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Panghiyangani, Roselina
Departemen Biomedik, Fakultas Kedokteran, Universitas Lambung Mangkurat
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Prevalensi Anemia Defisiensi Besi dan Faktor-Faktor yang Memengaruhi pada Anak Balita dengan Gizi Buruk Intan Zorena Rezky; Harapan Parlindungan Ringoringo; Roselina Panghiyangani; Edi Hartoyo; Rahmiati Rahmiati
Homeostasis Vol 5, No 2 (2022)
Publisher : Homeostasis

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Abstract: Iron deficiency anemia (IDA) is anemia due to impaired erythrocyte formation due to a lack of iron in the body. This research aims to obtain data on the prevalence of iron-deficient anemia and iron-deficient; and to find out the relationship between children's nutritional status, mother's education/occupation/parity, and family income to the prevalence of iron deficiency anemia experienced by children under five at the Cempaka Health Center Banjarbaru. The method used is analytic observational with a cross-sectional approach. Determination of the sample using a consecutive sampling technique. The sample consisted of 30 children who performed anthropometric examinations and a complete peripheral blood laboratory. Based on the result obtained, it show that the prevalence of non-iron-deficient and iron-deficient anemia were 27%, 10%, and 73%, respectively. The tests carried out in analyzing the data were the chi-square test and Fisher's exact test with a 95% confidence level. The results of the analysis of the relationship between the prevalence of iron deficiency anemia with the nutritional status of children (p=0.195), mother's education (p=0.210), mother's occupation (p=1), mother's parity (p=0.210), and family income (p=0.267). It can be inferred that the prevalence of iron deficiency anemia and the factors that affect children under five are not related (p>0.05). Keywords: iron deficiency anemia, child nutritional status, maternal education, maternal occupation, maternal parity, family’s income Abstrak: Anemia defisiensi besi (ADB) adalah anemia akibat pembentukan eritrosit terganggu karena kurangnya jumlah zat besi dalam tubuh. Penelitian ini bertujuan memperoleh data prevalensi anemia terdefisiensi besi serta terdefisiensi besi; dan mengetahui hubungan status gizi anak, pendidikan/pekerjaan/paritas ibu, dan penghasilan keluarga terhadap prevalensi anemia defisiensi besi yang dialami anak balita di Puskesmas Cempaka Banjarbaru. Metode yang digunakan yaitu observasional analitik dengan pendekatan cross-sectional. Penentuan sampel menggunakan consecutive sampling technique. Sampel berjumlah 30 anak yang melakukan pemeriksaan antropometri, dan laboratorium darah tepi lengkap. Berdasarkan hasil penelitian menunjukkan bahwa prevalensi anemia terdefisiensi besi dan terdefisiensi besi berturut-turut yaitu 27%, 10% dan 73%. Uji yang dilakukan dalam menganalisis data yaitu chi-square test dan Fisher’s exact test dengan confidence level 95%. Hasil analisis hubungan antara prevalensi anemia defisiensi besi dengan status gizi anak (p=0,195), pendidikan ibu (p=0,210), pekerjaan ibu (p=1), paritas ibu (p=0,210), dan penghasilan keluarga (p=0,267). Dapat disimpulkan bahwa antara prevalensi anemia defisiensi besi dengan faktor-faktor yang mempengaruhi balita tidak saling berhubungan (p>0,05). Kata-kata kunci: anemia defisiensi besi, status gizi anak, pendidikan ibu, pekerjaan ibu, paritas ibu, penghasilan keluarga
Hubungan Kadar Albumin, Limfosit, dan Komorbiditas dengan Lama Rawat Inap Aisy Samara Istiqomah; Wiwit Agung Sri Nur Cahyawati; Roselina Panghiyangani
