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All Journal Jurnal Farmasi Udayana Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Cancer Chemoprevention Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Indonesian Journal of Chemical Science IDJP (Indonesian Journal of Pharmaceutics) Chimica et Natura Acta CARADDE: Jurnal Pengabdian Kepada Masyarakat Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) FITOFARMAKA: Jurnal Ilmiah Farmasi JURNAL FARMASI GALENIKA Jurnal Ilmiah Farmako Bahari Indonesian Journal of Biological Pharmacy Jurnal Sains dan Teknologi Farmasi Indonesia Media Kesehatan Politeknik Kesehatan Makassar Jurnal Farmasi Galenika ETHOS: Jurnal Penelitian dan Pengabdian kepada Masyarakat Jurnal Kesehatan Masyarakat
Diah Lia Aulifa
Padjadjaran University
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati

 1 
In Silico Study of Hops Plant Compounds (Humulus lupulus L.) as Phytoestrogens for Insulin Resistance Siagian, Johanna Berliana; Hermansyah, Inas Fathinah; Pendy, Violent Irene; Wibowo, Mutia Amara Putri; Haq, Dhiya'Ul; Pramudita, Fransisca Widi; Aulifa, Diah Lia
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 10, No 3 (2025): October 2025
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v10i3.12143

Abstract

Postmenopausal women often experience insulin resistance, a condition linked to declining estrogen levels. Structurally similar to endogenous estrogen, phytoestrogens derived from Humulus lupulus L. (hops) hold potential as natural agents in hormone replacement strategies. This research utilized a comprehensive in silico methodology to assess 20 bioactive hop-derived compounds for their ability to act as agonists of estrogen receptor alpha (ERα). The evaluation involved Lipinski’s Rule of Five, ADME-Tox profiling, pharmacophore-based screening, and molecular docking analyses. Seven compounds satisfied the pharmacophore model criteria. Among them, Isoxanthohumol and 8-prenylnaringenin displayed the most favorable binding affinities, while Desmethylxanthohumol and Naringenin showed interaction patterns closely aligned with those of the native ligand. Although the majority demonstrated favorable pharmacokinetic properties, a few compounds presentedpotential mutagenic or carcinogenic effects. Considering binding performance, interaction resemblance, and predicted safety, these four compounds emerge as strong phytoestrogen candidates for ERα modulation in insulin resistance. Experimental validation through biological studies is necessary to substantiate these computational findings.
Co-Authors Ahsanul Haq, Fahmi Al Shofwan, Adnan Aly Almattin, Bilqis Na'ilah Alya Puteri Agustina Pribadi Amirah, Siti Rafa Angela Alysia Elaine Anggi, Joseph Fide Anisa Pebiansyah Arif Budiman Audry Rahma Dewayani Augustina, Yeni Ayodduki, Zahra Noor Silmi Hermawan Ayu Permatasari Bernap Dwi Putra Sitinjak Diffa Hauna F. Pakhrul Diki Prayugo Wibowo Elaine, Angela Alysia Emamia, Evelyn Stepania Faizal Hermanto Febriani, Yessi Firman Firman Firman Firman Fitriansyah, Sani Nurlaela Guspira, Yunitasya Hadiwijaya, Nathannael Adrya Halwa Aulia Nurdin Haq, Dhiya'Ul Hartono, Sugianto Ayudha Helmi, Nyai Ayu Sylfia Stannia Puspitasari Hermansyah, Inas Fathinah Hesti Riasari Husna Muharram Ahadi Hutapea, Ezra Calista Izzaturrahmi, Ahda Salsabila Jhoni, I Made Jutti Levita Kamaludin, Asilla Mauri Ramdini Karim, Bilqisti Kanzabila Kevin Gabriel Liawardi, Petra Pahlawanda Chrisanto Maharani, Devita Salsa Maria Selviana Rendo Maya Andani, Maya Mei, Kaila Keyshia Muchtaridi Muchtaridi Mulyadi, Ananda Putri Aulia Muntashir, Ilham Mohammad Nahariyah, St. Rohmani Natashya Parameswari Natasya Prameswari Nursuhud Nurulaini, Siti Nunung Nurviana, Destawesty Nyi Mekar Saptarini Parameswari, Natashya Pauziah, Ai Syipa Ulfah Pendy, Violent Irene Permatasari, Ayu Pramudita, Fransisca Widi Pratomo, Muhammad Fadhil Priana, Diva Dhaifina Mazaya Pribadi, Alya Puteri Agustina Puspitasari, Citra Dewi Ramadhiany, Ziyan Zulfah Redjeki, Sarah Gustia Resmi Mustarichie Riasari, Hesti Richa Mardianingrum Riezki Amalia Riki - Nugraha Rini Hendriani Rizky Prasiska Wulandari Rosandi, Nurul Fauziah Sabetta, Oktavia Sabiq Salmandhiya Harits Salsabil Ghaliya Sani nurlaela fitriansyah Sani Nurlaela Fitriansyah Setyawati, Luthfi Utami Siagian, Johanna Berliana Sinala, Santi Siti Uswatun Hasanah Sitinjak, Bernap Dwi Putra Sitinjak, Feggy Yustika Sitinjak, Gloria Maharyani Lastiar Sudirman, Virgiana Keisha Rajabi Johni Sunani, Sunani Susy Tjahjani Swarga, Kirana Fayruz Tsamarah, Dinda Firanitha Virliana, Amrina Wibowo, Mutia Amara Putri Winingsih, Wiwin Wiwin Winingsih Yeni Augustina Yessi - Febriani Yessi Febriani Zahira, Annisa