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All Journal HAYATI Journal of Biosciences ILMU KELAUTAN: Indonesian Journal of Marine Sciences International Journal of Integrated Health Sciences Althea Medical Journal Indonesian Journal of Urology Indonesian Journal of Cancer Chemoprevention Molecular and Cellular Biomedical Sciences (MCBS) JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Jurnal Pengabdian Pada Masyarakat Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Hydrogen: Jurnal Kependidikan Kimia JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Bashari, Muhammad Hasan
Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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Journal : Althea Medical Journal

 1 
Anti-migration Effect of Aaptos suberitoides Fraction in HCT-116 Colorectal Cancer Cell Line Dany Muhammad Daffa; Muhammad Hasan Bashari; Eko Fuji Ariyanto; Tenny Putri; Nurul Qomarilla
Althea Medical Journal Vol 8, No 1 (2021)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v8n1.2231

Abstract

Background: Colorectal cancer is the second leading cause of mortality and the most prevalent cancer worldwide. Most patients, who come with late-stage, have ineffective treatments and some side effects in chemotherapy. Aaptos suberitoides has potential anti-cancer effects due to its bioactive compounds such as aptamine. This study aimed to evaluate the migration inhibition effect of Aaptos suberitoides fraction in HCT-116 cell line.Methods: This study was an experimental study. Aaptos suberitoides specimen was taken in Tinjil Island and fractionated with ethyl acetate. HCT-116 cell line was added with Aaptos suberitoides fraction and cellular migration activity was observed in 48 hours of which the scratch assay was performed. The gap closure area was determined with ImageJ software.Results: The data showed that a low concentration of Aaptos suberitoides fraction inhibited migration activity in HCT-116 cell line as follow; 1 and 5 mg/L Aaptos suberitoides fraction inhibit 3-4 % cancer cell migration in 24 hours, and 10-11% inhibition in 48 hours, respectively. However, 10 mg/L fraction concentration only inhibited 7-14% of the migration effect.Conclusion: Aaptos suberitoides fraction suggests insignificant migration inhibition in colorectal cancer cells and only inhibits less than 15 % HCT-116 cell line.
Snakebites and the Effect of Serum Anti Bisa Ular (SABU) Antivenom at Dr. Hasan Sadikin General Hospital Bandung, Indonesia: an Overview Period 2015–2019 Sharon Noor Alya; Enny Rohmawaty; Achadiyani Achadiyani; Muhammad Hasan Bashari; Hardisiswo Soedjana
Althea Medical Journal Vol 9, No 1 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v9n1.2392

Abstract

Background: Snakebite is considered a global health issue, especially in the Southeast Asian region. However, data regarding snakebite cases in Indonesia are still very limited. This study aimed to explore the venomous snakebite cases and the serum anti bisa ular (SABU) antivenom effect in treating venomous snakebite caused by other than the snake species indicated in currently available SABU antivenom formulas.Methods: The analytical descriptive method with a cross-sectional study design was conducted in 2021 using a total sampling from the medical records of 63 patients diagnosed with snakebite at Dr. Hasan Sadikin General Hospital Bandung from 2015 to 2019. Characteristics of patients, clinical manifestation, and correlation between snakes species and outcomes after treatment with or without administration of SABU antivenom were collected.Results: Out of 63 patients, males (79%) were predominant with an average age of 39 years. Fifty-six patients arrived at the Emergency Room less than 24 hours after the occurrence (89%). Most cases were categorized as grade 2 (41.%) where the upper extremities were commonly bitten the body area (64%). Edema (83%) was the most common manifestation. There was no correlation between snake antivenom administered to a specific snake species and the stated outcome (p=0.053), meaning that SABU antivenom might be an effective alternative to treat more types of snakebites.Conclusions: Snakebites are most common in males, attack the upper extremities, categorized as grade 2 with edema. Administration of SABU antivenom provides the similar outcome compared to the group caused by the Javan spitting cobra, Banded krait, and Malayan pit viper.
Curcuma longa L. Prevents Hepatotoxicity Induced Isoniazid and Rifampicin: An Experiment in Wistar Rats Model Rahman, Putri Halleyana; Dwiwina, Resti Gradia; Pratiwi, Yuni Susanti; Bashari, Muhammad Hasan
Althea Medical Journal Vol 11, No 2 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n2.3161

Abstract

Background: Hepatotoxicity induced by the combination of isoniazid (INH) and rifampicin (RIF) in the treatment of tuberculosis (TB) remains a major concern. Oxidative stress has a role in mechanism of hepatotoxicity. Curcuma longa L. has been widely used as a traditional medicine and has shown antioxidant activity. This study aimed to provide evidence of Curcuma longa L as protection against oxidative stress induced by isoniazid and rifampicin therapy.Methods: This was an experimental study on male Wistar rats weighing 150-200 grams, aged 8-10 weeks which were divided into a negative control group (K0), a positive control group with INH + RIF (K1), a treatment group with a dose of 2.2 gr/kg/day Curcuma longa L powder (K2), and treatment group with INH+RIF and additional 2.2 gr/kg/day turmeric rhizome powder (K2+). SGOT and SGPT were measured from blood plasma on the 28th day; then hepatic tissue was obtained to measure MDA levels and observed histologically. Statistical analysis was done using ANOVA and continued with Duncan procedure using SPSS ver. 27.Results: SGOT, SGPT, the highest average MDA level in the liver, and the highest mean necrotic cell count in the positive control group showed a significant difference (p<0.05). The treatment group had a smaller average number of necrotic cells than the positive control group with a significant difference (p <0.05).Conclusion: Curcuma longa L powder has been shown to prevent elevation in SGOT, SGPT, MDA of liver tissue and hepatocyte necrosis, indicating its potential in protecting the liver from oxidative stress.
Rationality of Empirical Antibiotic Usage among Digestive Surgery Inpatients at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia: Gyssens Criteria Analysis Yunivita, Vycke; Assyifa, Nanda; Yarman, Indra Prasetya; Bashari, Muhammad Hasan; Satriasih, Tulus
Althea Medical Journal Vol 11, No 3 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n3.3299