Homeostasis Vol 5, No 2 (2022)
Publisher : Homeostasis

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Abstract: Hypoalbuminemia is common in the elderly patients. Along with aging there is a decrease in physiological functions including the immune system which causes lymphopenia. Comorbidities also increase significantly with age. This research is analytic observational with cross-sectional method aimed to analyze the correlation of albumin, lymphocytes, and comorbidities with the length of stay of elderly patients. The research sample of 31 elderly people was obtained using a total sampling technique according to the inclusion and exclusion criteria. The mean albumin level was 3.07±0.61 gr/dl. The mean lymphocyte value was 17.84±9.68 %. The median comorbidity score was 2 with a minimum was 0 and the maximum was 4. The average length of stay for elderly patients was 7±3.84 days. There is a significant correlation between lymphocytes and LOS in elderly patients (r=-0,45;p=0,011). There is a significant correlation between comorbidities and LOS in elderly patients (r=0,368;p=0,042). There is no correlation between albumin and LOS of elderly patients (p>0.05) in the Internal Medicine Ward at Ulin Hospital Banjarmasin. Keywords: albumin levels, lymphocyte, comorbidity, length of stay, elderly Abstrak: Hipoalbuminemia umum ditemukan pada lansia. Seiring dengan peningkatan usia terjadi penurunan fungsi fisiologis termasuk pada sistem imunitas yang pada akhirnya menyebabkan limfopenia. Komorbiditas pun meningkat secara signifikan seiring bertambahnya usia. Penelitian ini bersifat observasional analitik dengan metode cross-sectional dan bertujuan untuk menganalisis korelasi albumin, limfosit, dan komorbiditas dengan lama rawat inap pasien lansia. Sampel penelitian sejumlah 31 lansia diperoleh menggunakan teknik total sampling sesuai kriteria inklusi dan eksklusi. Rerata kadar albumin 3,07 gr/dl±0,61. Rerata nilai limfosit 17,84%±9,68. Median skor komorbiditas didapatkan skor 2 dengan minimal 0 dan maksimal 4. Rerata lama rawat inap pasien lansia adalah 7±3,84 hari. Terdapat korelasi signifikan antara limfosit dan lama rawat pasien lansia (r=-0,45; p=0,011). Terdapat korelasi signifikan antara komorbiditas dan lama rawat pasien lansia (r=0,368; p=0,042). Tidak terdapat korelasi antara albumin dengan lama rawat pasien lansia (p>0,05) di Ruang Rawat Penyakit Dalam RSUD Ulin Banjarmasin. Kata-kata kunci: kadar albumin, limfosit, komorbiditas, lama rawat inap, lansia
Profil Hematologi pada Anak dengan Suspek Covid-19 di RSD Idaman Banjarbaru Tahun 2020 – 2021 Sarah Nur Azizah; Roselina Panghiyangani; Harapan Parlindungan Ringoringo; Edi Hartoyo; Rahmiati Rahmiati
Homeostasis Vol 5, No 2 (2022)
Publisher : Homeostasis

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Abstract: Corona virus disease (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). COVID-19 affects all age groups from neonates to the elderly. Haematological profile have been used as important diagnostic and prognostic indicators in COVID-19. The aim of this study is to determine the hematological parameters including erythrocytes, haemoglobin (Hb), hematocrit, Mantzer index (IM), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC), leukocytes (type count: basophils, eosinophils, band neutrophils, segments neutrophil, lymphocytes, monocytes), platelets, and Neutrofil Limphocytes Ratio (NLR) in children with suspected COVID 19 at Idaman Hospital Banjarbaru 2020-2021. This study is done using descriptive retrospective method of the suspected COVID-19 pediatric