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Nurul Auliasari
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Jurnal Ilmiah Farmako Bahari
Published by Universitas Garut
ISSN : 20870337     EISSN : 27159949     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology
Jurnal Ilmiah Farmako Bahari fokus pada bidang Farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 190 Documents
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HYPNOTIC-SEDATIVE ACTIVITY TEST OF 70% ETHANOL EXTRACT OF LETTUCE (Lactuca sativa L.) IN MALE WHITE MICE SWISS WEBSTER STRAIN Sadino, Asman; Renggana, Hesti; Suwendar, Suwendar; Apriani, Riza; Nurhandayani, Yuni
Jurnal Ilmiah Farmako Bahari Vol 15, No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3090

Abstract

Humans who use medicines for insomnia may experience a variety of adverse effects, including dependence. Traditional medicine frequently uses lettuce (Lactuca sativa L.) to treat various conditions, including sleep difficulties. Terpenoids, which are secondary metabolites found in lettuce plants, are to blame for this. This study aimed to see if an ethanolic extract of lettuce leaf had any sedative-hypnotic activity in Swiss Webster strain male white mice induced by phenobarbital at a dose of 90 mg/KgBB intraperitoneally. In this study, the post-test-only control strategy was employed. The animals were divided into six groups (n = 4): negative (aqua dest), positive (Na-CMC 0.5%), comparison (diazepam 1.3 mg/KgBB), and ethanolic extract of lettuce leaf at doses of 300 mg/KgBB, 400 mg/KgBB, and 500 mg/KgBB. The parameters observed in this study were a combination of parameters from previous studies, namely the number of falls, sleep onset, and sleep duration in mice. The data obtained were then processed statistically using the one-way ANOVA (analysis of variance) and post-hoc test follow-up analysis with the LSD (least significant difference) test. The results showed that the ethanolic extract of lettuce leaves at 300, 400, and 500 mg/KgBB had a sedative-hypnotic effect. Doses of 300 mg/KgBB only increased sleep duration. In contrast, 400 and 500 mg/KgBB increased the number of falls, rapid sleep onset, and increased sleep duration, significantly different from positive controls (p<0.05). The effective dose of ethanolic extract of lettuce leaf as a sedative-hypnotic was 400 mg/KgBB.
FUCOIDAN NANOENCAPSULATION FROM BROWN ALGAE (Sargassum polycystum) AS A POTENTIAL MARINE IMMUNOMODULATORY AGENT Purwanto, Ungsari Rizki Eka; Ikasari, Endang Diyah; Bagiana, I Kadek; Kusmita, Lia; Trisnayanthi, Ni Nyoman Ayu Indah; Mudianta, I Wayan; Prasetijo, Rahmadi
Jurnal Ilmiah Farmako Bahari Vol 15, No 1 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i1.3207

Abstract

The quest for better and more effective treatments has encouraged the search for therapies derived from natural sources to obtain effective immune therapy, considering that several pandemics have arisen caused by viruses. Developing fucoidan from brown algae in drug encapsulation as an immunomodulator could be more promising. This study aimed to produce nanoencapsulation loaded with fucoidan-purified extract from brown algae and to evaluate the influence of nanoencapsulation formulation on the immunomodulatory activity of fucoidan. Fucoidan was obtained from brown algae and extracted by hot aqueous, followed by ethanol purification. Nanoencapsulation of fucoidan purified extract was prepared using the ionic gelation method. The carbon clearance method was carried out for the immunomodulatory activity test of the nanoencapsulation of fucoidan purified extract. Nanoencapsulation of fucoidan purified extract with the optimum composition of maltodextrin 9.9% and S-TPP 0.1% (1:5) resulted in particle size of 715.4 nm, zeta potential -0.1 mV, pH 7.54, transmittance 97.54%+0.08, and entrapment efficiency 89.94%+0.17. The carbon clearance test showed that the nanoencapsulation of fucoidan was a strong immunostimulant with a phagocytosis index of 1.65. The development of nanoencapsulation could increase the phagocytosis index of fucoidan purified extracts from brown algae. Further molecular studies are needed to demonstrate the molecular activity of this preparation as an immunomodulator.
EVALUASI PENGGUNAAN OBAT ARB DAN DIURETIK PADA PASIEN RAWAT INAP DENGAN DIAGNOSIS GAGAL JANTUNG DI RUMAH SAKIT KECAMATAN BALEENDAH PROVINSI JAWA BARAT Septiani, Vina; Margayani, Eni; Suherman, Linda P; Meicareena, Meira
Jurnal Ilmiah Farmako Bahari Vol 15, No 1 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i1.2544

