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All Journal Medula Jurnal Kreativitas PKM Jurnal Ilmu Kedokteran dan Kesehatan JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Pengabdian Kepada Masyarakat (JPKM) Tabikpun Buguh: Jurnal Pengabdian Kepada Masyarakat Jurnal Kedokteran Ibnu Nafis JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Risti Graharti
Bagian Ilmu Patologi Klinik, Fakultas Kedokteran Universitas Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Update on Hypertension Guidelines: A Literature Review Andika, Gede Agus; Graharti, Risti
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1682

Abstract

Hypertension is one of the major worldwide health problems, with its prevalence continuing to increase year by year. This condition is known as the “silent killer” because it often does not cause specific symptoms, but is closely related to increased morbidity and mortality due to cardiovascular and non-cardiovascular complications. Various epidemiological studies show that hypertension contributes to high rates of coronary heart disease, stroke, kidney failure, and premature death. Recent literature also confirms that risk factors for hypertension include unhealthy lifestyles, high-salt diets, obesity, stress, and genetic predisposition. The diagnosis of hypertension requires accurate blood pressure measurement using standard protocols, either through examinations at healthcare facilities or self-monitoring at home. Various international guidelines, such as ACC/AHA, ESC/ESH, and national guidelines such as PERKI, emphasize the importance of early detection and blood pressure control with specific targets. Hypertension management strategies include non-pharmacological approach such as lifestyle modifications, as well as pharmacological approach using evidence-based antihypertension medications, such as diuretics, ACE inhibitors, ARBs, CCBs, and beta blockers. This literature concludes that hypertension management must be comprehensive, integrated, and sustained to prevent complications. These efforts does not only depend on medical interventions, but also involve patient education, routine monitoring, and health system support to reduce the burden of hypertension in the future.
Hubungan Daerah Tempat Tinggal dengan Kejadian Dermatitis Atopik Izdihar, Adinda Fairuz; Sibero, Hendra Tarigan; Graharti, Risti; Carolia, Novita
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1311

Abstract

Atopic dermatitis is a frequently occurring skin inflammation characterized by pruritus and lesions in specific areas such as the face and extremities. The majority of cases manifest during the first year of life, with a high prevalence among children under five years of age. In Europe, 118 million cases were recorded in 2023, whereas in Indonesia, the prevalence reached 10-20% among children and 1-3% among adults. This condition involves an interplay of exogenous and endogenous factors, including environmental exposure, genetic predisposition, immunological mechanisms, and colonization by Staphylococcus aureus. Environmental factors contributing to the incidence of atopic dermatitis include exposure to pollutants such as carbon monoxide, nitrogen dioxide, PM2.5, PM10, and volatile organic compounds (formaldehyde). Such exposure is a significant risk factor for atopic dermatitis in urban areas. This study aimed to analyze the correlation between residential areas and the incidence of atopic dermatitis at RSUD Dr. H. Abdul Moeloek during the period of January 2022 to July 2024. Data were collected from medical records, encompassing a total sample size of 82 patients. The chi-square test revealed a statistically significant relationship between residential area and the occurrence of atopic dermatitis, with individuals residing in urban areas being 0.23 times more likely to develop atopic dermatitis compared to those living in non-urban areas (p=0.02; OR=0.23)
Challenges and Strategies in Dealing Children with Autism Spectrum Disorder: A Literature Review Nisa, Lutfi Khoirun; Perdani, Roro Rukmi Windi; Graharti, Risti; Wardhani, Dyah Wulan Sumekar Rengganis; Fiana, Dewi Nur; Rahmayani, Fidha
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1356

