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Hilwan Yuda Teruna
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Pengurus Pusat Ikatan Apoteker Indonesia Jalan Wijayakusuma No. 17 Tomang, Jakarta Barat Jakarta 11430
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INDONESIA
Jurnal Farmasi Indonesia
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : https://doi.org/10.35617/jfionline
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Indonesia adalah jurnal nasional (peer-reviewed) yang diterbitkan oleh Ikatan Apoteker Indonesia dua kali dalam setahun sebagai sarana diseminasi ilmu pengetahuan di bidang farmasi, yaitu: farmasi klinis, farmasi masyarakat/komunitas, kimia farmasi, biologi farmasi/famakognosi, farmakologi, pengembangan obat/kimia medisinal, formulasi dan bidang terkait. Artikel yang dipublikasi berupa hasil penelitian dan mini-review. JFIOnline telah mulai diterbitkan sejak tahun 2009 dalam edisi cetak. Pada tahun 2014 mulai dibuat edisi online. Akses artikel pada jurnal tidak berbayar, tetapi dikenakan biaya proses publikasi untuk penulis (open access journal). Mulai bulan Juli 2019 jurnal ini dapat diakses di alamat yang baru yaitu www.jfi-online.org dari alamat sebelumnya www.jfionline.org.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 149 Documents
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IMMUNOREGULATION OF MULTIPLE SCLEROSIS BY HELMINTH THERAPY Editha Renesteen
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 2 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (444.019 KB) | DOI: 10.35617/jfionline.v12i2.49

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) which is characterized by the recruitment of T cells into the CNS, leading to demyelination and axonal damage. Currently, there are limited options for MS therapy, thus researchers start to use helminths therapy as a new therapeutic agent. Helminths are promising organisms to treat autoimmune diseases like MS by interfering the host’s immune responses. Several helminths, including Trichinella spiralis, Trichuis suis, Fasciola hepatica, Schistosoma japonicum and Schistosoma mansoni are under investigation in animal models for MS, experimental autoimmune encephalitis (EAE). Furthermore, Trichuis suis, Fasciola hepatica and Schistosoma mansoni are being examined in patients. This review outlines basic insight of MS, immunoregulation mechanisms induced by helminths, current helminths therapy for MS as well as helminths therapy for MS application in the future.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAN FRAKSI DARI AKAR DAN BATANG TUMBUHAN SEKUNYIT (Fibraurea tinctoria Lour) Rahayu Utami; Dwi Winarsih; Armon Fernando; Haiyul Fadhli; Mustika Furi; Emma Susanti
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 2 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (530.712 KB) | DOI: 10.35617/jfionline.v12i2.50

Abstract

Sekunyit (Fibraurea tinctoria Lour) is plant species that has been using widely as traditional medicine such as a cure for diarrhea. This study was conducted to determine the antibacterial activity of extract and fractions of its root and stem against bacteria that cause diarrhea. The sample of root and stem were macerated with ethanol and then followed by ultrasonication process for 30 minutes. Fractionation process was performed by acid-base method using three different solvents which were n-hexane, chloroform and n-butanol. The extract and fractions were tested for its antibacterial activity using agar diffusion method at tested concentrations of 30; 15; 7.5; 3.75 and 1.88%. The result showed that the ethanol extract, n-hexane, chloroform A and chloroform B fractions of the root and stem provided antibacterial activity against all tested bacteria with weak to medium activity. Whereas the n-butanol fraction did not give any activity, either to Escherichia coli, Salmonella typhi, Staphylococcus aureus as well as Vibrio cholerae.
The relationship of secretory phospholipase A2 type IIA levels with glomerulus filtration rate in type 2 DM patients Nadifa Kartika Dewi; Mila Citrawati; Dhigna Luthfiyani; Harli Amir Mahmudji
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 1 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (378.923 KB) | DOI: 10.35617/jfionline.v12i1.51

