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Penentuan Nilai LC₅₀ Ekstrak Etanol 80% Daun Trembesi (Samanea saman (Jacq.) Merr.) Menggunakan Metode BSLT Haryanto Haryanto; Resky Aulifiyah Haswari.B; Aulya Nurul Imama R; Agung Nur Aqdi; Rahasia Rahasia; Ilmi Nurashilah; Alya Salsabila; Risya Nida Kaffyiah Sereang; Mawar Sahid
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 4 (2026): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i4.2353

Abstract

Samanea saman (Jacq.) Merr. leaves contain various secondary metabolites with potential biological activities; therefore, preliminary toxicity testing is necessary to evaluate their safety and bioactive potential. This study aimed to determine the Lethal Concentration 50 (LC₅₀) value of the 80% ethanol extract of Samanea saman leaves using probit analysis and to classify its toxicity level. An experimental study was conducted using the Brine Shrimp Lethality Test (BSLT) with Artemia salina Leach larvae as the test organism. The extract was tested at concentrations of 10, 100, 500, 1,000, and 5,000 ppm. Larval mortality was recorded after the incubation period, and the data were analyzed using probit analysis to determine the LC₅₀ value. The results showed that larval mortality increased with increasing extract concentration, reaching 18.42%, 23.33%, 45.83%, 70.83%, and 88.89%, respectively. Probit analysis revealed an LC₅₀ value of 301.72 mg/L (ppm). Based on the toxicity classification, this value falls into the moderately toxic category, indicating that the 80% ethanol extract of Samanea saman leaves exhibits toxic activity against Artemia salina larvae. These findings suggest that the extract has promising potential as a source of bioactive compounds and warrants further investigation, including the isolation and identification of active constituents, cytotoxicity evaluation, and safety assessment in more complex biological systems.
MANAJEMEN NYERI ASAM URAT PADA LANSIA MELALUI PELATIHAN PEMBUATAN MINYAK PIJAT AROMATERAPI Zakiah Thahir; Haryanto; Andi Budirohmi; Muhammad Taufiq Duppa; Anshari Masri
JURNAL PENGABDIAN MASYARAKAT YAMASI Vol. 5 No. 1 (2026): Jurnal Pengabdian Masyarakat Yamasi
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/w2ed2s68

Abstract

Nyeri sendi akibat asam urat merupakan salah satu masalah kesehatan yang sering dialami kelompok lansia dan dapat berdampak pada keterbatasan aktivitas serta penurunan kualitas hidup. Penatalaksanaan nonfarmakologis menjadi salah satu pendekatan yang dapat dilakukan untuk membantu mengurangi keluhan nyeri, salah satunya melalui pijat aromaterapi berbahan herbal. Namun, pengetahuan dan keterampilan lansia mengenai pemanfaatan terapi komplementer tersebut masih terbatas. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan pengetahuan dan keterampilan lansia dalam manajemen nyeri sendi akibat asam urat melalui edukasi kesehatan, demonstrasi pijat aromaterapi, serta pelatihan pembuatan minyak aromaterapi berbahan herbal. Kegiatan dilaksanakan pada tanggal 7 Oktober 2025 di Sekolah Lansia Lontara Balai UPT KB Kecamatan Rappocini, Kelurahan Minasa Sari, Kota Makassar dengan jumlah peserta sebanyak 24 orang. Metode yang digunakan berupa penyuluhan kesehatan, diskusi interaktif, demonstrasi teknik pijat aromaterapi, praktik pembuatan minyak aromaterapi berbahan herbal menggunakan minyak cengkeh, minyak sereh, minyak jahe, dan minyak lavender, serta evaluasi melalui pre-test dan post-test. Hasil kegiatan menunjukkan adanya peningkatan pengetahuan dan keterampilan peserta mengenai penanganan nyeri sendi akibat asam urat. Tingkat pengetahuan dan keterampilan peserta sebelum edukasi sebesar 17,21% meningkat menjadi 82,79% setelah kegiatan. Peserta juga menunjukkan antusiasme tinggi selama praktik dan mampu memahami tahapan pembuatan minyak aromaterapi serta teknik pijat sederhana yang dapat diterapkan secara mandiri di rumah. Kegiatan pengabdian kepada masyarakat ini memberikan dampak positif dalam meningkatkan pengetahuan dan keterampilan lansia terkait manajemen nyeri sendi akibat asam urat melalui pendekatan nonfarmakologis berbasis pijat aromaterapi dan pemanfaatan bahan herbal. Program ini diharapkan dapat mendukung kemandirian lansia dalam mengelola keluhan nyeri serta berkontribusi terhadap peningkatan kualitas hidup.
Efektifitas Ekstrak Daun Kesemek Hitam (Diospyros Nigra) Sebagai Alternatif Penurunan Kadar Glukosa Tikus Putih (Rattus Norvegicus) Haryanto Haryanto; Suci Aulia Rahmadani; Rana Muthia Najwa; Afandi Afandi
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 3 No. 2 (2025): Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v3i2.4912

