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Jurnal Ilmiah Farmako Bahari
Published by Universitas Garut
ISSN : 20870337     EISSN : 27159949     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology
Jurnal Ilmiah Farmako Bahari fokus pada bidang Farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 190 Documents
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PRODUKSI ASAM LAKTAT OLEH LACTOBACILLUS ACIDOPHILUS DALAM MEDIA FERMENTASI KOMBINASI LIMBAH CAIR TAHU DAN MANGGA (Mangifera indica l.) Amir, Mellova; Sopiatunnisa, Neng; Abna, Inherni Marti
Jurnal Ilmiah Farmako Bahari Vol 15, No 1 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i1.2918

Abstract

Lactic acid is a hydroxycarboxylic organic acid used for various purposes and can be obtained through the fermentation of sugar from various sources. This research aimed to determine the ability of Lactobacillus acidophilus in a combination of tofu and mango waste to produce lactic acid using the fermentation method. Variations in media concentration for the combination of tofu and mango liquid waste are 0%, 25%, 50%, and 100% used with the basic fermentation media. The initial stage is the cultivation of L acidophilus, the growth curve, and then the fermentation process, determining the PH and levels of lactic acid produced using spectrophotometry. The research showed that L. acidophilus, combining tofu and mango liquid waste media, could produce lactic acid. Lactic acid levels in 0% combination media with 100% basic media were 2,040 mg/L, 25% combination media, 75% basic media, 2,081 mg/L, 50% combination media, 50% basic media, 2,316 mg/L, combination media 100 % of 2,440 mg/L. The highest levels of lactic acid were produced using a combination of 100% tofu and mango liquid waste at the 48th hour, amounting to 2,440 mg/L.
PENILAIAN SIFAT ANTIOKSIDAN DAN STANDARISASI HERBA Centella asiatica L. Urb DARI BERBAGAI DAERAH DI JAWA BARAT Fajarwati, Kania; Budiana, Wempi; Kusriani, Herni; Mardiana, Neng Dian; Fakih, Taufik Muhammad
Jurnal Ilmiah Farmako Bahari Vol 15, No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.2520

Abstract

Herba pegagan (Centella asiatica L.Urb) merupakan tanaman yang memiliki khasiat dan salah satunya adalah sebagai antioksidan yang berperan dalam menetralkan radikal bebas dan mencegah kerusakan sel yang disebabkan oleh radikal bebas. Radikal bebas diketahui terlibat dalam timbulnya berbagai penyakit. Senyawa yang terkandung dalam herba pegagan yang berpotensi sebagai antioksidan yaitu tanin, flavonoid, dan terpenoid. Tujuan dari penelitian yaitu untuk menentukan parameter standarisasi herba pegagan dan untuk mengetahui aktivitas antioksidan dari kelima daerah herba pegagan (Centella asiatica L.Urb). Pada hasil standarisasi parameter spesifik dan non spesifik hasil yang diperoleh telah memenuhi persyaratan sesuai dengan Farmakope Herbal Indonesia. Sampel diekstraksi dengan cara maserasi menggunakan pelarut etanol 96%. Ekstrak kemudian dipantau dan diuji aktivitaas antioksidannya secara kualitatif menggunakan kromatorafi lapis tipis dan secara kuantitatif menggunakan spektrofotometer sinar tampak. Uji aktivitas antioksidan dengan metode DPPH (1,1-difenil-2-pikrihidrazil) diperoleh rentang nilai IC50 67,61-89,32 μg/mL, dimana ekstrak yang paling aktif memiliki aktivitas antioksidan adalah ekstrak pegagan dari daerah pangandaran dengan nilai 67,61 μg/mL dibandingkan terhadap pembanding asam askorbat dengan nilai 4,22 μg/mL. kelima ekstrak herba pegagan berpotensi sebagai antioksidan.
ANTIBACTERIAL ACTIVITY OF BACANG MANGO (Mangifera foetida L.) LEAVES ETHANOL EXTRACT IN GEL FORMULATION AS ANTI-ACNE Aditya, Aditya; Jannati, Zahra Shaumi Jasmin; Hartianty, Eka Pebi; Tsurayya, Nadya
Jurnal Ilmiah Farmako Bahari Vol 15, No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3071

