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All Journal Majalah Obat Tradisional JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Mandala Pharmacon Indonesia Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Klinik dan Sains KOPEMAS
Muhammad Ma'ruf
Faculty of Pharmacy, Ahmad Dahlan University, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Other

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Antihypertensive Activity of Black Garlic Extract in Rats and Its Phytochemical Analysis using GC-MS Estiningsih, Daru; Saiful Bachri, Moch; Hayu Nurani, Laela; Ma’ruf, Muhammad; Yuliani, Sapto; Sofia, Vivi; Prasasti, Dian
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.67-74

Abstract

Background: Hypertension is defined as a medical condition where blood pressure rises above 140/90 mmHg. Black garlic is recognized as a natural remedy that may help lower high blood pressure, primarily due to its abundant antioxidant properties, which are believed to inhibit the function of the angiotensin-converting enzyme (ACE) that is essential for regulating blood pressure. Objective: This study aimed to identify the chemical composition of black garlic using GC-MS and assess its antihypertensive effects in rat models. Methods: This study characterized the chemical composition of black garlic using GC-MS (Agilent 7890A) and evaluated its antihypertensive effects in rats. Hypertension was induced by oral administration of NaCl at a dose of 3.75 g/20 g body weight (BW) from day 0 to day 14. Blood pressure measurements were taken on days 0, 14, and 21. Black garlic extract was administered at three dose levels 4.2 mg/20 g BW, 8.4 mg/20 g BW, and 12.4 mg/20 g BW to evaluate dose dependent antihypertensive responses. Statistical analysis included the Kolmogorov-Smirnov test for normality, homogeneity testing, One-Way ANOVA Results: The GC-MS analysis identified 9-octadecenoic acid as the dominant compound in black garlic, accounting for 34.53% of its total composition. The antihypertensive activity test showed that administering black garlic at a dose of 12.4 mg/20 g BW significantly lowered systolic, diastolic, and mean arterial blood pressure while enhancing nitric oxide levels in hypertensive rats. Conclusion: Black garlic has the potential as an effective herbal treatment to lower blood pressure.
KARAKTERISTIK PARAMETER SPESIFIK DAN NON SPESIFIK DAUN KRATOM (Mitragyna speciosa Korh.) ASAL KALIMANTAN SELATAN Febrianti, Dwi Rizki; Wahyuono, Subagus; Fakhrudin, Nanang; Riski, Akhmad; Kumalasari, Eka; Normilawati; Niah, Rakhmadhan; Mar'uf, Muhammad
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2786

Abstract

Standardization is a process of fulfilling the requirements for raw materials of traditional medicine, aimed at ensuring and maintaining safety, consistent quality, and efficacy. Kratom leaves (Mitragyna speciosa) are a traditional medicinal plant found in the interior regions of Kalimantan. This plant functions as a source of energy due to its stimulant properties. This study aims to determine the standardization of kratom leaf extract simplicia, including both specific and non-specific parameters. The extraction method used in this study was maceration with ethanol. The results showed that the scientific name of kratom leaves is Mitragyna speciosa. The standardization of kratom leaf simplicia powder includes parameters such as loss on drying, total ash, water-insoluble ash, acid-insoluble ash, total microbial count (ALT), total yeast and mold count (AKK), and heavy metal contamination, with the following results: 9.5%; 5.51%; 3.58%; 0.39%; 6.9 × 10² cfu/g; >3.0 × 10³ cfu/g; <0.001 mg/kg. Meanwhile, the standardization of kratom leaf extract includes ash content and heavy metal contamination, with results of 6.06% and <0.001 mg/kg, respectively. The active compounds contained in the kratom leaf simplicia and extract are alkaloids, flavonoids, and tannins.
THE TREND OF STUDIES RELATED TO MYASTHENIA GRAVIS AND GENETICS IN VARIOUS POPULATIONS AROUND THE WORLD Fitri, Dwiki; Irham, Lalu Muhammad; Sulistyani, Nanik; Adikusuma, Wirawan; Sianu, Rahman S; Ma’ruf, Muhammad
Jurnal Farmasi Klinik dan Sains Vol 5, No 2 (2025): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v5i2.1944