Abstract

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder that affects children permanently. The exact cause of GSA is not yet known and affects more men than women with a ratio of 4:1. This autism disorder in children appears from birth or a few months after birth, but is often diagnosed when the child is less than 3 years old. Confirmation of GSA diagnosis can use two screening tools, namely DSM-5 and M-CHAT. The management that can be given to children with GSA can be pharmacological and non-pharmacological treatment. According to the World Health Organization (WHO) in 2022, 1 in 100 children in the world is diagnosed with autism. Children with GSA have many disorders that can affect their daily activities, both verbally and non-verbally. The main symptoms that are often encountered in children with GSA are difficulties in social interaction, problems in communication, including difficulty learning language or abnormalities in speech, and a tendency to be obsessive about maintaining a consistent daily routine and environment. The prognosis of GSA depends on the severity of each individual and the accompanying disease. This of course makes parents who have children with GSA will be faced with specific challenges in raising their children because children with GSA have different characteristics. Effective strategies that can be carried out to improve disorders in GSA children include the use of visual aids, the creation of a structured daily schedule, good interpersonal communication, the application of the Applied Behavior Analysis (ABA) method, integrated sensory therapy, occupational therapy, and play therapy. In addition, to overcome the stress experienced by parents of children with GSA, especially in mothers, it can be done by providing parenting education through psychoeducation.
Tekanan Darah Pada Atlet Al Ghifari, Ghaza Ahmad; Berawi, Khairun Nisa; Graharti, Risti; Kurniati, Intanri
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1398

Abstract

Blood pressure in athletes is an important topic in exercise physiology studies, given its influence on performance and long-term health. In general, athletes exhibit lower blood pressure at rest compared to sedentary individuals, as a result of the body's adaptation to regular physical exercise. The purpose of this method is to analyze and collate knowledge relevant to the research topic. In this study, 12 articles from national and international journals published between 2015 and 2023 were used. The articles were obtained from databases such as PubMed and Google Scholar. The collected sources were then analyzed using the systematic literature review method. The result of this study is that blood pressure in athletes can be different compared to individuals who are not involved in intense physical activity, due to the body's adaptation to regular exercise. Blood pressure in athletes is influenced by a variety of factors, including sport type, training pattern, age, gender, as well as genetic and environmental factors. Understanding these blood pressure patterns is important for optimizing performance and maintaining cardiovascular health in athletes.
Gambaran Tingkat Stres Kerja Perawat Di Ruang IGD, ICU, Dan NICU RSUD Dr. H. Abdul Moeloek Bandar Lampung Maulida, Syakira Zahra; Mayasari, Diana; Graharti, Risti; Sutarto, Sutarto
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1407

Abstract

Job stress is one of the factors that can lead to decreased performance. Occupations with the highest prevalence of work stress are owned by health workers. Nurses are more prone to stress than other health workers because nurses often have heavier workloads. The impact of stress that arises in the form of physiological, psychological and behavioral responses. the most influential factors causing nurses' work stress are individual and work factors. In addition, nurses in the emergency room and intensive care of hospitals are considered to have higher levels of job stress than other units. The purpose of this study was to determine the description of the level of work stress of emergency room, ICU, and NICU nurses at Dr. H. Abdul Moeloek Hospital Bandar Lampung. The type of research used is descriptive quantitative using primary data in the form of Perceived Stress Scale questionnaire. Sampling using proportional sampling technique with a total sample of 75 people consisting of 26 emergency room nurses, 26 ICU nurses, and 23 NICU nurses and the data will be analyzed univariately and then presented in tabular form. Based on the results of the study, 19 nurses (25.3%) were at a mild stress level and 56 nurses (74.7%) were at a moderate stress level. Levels of job stress that are too low or too high can lead to decreased job satisfaction and achievement so that it is necessary.
Cystatin C sebagai Biomarker Fungsi Ginjal: Literature Review Pestalozi, George; Akbar, Fareel Wahyu; Ramadhian, Muhammad Ricky; Graharti, Risti; Lisiswanti, Rika
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1410

Abstract

Kidneys are the primary organs responsible for the excretion of metabolic waste products. Glomerular Filtration Rate (GFR) serves as a critical parameter for assessing renal function, with serum creatinine traditionally utilized as the primary biomarker. However, the accuracy of creatinine-based assessments is limited by its susceptibility to external variables, including age, sex, muscle mass, and dietary intake. These factors can lead to variability in results and reduce diagnostic precision. To overcome these limitations, cystatin C (CysC) has gained prominence as a superior alternative biomarker. Unlike creatinine, serum CysC levels are minimally influenced by external factors, offering greater stability and sensitivity in detecting acute kidney injury (AKI), chronic kidney disease (CKD), and other renal impairments such as diabetic nephropathy. Cystatin C provides notable advantages in the reclassification of CKD stages, particularly in cases where GFR measurements are borderline. CysC has demonstrated superior reliability over creatinine in predicting complications such as delayed graft function (DGF), a condition often necessitating hemodialysis. Preoperative measurement of CysC levels is instrumental in predicting long-term renal function and identifying patients at elevated risk for adverse outcomes. Elevated serum CysC concentrations in patients with renal cell carcinoma (RCC) have been correlated with poorer prognoses and an increased likelihood of postoperative renal injury. Despite its clinical advantages, the routine adoption of CysC is constrained by certain limitations. Chief among these is the significantly higher cost of CysC assays compared to traditional creatinine tests, which restricts its widespread application to confirmatory diagnostics or complex clinical scenarios.
Relationship Between Work Duration and Work Experience with the Occurrence of Low Back Pain in Online Motorcycle Drivers Farhah, Putri Dzahabiyyah; Setiorini, Anggi; Graharti, Risti; Saftarina, Fitria
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1429