Abstract

Phospholipase/sPLA2 type IIA is a mediator that connects the pathogenesis of diabetes and its complications. Diabetic nephropathy is the most frequent microvascular complication, with albumin urine and changes in glomerular filtration rate. This study aimed to discover the relation between sPLA2 type IIA levels in diabetic patients with glomerular filtration rate (GFR). This study used the crossectional method in 62 samples in RSJ. Prof. Dr. Soerojo Magelang. Sampling was done by total sampling, and medical records were used as an instrument. This research was conducted in patients with sPLA2 type IIA levels and had complete laboratory examination data in 2016. The results showed that the level of sPLA2 type IIA was very high in diabetic patients, and GFR was below standard. Pearson correlation analysis showed no significant correlation between type IIA sPLA2 and GFR (p=0.318), with a positive but weak correlation (r=0.129) with the diabetic duration of 8 years. Pearson correlation analysis was conducted in 21 samples in which GFR values were ≤60 (p=0.0712), resulting in a negative direction (r=-0.086) with a diabetes duration of 11 years. It was shown that diabetic patients with increased levels of sPLA2 type IIA and more extended periods of diabetes would affect the decrease in GFR value.
Monitoring efek samping obat antituberkulosis fase intensif dan lanjutan pasien dewasa tuberkulosis di RSUD Kota Bandung Siti Thannisa Aisiyah Gumanti; Dhigna L. C. P.; Via Rifkia
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 1 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (362.707 KB) | DOI: 10.35617/jfionline.v12i1.52

Abstract

Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis which can be transmitted through sputum splashes. The use of antituberculosis drugs can cause a variety of side effects depending on the duration of TB treatment. Based on TB treatment conditions that have a long duration of drug administration and many types of drugs, there will be a high risk of side effects or toxicity. The purpose of this study was to determine the description of side effects arising from TB drugs at the Bandung City Hospital and the factors causing the incidence of side effects during TB treatment. This research method the author uses a descriptive observational method with a cross sectional approach. The sampling technique uses purposive sampling based on inclusion criteria with a minimum sample of 34 and excursion criteria for TB patients with sepsis complications. The results of the comparative test obtained a p-value of 0.549 > 0.05 which showed that there was no significant difference between the side effects of the drug that arose in new patients and relapse patients.
Brine shrimp lethality test on aqueous extract of Caesalpinia Sappan L. Satya, Nathasya Angelia; Pradana, Dhigna Luthfiyani Citra; Kolib, Abdul; Aprilia, Citra Ayu
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 1 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (345.073 KB) | DOI: 10.35617/jfionline.v13i1.54

Abstract

Caesalpinia sappan L. is a plant in the Fabaceae family and has long been used as a medicinal plant. Caesalpinia sappan L. wood contains active compounds in brazilin, flavonoids, tannins, alkaloids, saponins, and terpenoids, which have antioxidant, anti-inflammatory, antibacterial, antiviral, and anticancer properties. The purpose of this study was to find out the lethal concentration (LC50) in the aqueous extract of Caesalpinia sappan L. wood using the Brine Shrimp Lethality Test (BSLT). LC50 is the concentration value of the compound that causes up to 50% death in Artemia salina Leach. This study used four concentration treatments of 1000 ppm, 500 ppm, 100 ppm, and 50 ppm, and negative control repeated three times. Each concentration and the control negative used 10 Artemia salina Leach larvae. The larval mortality was observed after 24 hours of treatment. An LC50 value of 322.54 ppm indicates an aqueous extract of Caesalpinia sappan L. Therefore, it was moderately toxic in this category.
Faktor resiko kejadian peningkatan kadar transminase pada penggunaan obat antituberkulosis pasien tuberkulosis paru di RST Wijayakusuma Purwokerto Alya Andina Dasuki; Annisa Farida Muti; Hany Yusmaini
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 2 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (470.134 KB) | DOI: 10.35617/jfionline.v12i2.55