Abstract

Plants contain several active ingredients beneficial for health, one of which is the persimmon plant, known for its tannins and phenolic compounds. This research aims to determine the effect of Black Persimmon Leaf Extract (Diospyros nigra) as an alternative for lowering glucose levels in White Rats (Rattus norvegicus). This is a True Experimental research, which controls all external variables that could affect the experimental results. There are four control groups: a negative control using glucose and positive controls using extracts with concentrations of 15%, 30%, and 60%. The research data were measured using a UV-Vis Spectrophotometer and analyzed using One Way ANOVA with SPSS. The results of the Shapiro-Wilk normality test showed a significance value >0.05; Levene's Test for homogeneity showed a significance value >0.05; the One Way ANOVA test showed a significance value <0.05; and the Tukey HSD test showed a significance value >0.05. The objective of this research is to test the effectiveness of black persimmon leaves (Diospyros nigra) as an alternative to lowering blood glucose levels in white rats (Rattus norvegicus). Sample absorbance data were obtained using UV-VIS Spectrophotometry and analyzed using One Way ANOVA in SPSS.
Uji Efektivitas Daun Bungur (Lagerstroemia speciosa L.) terhadap Penghambatan Transportasi Glukosa Tikus Putih Galur Wistar (Rattus norvegicus) Haryanto Haryanto; Muhammad Halim Ramadhan; Rifdah Rifdah; Dian Indra Aulia; Harianti Harianti; Nadia Azzahra
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 3 No. 2 (2025): Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v3i2.4913

Abstract

This study investigated the effects of bungur leaves containing saponins, flavonoids and tannins on glucose and cholesterol levels in rat (Rattus norvegicus) test animals. Spectrophotometry results showed a significant decrease in glucose levels at different concentrations. SPSS analysis indicated that the data were normally distributed, and comparison of average glucose levels between treatment groups showed similar homogeneity. The significant value of bungur obtained was 0.014 < 0.05 from the ANOVA test, strengthening the conclusion that bungur leaves can contribute to glucose control which aims to increase the potential of active compounds contained in bungur samples in inhibiting blood glucose absorption.
Studi Perbandingan Efek Anestesi Eter dan Kloroform pada Tikus Wistar (Rattus norvegicus) : Analisis Waktu Induksi dan Durasi Anestesi Haryanto Haryanto; Zulkifli Zulkifli; Firly Ananda Pertiwi; Syabila Putri Amalia; Nurpinanda Nurpinanda; Ulfa Adelia Dwi Putri
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 3 No. 3 (2025): Juli : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v3i3.5418

Abstract

Anesthesia is a procedure that eliminates pain centrally with reversible unconsciousness. The purpose of this study was to compare the effects of ether and chloroform anesthesia on Wistar rats, with a particular focus on the induction time and duration of anesthesia associated with both anesthetic agents. Twelve male Wistar rats were divided into two treatment groups: the ether group and the chloroform group. The results showed that chloroform had a faster onset compared to ether, approximately 6.84 minutes faster, and a longer duration, approximately 22.41 minutes longer. The fastest onset was observed with chloroform, while the shortest duration was observed with ether. Based on these findings, these results can serve as a reference for the duration of anesthesia in experimental animals when using ether and chloroform.
Uji Efektivitas Infusa Daun Kubis (Brassica oleracea) terhadap Respons Nyeri Mencit Jantan Putih: Inovasi Herbal Menuju Terapi Alternatif Aman Haryanto Haryanto; Kartini Kartini; Nurul Fadillah; Nurfaida Nurfaida; Nurhana Nurhana; Miftahul Jannah; Suriyana Suriyana; Zafira Zah’ra; Zahratun Nisa
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 3 No. 3 (2025): Juli : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v3i3.5437

