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INDONESIA
Jurnal Insan Farmasi Indonesia
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 26213184     EISSN : 26214032     DOI : https://doi.org/10.36387/jifi
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Physics
Focus and Scope Jurnal Insan Farmasi Indonesia (JIFI) is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIFI is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 336 Documents
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AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL 96% DAUN BANGKAL (Nauclea subdita) TERHADAP BAKTERI Staphylococcus aureus Monica, Cahya; Zamzani, Irfan; Siti Nashihah
Jurnal Insan Farmasi Indonesia Vol 7 No 2 (2024): JIFI : Special edition
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v7i2.2129

Abstract

Bangkal (Nauclea subdita) is a typical plant in the southern part of the island of Borneo. In everyday life, bangkal leaves are used to treat wounds, ulcers, toothache, fever and diarrhea. The purpose of this study was to measure and determine the antibacterial activity of the ethanol extract of bangkal leaves against Staphylococcus aureus using the Ultrasonic Assisted Extraction (UAE) method. Bangkal leaves were extracted by UAE using 96% ethanol. The antibacterial inhibition test was carried out using the Kirby-Bauer disc diffusion method. Testing of antibacterial inhibition zones of Bangkal leaf extract against Staphylococcus aureus bacteria had an effect or significantly different with concentrations of 40%, 60%, 80%, 100% respectively and produced antibacterial activity with inhibition zones of 12.7±0.06 respectively. mm, 13.9±0.00 mm, 15±0.00 mm, 16±0.00mm. The results of the antibacterial activity examination showed that the ethanolic extract of bangkal leaves could inhibit the growth of Staphylococcus aureus at a concentration of 40% with an inhibition zone diameter of 12.7 mm and the highest concentration at 100% with an inhibition zone diameter of 16.00 mm. This indicates that the extract of bangkal leaves has antibacterial activity against Staphylococcus aureus which has an inhibition zone with a moderate to strong category.
PEMANFAATAN TRIGGER TOOL DALAM MONITORING DAN DETEKSI ADVERSE DRUG REACTION PADA PASIEN RAWAT INAP GERIATRI DI RSI PKU MUHAMMADIYAH PEKAJANGAN PEKALONGAN Prasetya, Henry Budiman; Lolita
Jurnal Insan Farmasi Indonesia Vol 7 No 2 (2024): JIFI : Special edition
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v7i2.2133

Abstract

The importance monitoring and detection ADR in geriatric inpatients cannot be overstated. Geriatric patients are susceptible to adverse drug effects due physiological changes associated with aging, increased amounts medication consumed, and increased sensitivity drug effects. This study aimed to detect ADR using trigger tools in geriatric inpatients and determine relationship between patient characteristics and incidence ADR. The method used observational with cohort study design retrospective. The samples were all geriatric patients aged ≥ 60 years and who had been hospitalized more than 48 hours period July - September 2023. The instrument used trigger tools from Dutch geriatric guidelines. Analysis using Microsoft Excel 2016 and SPSS 21.0 software. The results detected 393 trigger drug combinations in 34.1% (n = 197/577) patients. Triggers renal insufficiency, hyperglycemia, hyponatremia, hypotension/dizziness, and diarrhea/vomiting accounted for 86.5% (n = 340/393). The overall positive predictive value (PPV) triggers was 49.4%, the majority ADRs were caused by angiotensin receptor blocker (ARB), loop diuretics, NSAIDs, potassium-sparing diuretics, and corticosteroids, which accounted for 69% all drugs involved causing ADR. Analysis relationship shows age factor influences the occurrence ADR. The conclusion shows value trigger drugs as a tool for detecting ADR in inpatient geriatric patients at RSI PKU Muhammadiyah Pekajangan Pekalongan.
EVALUASI TEPAT PASIEN, TEPAT OBAT DAN TEPAT DOSIS ANTIPSIKOTIK PASIEN RAWAT INAP SKIZOFRENIA PARANOID DI RSJ SAMBANG LIHUM Alexxander, Alexxander; Pratiwi, Restu Dwi
Jurnal Insan Farmasi Indonesia Vol 7 No 2 (2024): JIFI : Special edition
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v7i2.2140

Abstract

Schizophrenia is a severe brain disorder which is a combination of hallucinations, delusions, disordered thinking and behavioral disturbances. Paranoid schizophrenia is known to be the most common type in Sambang Lihum Hospital in 2023. The main therapy for the treatment at schizophrenia is antipsychotics with a strong effect, which treat behavioral disorders, including psychosis. Improvement of symptoms seen from the PANSS-EC which is an assessment instrument in patients with severe mental disorders/schizophrenia, so that rationality is very important to consider the principle of clinical use benefits. This study aims to determine the percentage pattern of use and rationality of antipsychotics on the successful outcomes of paranoid schizophrenia patients at Sambang Lihum Sambang Hospital, South Kalimantan in 2023.The results of the study showed that the most common drug use patterns in the typical-atypical combination category were haloperidol and clozapine, and the rationality for accuracy was 100% correct dose, 100% correct drug and 99.1% correct patient, with the outcome of successful PANSS-EC discharge of ≤ 15 was 100%.
PERBANDINGAN PELARUT ETANOL-AIR DALAM PROSES EKSTRAKSI DAUN BAWANG DAYAK (Eleutherine palmifolia Linn) TERHADAP AKTIVITAS ANTIOKSIDAN DENGAN METODE DPPH Kumalasari, Eka; Musiam, Siska
Jurnal Insan Farmasi Indonesia Vol 2 No 1 (2019)
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v7i3.2290