Abstract

Myasthenia gravis (MG) is an autoimmune disease involving the neuromuscular junction, mainly influenced by antibodies to acetylcholine receptors. In addition, antibodies to Muscle-Specific Kinase (MUSK), Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4). It is essential to determine publication trends regarding Myasthenia gravis because, currently, there are no studies that describe Myasthenia gravis publication trends related to genes in this field of study. Bibliometric analysis is used to see research trends, including frequently used keywords, most published journals, most cited publishers, author agencies, and collaboration between authors depicted in visualization using the VOSViewer application. Bibliometric analysis shows that the research trend is increasing from 1969 to 2023. The most frequently used keywords are myasthenia gravis, human, autoimmune disease, genetics, and article. The leading information related to the data is that the average annual publication is 5.89%, and the average citation for documents is 13.9%. Indonesia, as one of the countries experiencing Myasthenia gravis, has excellent potential to increase the number of research articles, which can be a means of exchanging knowledge, ideas, and technology and also has the potential for collaboration with other countries
Identifikasi Mutu Simplisia dan Ekstrak Serta Uji Aktivitas Antioksidan Ekstrak Daun Sungkai (Peronema canescens Jack) Ma'ruf, Muhammad; Febrianti, Dwi Rizki; Kumalasari, Eka; Amukti, Danang Prasetyaning; Santoso, Blegoh Iwan
Jurnal Farmasi Klinik dan Sains Vol 5, No 2 (2025): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v5i2.1862

Abstract

Sungkai (Peronema canescens Jack.) merupakan salah satu tanaman yang telah lama dimanfaatkan oleh masyarakat sebagai obat tradisional untuk berbagai jenis penyakit. Tanaman ini khususnya pada bagian daun diketahui mengandung flavonoid alkaloid saponin tanin dan terpenoid atau steroid yang berperan sebagai antioksidan. Namun data terkait variasi mutu simplisia dan ekstrak daun sungkai masih terbatas sehingga berpotensi memengaruhi konsistensi aktivitas dan kualitas produk herbal. Penelitian ini bertujuan untuk mengetahui kandungan kimia dalam simplisia dan ekstrak daun sungkai, serta menguji kemampuan antioksidannya dengan metode DPPH. Penelitian ini diawali dengan pengambilan daun sungkai segar yang kemudian diolah menjadi simplisia dan diekstraksi menggunakan etanol 96% melalui metode maserasi. Karakterisasi simplisia dan ekstrak dilakukan melalui uji organoleptik, penetapan parameter spesifik dan nonspesifik, serta skrining fitokimia. Uji aktivitas antioksidan dilakukan dengan metode DPPH menggunakan vitamin C sebagai pembanding serta mengacu pada kriteria klasifikasi nilai IC₅₀ untuk menentukan tingkat kekuatan aktivitas antioksidan. Hasil penelitian ini menunjukkan bahwa simplisia dan ekstrak daun sungkai mengandung alkaloid, flavonoid, saponin, tanin, serta terpenoid/steroid. Parameter mutu simplisia memenuhi standar Farmakope Herbal Indonesia. Uji DPPH menghasilkan nilai IC₅₀ vitamin C sebesar 7,80 ppm dan ekstrak daun sungkai sebesar 14,55 ppm. Keduanya termasuk kategori aktivitas antioksidan sangat kuat, meskipun ekstrak daun sungkai sedikit lebih rendah dibanding vitamin C. Temuan ini menunjukkan bahwa daun sungkai berpotensi dikembangkan sebagai sumber antioksidan alami serta menjadi dasar dalam upaya standardisasi bahan baku dan pengembangan sediaan herbal.
Co-Authors Agus Suryono Amelia, Senya Puteri Any Guntarti Ariani, Novia Arina Roikhana Arina Roikhana Citra Ariani Edityaningrum, Citra Danang Prasetyaning Amukti Daru Estiningsih Daud, Intan Desi Eko Wulansari Dian Prasasti Durrotul Hasanah Durrotul Hasanah Dwi Retno Nengtyas Eka Kumalasari Febrianti, Dwi Rizki Fitri, Dwiki Ghomamul Karim Hamdani Dwi Prasetyo Hidayati, Sholihatil Imam Hanafi Kaffah, Silmi Laela Hayu Nurani Laela Hayu Nurani Lailatul Maghfirah Lailatul Maghfirah Lalu Muhammad Irham Moch Saiful Bachri Moch. Saiful Bachri Moch. Saiful Bachri Moch. Saiful Bachri Muhammad Hafizh Abiyyu Fathin Fawwazi Nanang Fakhrudin, Nanang Nanik Sulistyani Niah, Rakhmadhan Normilawati Nur Mufida Nur Mufida Prihandiwati, Erna Putri Dwi Lestari Rini Sulistyawati Riski, Akhmad Riyanto Riyanto Rizki Amelia Sama’ Iradat Tito Santoso, Blegoh Iwan Sapto Yuliani Sapto Yuliani Sianu, Rahman S Silmi Kaffah Siska Musiam Subagus Wahyuono Sulis Setiawati Sulis Setiawati Sulistyorini, Dwi Agustin Vivi Sofia Wahyu Widyaningsih Wiki Yuli Anita Wirawan Adikusuma Zuhrotul Chumairoh Zuhrotul Chumairoh