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INDONESIA
Jurnal Insan Farmasi Indonesia
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 26213184     EISSN : 26214032     DOI : https://doi.org/10.36387/jifi
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Physics
Focus and Scope Jurnal Insan Farmasi Indonesia (JIFI) is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIFI is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 336 Documents
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UJI AKTIVITAS ANTIBAKTERI FRAKSI ETIL ASETAT DAUN JAMBU METE (Anacardium occidentale L.) TERHADAP BAKTERI Bacillus Subtilis dan Pseudomonas aeruginosa Irawan, Ade; Ulfah, Mariam; Mansor, Khaeron
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/gaha7y05

Abstract

Infectious diseases are caused by various microorganisms including bacteria, viruses, fungi, and parasites. Cashew plants are plants that have antibacterial properties. Saponins, tannins, alkaloids, phenolics and flavonoids have antibacterial properties in cashew leaves. The purpose of this study was to determine the antibacterial activity of the ethyl acetate fraction of cashew leaves against Bacillus subtilis and Pseudomonas aeruginosa bacteria. This research is an experimental study. Ethyl acetate fraction was obtained by liquid-liquid fractionation method. Antibacterial test used concentrations of 10%, 20% and 30%, positive control Ciprofloxacin, negative control DMSO 10% with paper disc diffusion method. The results of phytochemical screening of ethyl acetate fraction of cashew leaves were positive for flavonoids, saponins and tannins. The average diameter results of the antibacterial test of Bacillus subtilis concentrations of 30% (4.5 mm), 20% (3.5 mm) and 10% (2.5 mm), while Pseudomonas aeruginosa concentrations of 30% (5 mm), 20% (3.8 mm) and 10% (1.6 mm). The ethyl acetate fraction of cashew leaves showed antibacterial activity against Bacillus subtilis and Pseudomonas aeruginosa bacteria.
ISOLASI BAKTERI ENDOFIT DARI TUMBUHAN KELAKAI (Stenochlaena palustris (Burm) Bedd). Oksal, Efriyana; Ngazizah, Febri Nur; chuchita; Irawan, Ahmad; Pereiz, Zimon
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/8x82wj94

Abstract

Kelakai (Stenochlaena palustris) is a type of medicinal fern used by the Dayak ethnic community in traditional medicine. The diverse bioactivity of kelakai is closely related to its high antioxidant content. The phytochemical compounds found in kelakai, such as phenols, flavonoids, anthocyanins, hydroxycinnamic acid, proanthocyanidins, tannins, alkaloids, saponins, carotenoids, and terpenoids, are believed to be produced by the endophytic microbes present in kelakai. Endophytic bacteria can be isolated from the plant, such as leaves, stems, bark, and roots. This research aims to isolate and identify endophytic bacteria from S. palustris. The method used is direct planting. The samples used are the leaves and stems of S. palustris. The results of the research conducted revealed six isolates of endophytic bacteria found in the leaves and stems, namely D1, D2, B1, B2, B3, and B4, which exhibit different colony morphology on the surface and color, while having similar shapes and edges. The results of the Gram staining test on the endophytic bacteria showed negative results and they are rod-shaped. In this study, endophytic bacteria S. palustris were successfully obtained from leaves and stems, which can be further analyzed for their activity.
EFEKTIVITAS EKSTRAK ETANOL DAN EKSTRAK KLOROFORM SIPUT ONCHIDID (Onchidium thyphae) SEBAGAI PENUMBUH RAMBUT PADA TIKUS (Rattus norvegicus) Wijianto, Bambang; Wijianto, Bambang Wijianto; Pratiwi, liza; Utami, Amanda Yanasari
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/fba2x720

