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All Journal Majalah Obat Tradisional JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Mandala Pharmacon Indonesia Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan KOPEMAS
Muhammad Ma'ruf
Faculty of Pharmacy, Ahmad Dahlan University, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Physics Public Health Social Sciences Other

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Antihypertensive Activity of Black Garlic Extract in Rats and Its Phytochemical Analysis using GC-MS Estiningsih, Daru; Saiful Bachri, Moch; Hayu Nurani, Laela; Ma’ruf, Muhammad; Yuliani, Sapto; Sofia, Vivi; Prasasti, Dian
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.67-74

Abstract

Background: Hypertension is defined as a medical condition where blood pressure rises above 140/90 mmHg. Black garlic is recognized as a natural remedy that may help lower high blood pressure, primarily due to its abundant antioxidant properties, which are believed to inhibit the function of the angiotensin-converting enzyme (ACE) that is essential for regulating blood pressure. Objective: This study aimed to identify the chemical composition of black garlic using GC-MS and assess its antihypertensive effects in rat models. Methods: This study characterized the chemical composition of black garlic using GC-MS (Agilent 7890A) and evaluated its antihypertensive effects in rats. Hypertension was induced by oral administration of NaCl at a dose of 3.75 g/20 g body weight (BW) from day 0 to day 14. Blood pressure measurements were taken on days 0, 14, and 21. Black garlic extract was administered at three dose levels 4.2 mg/20 g BW, 8.4 mg/20 g BW, and 12.4 mg/20 g BW to evaluate dose dependent antihypertensive responses. Statistical analysis included the Kolmogorov-Smirnov test for normality, homogeneity testing, One-Way ANOVA Results: The GC-MS analysis identified 9-octadecenoic acid as the dominant compound in black garlic, accounting for 34.53% of its total composition. The antihypertensive activity test showed that administering black garlic at a dose of 12.4 mg/20 g BW significantly lowered systolic, diastolic, and mean arterial blood pressure while enhancing nitric oxide levels in hypertensive rats. Conclusion: Black garlic has the potential as an effective herbal treatment to lower blood pressure.
Co-Authors Agus Suryono Amelia, Senya Puteri Any Guntarti Ariani, Novia Arina Roikhana Arina Roikhana Citra Ariani Edityaningrum, Citra Danang Prasetyaning Amukti Daru Estiningsih Daud, Intan Desi Eko Wulansari Dian Prasasti Durrotul Hasanah Durrotul Hasanah Dwi Retno Nengtyas Eka Kumalasari Ghomamul Karim Hamdani Dwi Prasetyo Hidayati, Sholihatil Imam Hanafi Kaffah, Silmi Laela Hayu Nurani Laela Hayu Nurani Lailatul Maghfirah Lailatul Maghfirah Moch Saiful Bachri Moch. Saiful Bachri Moch. Saiful Bachri Moch. Saiful Bachri Muhammad Hafizh Abiyyu Fathin Fawwazi Nur Mufida Nur Mufida Prihandiwati, Erna Putri Dwi Lestari Rini Sulistyawati Riyanto Riyanto Rizki Amelia Sama’ Iradat Tito Sapto Yuliani Sapto Yuliani Silmi Kaffah Siska Musiam Sulis Setiawati Sulis Setiawati Sulistyorini, Dwi Agustin Vivi Sofia Vivi Sofia Wahyu Widyaningsih Wiki Yuli Anita Zuhrotul Chumairoh Zuhrotul Chumairoh