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All Journal Journal of Food and Pharmaceutical Science Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Movere Journal Ta'dib: Jurnal Ilmiah Pendidikan dan Peradaban Islam Jurnal Bakti Untuk Negeri Jurnal Farmasi Klinik dan Sains GMPI Conference Series Herbal Medicine Journal Journal of Food and Pharmaceutical Sciences Balance: Jurnal Ekonomi
Ma’ruf, Muhammad
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Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Development of Self-Nano Emulsifying Drug Delivery System (SNEEDS) Containing Hibiscus sabdariffa L. Extract, an Anticancer against T47D Cells, as a Co-Chemotherapy of Cisplatin Nurani, Laela Hayu; Efiana, Nuri Ari; Wahyuningtyas, Nurma; Edityaningrum, Citra Ariani; Indratmoko, Septiana; Guntarti, Any; Ma’ruf, Muhammad
Journal of Food and Pharmaceutical Sciences Vol 14, No 1 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21378

Abstract

The first-line chemotherapy drug for breast cancer is cisplatin. However, it shows a high incidence of resistance. Therefore, Hibiscus Sabdariffa L (HS), containing strong anticancer compounds, was developed using a self-nano-emulsifying drug delivery system (SNEDDS), potentially as cisplatin co-chemotherapy. This study aimed to develop the HS SNEDDS providing anticancer activity against T47D breast cancer cells. The methods consist of the development of HS SNEDDS (F1-F7) with various surfactant and co-surfactant concentrations, followed by characterization of HS SNEDDS. The selected formulation was evaluated regarding the cytotoxicity on T47D cells and selectivity on Vero cells. The results showed that F7, as a selected formulation, indicated a transmittance, globule size, PI, zeta potential, and emulsification time of 97.80%, 15.68 ± 0.19 nm, 0.12 ± 0.01, -8.05 ± 1.88 mV, and 24.76 ± 0.29 seconds, respectively. Furthermore, according to the data of toxicity and selectivity studies, HS SNEDDS was proven to enhance the toxic properties of HS extract on T47D cells and be safe on normal cells. In conclusion, HS SNEDDS providing the required characteristics could be obtained, and potentially be used as a co-chemotherapy of cisplatin, showing the cytotoxic effect on T47D breast cancer cells.
Dampak Variasi Genetik terhadap Respon Terapi dan Potensi Hemolisis Anemia dari Penggunaan Primakuin melalui Pendekatan Farmakogenetika Sianu, Rahman Sumani; Ghifari, Annisa Abdi; Ma’ruf, Muhammad; Nur Jannah, Eka Yuni; Lestari, Putri Ayu
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.219

Abstract

Primaquine is essential for radical cure of Plasmodium vivax malaria but poses hemolysis risk in G6PD-deficient individuals and shows variable therapeutic responses. Genetic polymorphisms in drug-metabolizing enzymes and transporters contribute to these inter-individual variations. To investigate genetic variants in G6PD, SLCO2B1, and MAOA genes that influence primaquine safety and efficacy, and to assess their clinical implications for personalized antimalarial therapy. Method the database used in this study is PhramGKB. Genetic polymorphisms in four candidate genes were analyzed for associations with hemolysis, anemia, therapeutic efficacy, and malaria recurrence. Statistical analyses determined the strength and significance of genotype-phenotype associations. Result G6PD variants rs1050828 and rs1050829 showed strong associations with hemolysis (p<0.01) and anemia (p=0.001). SLCO2B1 variant rs12422149 was associated with reduced chloroquine-primaquine efficacy (p=0.01). MAOA variant rs6323 increased malaria recurrence risk (p=0.03). Conclusion multiple genetic variants significantly impact primaquine safety and efficacy. These findings support pharmacogenetic-guided personalized antimalarial therapy to optimize outcomes and minimize adverse events, contributing to malaria elimination efforts.
Co-Authors Abdulah, Zeni Malik Aisyah, Noor Alfiannor, M. Amartiwi, Utih Anisa Devi Kharisma Wibowo Annisa Abdi Ghifari Any Guntarti Ariani, Novia Baharuddin, Dahlia Chong, Rockie Citra Ariani Edityaningrum, Citra Efiana, Nuri Ari El Syam, Robingun Suyud Firman Firman Fitri, Dwiki Hadi Sumarsono Halimun, Naomi Kartikasari, Ayu Lifia Nur Khairi, Sabiah Kurniawan, Henny Laela Hayu Nurani Lalu Muhammad Irham Maria Ulfah Mas'ud, Masdar Muhammad Hafizh Abiyyu Fathin Fawwazi Nanik Sulistyani Niah, Rakhmadhan Normilawati, Normilawati Nugraha, Media Fitri Isma Isma Nur Jannah, Eka Yuni Nurjihan, Lu’lu Pranata, Satria Prihandiwati, Erna Priyatno, Aditya Rachman Puspitaningrum, Anisa Nova Putri Ayu Lestari Rifqi Muntaqo, Rifqi Riski, Akhmad Rustandi, Tedi Sekar Ayu Wulandari Sianu, Rahman S Sianu, Rahman Sumani Siswanto, Lalu Muhammad Harmain Susanto, Yugo Susilo, Yudi Hardi Wahyudi Wahyudi Wahyuni, Amaliyah Wahyuningtyas, Nurma Widodo, Arif Nur Wirawan Adikusuma Woro Supadmi Yumassik, Abdul Mahmud