Abstract

Acne was a chronic skin disorder that was most often found in adolescents, so it frequently caused psychological effects that made the acne fighters look for ways to treat it quickly. Although topical antibiotics effectively treat acne, excessive long-term use can cause resistance. This has led to an interest in natural antimicrobials as an alternative treatment for acne. The natural antibacterial activity of the ethanol extract of bacang mango (Mangifera foetida L.) leaves has previously been reported to have antibacterial effects against Propionibacterium acnes, but only in the form of extracts not formulated into pharmaceutical preparations. Therefore, this study aimed to re-test the antibacterial activity of this extract, which has now been formulated into a gel preparation against the same bacteria. The gelling agent used in the gel formulation was Na-CMC with three different concentrations: 3%, 4%, and 5%. The Agar stab technique tests the antibacterial activity for three different extract concentrations. Those were 10%, 15%, and 20% for optimization of inhibitory activity before being formulated. Based on the results of testing the antibacterial activity of the ethanol extract of bacang mango (Mangifera foetida L.) leaves, an extract concentration of 20% had a more potent inhibitory activity than the others so that this concentration was chosen to be formulated into a gel preparation. After the formulation of the extracted gel, Na-CMC with a concentration of 5% produced a better gel base than other formulations. In addition, the three formulations provided the same inhibitory activity of 10 mm, so it can be concluded that the differences in gelling agent concentrations did not affect the antibacterial activity of the extracts in the preparations. However, a 3 mm decrease in inhibition occurred in the extract after it was formulated into a gel preparation. Even so, the extract gel preparation still has antibacterial activity against Propionibacterium acnes with antimicrobial inhibition zone activity, which is in the moderate category.
REVIEW OF THE PHYTOTHERAPY FOR NEPHROLITHIASIS Ridwan, Hanna Salwa; Megantara, Sandra; Levita, Jutti
Jurnal Ilmiah Farmako Bahari Vol 15, No 1 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i1.2877

Abstract

Nephrolithiasis (kidney stone) cases have a prevalence ranging from 1% to 13%. The disease not only hampers kidney function but also elevates the risk of chronic kidney diseases. The pathophysiology of nephrolithiasis is closely linked to elevated concentrations of calcium, oxalate, and/or uric acid in the urine. Pharmacotherapy to manage nephrolithiasis includes thiazide diuretics, allopurinol, citrate supplements, and alpha-blockers that have been prescribed to relieve symptoms. In addition, there is growing interest in exploring the potential of phytotherapy. This review aims to identify suitable phytotherapy approaches by examining relevant articles on nephrolithiasis. The research methodology involved searching PubMed articles using the keywords of (("Plant Extracts") AND ("Nephrolithiasis")) OR ("Ureterolithiasis"). The articles obtained from the initial search were n =123. 2 authors screened articles for their eligibility. The inclusion criteria were limited to articles written in English, topics related to nephrolithiasis and not other kidney diseases, the botanical names of the plants and the method of extraction are clearly described, complete studies with clear descriptions regarding the methods and results, not synthetic drugs, and not involving medical instruments or laser to remove the stones. Articles included in the review were n = 17. Water and hydro-alcohol were the solvents used to extract the plants. Twenty-two plants have confirmed their anti-nephrolithiasis activity, and nine articles described the assay by in vivo study, two by in vitro study, three by both in vitro and in vivo study, and only one article mentioned a study in humans by a randomized-control trial on a mixture of herbs. It is concluded that Rhizoma alismatis, Poria cocos, Polyporus umbellatus, Atractylodis macrocephalae, and Cinnamomi Cassiae prepared as a mixture in the Wu-Ling-San formula have a potential therapeutic effect on nephrolithiasis, as this formula has been studied in humans.
UJI EVALUASI FISIK DAN AKTIVITAS ANTI JAMUR SEDIAAN OVULA EKSTRAK BAWANG PUTIH TERHADAP CANDIDA ALBICANS Nurdianti, Lusi; Adhani, Ai Gita Aisah; Hidayat, Taufik; Setiawan, Fajar; Aprillia, Ade Yeni; Tuslinah, Lilis; Firmansya, Ardianes
Jurnal Ilmiah Farmako Bahari Vol 15, No 1 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i1.2671

