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All Journal Jurnal Veteriner Indonesia Medicus Veterinus Majalah Kedokteran Bandung Jurnal Kesehatan Masyarakat Althea Medical Journal Journal of Biomedicine and Translational Research Jurnal Kesehatan Andalas Jurnal Farmasi Klinik Indonesia Global Medical and Health Communication MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Universa Medicina Journal of Medicine and Health JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Jurnal SPORTIF : Jurnal Penelitian Pembelajaran PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JOURNAL OF SPORT EDUCATION (JOPE) Jurnal Ilmu Faal Olahraga Indonesia Journal of Medicine and Health Folia Medica Indonesiana
Hanna Goenawan
Departemen Anatomi, Fisiologi Dan Biologi Sel Fakultas Kedokteran Universitas Padjadjaran, Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Althea Medical Journal

 1 
Presence of Multidrug Resistance (MDR) Escherichia coli in the Citarum River located in Greater Bandung Area, Indonesia Megantara, Imam; Muhtado, Azmi Raffi; Pradini, Gita Widya; Goenawan, Hanna; Sylviana, Nova
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n3.2765

Abstract

Background: One of the main problems of the Citarum River is the contamination of E. coli due to livestock activities, washing toilets, and industry. In addition, irrational use of antibiotics in the community and livestock can increase E. coli resistant strains to antibiotics. This study aimed to identify the presence of multidrug resistance (MDR) and extended-spectrum β-lactamase (ESBL) E. coli strains in Citarum river clusters, namely industrial, livestock, and residential clusters.Methods: This was a descriptive study. A sample of 100 mL surface water from each Citarum cluster. Culture, antibiotic sensitivity test, and PCR to identify blaCTX-M-15 gene carriers of ESBL E. coli were carried out in the sample.Results: There were 37 isolates of E. coli, with 24% of these isolates showing MDR properties, which can be found in industrial, livestock, and residential clusters at 13%, 8%, and 3% respectively. The most E. coli-resistant antibiotics found in these samples were ampicillin (45%), followed by tetracycline (37%), and azithromycin (29%). The PCR examination did not find the blaCTX-M-15 gene carrying ESBL properties in all three Citarum river clusters.Conclusion: The presence of E. coli isolates in each Citarum river cluster suggests the occurrence of river pollution due to animal, human or industrial waste.  Therefore, it is necessary to make better government regulations regarding sanitation and education for the surrounding community regarding the importance of keeping the river clean.
Effects of Moderate-Intensity Treadmill Training on Cardiac Mitochondrial Mitophagy and Dynamics in Young and Aged Wistar Rats Gunadi, Julia Windi; Ramadhan, Difa Hidayat; Safira, Bernike Tirsa; Ramadhan, Andra Alifya; Wahyudianingsih, Roro; Limyati, Yenni; Goenawan, Hanna; Lesmana, Ronny
Althea Medical Journal Vol 13, No 1 (2026)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v13n1.4553

Abstract

Background: Cardiac aging is closely associated with mitochondrial dysfunction and impaired quality control mechanism. Exercise has been shown to modulate mitochondrial homeostasis, however, its effects on cardiac mitophagy and mitochondrial dynamics during aging remain unclear. This study investigated the effects of moderate-intensity treadmill training on mitochondrial maintenance-related gene expression in the hearts of young and aged Wistar rats.Methods: Young and aged rats were divided into four groups: young control, young exercise, aged control, and aged exercise (n=6 per group). Exercise groups performed treadmill running at 20 m/min for 30 minutes/day, 5 days/week for 8 weeks. Cardiac gene expression levels of Pink1, Parkin, Mfn1, Mfn2, Opa1, Drp1, and Fis1 were analyzed using semi-quantitative polymerase chain reaction (PCR). Data were analyzed using one-way ANOVA or Kruskal–Wallis test followed by appropriate post hoc analyses.Results: Exercise significantly increased Mfn2 expression in aged exercise rats compared with aged controls (p=0.029), suggesting partial restoration of age-related decline. Expression of Mfn1 and Drp1 varied among groups but showed no significant pairwise differences. Expression levels of Opa1, Fis1, Pink1, and Parkin remained unchanged. These results indicate that moderate exercise selectively enhances mitochondrial fusion capacity while maintaining balanced fission and basal mitophagy activity.Conclusion: Moderate-intensity treadmill training promotes mitochondrial  fusion-related adaptation in aging cardiac tissue. Regular moderate exercise may represent a potential non-pharmacological strategy to support mitochondrial function and mitigate cardiovascular aging.  
Co-Authors . SETIAWAN Abdul Hadi Hassan Adjat Setiadjati Rasjad Ahmad Kurniawan Ahmad Kurniawan Aldo, Mochammad Ali Satia Graha Ambrosius Purba Ambrosius Purba Ambrosius Purba Andi Wijaya Arto Yuwono Soeroto Astrid Feinisa Khairani Astrid, Stephanie Averina Octaxena Aslani Aziis Mardanarian Rosdianto Aziiz Mardanarian Rosdianto Aziiz Mardanarian Rosdianto Bahjah, Firda Hanan Baniasih, Akbar I. Baniasih, Akbar I. Bela Ita Karina Bertha Pangaribuan Daba, Mariel Daniel Womsiwor Darmayanti, Meita Decky Gunawan, Decky Diana Krisanti Jasaputra Dimpuulina Erna Mariati Edward J Hadi Elvine Gunawan Euis Julaeha Fachrul Ihsan, Muhammad Fani Rahma Yenita Felix Samuel Ferdyan Efza Fifi Veronica Fitri Fadhilah Genta Syaifrin Laudza Gilang Muhamad Nur Iqbal Gita Widya Pradini Goenadi, Julia Windi Gunadi, Julia Windi Herry Herman Hidayat, Shaffana Huda, Fathul Huda, Fathul Imam Megantara Irma Ruslina Defi Isa Mahendra Iwan Setiawan Iwan Setiawan Iwan Setiawan Jatnika, Danti Dja Julia Windi Gunadi Julia Windi Gunadi Juliati Juliati Kartika Hajar Kirana, Kartika Hajar Kastella, Faysal Lisda Amalia Mariel Daba Mas Rizky A.A. Syamsunarno Melisa I. Barliana Muhtado, Azmi Raffi Mulyanaga, William Giovanni Nova Sylviana Nuroh Najmi Nurunnisa Sholeha Letto Oktorina, Lenny Prasetyo, Wibowo Budi Prayudi Santoso Qiantori, Adziqa Ammara Radhiyanti, Putri Teesa Rahdiyanti, Putri Teesa Ramadhan, Andra Alifya Ramadhan, Difa Hidayat Ramadhanti, Julia Ray, Hamidie Ronald Daniel Reni Farenia Reni Farenia Ronny Lesmana Roro Wahyudianingsih Roro Wahyudianingsih, Roro Rosdianto, Aziis Mardanarian Rosdianto, Aziiz Mardanarian Safira, Bernike Tirsa Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Siti Baitul Mukarromah Sofiyanti, Santi Sri A. Sumiwi sugianli, Adhi Sunarjati Sudigdoadi Supriatno Salam Susanti Husen Susianti Susianti Tarawan, Vita M. Taufik Hidayat Teddy Hidayat Teresa Lucretia, Teresa Tiodora Arimenda Br. Subekti Titing Nurhayati Trianing Tyas Kusuma Unang Supratman Upik Rahmi, Upik Vita Murniati Tarawan Vita Murniati Tarawan Lubis Wahyu Widowati Wuri, Rahmitiana Yenni Limyati Yudi Feriandi Yulia Sofiatin Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi, Yuni Susanti