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Journal : Jurnal Kesehatan Masyarakat

The Ins and Outs of Alpha-mangostin’s Potential as an Antimalarial Tjahjani, Susy; Hermanto, Faizal; Muchtaridi, Muchtaridi; Aulifa, Diah Lia; Ahsanul Haq, Fahmi
Jurnal Kesehatan Masyarakat Vol. 20 No. 4 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i4.19307

Abstract

Malaria drug resistance, including to development of resistance against artemisinin based treatments, poses a major challenge to elimination efforts. Alpha-mangostin, an antioxidant with in vitro antimalarial activity, is hindered by its poor solubility. This study explores the antimalarial effects of water-soluble alpha-mangostin chitosan-alginate nanoparticles (ACAN) in mice with berghei malaria. Mice were treated with various doses of ACAN, compared to alpha-mangostin in polyethylene glycol (PEG), as well as in corn oil (ACO) and chloroquine as a standard. Growth inhibition rates were assessed, revealing no inhibition in the PEG and normal control (NC) groups, while ACO was less active. The effective dose 50 (ED50) of ACAN was 264.5 mg/kg BW, containing only 15.87 mg of alpha-mangostin, suggesting that alpha-mangostin in ACAN may offer promising in vivo antimalarial activity. Further investigation is needed.
Co-Authors Ahsanul Haq, Fahmi Al Shofwan, Adnan Aly Almattin, Bilqis Na'ilah Alya Puteri Agustina Pribadi Amirah, Siti Rafa Angela Alysia Elaine Anggi, Joseph Fide Anisa Pebiansyah Arif Budiman Audry Rahma Dewayani Augustina, Yeni Ayodduki, Zahra Noor Silmi Hermawan Ayu Permatasari Bernap Dwi Putra Sitinjak Diffa Hauna F. Pakhrul Diki Prayugo Wibowo Elaine, Angela Alysia Emamia, Evelyn Stepania Faizal Hermanto Febriani, Yessi Firman Firman Firman Firman Fitriansyah, Sani Nurlaela Guspira, Yunitasya Hadiwijaya, Nathannael Adrya Halwa Aulia Nurdin Hartono, Sugianto Ayudha Helmi, Nyai Ayu Sylfia Stannia Puspitasari Hesti Riasari Husna Muharram Ahadi Hutapea, Ezra Calista Izzaturrahmi, Ahda Salsabila Jhoni, I Made Jutti Levita Kamaludin, Asilla Mauri Ramdini Karim, Bilqisti Kanzabila Kevin Gabriel Liawardi, Petra Pahlawanda Chrisanto Maharani, Devita Salsa Maria Selviana Rendo Maya Andani, Maya Mei, Kaila Keyshia Muchtaridi Muchtaridi Mulyadi, Ananda Putri Aulia Muntashir, Ilham Mohammad Nahariyah, St. Rohmani Natashya Parameswari Natasya Prameswari Nursuhud Nurulaini, Siti Nunung Nurviana, Destawesty Nyi Mekar Saptarini Parameswari, Natashya Pauziah, Ai Syipa Ulfah Permatasari, Ayu Pratomo, Muhammad Fadhil Priana, Diva Dhaifina Mazaya Pribadi, Alya Puteri Agustina Puspitasari, Citra Dewi Ramadhiany, Ziyan Zulfah Redjeki, Sarah Gustia Resmi Mustarichie Riasari, Hesti Richa Mardianingrum Riezki Amalia Riki - Nugraha Rini Hendriani Rizky Prasiska Wulandari Rosandi, Nurul Fauziah Sabetta, Oktavia Sabiq Salmandhiya Harits Salsabil Ghaliya Sani nurlaela fitriansyah Sani Nurlaela Fitriansyah Setyawati, Luthfi Utami Sinala, Santi Siti Uswatun Hasanah Sitinjak, Bernap Dwi Putra Sitinjak, Feggy Yustika Sitinjak, Gloria Maharyani Lastiar Sudirman, Virgiana Keisha Rajabi Johni Sunani, Sunani Susy Tjahjani Swarga, Kirana Fayruz Tsamarah, Dinda Firanitha Virliana, Amrina Winingsih, Wiwin Wiwin Winingsih Yeni Augustina Yessi - Febriani Yessi Febriani Zahira, Annisa