Abstract

Gagal jantung adalah kondisi klinis di mana jantung tidak dapat memompa darah yang cukup untuk memenuhi kebutuhan tubuh. Penelitian ini bertujuan untuk mengetahui pola penggunaan obat golongan ARB dan diuretik mengetahui ketepatan terapi gagal jantung golongan ARB dan diuretik serta meliputi parameter tepat indikasi, tepat pemilihan obat, dan tepat dosis pada pasien rawat inap di salah satu Rumah Sakit di Provinsi Jawa Barat tahun 2021 untuk meningkatkan penggunaan obat yang rasional. Penelitian ini merupakan penelitian non eksperimental yang melakukan penelitian deskriptif dan mengumpulkan data dari rekam medis pasien secara retrospektif. Untuk pengambilan sampel, digunakan metode purposive sampling. Data diambil dari sampel yang memenuhi kriteria inklusi kemudian dianalisis baik secara kuantitatif dan kualitatif. Populasi pasien tahun 2021 sebanyak 152 pasien dan yang memenuhi kriteria inklusi sebanyak 48 pasien. Berdasarkan hasil penelitian pada pasien gagal jantung tahun 2021, diperoleh bahwa pasien gagal jantung lebih banyak pada pasien laki- laki sebesar 56,25% dan rentang usia yang lebih banyak pada usia 56-65 tahun sebesar 47,92%. Obat gagal jantung yang paling banyak diresepkan adalah kombinasi 2 obat yaitu Candesartan + Furosemide sebesar 43,5%. Hasil analisis kualitatif penggunaan obat pasien gagal jantung di salah satu Rumah Sakit di Provinsi Jawa Barat tahun 2021 diperoleh bahwa pasien sudah 100% tepat indikasi, 100% tepat pemilihan obat, dan 98% tepat dosis.
FORMULASI SEDIAAN TABLET EKSTRAK ETANOL DAUN SEMBUNG RAMBAT (Mikania micrantha) SEBAGAI ANTIDIARE SERTA PENGUJIAN KANDUNGAN FLAVONOID TOTAL Aslam, M.Muzhil; Estiningsih, Daru; Fatmawati, Annisa
Jurnal Ilmiah Farmako Bahari Vol 15, No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3044

Abstract

Prevalensi diare di Indonesia menurut Riskesdas 2018 diperkirakan 9% pada usia kurang dari 1 tahun , 11,5% usia 1 sampai 4 tahun, 6,2% usia 5 sampai 14 tahun, dan 6,7% berusia 15 sampai 24 tahun. Flavonoid pada daun M.micrantha memiliki aktivitas antidiare dengan menghambat motilitas usus. Tujuan penelitian ini adalah untuk mengetahui perbedaan sifat fisik tablet EEDSR 96% dengan beberapa variasi komposisi bahan pengisi (laktosa, amilum, kalium fosfat) dan mengetahui perbedaan nilai kadar flavonoid total yang terkandung di dalamnya. Jenis penelitian ini eksperimental menggunakan metode spektrofotometri UV Vis. Evaluasi sifat fisik tablet ekstrak etanol daun sembung rambat (EEDSR) 96% meliputi keseragaman bobot tablet, keseragaman ukuran, kekerasan, kerapuhan dan waktu hancur tablet. Uji kadar flavonoid total menggunakan metode spektrofotometri UV-Vis pada sediaan tablet dan kuersetin sebagai pembanding. Hasil: Evaluasi sifat fisik tablet EEDSR 96% dari uji granul dan sifat fisik tablet memenuhi persyaratan. Kadar flavonoid total pada tablet EEDSR 96%, formula I, II dan III adalah 1,37±0,04 mgEQ/100mg, 1,61 ± 0,03 mgEQ/100mg, dan 1,58 ± 0,02 mgEQ/100mg. Kesimpulan: Tablet dengan variasi komposisi bahan pengisi memiliki sifat fisik yang berbeda bermakna pada parameter waktu hancur dan kadar total flavonoid total. Kadar flavonoid total pada masing-masing formula tablet EEDSR 96% diperoleh nilai rata-rata yang berbeda makna.
OVERVIEW PRESCRIBING WITH DUPLICATED NSAID THERAPY WITHOUT GASTRIC PROTECTIVE AGENTS AT A HOSPITAL IN INDONESIA Nurmesa, Adi; Rachman, Abu; Jannah, Wardatul
Jurnal Ilmiah Farmako Bahari Vol 15, No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3179

