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Setyaningsih, Yuni
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Anti-inflammatory and hepatoprotective effects of Moringa oleifera fruit in obesity-induced liver injury Susantiningsih, Tiwuk; Thadeus, Maria Selvester; Citrawati, Mila; Setyaningsih, Yuni
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i1.30081

Abstract

Background: Hepatic metabolic disorders are closely associated with obesity and are characterized by systemic inflammation and liver injury. Moringa oleifera fruit contains various bioactive compounds with potential anti-inflammatory and hepatoprotective properties. However, evidence regarding its effects on obesity-induced liver injury remains limited..   Objective: This study aimed to evaluate the anti-inflammatory and hepatoprotective effects of Moringa oleifera fruit extract in an obesity-induced rat model..   Methods: This experimental study used 30 male Sprague-Dawley rats divided into five groups: normal control (N), obese control (O), obese rats treated with Moringa oleifera fruit extract at 500 mg/kg body weight once daily (OEMO1), twice daily (OEMO2), and obese rats treated with vitamin C (OC). Systemic inflammation was assessed by measuring serum C-reactive protein (CRP) levels using ELISA, while hepatic changes were evaluated through biochemical markers and histopathological analysis. Data were analyzed using one-way ANOVA followed by post hoc testing.   Results: Obese rats exhibited significantly elevated serum CRP levels and marked hepatic alterations compared to normal controls (p < 0.05). Administration of Moringa oleifera fruit extract significantly reduced CRP levels and improved hepatic histoarchitecture in obese rats, with the greatest effect observed in the twice-daily treatment group (OEMO2) (p < 0.05). The effects were comparable to or greater than those observed with vitamin C. Conclusions: Moringa oleifera fruit extract demonstrates significant anti-inflammatory and hepatoprotective effects in an obesity-induced rat model, suggesting its potential as a natural therapeutic agent for obesity-related liver injury.
Co-Authors Agnes Tuti Rumiati Agneta Irmarahayu Agus Jaenudin Akbar, Rafi Thoriq Andri Pramesyanti Pramono Angelica, Tracy Astari, Riezky Valentina Azril, Muh Bintang Bayu Aryandi Cantika, Yara Cut Fauziah Djasfar, Seftiwan Pratami Eko Budi Santoso Fachri Razi Faizah, Shafa Alya Nur Fajriati Zulfa Fardani, Nabil Radif Fathurrahman, Achmad Fuad Hikmah Muktamiroh Humaira, An Nisaa Siti Hutasoit, Chintya Mei Desia Irawan, Shafira Aulia Rosyida Joanne, Anastasia Jonesti, Wilfadri Putra Makkiyah, Feda Anisah Marcella Marhaditya, Muhammad Faiz Maria Selvester Thadeus Maria, Ima Meiskha Bahar Melly Kristanti Mila Citrawati Mumtaz, Syifa Afifah Nela Azalina Aziz Ni Gusti Made Rai, Ni Gusti Made Nisrina, Rumaysha Gikha Palgunadi, Muhammad Alriefqi Prasetyo, Banu Pratama, Muhammad Rafli Pritha Maya Savitri Rahadiantino, Lienggar Rahmawati, Deti Randy Alihusni Wardana Ratu, Aurelius Satiawan, Putu Rudy Savitri, Eka Dian Simanjuntak, Kristina Sungkar, Mustofa Lukman Sutikno Sutikno Tiwuk Susantiningsih Tri Faranita, Tri Ubaidillah Ubaidillah Yanti Harjono Hadiwiardjo