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ANALISIS KESESUAIAN PELAYANAN FARMASI KLINIK BERDASARKAN PERMENKES NO. 73 TAHUN 2016 DI APOTEK KABUPATEN JEPARA Nova Oktaviana; Ria Etikasari; Ahmad Suriyadi Muslim
Nusantara Hasana Journal Vol. 5 No. 8 (2026): Nusantara Hasana Journal, January 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i8.1856

Abstract

Clinical pharmacy services in pharmacies play a very important role in ensuring the safe, rational, and effective use of medicines. The provisions regarding clinical pharmacy services are regulated in the Ministry of Health Regulation No. 73 of 2016 concerning Standards of Pharmacy Services in Pharmacies. This study aims to analyze the compliance of pharmacies in Jepara Regency with the implementation of clinical services based on the Ministry of Health Regulation No. 73 of 2016 and to assess the extent to which the seven aspects of clinical pharmacy services—prescription assessment and services, dispensing, drug information services, patient counseling, home pharmacy care, drug therapy monitoring, and adverse drug reaction monitoring—have been carried out according to the standard. The research method used was a descriptive and evaluative quantitative approach, with data collected through questionnaires distributed to the pharmacists in charge of the pharmacies. The analysis was conducted using descriptive statistics to determine the level of compliance with pharmacy service standards. Based on the results, most pharmacies in Jepara Regency have implemented the seven aspects of clinical pharmacy services in accordance with the standards, as indicated by the high percentage of compliance in prescription assessment, dispensing, drug information services, and counseling, with several indicators reaching 100%. Home pharmacy care has been implemented by 51 pharmacies with a high level of compliance, while drug therapy monitoring and adverse drug reaction monitoring still show several indicators that have not been fully carried out by all pharmacies. Overall, the level of compliance of clinical pharmacy services in Jepara Regency falls into the good category and demonstrates that most pharmacies have met the standards set by the Ministry of Health Regulation No. 73 of 2016.
PENGARUH MUTU PELAYANAN KEFARMASIAN TERHADAP LOYALITAS PASIEN RAWAT JALAN DI INSTALASI FARMASI RSUD dr. R. SOETIJONO BLORA Dhevi Novitasari; Ahmad Suriyadi Muslim; Ulviani Yulia Husna
Nusantara Hasana Journal Vol. 5 No. 9 (2026): Nusantara Hasana Journal, February 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i9.1872

Abstract

Pharmaceutical services provided by pharmacists and pharmacy personnel in healthcare facilities must consistently maintain high service quality. In addition to ensuring the safety and effectiveness of therapy, good service quality can enhance patient satisfaction and loyalty. The objective of this study was to determine the effect of the quality of clinical pharmaceutical services on outpatient loyalty at dr. R. Soetijono Regional General Hospital, Blora. This study employed a quantitative design with a cross-sectional approach. The research sample was selected using purposive sampling, with inclusion criteria consisting of outpatients who had received pharmaceutical services at least once. Data were analyzed using the chi-square statistical test to examine the effect of pharmaceutical service quality on patient loyalty. The results from 400 respondents indicated that the overall quality of pharmaceutical services was rated as good by 278 respondents (69.5%), and 303 respondents (75.8%) were categorized as loyal patients. Chi-square analysis yielded a p-value of < 0.001, indicating a significant effect of pharmaceutical service quality on outpatient loyalty at dr. R. Soetijono Regional General Hospital, Blora.
Molecular docking study of catharanthus roseus compounds as potential ABL1 inhibitors for leukemia treatment Muhammad Farid; Shalahuddin Al Madury; Ahmad Suriyadi Muslim; Zakiyyah Qurrotul ‘Aini
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.235

Abstract

Leukemia is one type of cancer with a high mortality rate, caused by the proliferation of abnormal white blood cells that disrupt hematopoiesis function. Conventional therapies, such as chemotherapy and targeted therapy, often face challenges in the form of side effects and drug resistance. This study aims to evaluate the potential of Catharanthus roseus as a leukemia therapeutic agent through in silico. The docking process uses autodock, and ADMET prediction uses SwissADME and PKCMS. The study used the ABL1 protein (PDB ID: 4TWP) as a target with active compounds of Catharanthus roseus. The validation process of the docking method showed an RMSD value of 0.705 Å, indicating that the method used was valid. The results of the docking simulation showed that vindoline had the best affinity after native ligands with a binding energy of -8.64 kcal/mol, followed by catharanthine -6.16 kcal/mol and tryptophan -3.87 kcal/mol. ADMET prediction analysis showed that vindoline and catharanthine had promising pharmacokinetic and toxicity profiles, such as good blood-brain barrier (BBB) permeability and did not inhibit the CYP3A4 enzyme. These results indicate that vindoline and catharanthine are potential alternative leukemia treatments with high efficacy and low risk of side effects. This study provides a basis for further exploration of Catharanthus roseus in the development of effective and safe leukemia therapies.