Abstract

Kandidiasis vulvovagina merupakan penyakit umum di kalangan wanita yang membutuhkan penanganan cepat. Kandidiasis vagina dapat diakibatkan oleh infeksi jamur, terutama Candida albicans menyebabkan gejala seperti gatal-gatal, keputihan, kemerahan vagina, dan ketidaknyamanan saat berhubungan seksual serta buang air kecil. Bawang putih (Allium sativum L.), khususnya senyawa allicin memiliki potensi sebagai antibakteri dan antijamur. Selain itu, bawang putih juga mengandung saponin dan flavonoid. Penelitian ini bertujuan untuk mengevaluasi potensi ekstrak etanol Allium sativum L sebagai antijamur terhadap Candida albicans dan untuk mengembangkan sediaan ovula berbasis gelatin dengan konsentrasi ekstrak 20%, 25%, dan 30%. Pengujian daya hambat ovula ekstrak Allium sativum L dilakukan dengan metode sumuran menggunakan Cylinder cup. Hasil penelitian menunjukkan bahwa ovula ekstrak Allium sativum L dengan konsentrasi 20%, 25%, dan 30% memiliki daya hambat rata-rata masing-masing 6,1±0,290 mm, 8,06±0,750 mm dan 11,33±0,460 mm. Analisis ANOVA dilanjutkan dengan uji Least Significant Difference (LSD) menunjukkan perbedaan signifikan dalam kemampuan ovula menghambat pertumbuhan Candida albicans. Oleh karena itu, disimpulkan bahwa ovula ekstrak Allium sativum L memiliki potensi sebagai antijamur yang efektif.
KANDUNGAN Na/K DALAM BUAH TROPIS DI TIGA NEGARA ASEAN: KAJIAN PUSTAKA Andini, Alfita Nur; Hasanah, Aliya Nur; Mutakin, Mutakin
Jurnal Ilmiah Farmako Bahari Vol 15, No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.2923

Abstract

Hipertensi pada masyarakat mengalami peningkatan prevalensi disebabkan oleh faktor gaya hidup dan pola makan. Hipertensi dapat dicegah dengan manajemen konsumsi makanan seperti buah-buahan dalam mempertahankan asupan kalium. Buah merupakan salah satu sumber makanan yang mengandung tinggi kalium. Kalium dapat mempertahankan tekanan darah dalam rentang normal jika bekerja bersama natrium. Tingginya konsumsi kalium dalam buah dapat membantu proses natriuresis sehingga tekanan darah sistolik dan diastolik akan turun. Tujuan dari ulasan ini adalah mengetahui kadar natrium dan kalium dalam buah tropis di tiga negara ASEAN untuk mengontrol tekanan darah pada masyarakat. Studi ini melibatkan 12 jurnal dan artikel nasional maupun internasional sesuai dengan kata kunci yang digunakan yaitu “kadar, kalium, natrium, buah tropis”. Buah tropis mengandung lebih banyak kalium dengan rasio 0,5-100 kali kadar natrium yang dapat membantu dalam mengontrol tekanan darah. Hasil studi ini menunjukkan buah tropis dengan kandungan kalium tinggi terdapat pada durian chanee kadar mencapai 4358,6 mg/100g, sedangkan kandungan natrium tinggi terdapat pada buah merah dengan kadar mencapai 166,67 mg/100g.
IN SILICO STUDY: SECONDARY METABOLITES FROM JAMBOLAN (Syzygium Cumini L.) AS POTENTIAL BREAST CANCER TREATMENTS Suherman, Meilia; Junaedi, Effan Cahyati; Prasetiawati, Riska; Purnamasari, Ade Rena
Jurnal Ilmiah Farmako Bahari Vol 15, No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3254

Abstract

Breast cancer ranks second in world cancer incidence rates in 2020, contributing to 2,261,419 new cases, or 11.7% of all new cancer cases globally. The search for cancer drugs that work selectively continues to be encouraged to obtain safe and effective therapy, particularly those derived from medicinal plants. Jambolan is a plant that can thrive in both subtropical and tropical climates, including Indonesia. Jambolan (Syzygium cumini L.) has 89% antioxidant activity and 69% cytotoxic activity against T47D cells. Pharmacophore modelling and molecular docking were used to study the binding of 117 active jambolan drugs to alpha and beta estrogen receptors. Rutin was found to be potentially selective for ER-Beta receptors, with a fit score of 53.13. Molecular docking to ER-Beta revealed that rutin has breast cancer activity with a free bond energy value of -10.5 kcal/mol and better conformation and affinity than native ligands (genistein). It also binds to essential amino acids as an anticancer breast at ARG 346 and GLU 305. Lipinski's rule of five prediction results and in silico ADMET prediction from rutin yielded results that met the candidate drug's parameters. Rutin is a potential therapeutic option for treating breast cancer by targeting the ER-Beta receptor.
COMPARISON OF ABTS (2,2-AZINOBIS(3-ETHYLBENZOTHIAZOLINE)-6-SULFONIC ACID) AND DPPH (1,1-DIPHENYL-2-PICRYLHYDRAZYL) ASSAYS TO MEASURE THE ANTIOXIDANT ACTIVITY OF ETANOL EXTRACT OF RED ALGA (Gelidium sp) Martiani, Isye; Rustamsyah, Ardi; Puspitasari, Tien Ellita Endah; Sujana, Dani
Jurnal Ilmiah Farmako Bahari Vol 15, No 1 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i1.3461