patients. The data used on this study is medical records of the pediatric patients with suspected COVID-19 at Idaman Hospital Banjarbaru 2020-2021. The results showed that children with suspected COVID-19 had normal values of the hematological parameters including RBC 69.81%, Hb 69.8%, hematocrit 73.5%, MCV 67.92%, MCH 58.49%, MCHC 84.90%, leukocytes 67.92%, basophils 98.11%, platelets 69.81% and RNL 66.03%. The decrease in value occurred in the eosinophil parameter as much as 62.26%, bands neutrophils 88.6% and segment neutrophils 45.28%. An increase in the value occurred in the hematological parameters of lymphocytes as much as 41.5%, monocytes 49.05%, and Mantzer index 92.47%. Keywords: children, COVID-19, haematology profile Abstrak: Corona virus disease (COVID-19) merupakan penyakit menular yang diakibatkan Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). COVID-19 menyerang semua kelompok usia dari neonatus hingga lanjut usia. Parameter hematologi penting dalam mendiagnosis COVID-19 dan menilai prognosis pasien. Tujuan dilaksanakannya penelitian ini untuk mengetahui profil hematologi, meliputi eritrosit, hemoglobin (Hb), hematocrit, Indeks Mantzer (IM), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC), leukosit (hitung jenis: basofil, eosinofil, neutrofil batang, neutrofil segmen, limfosit, monosit), trombosit, dan Rasio Neutrofil Limfosit (RNL) pada anak dengan suspek COVID-19 di RSD Idaman Banjarbaru 2020-2021. Rancangan penelitian ini menggunakan metode penelitian deskriptif retrospektif, menggunakan data rekam medis pasien anak dengan suspek COVID-19 di RSD Idaman Banjarbaru Tahun 2020-2021. Hasil penelitian menunjukkan bahwa anak dengan suspek COVID – 19 lebih banyak memiliki nilai normal pada parameter hematologi RBC sebanyak 69,81%, Hb 69,8%, hematokrit 73,5%, MCV 67,92%, MCH 58,49%, MCHC 84,90%, leukosit 67,92%, basofil 98,11%, trombosit 69,81% dan RNL 66,03%. Penurunan nilai terjadi pada parameter eosinofil sebanyak 62,26%, neutrofil batang 88,6% dan neutrofil segmen 45,28%. Peningkatan nilai terjadi pada parameter hematologi limfosit sebanyak 41,5%, dan monosit 49,05% dan Indeks Mantzer sebanyak 92,47%. Kata-kata kunci: anak, COVID-19, profil hematologi
Literature Review: Perbandingan Kekuatan Otot Pasien DM Tipe 2 dan Non-DM pada Lansia Asmah Aulia; Wiwit Agung Sri Nur Cahyawati; Roselina Panghiyangani
Homeostasis Vol 4, No 2 (2021)
Publisher : Homeostasis

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Abstract: Elderly is someone over 60 years of age who experiences a natural aging process characterized by decreased physical ability due to changes in the function of organs and body systems which results in various diseases, one of which is type 2 diabetes. Aging is related to a progressive decrease in skeletal muscle strength. The purpose of this review literature is to determine the differences in muscle strength in patients with type 2 diabetes and non-DM patients in the elderly by analyzing the related literature obtained from search results in medical journal databases, namely Pubmed-MEDLINE and Google Scholar. There are 20 articles included in English and published in 2004-2020. Decreased muscle strength in the elderly due to increased visceral fat and intramuscular fat while subcutaneous fat, the number and size of muscle fibers decreased. The decrease in muscle strength in DM is due to insulin resistance resulting in a decrease in protein synthesis and an increase in protein degradation. So it can be concluded that the elderly with type 2 DM have lower muscle strength than non-DM. Keywords: elderly, muscle