat masing masing 19,23 mm dan 18,30 mm. Konsentrasi hambat minimum enzim bromelin dari kulit dan bonggol Nanas adalah 1% dengan zona hambat masing-masing 11,45 mm dan 12,24 mm. Enzim bromelin dari kulit dan bonggol Nanas memberikan aktivitas yang sama dalam menghambat pertumbuhan bakteri Staphylococcus aureus. Kata kunci : Bromelin; Kosentrasi Hambat Minumum; Presipitasi Amonium Sulfat.   ABSTRACT The Bromelains are proteolytic enzymes that have the ability to hydrolyze proteins so they can act as antibacterial. Bromelain enzymes can be isolated from the peel, fruit, and stem of pineapple (Ananas comosus (L.) Merr). The purpose of this study was to obtain the concentration of bromelain enzymes from the peel and stem of Pineapple in inhibiting the growth of Staphylococcus aureus. Bromelain was isolated by extraction with phosphate buffer, purified with 60% of ammonium sulfate. Antibacterial activity tests of bromelain enzymes from the peel and stem of pineapple against Staphylococcus aureus were carried out in vitro using disc diffusion by measuring clear zones. The bromelain enzyme concentration used was 1%, 2%, 3% and 4% with chloramphenicol antibiotics as a positive control. The results showed that bromelain enzymes from peel and stem of pineapple at 4% concentration inhibited the growth of Staphylococcus aureus with inhibition zones of 19.23 mm and 18.30 mm respectively. The minimum inhibitory concentration of bromelain enzymes from peel and stem of pineapple was 1% with inhibition zones of 11.45 mm and 12.24 mm respectively. Bromelain enzymes from the peel and stem of pineapple provide the same activity in inhibiting the growth of Staphylococcus aureus bacteria. Keywords : Bromelain; minimum inhibition concentration; ammonium sulfate precipitation
Formulasi Gel dari Fraksi Etil Asetat Batang Jarak Cina (Jatropha multifida L.) Efektivitas Terhadap Luka Bakar Giovana Zola, Elpa; Hartesi, Barmi; Anggresani, Lia
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.966

Abstract

Background: Burns represent a condition of damaged or lost skin tissue due to high-temperature exposure. Oral therapy has limitations in penetrating hardened skin tissue, necessitating topical preparations such as gels that offer advantages in comfort, absorption capability, and ease of application. The stem of physic nut (Jatropha multifida L.) contains bioactive compounds including alkaloids, flavonoids, saponins, and tannins that may accelerate burn wound healing, particularly in its ethyl acetate fraction. Objective: This study aimed to formulate the ethyl acetate fraction of physic nut stem into a gel preparation and evaluate the effect of concentration variations on burn wound healing efficacy. Methods: Physic nut stems were extracted with 96% ethanol, then fractionated using n-hexane, ethyl acetate, and ethanol solvents. The ethyl acetate fraction was formulated into a hydrophilic gel at concentrations of 0.140%, 0.281%, and 0.421%. The gel preparations were evaluated through organoleptic tests, homogeneity, pH, spreadability, stability, irritation, and burn healing efficacy tests in rabbits. Results: Phytochemical screening revealed that the ethyl acetate fraction contained alkaloids, flavonoids, saponins, and tannins. All gel formulations met physical preparation requirements with skin-compatible pH (5.95-6.37). Formula F1 (0.140%) demonstrated optimal burn healing efficacy, equivalent to positive control (p > 0.05), and was topically safe (non-irritating). Conclusion: The ethyl acetate fraction of physic nut stem was successfully formulated into a stable and effective gel preparation for burn wound healing, with 0.140% as the optimal concentration. Further studies are required to examine toxicity and the mechanism of action of active compounds.
AKTIVITAS KOAGULAN DARI DAUN SEMBUNG RAMBAT (Mikania micrantha Kunth) SECARA IN VITRO Andriani, Lili; Perawati, Santi; Putri, Nadia; Hartesi, Barmi
Media Farmasi: Jurnal Ilmu Farmasi Vol. 17 No. 1: Maret 2020
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v17i1.16004

