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All Journal Dentika Dental Journal Pendas : Jurnah Ilmiah Pendidikan Dasar Fair Value: Jurnal Ilmiah Akuntansi dan Keuangan JURNAL FARMASIMED (JFM) Jurnal Informasi dan Teknologi Journal of Stem Cell Research and Tissue Engineering Jurnal Riset Pembelajaran Matematika Al-Kharaj: Journal of Islamic Economic and Business Jurnal Pengabdian Kepada Masyarakat Ungu ( Abdi Ke Ungu) Jurnal Fakultas Keguruan dan Ilmu Pendidikan UNISA Kuningan Berdikari : Jurnal Ekonomi dan Statistik Indonesia International Journal of Social Science, Educational, Economics, Agriculture Research, and Technology (IJSET) PAKDEMAS : Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Buana Bastra: Bahasa, Susastra, dan Pengajarannya Jurnal Pengabdian Masyarakat Journal of Trends Economics and Accounting Research Syams: Jurnal Kajian Keislaman Jurnal Praktik Baik Pembelajaran Sekolah dan Pesantren Journal of Accounting Research, Utility Finance and Digital Assets (JARUDA) Jurnal Pengabdian Masyarakat dan Riset Pendidikan Jurnal Media Akademik (JMA) Jurnal Intelek Dan Cendikiawan Nusantara Jurnal Pengabdian Masyarakat Indonesia (JPMI) INTERDISIPLIN: Journal of Qualitative and Quantitative Research Jurnal Pancasila dan Kewarganegaraan (JUPANK) Rihlah Iqtishad: Jurnal Bisnis dan Keuangan Islam Jurnal Kajian Hukum Dan Kebijakan Publik Jurnal Pengabdian kepada Masyarakat Multidisiplin (JUPENGEN) Media Keperawatan: Politeknik Kesehatan Makassar Jurnal Citra Kuliah Kerja Nyata Ekraf: Jurnal Ekonomi Kreatif dan Inovatif Indonesia
Melisa
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Journal : JURNAL FARMASIMED (JFM)

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Gastroprotective Effectiveness Test of 70% Ethanol Extract of Karamunting Leaves on White Male Rats (Rattus norvegicus) Rangkuti, Saru Noliqo; Nuraini, Nuraini; Melisa
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/1w27kw61

Abstract

Background: Gastritis is a health disorder in digestion, especially the stomach. Treatment of gastritis can be cured by using medicinal plants which are thought to have compounds that are efficacious as gastroprotective. The karamunting plant is one of the biodiversity that must be developed because the karamunting plant has one of the properties as a gastroprotective. Karamunting, among others, has various kinds of ingredients such as flavonoids, saponins, tannins, alkaloids, and triterpenoids which are useful as herbal medicines. Objective: This study aims to determine the content of secondary metabolites, determine the effectiveness of healing gastritis in rats and determine what dose of 70% ethanol extract of karamunting leaves has the effectiveness of gastroprotective healing in rats. Method: Test animals were divided into 6 groups consisting of group I negative control CMC 0.5%; group II positive control of 500mg/5ml sucralfate; group III induction control 1000mg/kgBB; groups IV, V, VI 70% ethanol extract of karamunting leaves at a dose of 20mg/200g BW of rats, a dose of 40mg/200g BW of rats and a dose of 60mg/200g BW of rats. After the treatment, the animals were dissected and the stomach was observed macroscopically. Result: Data were analyzed with the Kruskal Wallis test, and followed by the Mann-Whitney test. The results of this study showed that 70% ethanol extract of karamunting leaves has effectiveness as a gastroprotective. A dose of 20mg/200gBW rats has a % protection value of 76%, a dose of 40mg/200gBW rats has a % protection value of 75%, and a dose of 60mg/200gBW rats has a % protection value of 100%. Statistical test results showed that there was a significant difference in each group on gastroprotective effectiveness (p <0.05). Conclusion: The conclusion of this study was that the 70% ethanol extract of caramunting leaves had the most optimal gastroprotective effectiveness at dose III, namely 60mg/200gBW rats.
Co-Authors ., Rohaini Adibah, Syifa Adit Widaryono Afiota, Meilita Alex Chandra Alya Azhara Amelia, Lilis Amru Usman Andika Rusli ANDRIANSYAH Anggellya, Febby Anna Cesaria April Lia Hananto Arnando Asriany Atik Rosanti Ayu Anggraini Basriyah, Khusnul Caesare, Muh Raditya Delfa satingi Desi Erawati, Desi Dewiyanti Mitasari Dian Lestari Siregar Dika Setiagraha, Dika Doli Oktamira Dona Sariani Dwi Oktavallyan Eka Safitri, Puput Ersi Sisdianto Fadhilasari, Icha Fanni Tanisya Farid, Muhammad Sultan Felyo, Aldo Fiona Livianti Ghozali, Muhammad Shiddiq Al Gusriyanti, Nabila Hafizah Delyana, Hafizah Hakim, Bustanul Hananto, Agustia Haryadi Sarjono Husain, Hastuti Icha Saswyta Manurung Ika Candra Destiyanti Ikhsan Hidayat Ivan Cristhian Ivori Gracia Simanjuntak Janusi Waliamin Jayanti Khairunnisa, Athalia Shafa Kholifatu Amalia Shofiani, Arisni Leono, Melfinna Lucky Heriyanti Jufri, Lucky Heriyanti Lusi Afriliana M. Faqiul Kamal Maya Marselia Meila Rizqi Adenia Muhammad Aji Al Azhar Muhammad Dicky Syamsuddin Muhammad Haris Saputra Mulia Suryani Mur'ah Nada, Ayu Khusnun Narti Prihartini Ni’matul Fatihah Noferianto Sitompul NOVIYANTI Nur Aisyah, Rohani Nur ‘Azah Nuraini Nuraini Nurfadilah Pakaya Nurhayati Harahap Nurmalia Dewi Nurwijayanti Ony Garindra Saputra Patul, Hali Puspita, Veny Putri Sri Delviani Putri, Aulia Eka Rahmadhani Rangkuti, Saru Noliqo Ratri, Ratri Yulia Ningsih Repina Rey jordi Paputungan Ridwan, Saefatul Riska Yanti Risnita Tri Utami Salsabila Sandy, Chelsea Anggita Nurramah Seri Wahyuni Sintia Safrianti Soeratin, Boyke Setiawan Subriah Tri Yusufi Mardiana Trisna Eka Sari Vidyan Lim Wahyu Alfanda Welan Widya Lestari, Era Wijayadi, Andri Wahyu Yuni Dhea Utari Zulfikar Hasan