Abstract

Seaweeds have an ecological function as primary producers in marine waters. It also has an important economic value as a producer of hydrocolloids (alginate, agar, and carrageenan) used in various food and pharmaceutical industries. This study aims to determine the antioxidant activity of red algae (Gelidium sp). Extraction was done using the maceration method using 96% ethanol and concentrated by rotary evaporation. The antioxidant activity of the extract was tested using ABTS and DPPH methods. Antioxidant activity was seen from the IC50. The results showed that IC50 from ethanol extract of red algae (Gelidium sp) with the DPPH method is 3,9154 ppm. Then, using the ABTS method, IC50 from ethanol extract of red algae (Gelidium sp) is 9,1178 ppm. This result shows that the ethanol extract from red algae (Gelidium sp) has very strong antioxidant activity (<50 ppm).
PENINGKATAN KELARUTAN DAN LAJU DISOLUSI GLIKLAZID DENGAN POLIMER SILIKA MIKROSFER (SM) Purwanto, Aris; Muthaharah, Mustika; Andika, Andika
Jurnal Ilmiah Farmako Bahari Vol 15, No 1 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i1.3109

Abstract

Cara yang dilakukan dengan menambahkan koformer dan Mikrosfer Silika Mesopore (MSM) yang dihasilkan dari sintesis sebelumnya. Menggunakan perbandingan 4 mmol gliklazid : 4 mmol koformer dilarutkan kedalam metanol untuk menghasilkan bentuk kokristal, perbandingan yang sama dengan penambahan silika mikrosfer sebanyak 800 mg untuk menghasilkan nano- confined coamorphous (NCA), dengan cara yang sama MSM dimasukkan kedalam gliklazid untuk mendapatkan gliklazid amorf. Karakterisasi berupa uji kelarutan menggunakan cara Higuchi and Connor, uji disolusi, FTIR dan DSC. Hasil kelarutan kokristal mengalami kenaikan 2,5 kali, gliklazid amorf mengalami kenaikan 1,3 kali dan NCA sistem naik 1,6 kali lipat dari gliklazid murni. Data hasil uji disolusi pada menit (60) gliklazid murni hanya terlarut 46,83%, bentuk kokristal 69,69%, berbeda pada gliklazid amorf yang sudah mencapai 98,15% dan sistem NCA mencapai 98,64%. Karakterisasi menggunakan FTIR terlihat pergeseran puncak serapan setelah gliklazid mengalami perubahan bentuk kokristal, amorf dan koamorf sedangkan hasil karakterisasi DSC penurunan intensitas pola difraksi mengalai perubahan setelah dilakukan proses dispersi.
UJI PENENTUAN NILAI SPF (Sun Protection Factor) PADA SEDIAAN EMULGEL EKSTRAK KULIT BUAH MANGGIS (Garcinia mangostana L.) SEBAGAI TABIR SURYA Nurlaila, Putri Saniah; Makiyatuzahro, Dede Avissa; Kuncoro, Aditiya; Mardianingrum, Richa
Jurnal Ilmiah Farmako Bahari Vol 15, No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3187

Abstract

Salah satu produk perawatan kulit yang melindungi dari sinar UV adalah tabir surya. Kulit Manggis, yang kaya akan senyawa antioksidan seperti turunan benzofenon, dapat diformulasikan menjadi tabir surya dalam bentuk emulgel untuk meningkatkan kenyamanan dan efektivitas penggunaan. Evaluasi sifat fisik dari emulgel yang mengandung ekstrak etanol 96% Kulit Manggis (Garcinia mangostana L.) dengan berbagai konsentrasi dilakukan untuk menentukan nilai Sun Protection Factor (SPF) menggunakan spektrofotometri UV-Vis. Penelitian ini dilakukan dengan metode eksperimental, dimulai dari ekstraksi kulit buah Manggis menggunakan metode maserasi, diikuti dengan pembuatan formulasi emulgel, dan penentuan SPF secara in vitro berdasarkan metode perhitungan yang dikembangkan oleh Mansur dan A.J. Petro. Hasil uji sifat fisik sediaan emulgel yang terdiri dari Uji organoleptis dan homogenitas, Uji pH, Uji Viskositas memenuhi persyaratan sediaan emulgel yang baik. Hasil penelitian menunjukkan adanya SPF (Sun Protection Factor) dengan konsentrasi 2% sebesar 19,366 SPF, konsentrasi 4 % sebesar 19,906 SPF, konsentrasi 6 % sebesar 26,440 SPF. Dapat disimpulkan sediaan emulgel ekstrak kulit  Manggis mampu sebagai agen tabir surya yang memiliki nilai SPF (Sun Protection Factor) dengan kategori proteksi ultra..

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