Abstract

Hair loss is a problem that can affect appearance. A natural ingredient that can address hair loss treatment is the extract of the onchidiid snail. This study aims to test the hair growth effectiveness of ethanol and chloroform extracts of the onchidiid snail on white rats (Rattus norvegicus). The test groups of rats were divided into several groups: the Negative Group (CN), the Positive Group (CP) with candlenut oil, Treatment Group I (K1) with Chloroform Extract of the Onchidiid Snail, and Treatment Group II (K2) with Ethanol Extract of the Onchidiid Snail. Hair growth length was measured daily and processed using Image J software. The hair growth effectiveness test showed that over 14 days, the chloroform extract (K1) produced faster results compared to the other three groups, with a hair growth result of 1.61 cm on the 14th day. The findings of this study conclude that the chloroform extract of the onchidiid snail effectively promotes hair growth in male Wistar strain white rats.
AKTIVITAS ANTIOKSIDAN SERTA PENETAPAN KADAR b-KAROTEN, FLAVONOID DAN FENOL TOTAL EKSTRAK ETANOL LABU KUNING (Cucurbita moschata, (Duch.) Poir) -, Nova Anggreni; Anggreni, Nova; Mulyaningsih, Sri; Saiful Bachri, Moch.
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/ta8v4w29

Abstract

Yellow pumpkin (Cucurbita moschata) is a horticultural plant belonging to the Cucurbitaceae family. Yellow pumpkin fruit contains polysaccharides, various vitamins (including β-carotene, vitamin A, vitamin B2, tocopherol, vitamin C, and vitamin E). The abundant β-carotene in yellow pumpkin fruit has been proven to have activity in combating the negative effects of free radicals. This study aimed to determine the levels of β-carotene, total flavonoids, total phenols, and antioxidant activity in yellow pumpkin fruit (Cucurbita moschata) extracted using the maceration method with 96% ethanol solvent. The extract was qualitatively tested using thin-layer chromatography (TLC) and quantitatively tested using a UV-Vis spectrophotometer. Antioxidant activity was performed using DPPH method. The total flavonoid content in the yellow pumpkin fruit extract was 1.8 ± 0.025 mgQE/g extract, and the total phenol content was 13.9 ± 0.04 mg GAE/gram extract. Meanwhile, the β-carotene content was 16.99%, and the antioxidant activity of the yellow pumpkin fruit extract resulted in an IC50 value of 12.13 ppm, which can be classified as a very strong antioxidant.
ISOLASI DAN IDENTIFIKASI ANTIOKSIDAN JAMUR ENDOFIT UMBI TALAS (Colocasia esculenta (L.) Schott) MENGGUNAKAN PEREAKSI SEMPROT DPPH SECARA BIOAUTOGRAFI Hidayah Syaro Abesah, Nur; mahfur, mahfur
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/de26jz52

Abstract

The development of exploration of bioactive compounds by utilizing plant endophytic fungi is a solution to prevent ecological damage due to plant exploitation due to the production of endophytic fungi without large biomass and in a relatively short time. Therefore, this study aims to isolate endophytic fungi of taro tubers (Colocasia esculenta (L.) Schott) and identify the presence of antioxidant activity produced by endophytic fungi of taro tubers by bioautography method. The taro tuber endophytic fungus extract was obtained through the stages of isolation, purification, fermentation, and extraction with ethyl acetate solvent. Antioxidant testing was carried out by TLC-bioautography method using DPPH spray reagent that has been eluted with n-hexan:methanol (1:5) eluent. The results of the isolation of endophytic fungi of taro tubers obtained three fungal isolates coded HJ, HT, and PT. The results of the antioxidant test showed positive results marked by a yellow color change on a purple background after spraying DPPH, where isolates HJ and HT gave a reaction to the spot with Rf values of 0.87 and isolate PT gave a reaction to the spot with an Rf value of 0.90.
PEMILIHAN KOMPOSISI VARIASI BASIS FORMULA SEDIAAN SERUM EKSTRAK DAUN KELOR (Moringa oleifera L.) DARI TINJAUAN FORMULA DAN KENYAMANAN PEMAKAIAN Indriastuti, Marlina; Puspita, Erna
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/pvpq4d81