strength, diabetes mellitus type 2, non DM, hand grip strength. Abstrak: Lansia adalah seseorang berusia diatas 60 tahun yang mengalami proses penuaan alami ditandai menurunnya kemampuan fisik akibat perubahan fungsi organ dan sistem tubuh yang berakibat pada berbagai penyakit salah satunya DM tipe 2. Penuaan berkaitan dengan menurunnya kekuatan otot rangka secara progresif. Tujuan literatur review ini untuk mengetahui perbedaan kekuatan otot pasien DM tipe 2 dan non DM pada lansia dengan menganalisis literatur terkait yang didapatkan dari hasil pencarian pada database jurnal kedokteran, yaitu Pubmed-MEDLINE dan Google Scholar. Artikel yang disertakan sebanyak 20 menggunakan bahasa inggris dan dipublikasikan pada tahun 2004-2020. Penurunan kekuatan otot pada lansia karena lemak visceral dan lemak intramuscular meningkat sedangkan lemak subkutan, jumlah dan ukuran serat otot menurun. Penurunan kekuatan otot pada DM disebabkan resistensi insulin  sehingga terjadi penurunan sintesis protein dan peningkatan degradasi protein. Sehingga dapat disimpulkan lansia dengan DM tipe 2 memiliki kekuatan otot yang lebih rendah dibandingkan non DM. Kata-kata kunci:  lansia, kekuatan otot, diabetes melitus tipe 2, non DM, hand grip strength.Abstract:Elderly is someone over 60 years of age who experiences a natural aging process characterized by decreased physical ability due to changes in the function of organs and body systems which results in various diseases, one of which is type 2 diabetes. Aging is related to a progressive decrease in skeletal muscle strength. The purpose of this review literature is to determine the differences in muscle strength in patients with type 2 diabetes and non-DM patients in the elderly by analyzing the related literature obtained from search results in medical journal databases, namely Pubmed-MEDLINE and Google Scholar. There are 20 articles included in English and published in 2004-2020. Decreased muscle strength in the elderly due to increased visceral fat and intramuscular fat while subcutaneous fat, the number and size of muscle fibers decreased. The decrease in muscle strength in DM is due to insulin resistance resulting in a decrease in protein synthesis and an increase in protein degradation. So it can be concluded that the elderly with type 2 DM have lower muscle strength than non-DM. Keywords: elderly, muscle strength, diabetes mellitus type 2, non DM, hand grip strength. Abstrak: Lansia adalah seseorang berusia diatas 60 tahun yang mengalami proses penuaan alami ditandai menurunnya kemampuan fisik akibat perubahan fungsi organ dan sistem tubuh yang berakibat pada berbagai penyakit salah satunya DM tipe 2. Penuaan berkaitan dengan menurunnya kekuatan otot rangka secara progresif. Tujuan literatur review ini untuk mengetahui perbedaan kekuatan otot pasien DM tipe 2 dan non DM pada lansia dengan menganalisis literatur terkait yang didapatkan dari hasil pencarian pada database jurnal kedokteran, yaitu Pubmed-MEDLINE dan Google Scholar. Artikel yang disertakan sebanyak 20 menggunakan bahasa inggris dan dipublikasikan pada tahun 2004-2020. Penurunan kekuatan otot pada lansia karena lemak visceral dan lemak intramuscular meningkat sedangkan lemak subkutan, jumlah dan ukuran serat otot menurun. Penurunan kekuatan otot pada DM disebabkan resistensi insulin  sehingga terjadi penurunan sintesis protein dan peningkatan degradasi protein. Sehingga dapat disimpulkan lansia dengan DM tipe 2 memiliki kekuatan otot yang lebih rendah dibandingkan non DM. Kata-kata kunci:  lansia, kekuatan otot, diabetes melitus tipe 2, non DM, hand grip strength.
