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All Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Biomedika Indonesian Journal of Medicine MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Health Information : Jurnal Penelitian Jurnal Untuk Masyarakat Sehat (JUKMAS) CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Proceeding ISETH (International Summit on Science, Technology, and Humanity) Gelora: Jurnal Pendidikan Olahraga dan Kesehatan IKIP Mataram Prosiding University Research Colloquium Jurnal Pengabdian Masyarakat Medika Jurnal Terapi Wicara
Lestari, Nining
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Biomedika

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DIABETES MELITUS SEBAGAI FAKTOR RISIKO KEPARAHAN DAN KEMATIAN PASIEN COVID-19: META-ANALISIS Lestari, Nining; Ichsan, Burhannudin
Biomedika Vol 13, No 1 (2021): Biomedika Februari 2021
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v13i1.13544

Abstract

ABSTRAKCOVID-19 merupakan penyakit infeksi saluran nafas akut yang disebabkan oleh Coronavirus tipe SARS-Cov-2. COVID-19 masih menjadi ancaman seluruh dunia karena morbiditas dan mortalitasnya yang tinggi. Tingkat keparahan dan kematian pasien COVID-19 dipengaruhi oleh diabetes melitus, hipertensi, usia dan obesitas. Namun saat ini masih terdapat kontroversi dalam hasil penelitian mengenai faktor komorbid diabetes ellitus tipe 2 (DM tipe 2) pada COVID-19. Penelitian ini bertujuan mengetahui pengaruh antara DM tipe 2 terhadap keparahan dan kematian COVID-19. Artikel diambil dari PubMed, ScienceDirect, Google Scholar, ProQuest, dan Springer Link. Artikel yang dianalisis adalah artikel yang diterbitkan Desember 2019- Agustus 2020, fulltext dengan desain studi observasional, analisis multivariat, dan mencantumkan adjusted odds ratio (aOR). Kata kunci yang dipakai untuk pencarian artikel adalah (Type 2 diabetes mellitus OR diabetic) AND (mortality OR severity) AND (COVID-19 OR Coronavirus OR SARS-CoV-2) AND ("adjusted odds ratio" OR "aOR"). Artikel dikumpulkan dengan diagram PRISMA dan dianalisis dengan Review Manager application 5.4 dengan model analisis random effect. Penelitian ini menganalisis10 artikel dan mendapati bahwa DM tipe 2 meningkatkan keparahan COVID-19 (aOR = 1,15; 95% CI= 1,11-2,15; p= 0,004) meningkatkan kematian COVID-19 (aOR = 1,65; 95% CI = 1,27-2,16; p 0,001). Kesimpulannya bahwa diabetes melitus tipe 2 meningkatkan risiko keparahan dan kematian pasien COVID-19.Kata kunci: Diabetes Melitus, Keparahan, Kematian, COVID-19 ABSTRACTCOVID-19 is an acute airway infection caused by Coronavirus (SARS-Cov-2). COVID-19 remains a worldwide threat due to its high morbidity and mortality. The severity and mortality of COVID-19 patients are mainly affected by diabetes mellitus, hypertension, age, and obesity. This study aims to determine the influence of type 2 diabetes mellitus on the severity and mortality of COVID-19. This was a systematic review and meta-analysis. The articles were obtained from PubMed, ScienceDirect, Google Scholar, ProQuest, and Springer Link. The articles were published from December 2019- August 2020, full-text articles with observational study design, multivariate analysis, and (adjusted odds ratio/aOR). Keywords to search for articles were (Type 2 diabetes mellitus OR diabetic) AND (mortality OR severity) AND (COVID-19 OR Coronavirus OR SARS-CoV-2) AND ("adjusted odds ratio" OR "aOR"). Articles collected using the PRISMA diagram and analyzed using Review Manager application 5.4 with a random effect model. Ten studies were included in the meta-analysis. The results showed that Type 2 DM increased the severity of COVID-19 (aOR = 1.15; 95% CI= 1,11-2,15; p = 0,04) and the mortality of COVID-19 (aOR = 1,65; 95% CI = 1,27-2,16; p 0,001). Conclusion: Type 2 diabetes mellitus increased the severity and mortality of COVID-19.Keywords: Diabetes Mellitus, Severity, Mortality, COVID-19 
PERBEDAAN PARAMETER HEMATOLOGI PADA PASIEN TUBERKULOSIS (TB) DENGAN DAN TANPA INFEKSI HUMAN IMMUNODEFICIENCY VIRUS (HIV) Hanif, Aulia; Jatmiko, Safari Wahyu; Dewi, Listiana Masyita; Lestari, Nining
Biomedika Vol 12, No 2 (2020): Biomedika Agustus 2020
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v12i2.10290

