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Hanna Goenawan
Departemen Anatomi, Fisiologi Dan Biologi Sel Fakultas Kedokteran Universitas Padjadjaran, Bandung
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Journal : Universa Medicina

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Effects of dietary protein combined with high-intensity exercise in restoring skin health in male rats Gunadi, Julia Windi; Lesmana, Ronny; Kastella, Faysal; Tarawan, Vita Murniati; Goenawan, Hanna; Gunawan, Decky; Jasaputra, Diana Krisanti
Universa Medicina Vol. 44 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.152-161

Abstract

Background Protein is essential for skin integrity, while exercise modulates cellular and molecular processes that regulate autophagy, mitochondrial biogenesis, and collagen synthesis. This study evaluates the combined effects of dietary protein restriction and varying exercise intensities on epidermal thickness, autophagy markers (LC3, p62), mitochondrial biogenesis (PGC1α), and collagen synthesis (Col1a1, Col3a1) in male Wistar rats.    Methods An experimental laboratory study was conducted involving 32 male Wistar rats. They were randomized into 8 groups: control, low protein, low intensity, group IV, moderate intensity, moderate intensity low protein, high intensity, and high intensity low protein. Low protein diet (5%) compared to the control (24%) was given for 60 days, while the exercise regimen was eight weeks of treadmill exercise (low/10 m per minute, moderate/20 m per minute, and high intensity/30 m per minute) for 30 minutes a day, five days a week. Epidermal thickness, LC3, p62, PGC1α, Col1a1, and Col3a1 mRNA expression were measured at the end of the study. One-way ANOVA/Kruskal-Wallis followed by Tukey HSD/Mann–Whitney test was used to analyze the data.   Results A low-protein diet significantly reduced epidermal thickness (p=0.048), increased LC3 (p=0.043) and p62 (p=0.011), indicating impaired skin regeneration and autophagy. However, exercise, especially at high intensities with low protein, mitigated this effect by increasing both LC3 (p=0.011) and PGC1α (p=0.011).   Conclusions These findings highlight the compensatory role of exercise in maintaining tissue integrity under protein-deprived conditions in male rats. High-intensity exercise potentially enhances autophagy and mitochondrial biogenesis.
Co-Authors . SETIAWAN Abdul Hadi Hassan Adjat Setiadjati Rasjad Ahmad Kurniawan Ahmad Kurniawan Aldo, Mochammad Ali Satia Graha Ambrosius Purba Ambrosius Purba Ambrosius Purba Andi Wijaya Arto Yuwono Soeroto Astrid Feinisa Khairani Astrid, Stephanie Averina Octaxena Aslani Aziis Mardanarian Rosdianto Aziiz Mardanarian Rosdianto Aziiz Mardanarian Rosdianto Bahjah, Firda Hanan Baniasih, Akbar I. Baniasih, Akbar I. Bela Ita Karina Bertha Pangaribuan Daba, Mariel Daniel Womsiwor Darmayanti, Meita Decky Gunawan, Decky Diana Krisanti Jasaputra Dimpuulina Erna Mariati Edward J Hadi Elvine Gunawan Euis Julaeha Fachrul Ihsan, Muhammad Fani Rahma Yenita Felix Samuel Ferdyan Efza Fifi Veronica Fitri Fadhilah Genta Syaifrin Laudza Gilang Muhamad Nur Iqbal Gita Widya Pradini Goenadi, Julia Windi Gunadi, Julia Windi Herry Herman Hidayat, Shaffana Huda, Fathul Huda, Fathul Imam Megantara Irma Ruslina Defi Isa Mahendra Iwan Setiawan Iwan Setiawan Iwan Setiawan Jatnika, Danti Dja Julia Windi Gunadi Julia Windi Gunadi Juliati Juliati Kartika Hajar Kirana, Kartika Hajar Kastella, Faysal Lisda Amalia Mariel Daba Mas Rizky A.A. Syamsunarno Melisa I. Barliana Muhtado, Azmi Raffi Mulyanaga, William Giovanni Nova Sylviana Nuroh Najmi Nurunnisa Sholeha Letto Oktorina, Lenny Prasetyo, Wibowo Budi Prayudi Santoso Qiantori, Adziqa Ammara Radhiyanti, Putri Teesa Rahdiyanti, Putri Teesa Ramadhanti, Julia Ray, Hamidie Ronald Daniel Reni Farenia Reni Farenia Ronny Lesmana Roro Wahyudianingsih Rosdianto, Aziis Mardanarian Rosdianto, Aziiz Mardanarian Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Siti Baitul Mukarromah Sofiyanti, Santi Sri A. Sumiwi sugianli, Adhi Sunarjati Sudigdoadi Supriatno Salam Susanti Husen Susianti Susianti Tarawan, Vita M. Taufik Hidayat Teddy Hidayat Teresa Lucretia, Teresa Tiodora Arimenda Br. Subekti Titing Nurhayati Trianing Tyas Kusuma Unang Supratman Upik Rahmi, Upik Vita Murniati Tarawan Vita Murniati Tarawan Lubis Wahyu Widowati Wuri, Rahmitiana Yudi Feriandi Yulia Sofiatin Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi, Yuni Susanti