Abstract

Most of the tuberculosis cases reported in Indonesia were in provinces with high population density, including Central Java. The combination of first-line antituberculosis drugs including pyrazinamide, isoniazide and rifampicin has the potential to cause hepatotoxicity as indicated by an increase in transaminase levels. Incidence of elevated transaminase levels leading to drug resistance and treatment failure. Early detection of elevated transaminase levels by antituberculosis drugs is important by studying predisposing risk factors. The purpose of this study was to determine the relationship between risk factors and the incidence of increased levels of transaminases due to the use of anti-tuberculosis drugs in patients with pulmonary tuberculosis at RST Wijayakusuma Purwokerto. This type of research is an observational analytic study with a cross-sectional design. A total of 80 samples were selected by random sampling. Data collection is done by viewing and recording the patient's medical record. Data were analyzed using the Chi-squared test and Logistic Regression test. The results of the bivariate analysis with the Chi-Square test showed that there was a significant relationship between old age (p = 0,000), female gender (p = 0.035), malnutrition (0,000), length of treatment (p = 0.026) and a history of taking other drugs. (p = 0.008). The most influential factor was the elderly (OR = 8.815) on the incidence of elevated transaminase levels; followed by nutrition status (OR=6,478).
PENENTUAN TOTAL FENOLIK, FLAVONOID DAN UJI AKTIVITAS ANTIOKSIDAN EKSTRAK DAN FRAKSI DAUN KEDABU (Sonneratia ovata Backer) Mustika Furi; Nursinta Al Basit; Ihsan Ikhtiarudin; Rahayu Utami
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 1 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (363.827 KB) | DOI: 10.35617/jfionline.v12i1.56

Abstract

Kedabu (Sonneratia ovata Backer) is plant that belongs to family Lytheraceae which has been used as traditional medicine. Determination of total phenolic and total flavonoid content as well as antioxidant activity of extract and fractions of its leaves have been conducted by colorimetric method using photometric measurements. The Folin Ciocalteu and gallic acid was used as reagent and standard for total phenolic determination, meanwhile AlCl3 and quercetin was prepared for total flavonoid content test. Antioxidant activity assay was performed using DPPH free radical scavenging method. Based on the result, it showed that ethyl acetate fraction afforded the highest total phenolic and total flavonoid content with values of 232 mgGAE/g and 180 mgQE/g, respectively. As for the antioxidant activity, the ethyl acetate fractions also demonstrated the most potential activity among others fraction and extract with IC50 value of 12,47 µg/mL.
Evaluasi Penyebab Cacat Lahir Berdasarkan Jenis Kelamin di Sumatra Selatan, Indonesia Michael, Michael; Ramatillah, Diana Laila; Dinli, Dwi Yunisa; Kezia, Valerie; Sutardi, Azzahrotul Qona'ah Ibnatus
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (384.921 KB) | DOI: 10.35617/jfionline.v14i2.58