Abstract

Pain is the body's natural physiological response to harmful or dangerous stimuli, and is often treated with synthetic analgesic drugs. However, long-term use of synthetic analgesics such as Ketorolac, Codeine, Etoricoxib, and Celecoxib can cause various side effects, including digestive disorders, liver damage, and dependence. Therefore, safer and more affordable alternative treatments are needed, one of which is through the use of herbal plants. This study aims to evaluate the effectiveness of cabbage leaf infusion (Brassica oleracea) as a natural analgesic agent in reducing pain. The study was conducted experimentally using a completely randomized design with five treatment groups: a negative control, four positive control groups (each given Ketorolac, Codeine, Etoricoxib, and Celecoxib), and one test group given 5 grams of cabbage leaf infusion. The pain model used was 0.6% acetic acid induction intraperitoneally in male white mice (Mus musculus), and the observed parameters were the number of writhing for 30 minutes post-induction. The results showed that cabbage leaf infusion inhibited the pain response with an inhibition percentage of 47.53%. Statistically, this effectiveness did not show a significant difference compared to the positive control group (p > 0.05). These findings indicate that cabbage leaf infusion has the potential to be an effective, safe, and economical natural analgesic alternative. This research supports the development of local plant-based herbal therapies for the management of mild to moderate pain.
Analisis Dosis dan Efek Neurofarmakologi Infusa Daun Tamarindus indica (L.) pada Hewan Uji Mencit Haryanto Haryanto; Sahrul Gunawan; Atiqah Ainunnisa' Andy Putri; Andi Eka Purwanti; Salsabila Ramadhani; Hilyah Muthiah; Saskiah Adiajuns; Sukma Febrianti sukri; Nur Aqila Novi Dwiyanti; Nurul Fazilawati Ode
Jurnal Ventilator Vol. 3 No. 4 (2025): Jurnal Ventilator
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ventilator.v3i4.2135