Abstract

Pain is a defence mechanism for the body that arises when the tissues in the body are being damaged. Pain therapy can be used in the form of NSAIDs. In prescribing NSAIDs, there is a risk of drug-related problems in the form of treatment duplication without gastroprotective. This study aims to determine the description of the type of duplication of NSAIDs without gastroprotective and explain pharmacist intervention efforts in reducing drug-related problems in prescribing NSAIDs. This retrospective observational study is conducted on all incoming prescriptions at the pharmacy satellite in March-June 2022 at one of the hospitals in Indonesia. The results of this study found 53 cases of duplication of NSAID therapy without gastroprotective from a total of 3,200 prescriptions, with the most duplication of NSAID therapy between Ibuprofen 400 mg and Mefenamic Acid 500 mg 24 cases. Pharmacist intervention in the form of clinical prescription screening is beneficial to avoid the risk of drug-related problems in prescribing NSAIDs.
HEALTH RELATED QUALITY OF LIFE (HRQoL) IN CHRONIC KIDNEY FAILURE PATIENTS AT ARIFIN AHMAD REGIONAL GENERAL HOSPITAL RIAU PROVINCE Octavia, Rickha; Sari, Seftika; Nisa', Fitriatun
Jurnal Ilmiah Farmako Bahari Vol 15, No 1 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i1.3243

Abstract

After tuberculosis, the illness with the highest death rate is chronic kidney failure. Renal function declines in patients with chronic kidney failure until, eventually, they are unable to filter and eliminate the body's electrolytes at all. Metrics about quality of life are necessary because the patient's health will suffer if medical therapy fails. This research aims to determine the description of health-related quality of life (HRQoL) in chronic kidney failure patients at the Arifin Achmad Regional General Hospital, Riau Province. The samples used in this study were chronic kidney failure patients who underwent treatment at the Arifin Achmad Regional General Hospital, Riau Province, in the period January-December 2022 and met the inclusion and exclusion criteria. This study is observational and descriptive. Non-probability sampling was employed to select 74 participants for the study. Based on the results of research that has been carried out regarding the description of health-related quality of life (HRQoL) in patients with chronic kidney failure at the Arifin Achmad Regional General Hospital, Riau Province, it was found that chronic kidney failure has an impact on the quality of life in health with an average utility value of EQ-5D -5L and VAS namely 0.6235 and 0.7177. Anxiety or depression (40.5%) and pain or discomfort (52.7%) were the most commonly reported health issues.
SYNTHESIS OF TETRACYCLINE IMPRINTED POLYMERS WITH METHACRYLIC ACID AS FUNCTIONAL MONOMER IN METHANOL-CHLOROFORM MIXTURE USING BULK AND PRECIPITATION POLYMERIZATION METHOD Suryana, Shendi; Shabrina, Kharisma Devy; Soni, Dang
Jurnal Ilmiah Farmako Bahari Vol 15, No 1 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i1.2790

Abstract

The content of tetracycline residues in poultry meat products can cause antibiotic resistance in humans who consume these products, so it is necessary to develop sensitive analytical techniques to determine the levels of tetracycline residues to assess the safety of these products for consumption. The molecular imprinting technique is a method to produce sorbents with molecular recognition capability of target compounds that can be used to increase the selectivity of solid phase extraction to extract tetracycline residues for further analysis. This study aimed to obtain a sorbent synthesized by molecular imprinting technique to analyze tetracycline in poultry meat products. The stages of the research began with the study of the interaction of functional monomers with template molecules, determining the association constants of functional monomers with template molecules, synthesis of imprinted polymer molecules using bulk and precipitation methods, evaluating the ability and adsorption capacity of the synthesized polymers, assess the selectivity of polymers for analog structures and physical characteristics with FTIR. The research showed that methacrylic acid was the best functional monomer with a binding energy value of -27.3776 kcal/mol. The higher adsorption capacity was achieved by Molecularly Imprinted Polymer (MIP) that was synthesized by precipitation method (MIP2) than the other MIP synthesized by bulk polymerization (MIP1) with a value of 0.8748 mg/g and 0.4077 mg/g, respectively. The analogous compounds' imprinting factor values for each MIP were 1.197 and 1.1272. The polymer synthesized by molecular imprinting technique is selective for extracting and analyzing tetracycline from poultry meat matrix.
ANALISIS PENGETAHUAN, PERILAKU, DAN KETEPATAN PENGGUNAAN OBAT ANALGESIK DALAM SWAMEDIKASI DI SALAH SATU APOTEK DI KOTA BANDUNG Anggriani, Ani; Fitriani, Dinda Amelia; Lisni, Ida
Jurnal Ilmiah Farmako Bahari Vol 15, No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.1376