Abstract

ABSTRAKTuberkulosis (TB) merupakan infeksi oportunistik yang paling sering pada infeksi HIV dan yang paling banyak menyebabkan kematian. Tuberkulosis meningkatkan progresivitas infeksi HIV. Pada pasien TB HIV dan TB non HIV dapat ditemukan berbagai variasi kelainan hematologi seperti leukopenia, trombositopenia dan anemia. Penelitian ini bertujuan untuk mengetahui perbedaan parameter hematologi pada pasien TB HIV dan TB non HIV. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan case control. Subjek penelitian adalah pasien TB HIV dan TB non HIV di Surakarta pada bulan Januari 2017- Oktober 2019. Pengambilan sampel menggunakan teknik consecutive sampling dengan total 60 sampel, terdiri dari 20 pasien TB HIV dan 40 TB non HIV. Pada uji T tidak berpasangan didapatkan perbedaan antara rerata jumlah leukosit, trombosit dan hemoglobin pada pasien TB HIV dan TB non HIV dengan nilai p masing-masing 0,001; 0,005;dan 0,003. Kami menyimpulkan bahwa terdapat perbedaan yang bermakna jumlah leukosit, trombosit dan hemogobin antara pasien TB HIV dan TB non HIV.Kata Kunci: Tuberkulosis, HIV, Leukosit, Trombosit, Hemoglobin ABSTRACTTuberculosis(TB) is the most frequent opportunistic infection in HIV infection and the highest cause of death. Tuberculosis raises progressivity of HIV infection. In TB HIV and TB non HIV patients can be found a wide variety of hematological disorders such as leukopenia, thrombocytopenia and anemia. This study aimed to determine differences in hematological parameters of TB HIV and TB non-HIV. This research is an analytical observational research with a case control approach. The subject of research is TB HIV patient and TB non-HIV at Surakarta in January 2017-October 2019. Sampling uses consecutive sampling techniques with a total of 60 samples, consisting of 20 TB HIV patients and 40 TB non-HIV.The result of independent T test, there is the difference between the number of leukocytes, platelets and hemoglobin in TB HIV and TB non-HIV TB patients with a value of p is 0.001; 0,005; and 0.003. We concluded there were differences in the number of leukocytes, platelets and hemogobin between TB HIV and TB non-HIV. Keywords: Tuberculosis, HIV, Leukocytes, Platelets, Hemoglobin
Co-Authors Agustina Aldisa, Isnan Almansyah, Wanda Emdia Andareza, Rahmita Anggraeny, Anisa Anika Candrasari Apriliani, Anindya Aurora Arismar, Fiqi Rahardian Arrohma, Farah Aryati, Mandarini Dwi Putri Asti Nurhayati Ayyasi, Quanta Bestari, Rochmadina Bintari, Hana Binuko, Raafika Studiviani Dwi Burhannudin Ichsan Devi Usdiana Rosyidah DIAH RACHMAWATI Dodik Nursanto Erika Diana Risanti Fauzi, Favian Fauziah, Nida Faradisa Firdausi, Nida Faradisa Handayani, Alya Nurkinasih Putri Hanif, Aulia Ichsan, Burhannuddin Iin Novita Nurhidayati Mahmuda Indri Susilawati Lili Indrawati Listiana Masyita Dewi Lulu Fitriani, Nadiya Mahensa, Noval Gentha Marsya, Vitania Maslahah, Syah Fillia Nurul Maylafaiza, Annisa Muhammad Jamal, Ibrahim Muhammad Shoim Dasuki N. Juni Triastuti Nafisa, Balqis Nendika Dyah Ayu Murika Sari Nida Faradisa Fauziyah Nur Mahmudah Pambudi (22003), Anggit Povitasari, P Pratama, Nur Putri, Aprida Rahayu, Destri Ramadhani, Marsyanda Retno Sintowati - Riandini Aisyah Safari Wahyu Jatmiko Salsabila, Naura Setiani, Hilda Setyo Nurwaini Siti Soekiswati Sri Wahyu Basuki Sri Wahyuni Sukardi, Nadya Sulistyani Sulistyani Sumaeni, Sumaeni suratmi, tri Talitha Tsania, Azza Talitha Tsania Tolibin, Restu Triwulandani Tri Agustina, Tri Widyaningtyas, Pintakasari Yaasiin, Putri Isa Maharani Yuni Prastyo Kurniati Yusuf Alam Romadhon Zainury, Muchamad Iqbal