Abstract

Low Back Pain (LBP) is one of the most prevalent musculoskeletal disorders globally and a leading cause of disability. One of the occupational groups at high risk of LBP is online motorcycle taxi drivers, who spend long hours in a static sitting position while riding. The primary factors contributing to LBP among online motorcycle taxi drivers include long working hours and extended work tenure. This study aims to analyze the relationship between working duration and work tenure with the occurrence of LBP among online motorcycle taxi drivers. Based on various studies, it has been found that working more than 8 hours per day can increase the risk of LBP by up to 3.6 times due to excessive muscle strain and spinal load. Additionally, work tenure exceeding 5 years is associated with a higher risk of LBP due to accumulated physical stress, which can reduce muscle performance and deteriorate overall physical condition. Studies conducted in various cities, such as Makassar, Surabaya, and Padang, have demonstrated a significant relationship between working duration, work tenure, and the incidence of LBP among online motorcycle taxi drivers. Implementing proper work time management and ensuring sufficient rest breaks during riding are crucial steps in reducing the risk of LBP among online motorcycle taxi drivers. Additionally, attention to ergonomic factors in riding posture is essential to minimize the negative impact on musculoskeletal health.
Case Report: Tonsilitis Kronik Pada Anak Usia 12 Tahun Retno Mareintika; Graharti, Risti; Hayati, Rina
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1670

Abstract

Chronic tonsillitis is one of the most common upper respiratory tract infections in children. This condition is characterized by recurrent inflammation of the tonsils, which can interfere with daily activities, reduce appetite, impair sleep quality, and increase the risk of severe complications such as peritonsillar abscess, parapharyngeal abscess, or sepsis. Appropriate management is essential to prevent recurrence and further complications.This case report describes a 12-year-old female patient who presented with complaints of odynophagia, a foreign body sensation in the throat, halitosis, recurrent fever, and snoring during sleep. Physical examination revealed T3–T3 tonsils with enlarged crypts and the presence of detritus, leading to a diagnosis of chronic tonsillitis or recurrent acute tonsillitis. Initial management included amoxicillin 500 mg three times daily for 10 days, paracetamol 10–15 mg/kgBW as needed for fever, and an antiseptic mouthwash. The patient and her family were also educated on medication adherence, maintaining oral hygiene, and avoiding triggering foods such as spicy meals, cold drinks, and unhygienic snacks.Conservative therapy provided temporary symptomatic improvement; however, considering the recurrent episodes and sleep disturbances, the patient was advised to undergo tonsillectomy as definitive therapy. This case emphasizes that chronic tonsillitis in children requires accurate diagnosis, comprehensive management, and timely intervention. Conservative treatment may alleviate symptoms, but tonsillectomy plays a pivotal role in preventing recurrence, reducing the risk of complications, and improving the patient’s quality of life.
Pengaruh Pemberian Ekstrak Etanol Daun Pucuk Merah (Syzygium myrtifolium Walp) Terhadap Gambaran Sel Hepatosit Tikus Putih Jantan Galur Sprague-Dawley Ruslani, Nada Oktista; Susianti, Susianti; Graharti, Risti; Rudianto, Waluyo
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1693