Abstract

Tumbuhan sembung rambat (Mikania micrantha Kunth) pada Suku Anak Dalam (SAD) Jambi digunakan untuk mengobati luka dan infeksi kulit yang bisa mengakibatkan perdarahan. Untuk menghindari perdarahan dibutuhkan senyawa yang kerjanya sebagai koagulan. Oleh karena itu pencarian senyawa koagulan penting dilakukan, salah satunya yang ada pada daun sembung rambat. Tujuan penelitian ini adalah untuk mengetahui aktivitas ekstrak dan fraksi daun sembung rambat sebagai koagulan secara in vitro. Metode penelitian yang digunakan yaitu ekstraksi daun sembung rambat menggunakan metode maserasi dengan pelarut etanol 70%, ekstrak etanol difraksinasi menggunakan metode ekstraksi cair-cair dengan pelarut n-heksan, etil asetat dan butanol. Aktivitas koagulan dilihat dengan cara melihat waktu pembekuan darah pada semua golongan darah (A, B, O dan AB) menggunakan metode Lee White dengan tiga konsentrasi ekstrak (10%, 20% dan 30%). Ekstrak daun sembung rambat pada semua konsentrasi menunjukkan aktivitas koagulan, dan fraksi etil asetat menunjukkan aktivitas koagulan yang lebih cepat untuk golongan darah O. Ekstrak dan fraksi daun sembung rambat memiliki aktivitas sebagai koagulan secara in vitro.
ANALISIS ASAM RETINOAT PADA KRIM PEMUTIH MALAM YANG BEREDAR DI KLINIK KECANTIKAN KOTA JAMBI PADA KECAMATAN JELUTUNG Hadriyati, Armini; Hartesi, Barmi; Fitri, Siska
Media Farmasi: Jurnal Ilmu Farmasi Vol. 17 No. 1: Maret 2020
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v17i1.16127

Abstract

Salah satu bahan pemutih berbahaya yang ditakutkan terdapat dalam krim adalah asam retinoat karena asam retinoat dapat menyebabkan kulit kering, rasa terbakar, teratogenik (cacat pada janin), dan menyebabkan kanker kulit. Tujuan penelitian ini untuk mengetahui apakah krim pemutih yang beredar di kecamatan Jelutung  kota Jambi mengandung asam retinoat serta untuk mengetahui berapa kadar asam retinoat yang terkandung dalam krim pemutih wajah tersebut. Metode yang digunakan untuk analisis asam retinoat pada krim pemutih menggunakan kromotografi cair kinerja tinggi fase terbalik. Hasil uji validasi menunjukkan nilai RSD 0,4887 %, parameter linearitas  r=0,9982, LOD 0,0468 ppm, LOQ 1,565 ppm. Hasil analisa kuantitatif kandungan asam retinoat pada krim 1 (0,032%), krim 2 (0,015%), krim 3 (0,014%) krim 4 (0,016%) dan krim 5 (0,011%). Berdasarkan persyaratan dari BPOM krim pemutih tidah boleh mengandung asam retinoat. Berdasarkan hasil penelitian dapat disimpulkan bahwa  krim pemutih wajah yang beredar di  kecamatan Jelutung kota Jambi mengandung asam retinoat.
REMINDER POLA HIDUP SEHAT SEBAGAI UPAYA PEMBERANTASAN MATA RANTAI SCABIES DI PESANTREN SA'ADATUDDAREN PROVINSI JAMBI Haflin, Haflin; Agusriani, Agusriani; Hartesi, Barmi
Abdi Panca Marga Vol 5 No 1 (2024): Jurnal Abdi Panca Marga Edisi Mei 2024
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LPPM) Universitas Panca Marga Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51747/abdipancamarga.v5i1.1735