Abstract

This study aims to investigate the effects of tamarind leaf extract (Tamarindus indica L.) on neuropharmacological activity in mice using calculated percentages of responses based on the parameters PSM, SSSP, DSSP, SL, RO, SM, PSL, and ANA. This research was conducted as a laboratory experiment using a completely randomized design (CRD) with three treatment concentrations: 1%, 2%, and 4%. Observations were performed to assess the percentage of activity produced by each sample concentration, followed by descriptive–quantitative analysis to determine the dose–response pattern. The results showed that tamarind leaf extract produced varying responses across concentrations. The SSSP, ANA, and RO effects demonstrated increased activity at the 2% concentration, whereas other parameters (PSM, PSL, SM, SL, and DSSP) showed decreased activity. Interestingly, the SSSP parameter exhibited a positive dose–response pattern with the highest activity of 55.84% at 2%. Overall, the effectiveness of tamarind leaf extract depends on the concentration level. The 2% concentration appears to be the optimal dose for several neuropharmacological effects, while the 4% concentration was most effective only for SSSP. These findings highlight the importance of multi-concentration testing to determine effective dosing of natural products for biological applications and the need for further investigation.
Co-Authors A. Alya Passalowongi A. Audia Yunasti A. Audia Yunasti A. Febi Aulia Mahrud A. Mutiara Annisa Idris Tana Abdul Rohim Saputra Adelia Rois Adinda Maharani Afandi Afandi Afni Nurul Aliyah Agung Nur Aqdi Ahmad Fauzan Pratama Ahmad Ramadhan Aidil Adhar Ainun Jariah Ainun Jariyah Alifiah Isnaeni Tahir Alya Nurul Pertiwi Alya Salsabila Alya Syahrani Amri Alwi Ana Munsir Ananda Miskiyah M Andi Alisa Alsa Andi Budirohmi Andi Eka Purwanti Andi Farahdiba Aswat Andi Latifa Aulia Andi Nur Athifah Andi Tenriani Awaliyah Andi Ulfah Magefirah Rasyid Andi Ulfah Magfirah Rasyid Andri Anugrah Pratama Anggun Aldiansa Anindya Rizke Handayani Anshari Masri Aqila, Jihan Arini Arianti Arisya Roudhina Arisya Roudhina Arsy Amalia Asri Asrianti Asrianti Atiqah Ainunnisa' Andy Putri Aulya Nurul Imama R Ayu Ayu Ayuni Fitria Ramadhani Azzahra Ramadani Besse Ramadhani Besse Ramadhani Desvita Maharani Dhini Andriani Dhiva Rabiatul Maulia Dian Fadillah Dian Indra Aulia Dinda Rahmadani Darwis Dzakiyyah Azizah Auliya Alja Elma Fanilam Putri Elma Fanilam Putri Fachria Ardila Baharuddin Febi Febrianti Febriyanti Aswinda felisa Fira Yulianti Firly Ananda Pertiwi Fitrah Amalia Fitri Adindasari Fitri Ramadani Fitrinaya Fitrinaya Fityatun Usman Gita Rahayu Hadira Hanabila Putri Hardianti Hardianti Harianti Harianti Hasry Awlia Haryanto Gite Hastata Hastata Hikmar Hairunnisa Hikmar Hairunnisa Hilda Kadir Hilyah Muthiah Husnul Hatima Husnul Khaerani Husnul Khatimah Ilmi Nurashilah Ince Moh. Raffi Zaky Irul Fatika Izzah, Aqila Nurul Kartini Kartini Maretta Kartika Ayu Ridwan Masnaeni Thamrin Masyhuri Muhaimin Mawar Sahid Meilani Fanny Fadilah Miftahul Jannah Muftiha Arrahmah Muh Aidil Pitrah Muh. Rizman Naim Muh. Yusuf Al-Habib Rachman Muhammad Chairul Anam Muhammad Guntur Muhammad Halim Ramadhan Muhammad Khairul Rasyid Aufa Nabil Muhammad Taufiq Duppa Murni Selviana Musfirah Musfirah Mychellianien Arkam Runa Bombing Nabila Ayu Pratiwi Nadia Azzahra Nadya Fachira Nafila Buna Nahla Aulia Azis Najwa Nur Sahdrina Najwa Nur Sandrina Nasifa kayla putri Nayla Musdalifah Rabbani Naylha Musdalifa Rabbani Naylha Salsabila Hs Nia Agustina Nia Ramadhani Nia Ramadhani Putri Syahyuti Niska Helendika Al Asyahra Nita Nurwahida Norita Norita Norita Noval Pratama Novi Ulfaidah Novi Ulfaidah Nur Ahya Alsabianti Nur Alam Rahayu Nur Amalinda Nur Annisa Ramadani Nur Antasasyah Putri Nur Aqila Novi Dwiyanti Nur Aulia A Nur Aulia A Nur Azizah Khairani Nur Fadila Rustam Nur Halisah Nur Isra Fadilla Nur Khadijah Anasyah Nur Rezky Amalia Nur Rizky Aulia Fitri Nur Sahra Nur Salsabila Nur Salsabila Nur Widya Lestari Nuralifah Fauziyyah Hasdi Nurfadilah Nurfadilah Nurfadillah Nurfadillah Nurfaida Nurfaida Nurhana Nurhana Nurica Nurpinanda Nurpinanda Nurul Amalia Nurul Ayuni Abni Nurul Azisa As Zahrah Nurul Fadillah Nurul Fazilawati Ode Nurul Hafifah Nurul Izzatul Jannah Nurul Nisai Putri Indah Ramadhani Rahasia Rahasia Rahma Atikah Ashara Rahmadani Rahmadani Raihan Rusyidi Ramli Ramadani Ramadani Ramadhani Hajir Rana Muthia Najwa Rarah Maulidya Putri Rarah Maulidya Putri Ratri Pramudita Resky Aulifiyah Haswari.B Resti Resti Rifdah Rifdah Rini Ariyanti Ririn Arianti Risma Asmiranti Rismawati Kalean Risya Nida Kaffyiah Sereang Sahrul Gunawan Salsabila Febrianti Sahar Salsabila Ramadhani Sari Anggraini Amir Saskiah Adiajuns Sisma Efendi Siti Nur Hadra Siti Suhrah Sri Ratna Angreni Sri Ratna Dewi Angraeni Sri Widyastuti Sry Rahmatia Rauf Suci Aulia Rahmadani Suci Ramadhani Sukma Febrianti sukri Sukma Saputri Dini Sukma Saputri Dini Sulaiman Sulaiman Sulaiman Sulaiman Sulfiana Sulfiana Sumiati Sumiati Sumiati Sumiati Suriyana Suriyana Syabila Putri Amalia Syafruddin Syafruddin Syifa Az Zahra Syifa Azzahra Sysca Adzzariaat Zalza Ulfa Adelia Dwi Putri Ummu Aidah Wildanah Muthia Yuniarsyah Yuniarsyah Yuyun Sri Wahyuni Zafira Zah’ra Zahra Hairana Rori Zahra Hairana Rori Zahratun Nisa Zakiah Thahir ZUL KIFLI, ZUL Zulkifli Halid zulkifli zulkifli