Korelasi Rasio Neutrofil Limfosit dengan Lama Rawat Inap Diah Ayu Wikan Nastiti; Wiwit Agung Sri Nur Cahyawati; Roselina Panghiyangani
Homeostasis Vol 5, No 1 (2022)
Publisher : Homeostasis

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Abstrack: Systemic inflammation can be characterized by an increased NLR. Systemic inflammation induce physiological changes, vulnerability, and even death. Elderly often experience various health complaints that cause prolonged hospitalization. Increased NLR is clinical marker that can be a preventive measure to predict length of stay. This study aims to analize correlation of NLR and length of stay of elderly. An analytical observasional with cross-sectional method using secondary data from medical records at RSUD Ulin Banjarmasin period July-November 2021.  Total 44 samples using total sampling technique. Data analysis used non-parametric correlation Spearman. Median NLR 7.7 (1,3-73,3). Median length of stay 5.5 (1-16) days, average age of the elderly 66±4.65 years. There is a significant relationship between NLR and length of stay with a weak correlation and positive direction (r=0.392; p=0.008). The conclution is there is a relationship between NLR and length of stay of elderly in Internal Room at RSUD Ulin Banjarmasin. Keywords: elderly, neutrophil lymphocyte ratio, length of stay. Abstrak: Inflamasi sistemik dapat ditandai dengan peningkatan RNL Inflamasi sistemik mengakibatkan perubahan fisiologis tubuh, kerentanan, bahkan kematian. Lansia sering mengalami berbagai keluhan yang menyebabkan rawat inap memanjang. Peningkatan RNL merupakan penanda klinis yang dapat menjadi upaya preventif untuk memprediksi lama rawat. Penelitian ini bertujuan menganalisis korelasi RNL dengan lama rawat inap pasien lansia. Penelitian observasional analitik dengan metode cross-sectional menggunakan data sekunder rekam medik RSUD Ulin Banjarmasin periode Juli-November 2021. Sampel sejumlah 44 menggunakan teknik total sampling. Analisis data menggunakan uji korelasi non-parametrik Spearman. Median RNL 7,7 (1,3-73,3). Median lama rawat inap 5,5 (1-16) hari, rerata umur lansia 66±4,65 tahun. Terdapat hubungan bermakna antara RNL terhadap lama rawat inap berupa korelasi lemah serta arah hubungan positif (r=0,392; p=0.008). Kesimpulan terdapat hubungan antara RNL dengan lama rawat inap pasien lansia di Ruang Rawat Penyakit Dalam RSUD Ulin Banjarmasin. Kata-kata kunci: lansia, rasio neutrofil limfosit, lama rawat inap. 
Prevalensi Reaksi Transfusi Darah Penderita Talasemia Beta Mayor yang Bergantung Transfusi di RSD Idaman Banjarbaru Tahun 2020-2021 Tasya Radhia Salsabila; Harapan Parlindungan Ringoringo; Roselina Panghiyangani; Edi Hartoyo; Rahmiati Rahmiati
Homeostasis Vol 5, No 1 (2022)
Publisher : Homeostasis

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Abstract: Patients with beta thalassemia major require regular and routine blood transfusions throughout life to maintain hemoglobin levels in order to survive. Blood transfusion in patients with beta thalassemia major who depend on transfusion can cause side effects and unwanted transfusion reactions. Transfusion reactions range from mild to life-threatening. The purpose of this study was to obtain data on the prevalence of transfusion reactions in transfusion-dependent beta thalassemia patients at Idaman Hospital Banjarbaru in 2020-2021. This study is a descriptive study that was taken retrospectively using patient medical record data. The results showed that there were 131 data on blood transfusion reactions of patients with beta thalassemia major who were dependent on transfusion from a total of 1591 data on transfusion at Idaman Hospital Banjarbaru for the period October 2020 - September 2021 with a prevalence of 8.2%. Moderate-severe transfusion reactions were the most common type, with 90 blood transfusion reactions (68.7%). The five main symptoms of a blood transfusion reaction that occur are