Abstract

Moringa plants (Moringa oleifera L.) are herbal plants that are used as food and alternative medicine because they have nutrients and potential as medicinal plants. Moringa leaves (Moringa oleifera L.) have antioxidant compounds, so it can be developed into one of the cosmetic preparations. This study aims to determine the formulation and physical evaluation of serum from moringa leaves using a variety of bases. Formulas were made into 3, namely formula 1 HPMC 3%, Carbopol 940 1.5%, and CMC Na 3.5%. Formulation 2 HPMC 2.5%, Carbopol 940 1%, and CMC Na 3%. Formulation 3 HPMC 2%, Carbopol 940 0.5%, and CMC Na 3%. The results showed that formula 3 fulfilled the physical evaluation of serum preparations in the pH test, viscosity test and adhesion test as indicated by the p-value (>0.05). The statistical results of the hedonic test based on color and odor obtained a p-value (>0.05) and the results of the Univariate General Linear Model analysis showed that formula 3 had the highest value of 3.28 on color and 2.16 on odor.
AKTIVITAS IMUNOMODULATOR REGIMEN ISOLAT MANGOSTIN, KURKUMINOID, PIPERIN, METIL SINAMAT DAN VITAMIN C DENGAN METODE CARBON CLEREANCE Fauzi, Novi Irwan; Sari, Nia Kurnia; Fathurrahman, Muhammad Hilmi; Firmansyah, Adang; Ferdiansyah, Rival; Ismayadi, Pupung; Herawati, Irma Erika
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/7sr0rm77

Abstract

The regimen of test materials consisting of mangostin isolate, curcuminoid, piperine, methyl cinnamate, and vitamin C is combined to help increase body immunity (immunostimulant). Immunostimulant activity testing was carried out using the carbon clearance method. 30 male Wistar rats were randomly divided into 5 groups, namely the normal control group, the comparison drug control, and dose groups I, II and III where the regimen of the test material was given at consecutive doses of 7.2; 72; 720 mg /kg respectively. The treatment was given for 6 days, then a carbon suspension dose of 0.5 mL / BW was given intravenously. Blood samples from the tail vein at 5, 10, and 15 minutes were measured for absorbance using a UV-Vis spectrophotometer at a wavelength of 650 nm. Phagocytosis constant and Phagocytosis Index (IF) were determined to assess immunostimulant activity. The phagocytosis constant in the regimentation of the test material showed a faster pattern in eliminating carbon compared to the normal control group and the reference drug. The regimentation of the test material also had an IF value > 1.5 which is a strong immunostimulant category.
KORELASI KEPATUHAN PENGOBATAN DENGAN KADAR GLUKOSA DARAH PASIEN DIABETES MELITUS TIPE 2 DI PUSKESMAS Amalia, Senya Puteri; Alfian, Riza; Fatmala, Yola; Wahyuni, Amaliyah; Ariani, Novia; Aisyah, Noor; Lestari, Desy Ayu
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/tq2vvk06

Abstract

Diabetes melitus (DM) merupakan suatu kelompok penyakit metabolik dengan karakteristik hiperglikemia akibat gangguan pada sekresi insulin, kerja insulin atau keduanya. Pengelolaan DM membutuhkan terapi obat jangka panjang. Ketidakpatuhan dalam pengobatan pasien DM dapat berdampak pada kadar gula darah yang tidak terkontrol. Penelitian ini bertujuan untuk melihat korelasi antara kepatuhan pengobatan dengan kadar gula darah pasien DM tipe 2 di Puskesmas Awayan Kabupaten Balangan. Desain penelitian yang digunakan yaitu observasional cross sectional dengan pengumpulan data secara prospektif. Data dikumpulkan dari pasien DM di Puskesmas Awayan Kabupaten Balangan pada periode bulan Juni-Juli 2024, dengan total sampel sebanyak 47 pasien yang diambil dengan teknik consecutive sampling. Tingkat kepatuhan pengambilan obat ulang oleh pasien diukur menggunakan kuesioner Adherence to Refills and Medications Scale (ARMS), sementara data kadar glukosa darah diperoleh dari hasil pengukuran tenaga kesehatan di Puskesmas Awayan. Analisis data dilakukan dengan uji korelasi Spearman. Hasil penelitian menunjukkan skor rata-rata kepatuhan pengobatan pasien DM 12,78 ± 1,06, sedangkan rata-rata kadar glukosa darah pasien sebesar 216,76 ± 52,11 mg/dL. Hasil uji korelasi antara kepatuhan dengan kadar glukosa darah memperoleh nilai 0,101 (p>0,05). Penelitian ini dapat menunjukkan bahwa kepatuhan pengobatan tidak memiliki hubungan yang signifikan dengan kadar glukosa darah pasien DM di Puskesmas Awayan Balangan.
VALIDASI METODE PENETAPAN KADAR HIDROKUINON PADA PRODUK KRIM PEMUTIH DENGAN METODE SPEKTROFOTOMETRI-UV Wahyuningsih, Putri Dewi; Kusumowati, Ika Trisharyanti Dian
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/ygqz8389