Abstract

Swamedikasi merupakan upaya masyarakat untuk mengobati dan memelihara kesehatan diri sendiri tanpa berkonsultasi dengan tenaga medis. Salah satu obat yang paling banyak digunakan dalam swamedikasi yaitu analgesik untuk mengatasi nyeri. Tingkat pengetahuan mengenai obat analgesik diperlukan dalam kegiatan swamedikasi untuk menghindari penggunaan obat yang tidak tepat. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan dan perilaku pasien serta ketepatan penggunaan obat pada swamedikasi analgesik di salah satu apotek di Kota Bandung. Penelitian ini merupakan penelitian korelasional analitik dengan metode cross sectional. Sampel yang digunakan sebanyak 100 responden. Hasil penelitian menunjukkan bahwa memiliki tingkat pengetahuan kurang sebanyak 30% responden, pengetahuan cukup 46%, dan pengetahuan baik 24%, untuk perilaku responden terdapat  86%  baik dan 14% tergolong cukup. Analisis statistik korelasi menggunakan rank spearman didapat nilai signifikansi sebesar 0,000 dan koefisien korelasi 0,703 yang menunjukkan adanya hubungan yang signifikan dengan arah yang positif antara tingkat pengetahuan dengan perilaku swamedikasi obat analgesik. Sebanyak 100% responden sudah tepat dalam pemilihan obat analgesik dan 96% responden sudah tepat dosis.
FORMULATION OF RED BETEL LEAF EXTRACT LOTION (Piper crocatum Ruiz & Pav) AS SUNSCREEN Rantika, Nopi; Hindun, Siti; Najihudin, Aji; Auliasari, Nurul; Khoerunisa, Winna; Sopiah, Siti
Jurnal Ilmiah Farmako Bahari Vol 15, No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3253

Abstract

Betel leaf is a natural ingredient that people use as a traditional medicine. One of the ingredients found in red betel leaves is a phenolic compound in the form of flavonoids, a photoprotective substance that can be used as protection from UV radiation. Sunscreen is a cosmetic preparation that can protect the skin from UV radiation and reduce the amount of radiation harmful to the skin. This study aimed to formulate a lotion preparation from red betel leaf extract that has activity as a sunscreen. Red betel leaf (Piper crocatum Ruiz & Pav) was extracted using the maceration method. Preparation formulations were made with variations of red betel leaf ethanol extract in each formula, namely with concentrations of 0.04% (F1), 0.05% (F2), 0.06% (F3), and base control (F0). The activity of sunscreen lotion extract is based on the Sun Protection Factor (SPF) value using UV-VIS spectrophotometry at wavelengths of 290–320 nm using the Mansur equation. The results of the SPF value of the lotion are F1 of 13.48, F2 of 16.71, and F3 of 18.7. The evaluation of the lotion results obtained a light green lotion with M/A emulsion type that met the requirements, including homogeneity, pH, spreadability, viscosity, centrifugation test, and freeze and thaw test. Research results show that betel leaf extract lotion is physically stable and has a high SPF value, so it has the potential to be a sunscreen.
ANTI-ACNE FACIAL WASH FORMULATION FROM RED BETEL LEAF EXTRACT (PIPER CROCATUM RUIZ & PAV) Hindun, Siti; Gazzali, Amirah Mohd; Najihudin, Aji; Hamdani, Siva; Rantika, Nopi; Azizah, Winanda Nur
Jurnal Ilmiah Farmako Bahari Vol 15, No 1 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i1.3259

Abstract

Acne can be caused by dust, sweat, and dirt that stick to the skin, forming blackheads. When blackheads become infected with bacteria, inflammation can occur. Therefore, it is essential to maintain good skin hygiene. One way to do this is by using natural ingredients with antibacterial properties. Red betel leaf is known to have antibacterial activity. This study aims to create a facial wash using red betel leaf extract that exhibits antibacterial properties against Propionibacterium acnes. The red betel leaf was extracted using the maceration method. Antibacterial testing was conducted against Propionibacterium acnes bacteria using the suitable diffusion method with a combination of red betel leaf extract at 10%, 15%, and 20%. The study found that facial wash products containing extract concentrations of 10%, 15%, and 20% demonstrated good physical stability, meeting the requirements of SNI-19-4380-1996 for pH, viscosity, specific gravity, and foam height. Additionally, the products showed potent antibacterial activity against Propionibacterium acnes bacteria, with inhibition zones of 29.0 mm, 32.6 mm, and 35.3 mm for the 10%, 15%, and 20% concentrations, respectively.

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