fever, chills, pruritus, angioedema, and urticaria. All transfusion reactions that occurred were acute transfusion reactions and used PRC blood components. Keywords: beta thalassemia major, transfusion dependent, blood transfusion, transfusion reactions, PRC (Packed Red Cells) Abstrak: Pasien talasemia beta mayor memerlukan transfusi darah secara teratur dan rutin sepanjang hidup untuk mempertahankan kadar hemoglobin guna bertahan hidup. Transfusi darah pada penderita talasemia beta mayor yang bergantung transfusi dapat menimbulkan efek samping dan reaksi transfusi yang tidak diinginkan. Reaksi transfusi tersebut dari ringan sampai mengancam jiwa. Tujuan penelitian ini adalah memperoleh data prevalensi reaksi transfusi penderita talasemia beta mayor yang bergantung transfusi di RSD Idaman Banjarbaru Tahun 2020-2021. Penelitian ini merupakan penelitian deskriptif yang diambil secara retrospektif menggunakan data rekam medis pasien. Hasil penelitian menunjukkan bahwa terdapat 131 data reaksi transfusi darah penderita talasemia beta mayor yang bergantung transfusi dari total 1591 data transfusi di RSD Idaman Banjarbaru periode Oktober 2020 – September 2021 dengan prevalensi sebesar 8,2%. Reaksi transfusi sedang-berat merupakan jenis yang paling banyak terjadi sebanyak 90 reaksi transfusi darah (68,7%). Lima gejala utama dari reaksi transfusi darah yang terjadi adalah demam, menggigil, pruritus, angioedema, dan urtikaria. Semua reaksi tranfusi yang terjadi adalah reaksi transfusi akut dan menggunakan jenis komponen darah PRC. Kata-kata kunci: talasemia beta mayor, bergantung transfusi, transfusi darah, reaksi transfusi, PRC (Packed Red Cells)
Profil Hematologi pada Bayi Baru Lahir dari Ibu Suspek Covid-19 di RSD Idaman Banjarbaru Tahun 2020-2021 Ellen Jovita Tjitradi; Harapan Parlindungan Ringoringo; Roselina Panghiyangani; Edi Hartoyo; Rahmiati Rahmiati
Homeostasis Vol 5, No 2 (2022)
Publisher : Homeostasis

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Abstract: Coronavirus Disease 2019 (COVID-19) is a disease caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and it is highly contagious. This study aims to determine the hematological profile which includes erythrocytes (RBC), RDW, Hb, hematocrit, MCV, MCH, MCHC, leukocytes (leukocyte differential Count: basophils, eosinophils, neutrophils, lymphocytes, monocytes), platelets, and NLR in newborns from mothers with suspected COVID-19 at the Idaman Hospital Banjarbaru 2020-2021. This research method is descriptive retrospective with data collection through patient medical records. The sampling technique is purposive sampling. In this study, a total sample of 83 neonates from pregnant women with suspected COVID-19 was obtained. However, from the 83 sample, the sample that has hematological profile data and meets the criteria is 69 sample. The results showed that 42 neonates (62,69%) with reactive IgM tests, and 51 neonates (76,12%) with nonreactive IgG tests. In the distribution of the hematological profile of newborns from mothers with suspected COVID-19, found an increase NLR in 33 neonates (47,83%), an increase hemoglobin in 8 neonates (11,59%), an increase hematocrit in 10 neonates (14,49%), an increase MCV in 8 neonates (11,59%), and decrease MCHC in 8 neonates (11,59%). Keywords: hematology profile, newborns, suspected COVID-19 Abstrak: Coronavirus Disease 2019 (COVID-19) adalah penyakit yang disebabkan oleh virus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) dan sangat menular. Penelitian ini bertujuan untuk mengetahui profil hematologi yang meliputi eritrosit (RBC), RDW, Hb, hematokrit, MCV, MCH, MCHC, leukosit (hitung jenis : basofil, eosinofil, neutrofil, limfosit, monosit), trombosit, dan NLR pada bayi baru lahir dari ibu suspek COVID-19 di RSD Idaman Banjarbaru Tahun 2020-2021. Metode penelitian ini adalah deskriptif retrospektif dengan pengambilan data melalui rekam medis pasien. Teknik pengambilan sampel adalah purposive sampling. Dalam