Abstract

Whitening cream is a type of cosmetic product that contains organic chemicals or other substances that can lighten the skin. One of the additional chemicals found in whitening creams is hydroquinone. The mechanism of hydroquinone in lightening the skin involves inhibiting melanin production. According to BPOM Regulation No. 23 of 2019, hydroquinone is only allowed for use in artificial nail preparations at a maximum concentration of 0.02% after mixing before use. This study aims to identify the concentration of hydroquinone in whitening cream products available in the Madiun City area. Hydroquinone identification was conducted qualitatively using 5% FeCl3. The quantitative determination of hydroquinone concentration was performed using UV spectrophotometry. Based on the validation parameter calculations, the equation obtained is Y = 0.0463x - 0.0734, with linearity represented by a correlation coefficient (r) of 0.999, LOD of 0.549 ppm, and LOQ of 1.832 ppm, precision with %RSD of 0.9075%, and % recovery of 99.47%. From the test results, it was found that 4 out of 5 samples of whitening cream products contained hydroquinone, with sample B having a concentration of 1.31979%, sample C 1.05197%, sample D 0.89791%, and sample E 1.28956%.
SINTESIS SENYAWA DIMETILTIMAH(IV) N-BENZILMETILDITIOKARBAMAT DAN UJI ANTIBAKTERI TERHADAP Salmonella typhi DAN Staphylococcus epidermidis Sanuddin, Mukhlis; Andriani, Medi; Yasril, Farih Rahma
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/fx3d9c23

Abstract

Antibacterial can inhibit growth or kill microorganisms. The purpose of this study is to synthesize and determine the antibacterial activity of the dimethyltin(IV) N-benzylmethylditiocarbamate. The research method used in this study is an experimental method. The compounds characterized using FTIR, 1H-NMR, 13C-NMR, compounds analyzed using FTIR obtained groups (C-H) 2912.51 cm-1, (C-N) 1192.01 cm-1, (C=S) 773.46 cm-1, (Sn-S) 360.69 cm-1, (Sn-C) 561.29 cm-1, (C-C) 1078.21 cm-1, the results of analysis from the 1H-NMR test were obtained 0.6552-0.8861 ppm (CH3), 2.5843-2.6479 ppm (CH2), and 7.0888-7.4345 ppm (Aromatic). The results of the analysis from the 13C-NMR test were obtained 4.1023-7.6992 ppm (CH3), 46.6439 ppm (CH2), 59.9685 ppm (C-N), 127-6009-135.1784 ppm (Caromatic), and 201.4111 (C-S2). Then the antibacterial activity test was carried out by the disc paper method with concentrations of 50 ppm, 60 ppm, and 70 ppm with the results of testing antibacterial activity with a concentration of 70 ppm resulting in the largest inhibitory zone with a strong category in Salmonella typhi 17.81 mm and Staphylococcus epidermidis 21.96 mm with a very strong category. Conclusion The compound dimethyltin(IV) N-benzylmethyldithiokarbate was successfully synthesized and formed a complex compound structure and has activity as an antibacterial agent with a very strong category.

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