Abstract

Syzygium myrtifolium Walp., commonly known as red shoot leaves, is an ornamental plant rich in bioactive compounds such as flavonoids, tannins, and terpenoids, which exhibit antioxidant, anticancer, and antibacterial properties. However, administration at high doses may lead to hepatotoxic effects. The liver plays a central role in drug metabolism and is the first organ exposed to toxic agents, making it highly susceptible to hepatocyte necrosis. This study aimed to evaluate the effect of ethanol extract of Syzygium myrtifolium leaves on liver histopathology in male white rats (Rattus norvegicus). This experimental study employed a post-test only control group design with three groups: control, 2000 mg/kgBW, and 5000 mg/kgBW. The extract was administered orally, and hepatocyte necrosis was assessed using a histopathological scoring system. Statistical analysis included Shapiro-Wilk, Levene’s Test, One Way ANOVA, and post hoc LSD. Histopathological examination revealed normal hepatocytes in the control group, focal necrosis in the 2000 mg/kgBW group, and extensive necrosis in the 5000 mg/kgBW group. Statistical analysis confirmed normally distributed and homogeneous data, while ANOVA indicated significant differences among groups (p=0.001). Post hoc LSD test further demonstrated significant differences between the control and treatment groups as well as between both treatment doses. In conclusion, oral administration of ethanol extract of Syzygium myrtifolium leaves induces hepatocyte necrosis in male white rats, with the severity of liver damage increasing in a dose-dependent manner.
Deteksi Dini Ulkus Kornea yang Mengancam Penglihatan dan Menurunkan Kualitas Hidup Masyarakat Pekon Kedaung Pringsewu Adjeng, Andi Nafisah Tendri; Himayani, Rani; Graharti, Risti; Adrifianie, Femmy; Oktoba, Zulpakor
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 7, No 8 (2024): Volume 7 No 8 (2024)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v7i8.12529