penelitian ini didapatkan total sampel 83 neonatus dari ibu hamil dengan suspek COVID-19. Namun, dari 83 sampel tersebut, sampel yang memiliki data profil hematologi dan memenuhi kriteria berjumlah 69 sampel. Hasil penelitian menunjukkan pada pemeriksaan rapid test IgM neonatus ditemukan hasil reaktif sebanyak 42 neonatus (62,69%) dan rapid test IgG ditemukan hasil non reaktif sebanyak 51 neonatus (76,12%). Distribusi profil hematologi bayi baru lahir dari ibu suspek COVID-19 ditemukan peningkatan NLR sebanyak 33 neonatus (47,83%), peningkatan hemoglobin sebanyak 8 neonatus (11,59%), peningkatan hematokrit sebanyak 10 neonatus (14,49%), peningkatan MCV sebanyak 8 neonatus (11,59%), dan penurunan MCHC sebanyak 8 neonatus (11,59%). Kata-kata kunci: profil hematologi, bayi baru lahir, suspek COVID-19
Relationship between Nutritional Status, Frailty, and Cognitive Function among Elderly at Dr. H. Moch. Ansari Saleh General Hospital Banjarmasin Wiwit Agung Sri Nur Cahyawati; Roselina Panghiyangani; Muhammad Syauqi Abid Muslim; Novia Belinda Rahman
Jurnal Kedokteran Brawijaya Vol. 32 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.01.10

Abstract

The elderly often have nutritional problems. The risk of malnutrition can stimulate the prevalence of frailty and declining cognitive function in the elderly. The study aimed to analyze the relationship between nutritional status, frailty, and cognitive function in the elderly at Dr. H. Moch. Ansari Saleh Hospital Banjarmasin. This study was analytic observational using a cross-sectional method. A sample of 93 elderly was obtained using a total sampling technique according to the inclusion and exclusion criteria. The nutritional status assessment was done using the Mini Nutritional Assessment-Short Form (MNA-SF), the Edmonton Frailty Scale (EFS), and the Mini-Mental State Examination (MMSE). The results showed that the mean of Mini Nutritional Assessment score was 12.00±2.126, the average frailty score was 4.41±1.872, and the average value of cognitive function was 25.98±2.923. Data were analyzed using the Spearman's non-parametric correlation test with a 95% confidence level. The correlation test results between nutritional status and frailty obtained p=0.000 and r=-0.490. The correlation test results between nutritional status and cognitive function obtained p=0.000 and r=0.595. In short, there is a relationship between nutritional status on frailty and cognitive function in the elderly at Dr. H. Moch. Ansari Saleh General Hospital Banjarmasin, it means that the good nutritional status in the elderly, the risk of frailty syndrome will decrease and improve cognitive function.
HUBUNGAN NILAI MINI NUTRITIONAL ASSESSMENT (MNA) DENGAN LAMA RAWAT INAP Siti Hafizhah Fatimah; Wiwit Agung Sri Nur Cahyawati; Roselina Panghiyangani
Homeostasis Vol 5, No 3 (2022)
Publisher : Homeostasis

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Abstract

Mini Nutritional Assessment (MNA) is an instrument for assessing and screening specific nutritional in the elderly. Elderly are vulnerable to malnutrition because of physiological and functional changes that contribute to increase length of stay. The purpose of this study was to determine the correlation between Mini Nutritional Assessment value with length of stay of elderly patients at RSUD Ulin Banjarmasin. This research is analytic observational with cross-sectional method. A sample of 32 elderly patients was analysis used Spearman correlation test. The  median MNA value was 20.00 points and the median length of stay was 8.00 days. The results of the correlation test showed that the value of p = 0.002 and value of r = -0.532 which means there is a significant correlation and a strong correlation with a negative direction. It can be concluded that there is a correlation between the Mini Nutritional Assessment (MNA) value with length of stay of elderly patients in internal medicine ward at RSUD Ulin Banjarmasin.