Abstract

Sa'adatuddaren Islamic Boarding School is one of the oldest Islamic boarding schools in Jambi City, located on the banks of the Batanghari River. One of the facilities provided by Islamic boarding schools is dormitories. Based on the survey conducted, problems were found, especially in female student dormitories. The dormitories are not kept clean, rubbish is strewn about, and female students use the Batanghari river water directly for bathing, defecating and washing. This condition causes health problems such as scabies, diarrhea, and others. Scabies is a major health problem at the Sa'adatuddaren Islamic Boarding School, Jambi Province. This is disturbing for students and dormitory supervisors, because it is difficult to apply PHBS to teenage students, at this age someone tends to be unstable and cannot control clean and healthy living habits, several supporting factors such as the condition of the Islamic boarding school, the students' busy routine and being far from their parents. Adolescence is the right age to form good habits, therefore MTs students are targets for socialization. Reminders are a solution for teenagers to create a scabies-free Islamic boarding school environment. The method involves conducting outreach, collecting data on students affected by scabies, treating infected students and implementing PHBS using Reminder stickers. The results of the outreach were an increase in knowledge, understanding and perspective of students at the Sa'adatuddaren Islamic boarding school in Jambi Province regarding scurvy and a healthy environmental cleanliness.
Co-Authors Agusriani, Agusriani Amelia Soyata Amelia Soyata Andini Ayodhia Fitri Anggi Rahmadani Anggresani, Lia ani astuti, ani Anis Yohana Chaerunisaa, Anis Yohana Ara Ofiana Ardia Risuana Ardilla Novianti Armini Hadriyati armini hadriyati, armini Astridawati, Indah Bunga Debi Lestari Cindy Dwi Saputri Cindy Dwi Saputri Dahlia, Dimbi Desi Sagita Dewi, Rasmala Diah Merdekawati, Diah Dian Oktavia Dyan Putri Oktaviani Fhatia Medina Fitri, Kurnia Fitri, Siska Fitria Fitria Fitriya, Nina Giovana Zola, Elpa Haflin Haflin Haflin Haflin Haflin Haflin, Haflin Helsa Raudatul Qalbi Hesty Murtiah Ikhwansyah Ikhwansyah Indah Astridawati Indah Permata Sari Indah Permata Sari Indri Meirista Irna Dila Jelly Permatasari Jessyca Jovanica Jovanica, Jessyca Kartika Mustofa Khairinisa, Miski Aghnia Kurniadi, Helman Lara Syahila Lesra Indriani Lestari, Bunga Debi Lia Anggresani Lili Andriani Lili Andriani Lili Andriani Lili Andriani Lufita, Lufita M. Kurnia Pratama Mahadma Bhima Whinata MAYANG KUSUMA DEWI, MAYANG KUSUMA Medina, Fhatia Mesra, Novia Dita Muhaimin Muhaimin Muhammad Randa Nadia Monika Nadia Putri Nadia Putri Nina Fitriya Novia Dita Mesra Novia Dita Mesra Nurhuda Nurhuda Oktavia, Dian Oktaviani, Dyan Putri Okti Lestari Pitriani Pitriani, Rosa Pratama, M. Kurnia Puja Ariska Putri Dwi Ramadanti Rahmadani, Anggi Rahmadevi Ramadani, Suci Ramadanti, Putri Dwi Randa, Muhammad Risuana, Ardia Rizky Yulion Robiatul A’dawiyah SE Rosa Pitriani Rozalti Rozalti Ruri Putri Mariska Safitri, Wiwit Wulan Santi Perawati Santi Perawati Santi Perawati Santi Perawati, Santi Saputri, Cindy Dwi Sari, Suci Indah SE, Robiatul A’dawiyah Shafira Al Fadhilah Siska Fitri Siti Chairani Siti Hamidatul 'Aliyah Sriwidodo Sriwidodo, Sriwidodo Suci Indah Sari Suci Ramadani Suci Ramadani Susanti Susanti Sutrisno , Deny Swinche, Ulfa Deni Ulfa Deni Swinche Whinata, Mahadma Bhima Wiwit Wulan Safitri Wulandari, Konita Yoga Windu Wardhana, Yoga Windu Yuli Fitri Utami Yuliawati Yuliawati Yuni Andriani ‘Aliyah, Siti Hamidatul