Abstract

The immune system can be damaged by the presence of free radicals. The formation of free radicals must be prevented by antioxidants. Humanes basically do not have antioxidant reserves in their her body, so that when there is exposure to excessive the radicals then the needs body antioxidant intake from the outside. At present it is encouraged the development of antioxidants derived from plants, which are relatively easier to obtain and safe for humans consumption. Potential to antioxidant plants one of them is dayak onion leaves. Dayak onion leaves are a typical plant Borneo Central used by the Dayak tribe as medicine. To get a high active ingredient in dayak onion leaves, it is necessary to optimize the type of maceration solvent. The types of solvents used are water and ethanol. Testing of antioxidant using activities DPPH (2,2-Diphenyl-1-picrylhydrazyl) as a free radical compound. The maximum wavelength of DPPH in this study is at 519 nm. The highest IC50 value was found on dayak onion leaf extract with water solvent which was 58.62 ppm, with ethanol-water solvent of 33.71 ppm, and the smallest with ethanol solvent of 26.98 ppm. Key: antioxydan, Eleutherine palmifolia of leave, DPPH
UJI AKTIVITAS ANTIDIARE EKSTRAK DAUN KESUM (Polygonum minus Huds) TERHADAP MENCIT PUTIH JANTAN (Mus musculus): BAHASA INDONESIA Dian kartikasari; Puspita, Weni; Puspa Sari, Heni; Inderiyani, Inderiyani; Yolanda, Riska
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/a1k8h275

Abstract

Diarrhea is a clinical symptom of digestive disorders which is characterized by an increase in the frequency of defecation more than usual and repeatedly accompanied by a change in the shape and consistency of the feces to become soft or liquid. The aim of this research is to determine the effect of antidiarrheal activity of extract (Polygonum minus Huds) on male white mice and to find out at what concentration of extract is needed for the antidiarrheal effect on male white mice. This research was carried out by inducing mice with oleum ricini, then giving extract, then observing the time when diarrhea occurred, stool consistency, frequency of diarrhea, and the duration of diarrhea. The results obtained showed that there was a significant difference between the positive control group, 0.25% extract, 0.5% extract and 0.75% extract against the negative control group. This indicates that the three test groups have. Then from these data it can be seen that the 0.25% extract group, 0.5% extract and 0.75% extract had no significant differences from the positive control group. This indicates that kesum leaf extract with concentrations of 0.25%, 0.5% and 0.75% has activity that is close to or similar to the positive group
PENGARUH PERBEDAAN KONSENTRASI PELARUT TERHADAP KADAR FLAVONOID TOTAL DAUN SEGAR DAN DAUN KERING TANAMAN MATOA (Pometia pinnata J.R. & G.FORS) Kurnianto, Erwan; Rahman, Ika Ristia; Kartikasari, Dian; Hairunnisa
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/fkdc2t80

Abstract

Matoa (Pometia pinnata J.R. & G.FORS.) is a plant that is spread in several regions in Indonesia. This plant contains secondary metabolites that can dissolve in ethanol solvents such as flavonoids. The right type of solvent is very necessary to obtain maximum levels of active compound. This study examines the effect of ethanol solvent concentration on the total flavonoid content of fresh and dry leaves of the matoa (Pometia pinnata J.R. & G.FORS). Extraction was done using the maceration method with 70%, 80%, and 96% ethanol solvent. The determination of total flavonoid levels was carried out using the UV-Vis spectrophotometric method and AlCl3 as a reagent. The results showed that the total flavonoid content of 70%, 80%, and 96% ethanol extract of fresh matoa leaves were respectively (2.539±0.1047 mgQE/g), (1.885±0.0202 mgQE/g), (1.320±0 .0669 mgQE/g) and dried matoa leaves were (1.110±0.0448 mgQE/g), (0.870±0.0096 mgQE/g), (0.539±0.0130 mgQE/g). Based on statistical tests using the Kruskal-Wallis Test, differences in solvent concentration provide significant differences (p<0.05). 
SENYAWA BIOAKTIF DARI DAUN MIANA SEBAGAI KANDIDAT PENGHAMBAT BETA-LAKTAMASE: STUDI KOMPUTASI Oktaviana, Lina; Moulana, Mohammad Zaeni; Rusdin, Agus; Lestari, Mila Ayu; Fathin, Nayla Maymuna; Novitasari, Dhania
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/392s0e44

