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All Journal Jurnal Kesehatan Masyarakat The Indonesian Journal of Occupational Safety and Health Jurnal Ilmiah Kedokteran Wijaya Kusuma Majalah Kesehatan FKUB Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Kreativitas PKM Journal Of Widya Medika Junior Medical Technology and Public Health Journal Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Kesehatan Tambusai Media Publikasi Promosi Kesehatan Indonesia (MPPKI) CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Jurnal Pengabdian Masyarakat Bangsa Gema Lingkungan Kesehatan Jurnal Widya Medika
Sincihu, Yudhiakuari
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Journal : Medical Technology and Public Health Journal

 1 
DAMPAK PEMBERIAN MIKROPLASTIK POLIETHILEN PERORAL TERHADAP HITUNG JENIS SEL LEUKOSIT DARAH RATTUS NORVEGICUS STRAIN WISTAR Yudhiakuari Sincihu
TEKNOLOGI MEDIS DAN JURNAL KESEHATAN UMUM Vol 6 No 1 (2022): Medical Technology and Public Health Journal March 2022
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mtphj.v6i1.2611

Abstract

Microplastics have been identified as food chain contaminants. Most plastic polymers are polyethylene. Microplastics in the gastrointestinal tract will undergo persorption through the cell gap at the end of the intestinal villi into the blood circulation to be distributed throughout the tissue. It is suspected that microplastics will trigger chronic inflammation. The aim of the study was to analyze the impact of oral exposure to polyethylene microplastics on the blood leukocyte cell count. Pure experimental research with posttest only control group design. Random allocation was used to divide 30 Rattus norvegicus wistar strains into each group of the same number. There were 4 exposure groups with a dose of D1=0.0375mg, D2=0.075mg, D3=0.15mg, D4=0.6mg of microplastic particles per day through an oral probe and 1 control group that was not given microplastics. Exposure is given for 90 days. One-way ANOVA test was used to analyze the difference in values ​​between groups. The results of this study show an increasing trend in the mean of leukocyte biomarkers, neutrophil and basophil counts in the exposure group (1,2,3,4) compared to the control (0). Statistical tests showed significant values ​​for leukocyte biomarkers (P= .048) and basophils (P= .040), where more exposure doses will cause an increase in the level of these biomarkers in the blood. Oral exposure to polyethylene microplastics had an effect on leukocytosis in the blood of Rattus norvegicus wistar strain.
Co-Authors A.L. Slamet Ryadi Adi P Hendrata Adinda Putri Studytasari Adithia, Felix Kurniawan Agusalim, Yonathan Ahmad Taufik Alecia Fransiska Khorianto Alvin Julian Andini Kartika Sari Andre Young Angeline Rivia Simanjuntak Anisah Machmudah Annisa Nurida Aranda, Biembee Nayoan Cosa Ari Christy Mulyono Arjuna, Sansan Rollens B, Lukas Slamet B. Triagung Ruddy Bella Agustina Andreani Benevitto, Axel Bernadette Dian Novita Cahyadi, Ranita Ivana Cahyani, Ni Putu Novi Christian Jaya Sumarto Putra Christin Setiawan Daeng, B. Handoko Dana Parama Julius David Karunia Jaya Dewa Ayu Liona Dewi Dewa Ayu Liona Dewi Dewi, Dewa Ayu Liona Dinata, Mulya Djoka, Marlyn Dwi Puspitasari Ekaristy, Mergivia Elicia Vincensa Epriyanto Tri Darmadi Ernawaty . Faustina, Danica Florentia, Marion Florentina Sustini Freddy Kurniawan FX Himawan Jong Grace, Paulina Holy Hamdani, Delincia Hanna Tabita Hasianna Silitonga Hartono, Felicia P Henry Ricardo Handoyo I Dewa Gede Pangestu Banu Ananta Inge Wattimena Inge Wattimena Inge Wattimena Irene Lingkan Parengkuan Irene Lingkan Parengkuan Irene Lingkan Parengkuan Irene Lingkan Parengkuan Ivita Tahta Murbarani Jasinda Dwiranti Jose Giovanny Juanita Harrisa Julian, Alvin Julio Cesar Adhyaksa de Fatima Kusuma Scorpia Lestari, Kusuma Scorpia Laura Wihanto Leonardo Suryanto Wicaksono Lilik Djuari Lukas Slamet Riadi Lukas Slamet Rihadi Lukas Slamet Rihadi Maramis, W F Marion Florentia Maulana, Irsyan Baginda Maya Syahria Saleh Melani Taurusia Minarni Wartiningsih Miza Nisrinah Morina, Shella Mujib Hannan Mulya Dinata Mulya Dinata Mulyasari, Tri Marthy Ni Putu Sudewi, Ni Putu Niluh Suwasanti Niluh Suwasanti Nindya Amalia Biharjo Putri Nirwana Mila Safitri Nita Kurniawati Nita Kurniawati Novita, Bernadette Dian Pangestu, Vennessa M Paul Jhosua Dayoh Prajitno, Subur Prehatin Trirahayu Ningrum Priskilla Naomi Palyama Puspitasari, Dyan Eka Putri Lisdiyanti Raharja, Davin Rezki, Muhammad Nur Rihadi, Lukas Slamet Robertus Saldi Cundawan Ruddy, B. Triagung Ruddy, B. Triagung Sagung Putri Maharani Salvador Benedictus Borromeu Samsudin, Kevin Sancha Melarisa Hilarius Sani’ah, Ni Luh Sita Rupini, sari, andini kartika Setiadi, Rocky Shallen Angelia Wijaya Sianty Dewi Silva, Theodora Emanuella da Simanjuntak, Angeline Rivia Soegeng, Kevin K Stefanus Supriyanto Steven Steven Steven Steven Steven Steven Wijono Steven, . Susetio, Mercy Mezia Suwasanti, Niluh Tang, Michelle Taurusia, Melany Theresia Arum Hanitani Valerie Grecia Vincentius Diamantino Supit Vincentius Michael Willianto Wienta Diarsvitri Wijono, Caroline Octaviana Winarjo, Givenchy Angela Wulandari, Yudita Wulansari, Nurlita Yofita, Fransiska Yola, Priska Yosephine Valentine Surya Young, Andre Yudistira .. Yusup, David R