Abstract

ABSTRAK Ulkus kornea memiliki dampak serius pada kualitas hidup, termasuk gangguan penglihatan, nyeri, sensitivitas cahaya, dan dampak sosial. Pengobatan dan manajemen yang tepat penting untuk mengurangi dampak negatif. Edukasi dan sosialisasi tentang ulkus kornea memiliki manfaat besar dalam mencegah komplikasi serius dengan meningkatkan pemahaman risiko terkait mata, serta mendukung kesadaran masyarakat dan deteksi dini ulkus kornea. Selain itu, dapat mengurangi biaya perawatan jangka panjang akibat komplikasi. Pengabdian masyarakat terhadap edukasi ini memiliki dampak positif yang luas, tidak hanya pada individu yang terkena dampaknya, tetapi juga pada masyarakat secara keseluruhan. Dengan meningkatkan pemahaman dan kesadaran tentang kondisi ini, insiden ulkus kornea dapat dikurangi, dan kualitas hidup dapat ditingkatkan. Metode yang digunakan dalam program ini melibatkan edukasi melalui ceramah, Penggunaan kuesioner dan keterlibatan profesional adalah metode yang digunakan secara komprehensif untuk memastikan pesan tentang ulkus kornea disampaikan dengan efektif. Sebelum sesi edukasi dimulai, peserta diminta mengisi kuesioner awal (Pre-Test) untuk mengukur tingkat pengetahuan awal mereka tentang ulkus kornea. Setelah edukasi selesai, peserta diminta untuk mengisi kuesioner kedua (Post-Test) yang identik dengan yang pertama. Hal ini membantu tim pengabdian mengevaluasi sejauh mana pengetahuan peserta telah meningkat setelah menerima edukasi. Hasil: Hasil pre-test menunjukkan pemahaman peserta terbatas tentang kornea dan ulkus kornea. Hasil post-test menunjukkan peningkatan signifikan tentang tindakan yang perlu dilakukan dalam menghadapi ulkus kornea, menghindari tindakan yang salah, memahami bahaya dan penyebabnya, serta mengenali ciri-cirinya. Perbedaan signifikan antara pre-test dan post-test, menegaskan bahwa pendekatan edukasi berdampak besar pada pengetahuan masyarakat Pekon Kedaung Pringsewu tentang ulkus kornea. Kata Kunci: Ulkus Kornea, Edukasi dan Sosialisasi, Pengabdian Masyarakat, Pekon Kedaung Pringsewu  ABSTRACT Corneal ulcers significantly impact the quality of life, including visual disturbances, pain, light sensitivity, and social consequences. Proper treatment and management are essential to reduce the negative effects. Education and socialization about corneal ulcers have significant benefits in preventing serious complications by increasing understanding of eye-related risks and supporting public awareness and early detection of corneal ulcers. Additionally, it can reduce long-term treatment costs due to complications. Community engagement in this education has a broad positive impact on affected individuals and the community as a whole. Enhancing understanding and awareness of this condition can reduce the incidence of corneal ulcers, improving overall quality of life. The methods used in this program involve educational lectures, the use of questionnaires, and professional involvement, all comprehensively used to ensure the effective dissemination of information about corneal ulcers. Before the educational sessions commence, participants are required to complete an initial questionnaire (Pre-Test) to assess their baseline knowledge of corneal ulcers. After the education is completed, participants are asked to complete a second questionnaire (Post-Test) identical to the first one. This helps the outreach team evaluate the extent to which participants' knowledge has improved after receiving the education. The pre-test results indicate limited understanding among participants regarding the cornea and corneal ulcers. The post-test results show a significant improvement in understanding what actions to take when dealing with corneal ulcers, avoiding incorrect actions, understanding their dangers and causes, and recognizing their characteristics. The significant difference between the pre-test and post-test, confirms that the educational approach has a substantial impact on the knowledge of the community in Pekon Kedaung Pringsewu regarding corneal ulcers. Keywords: Corneal Ulcers, Education and Socialization, Community Engagement, Pre-Test, Post-Test, Community Knowledge, Pekon Kedaung Pringsewu
Co-Authors Ade Yonata, Ade Adrifianie, Femmy Agatha Catherine Agustyas Tjiptaningrum Airlangga Damara Akbar, Fareel Wahyu Al Ghifari, Ghaza Ahmad Andika, Gede Agus Angga Wijaya, Angga Annisa Fath Ari Wahyuni Arif Yudho Prabowo Arnida Rahman Asep Sukohar Aulia Berliana Avisa Jinan Azura Ayu, Putu Ristyaning Bayu Anggileo Pramesona Benny Syahputra Gumay betta kurniawan Betta Kurniawan, Betta Boy K.H, High Devya Aulia Dewi Nur Fiana Diaru Fauzan Farizy Disaputera, Alfafa Tsalaatsa Djausal, Anisa Nuraisa Dorisman, Hari Dwiki WIjaya Rahman Evi Kurniawati Fardiansyah, Ahmad Irzal Farhah, Putri Dzahabiyyah Fatmasari, Dina Fitria Saftarina George Pestalozi Gigaramadan Sema Hadibrata, Exsa Hafizh, Ahmad Fauzan Happy, Terza Aflika Helmi Ismunandar Hendra Tarigan Sibero Idris, Mohamad Indri Windarti Indriyani, Reni Intanri Kurniati Izdihar, Adinda Fairuz Jati, Pandu Kumaya Khairun Nisa Kurniawaty, Evi Kusumaningrum, Desy Liana Sidharti, Liana Maharani, Atifah Fadilah Mallarangeng, Andi Nafisah Tendri Adjeng Maulida, Syakira Zahra Mayasari, Diana Muhammad Ihsan Fariqy Muhammad Maulana Muhammad Ricky Ramadhian Nisa, Lutfi Khoirun Novita Carolia Nurul Utami Oktoba, Zulpakor Prayogi, Norbertus Marcell Putri, Syalika Dianisa Putu Ristyaning Ayu Rachman Aziz Rahmat, Aprin Nabila Rahmayani, Fidha Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Reni Indriyani Retno Mareintika Rika Lisiswanti Rina Hayati Risal Wintoko rizki_novtarina21 Rodiani Roro Rukmi Windi Roro Rukmi Windi Perdani, Roro Rukmi Rudianto, Waluyo Ruslani, Nada Oktista Sangging, Putu Ristyaning Ayu Sany Setiawan Sema Gigaramadan Septiani, Linda Setiawan, Putri Ayundari Setiorini, Anggi Sheira Indah Anjani Soemarwoto, Retno Ariza Soeprihatini Sofyan Musyabiq Wijaya Suharmanto Sulthan Alam Yasyfa Susianti, Susianti Sutarto Sutarto Sutarto Sutarto Syahrul Hamidi Nasution Syazili Mustofa TA Larasati Tri Umiana Soleha Wardhani, Dyah Wulan Sumekar Rengganis Widjaja, Jovan Winda Trijayanthi Utama, Winda Trijayanthi