Abstract

Abstrak: Cacat lahir merupakan kelainan kondisi fisik atau genetik bawaan menyebabkan komplikasi Kesehatan dan keterlambatan perkembangan yang signifikan seperti dalam fungsi intelektual dan perilaku yang adaptif. Tujuan dari penelitian ini adalah untuk melihat jenis kecacatan, kategori kecacatan dan penyebab kecacatan pada anak laki-laki dan perempuan. Cross-sectional merupakan metode yang digunakan pada penelitian ini. Teknik pengambilan sampling yang digunakan pada penelitian ini adalah convenience sampling dengan membagikan questioner kepada orang tua yang bersedia menjadi responden pada sekolah luar biasa yang berada di Sumatra Selatan. Hasil pada penelitian ini melibat jumlah responden total 96 responden dengan 53 orang laki-laki dan 43 orang perempuan. Tidak ada perbedaan yang signifikan terhadap jenis cacat (0.49) yang diderita oleh anak laki-laki dan perempuan, tidak ditemukannya korelasi antara tingkat keparahan kecacatan (0.91) terhadap jenis kelamin serta tidak adanya perbedaan yang signifikan terhadap penyebab kecataan (0.35) antara anak laki-laki dan perempuan. Kecacatan intelektual (62.5%) dan kecacatan ringan (54.2%) merupakan kecacatan yang paling banyak ditemukan. Penyebab kecacatan yang utama adalah kekurangan asam folat dan mulitivitamins pada saat kehamilan yaitu 49%.
Hubungan Sosiodemografi dengan Hasil Klinis Pasien Covid-19 di RSUD Bengkulu Lukas, Stefanus; Ramatillah, Diana Laila; Aldi, Yufri; Wahyuni, Fatma Sri; Gloria, Fransisca; Michael, Michael; Wahyudi, Agung Aji; Astari, Lita Tri
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 1 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (411.839 KB) | DOI: 10.35617/jfionline.v14i1.59

Abstract

Coronavirus disease 2019 (Covid-19) adalah penyakit menular yang disebabkan oleh SARS-CoV-2 yang memiliki bentuk dan perilaku menyerupai virus SARS. Persentase angka kematian nasional adalah 4,23, yang berada di atas angka kematian rata-rata nasional. Tujuan penelitian untuk mengetahui faktor-faktor apa saja yang berhubungan dengan kematian pasien Covid-19 di RS Pemerintah Bengkulu.Dengan tujuan Mengetahui hubungan sosiodemografi dengan luaran klinis pasien COVID-19 di Bengkulu.dengan metode Penelitian kohort retrospektif dilakukan dalam penelitian ini. Penelitian ini hanya melibatkan pasien terkonfirmasi COVID-19, dengan total sampel 127 pasien yang dirawat di rumah sakit selama April, Mei, dan Juni 2021.Dan mendapatkan hasil Semua pasien yang dirawat di Rumah Sakit Pemerintah Bengkulu antara April dan Juni 2021 menggunakan azitromisin atau levofloxacin + oseltamivir + vitamin sebagai pengobatan. Hasil dari infeksi covid-19 memiliki beberapa faktor korelasi yang signifikan: usia (0,0001), pekerjaan (0,0001) dan penyakit penyerta (0,0001). Kesimpulan Outcome klinis terburuk paling banyak ditemukan pada pasien yang menderita Diabetes dan berusia lebih dari 50 tahun.
Faktor-Faktor yang Memengaruhi Efektivitas Hematinik pada Pasien Hamil di Puskesmas Kecamatan Matraman Nadia Farhanah Syafhan; Meiliani Shara Suria L; Azizahwati
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 1 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (327.669 KB) | DOI: 10.35617/jfionline.v12i1.61

Abstract

The government has been giving hematinic that contains 200 mg of ferro sulfas and 0.25 mg of folic acid to pregnant patient since 1970, but anaemia prevalence in pregnant patient at Matraman primary health care has been still relatively high. This research aimed to analyze factors that were influencing hematinic effectiveness that has been used by pregnant patient at Matraman primary health care. The method used for this research was cross-sectional study with purposive sampling technique. Data was obtained from the result of laboratory test for haemoglobin level and interview using valid and reliable questionnaire. Respondents of this research were pregnant patient who used hematinics that were given from government and their haemoglobin level had been measured at least twice during their pregnancy. Total respondent who met the inclusion criteria were 85 patients. Based on the result, there were significant association between tea consumption habits and haemoglobin level (p=0.000) and also significant association between patient adherence on hematinic consumption and haemoglobin level (p=0.004). But there were no significant association between dietary habit and haemoglobin level (p=0,105) and between how to consume hematinic and haemoglobin level (p=0,684). This study showed factors influencing hematinic effectiveness were tea consumption habits and patient adherence on hematinic consumption.

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