Abstract

Background: Many empirical antibiotics are prescribed unnecessarily, contributing to the rise in the incidence of antibiotic resistance. Preventing infection of surgical sites is one of the most frequent purposes of empirical antibiotic usage. Therefore, this study aimed to analyze the rationality of empirical antibiotic usage among digestive surgery inpatients based on the Gyssens criteria and clinical features outcomes.Methods: A descriptive method was used with a cross-sectional design. Data was collected from medical records of patients underwent digestive surgery and had received empirical antibiotic therapy post-surgery from July to September 2021 at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Subsequently, the data was analyzed using the Gyssens method to qualitatively assess the rationality of antibiotic use based on specific criteria, classified from rational (category 0) to various levels of irrational use (categories I-VI). Clinical outcomes were evaluated by assessing leukocyte count, clinical symptoms of fever, and the appearance of surgical site infection before and after administration of empirical antibiotics.Results: In total, 70 empirical antibiotic prescriptions were obtained from 42 patients, with only 40% of patients using rational antibiotics, whereas 60% of antibiotics were used inappropriately (category I-VI). Clinical evaluation showed no fever, edema, or erythema and reduced leukocytosis and exudate/pus post-therapy.Conclusions: Inappropriate empirical antibiotic prescription for digestive surgery inpatients at Dr. Hasan Sadikin General Hospital based on the Gyssens criteria is high. Nonetheless, clinical outcomes showed improvements in infection-related parameters. These results emphasize the importance of stricter adherence to antibiotic stewardship and regular evaluation of empirical antibiotic practices to optimize usage and patient outcomes.
Co-Authors Achadiyani Ahmad Agil Aisyah, Siti Zanuba Anglita Yantisetiasti Anjani, Gebby Reviana Annisa Dewi Nugrahani Apriliani, Ardhia Rizki Arima Kurnia Sari Dewi Nurcahyani Assyifa, Nanda Astrid Feinisa Khairani Atika Hana Ilyasa Ayu, Inna Puspa Beginer Subhan Damara, Fachreza Aryo Dany Muhammad Daffa Defi Ardia Pramesti Dika Widia Nur Azizah Dikdik Kurnia Dimas Erlangga Luftimas Dimas Erlangga Luftimas Dondy Arafat Dwi Andini Efahmi, Efahmi Eggy Raynaldi Rachman Nurhadi Eko Fuji Ariyanto Elfahmi Elfahmi, Elfahmi Enny Rohmawaty Erick Khristian Fachreza Aryo Damara Fadla Khairatu Ismi Gaga Irawan Nugraha Gita Tiara Dewi Nasution Gita Widya Pradini Hardani, Isna Nisrina Hardisiswo Soedjana Hermin Aminah Usman Huda, Fathul Isna Nisrina Hardani Julia Nur Jannah Julia Ramadhanti Kamilah, Mutiara Mila Khafifah, Dinda Salsa Labibah, Salma Nur Lala Yuliani Laraswita, Sarah Lia Faridah Mai Efdi Masyerli, Scify Bilqis Nawafi Meinarni, Retno Mohammad Ghozali Mohammad Ghozali Nadiah, Zahra Nadifah Diana Zalia Naura Mardhiyah Nazir, Arnengsih Nebuchadnezzar Akbar NEVIATY PUTRI ZAMANI Ni Kadek Dita Cahyani, Ni Kadek Dita Novi Vicahyani Utami Novriyandi Hanif Nugraha, Marwan Agung Nur Ramadani Meliani Syukri Nurhasanah Nurhasanah Nurul Qomarilla Pandji Irani Fianza Putri Halleyana Putri Halleyana Rahman Putri, Salsabila S S Putri, Tenny Qomarilla, Nurul Rahman, Putri Halleyana Rahman, Putri Halleyana A Ramadhanti, Julia Ramdhani, Muhammad Farid Rani Septriana Rani Septrina Ratu Safitri Resti Gradia Dwiwina Rika Mustika Rindra Rizqyahya Retossa Risqi Dwi Putra Sahiratmadja, Edhyana Kusumastuti Sani, Lalu M. Iqbal Satari, Mieke Hermiawati Satriasih, Tulus Savira Ekawardhani Sharon Noor Alya Syafrizayanti, Syafrizayanti Tenny Putri Tenny Putri Titing Nurhayati Trully Deti Rose Sitorus Truly Deti Rose Sitorus Untung Kurnia Agung, Mochamad Utami, Kharima Dwi Wijaya, Indra Yarman, Indra Prasetya Yosie Andriani Yuliarni, Dinda Yuni Susanti Pratiwi Yuni Susanti Pratiwi, Yuni Susanti Yuniarti, Eveline Yunivita, Vycke