Abstract

Antibiotic resistance occurs through several mechanisms, one of which is  increase in beta-lactamase which can inactivate beta lactam antibiotics. The approach in finding new sources of antibiotics can be done by utilizing natural resources, one of which could be developed is miana leaves (Coleus scutellarioides). However, there has been no evaluation study related the antibacterial potential of the bioactive content  miana leaves against beta-lactam. This study analyzed the potential of bioactive compounds from miana leaves as beta-lactamase inhibitors through a computational approach. The methods used include physicochemical and pharmacokinetic profile prediction analysis, followed by pharmacophore screening and molecular docking. The results showed that most of the bioactive compounds of C. scutellarioides fulfill Lipinski's rule and show a good ADMET profile. Pharmacophore analysis produced the best model with an area under curve (AUC) score of 0.87. Molecular docking studies showed the compound 1-(4-phenylcyclohexyl)-1-hexanone had the highest binding affinity to beta-lactamase with a binding energy of -7.2 kcal/mol. This molecular interaction involves hydrogen bonding with amino acid residue GLU272 and van der Waals interaction toward ALA292 and TYR150. Therefore, bioactive compounds from miana leaves show potential as beta-lactamase inhibitors and open opportunities for the development of new antibacterial therapies based natural resources.
HUBUNGAN ANTARA KONTROL GLIKEMIK DENGAN TINGKAT KUALITAS HIDUP PESERTA PROLANIS PENDERITA DIABETES MELITUS TIPE 2 DI PUSKESMAS PRAMBANAN SLEMAN Putri, Eva Dwi Monicha; Nurinda, Eva; Wulandari, Ari Susiana; Ananda, RA Dewinta Sukma
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/vj5xas02

Abstract

The Chronic Disease Management Program (Prolanis) is the key to controlling Diabetes Mellitus (DM) in Indonesia. The Special Region of Yogyakarta is one of the provinces of Indonesia that has the second highest prevalence of DM. The majority of DM patients are in Sleman Regency.  This Prambanan Community Health Center (Puskesmas) is the second public health center with the highest prevalence of DM in Sleman. Quality of life (QOL) is the ultimate goal and important result of medical intervention for DM patients. The research methodology was a cross-sectional study conducted among 34 subjects who met inclusion and exclusion criteria. The results of this study showed that among the Prolanis participants with T2DM, 20 participants (58.8%)  had controlled glycemic and 14 participants (41.2%) had uncontrolled glycemic. QOL was found to be higher among participants with controlled glycemic (80.0%) compared to participants with uncontrolled glycemic (28.6%), and the relationship was statistically significant (p<0.05). There was a relationship between glycemic control and quality of life.  
ANALISA DRUG RELATED PROBLEMS (DRPs) PADA PASIEN GAGAL GINJAL KRONIK YANG MENJALANI HEMODIALISA DI RSUD DR HARJONO PONOROGO Septiani, Dela Dwi; R.F.X Premihadi Putra; Susilowati
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/2j8jm038

Abstract

Chronic Kidney Disease (CKD) is a progressive condition that affects more than 10% of the world's population, with more than 800 million sufferers. Treatment for CKD includes conservative therapy and renal replacement therapy, such as transplantation. Management of comorbidities in CKD patients can increase the risk of Drug Related Problems (DRPs). This study aims to determine the characteristics of CKD patients, analyze kidney conditions based on Glomerular Filtration Rate (GFR), and identify the percentage of three categories of DRPs in hemodialysis patients at Dr. Harjono Ponorogo Hospital. The study was descriptive retrospective with purposive sampling technique based on inclusion and exclusion criteria. The results showed that the majority of patients were male (59.80%), aged 56-65 years (34.31%), and had comorbid renal anemia (82.35%). The largest GFR category was G5 (<15 mL/min/1.73 m²) at 92.16%. The percentage of DRPs includes overdose (0%), drug interactions (50%), and drugs for inappropriate indications (0%).
EFEKTIVITAS PENGGUNAAN ANTIBIOTIK PADA PASIEN PNEUMONIA ANAK DI INSTALASI RAWAT INAP DI RSUD ULIN BANJARMASIN TAHUN 2022 Nazhipah Isnani; Muliyani; Muhammad Zaini; Muhammad Muhatadin Jamil; Hadiah Akbar, Nabila
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/nxj6e492

Abstract

Pneumonia is a disease that is a problem in various developing countries, including Indonesia. Pneumonia that occurs in Indonesia tends to increase with age. This research is descriptive research with a retrospective data collection method using a sampling technique, namely total sampling. The retrospective was carried out based on previous data, referring to secondary data in the form of patient medical records while being treated at the Ulin Hospital, Banjarmasin, a sample of 98 medical records of pediatric pneumonia patients at the Ulin Banjarmasin Hospital inpatient installation for the period January-December 2022. Based on the research results obtained that patients suffering from pneumonia experienced fever for a maximum of 1-3 days totaling 87 people (89%). The highest number of antibiotics used was a single antibiotic in the cephalosporin group, namely 33 people (32%). Based on the effectiveness of antibiotics based on the duration of fever, the use of Ampicillin+gentamicin in 32 patients (31%) reduced fever more within a period of 1-3 days.

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