Molecular Docking of Citrus amblycarpa Active Compounds against FTO, Leptin, and Resistin Protein Roselina Panghiyangani; Juliyatin Putri Utami; Muhammad Akbar Baitullah; Novi Dwi Maulida
Molecular and Cellular Biomedical Sciences Vol 7, No 1 (2023)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v7i1.295

Abstract

Background: Citrus amblycarpa has been known to have various pharmacological activities, such as antioxidants, anticancer, antitumor, hepatoprotective, anti-inflammatory, antidiabetic, antiviral, antibacterial, and antifungal. Hesperidin, naringin, quercetin, rutin, gamma (γ)-aminobutyric acid (GABA), neoeriocitrin, and poncirin from C. amblycarpa were the major constituents that potentially act on some obesity proteins, such as fat mass and obesity-associated (FTO) protein, leptin, and resistin, the emerging targets in the treatment of obesity. This study aimed to investigate the interaction between major active compounds of C. amblycarpa with FTO, leptin and resistin.Materials and methods: The ligands of the docking study were seven major chemical compounds found in peel of C. amblycarpa, i.e., hesperidin, naringin, quercetin, rutin, GABA, neoeriocitrin, and poncirin. FTO, leptin and resistin structure were taken from Protein Data Bank, while the C. amblycarpa compounds were prepared using Open Babel integrated into PyRx 8.0. Molecular docking simulation was performed using Autodock Vina integrated into PyRx 8.0. Virtual prediction and visualization of protein–ligand complexes were analyzed and visualized using Discovery Studio.Results: All major compounds of C. amblycarpa peel used in this study did not have hepatotoxicity and AMES toxicity. Hesperidin had the lowest binding affinity score when interacted with FTO, leptin and resistin compared to other compounds. Moreover, GABA had the highest binding affinity score compared to other compounds.Conclusion: Hesperidin may be a candidate obesity protein antagonist and may have potential as a treatment for obesity.Keywords: Citrus amblycarpa, molecular docking, FTO, leptin, obesity, resistin
Co-Authors . Mashuri Achyar Nawi Husein Ahmad Husairi Aisy Samara Istiqomah Ajeng Dwi Novitasari Annisa Annisa Ari Yunanto Arifin Syamsul Asmah Aulia Asnawati Asnawati Atni Primanadini Budi Wiweko Dede Marizal Sesar Dewi Indah Noviana Pratiwi Diah Ayu Wikan Nastiti Diah Mutia Rahmawati Didik Dwi Sanyoto Dodo T. Suarnella Dona Marisa, Dona Dwi Anita Suryandari Edi Hartoyo Eka Yudha Rahman Eka Yudha Rahman Eka Yudha Rahman Ellen Jovita Tjitradi Fakhrurrazy Fakhrurrazy Fauzi Rahman Ferry Armanza Harapan Parlindungan Ringoringo Harapan Parlindungan Ringoringo Hasrul Nazar Hendra Sutapa Husaini Husaini Intan Nur ‘Ain Intan Zorena Rezky Isnaini Isnaini Iwan Aflanie Juliyatin Putri Utami Khatimah, Husnul Kurniati, Mala Lena Rosida Lena Rosida Lena Rosida Leni Marlinae Lisda Hayati Lisda Hayatie, Lisda Luluk Yunaini Mala Kurniati Meitria Syahadatina Noor Muhammad Akbar Baitullah Muhammad Syauqi Abid Muslim Nia Kania Nia Kania Nika Sterina Skripsiana Nila Nirmalasari Noor Ahda Noor Samirah Herviana Novi Dwi Maulida Novia Belinda Rahman Nurfadilah Nurfadilah NURUL HIDAYAH Pudji Andayani Pudji Sari Rahmiati Rahmiati Rahmiati Rahmiati Rahmiati Rahmimi Azmi Rosihan Adhani, Rosihan Rudi Fakhriadi Rusida, Esty Restiana Rusmiyati Rusmiyati Sarah Nur Azizah Sesar, Dede Marizal Sherly Limantara Sherly Limantara Siti Hafizhah Fatimah Siti Nurhayani Syarifah Kholishotunnisa Talia Zulfa Najmia Tasya Radhia Salsabila Triawanti Triawanti Utami, Juliyatin Putri Vinni Fioleta Angi Winda Wati Wiwit Agung Sri Nur Cahyawati