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All Journal Jurnal Veteriner Indonesia Medicus Veterinus Majalah Kedokteran Bandung Jurnal Kesehatan Masyarakat Althea Medical Journal Journal of Biomedicine and Translational Research Jurnal Kesehatan Andalas Jurnal Farmasi Klinik Indonesia Global Medical and Health Communication MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Universa Medicina Journal of Medicine and Health JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Jurnal SPORTIF : Jurnal Penelitian Pembelajaran PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JOURNAL OF SPORT EDUCATION (JOPE) Jurnal Ilmu Faal Olahraga Indonesia Quantum Wellness : Jurnal Ilmu Kesehatan Journal of Medicine and Health Folia Medica Indonesiana
Hanna Goenawan
Departemen Anatomi, Fisiologi Dan Biologi Sel Fakultas Kedokteran Universitas Padjadjaran, Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Is Cancer Immunotherapy More Hype Than Hope? Ronny Lesmana; Edward J Hadi; Hanna Goenawan
Journal of Medicine and Health Vol 2 No 6 (2020)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i6.2826

Abstract

The immunosurveillance system in the human body can detect and eradicate abnormal cells. However, cancer cells can avoid immune destruction by exploiting the immunosuppression system. Extensive research has been done to find therapeutic agents that could reverse this condition. Novel drugs called checkpoint inhibitors have been developed and showed a promising result. Besides, “living’’ drug, an engineered T-cells which can accurately target cancer cells, has increased public attention in immunotherapy. These immunotherapies might bring a new era of cancer management, a highly effective and specific treatment with fewer adverse effects. Keywords: Immunosurveillance; T-Cell; Therapeutic agents; Immunotherapies
Effects of dietary protein combined with high-intensity exercise in restoring skin health in male rats Gunadi, Julia Windi; Lesmana, Ronny; Kastella, Faysal; Tarawan, Vita Murniati; Goenawan, Hanna; Gunawan, Decky; Jasaputra, Diana Krisanti
Universa Medicina Vol. 44 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.152-161

Abstract

Background Protein is essential for skin integrity, while exercise modulates cellular and molecular processes that regulate autophagy, mitochondrial biogenesis, and collagen synthesis. This study evaluates the combined effects of dietary protein restriction and varying exercise intensities on epidermal thickness, autophagy markers (LC3, p62), mitochondrial biogenesis (PGC1α), and collagen synthesis (Col1a1, Col3a1) in male Wistar rats.    Methods An experimental laboratory study was conducted involving 32 male Wistar rats. They were randomized into 8 groups: control, low protein, low intensity, group IV, moderate intensity, moderate intensity low protein, high intensity, and high intensity low protein. Low protein diet (5%) compared to the control (24%) was given for 60 days, while the exercise regimen was eight weeks of treadmill exercise (low/10 m per minute, moderate/20 m per minute, and high intensity/30 m per minute) for 30 minutes a day, five days a week. Epidermal thickness, LC3, p62, PGC1α, Col1a1, and Col3a1 mRNA expression were measured at the end of the study. One-way ANOVA/Kruskal-Wallis followed by Tukey HSD/Mann–Whitney test was used to analyze the data.   Results A low-protein diet significantly reduced epidermal thickness (p=0.048), increased LC3 (p=0.043) and p62 (p=0.011), indicating impaired skin regeneration and autophagy. However, exercise, especially at high intensities with low protein, mitigated this effect by increasing both LC3 (p=0.011) and PGC1α (p=0.011).   Conclusions These findings highlight the compensatory role of exercise in maintaining tissue integrity under protein-deprived conditions in male rats. High-intensity exercise potentially enhances autophagy and mitochondrial biogenesis.
Study of Pre and Post Supplementation Green Tea Extracts to MDA Levels Goenawan, Hanna; Lesmana, Ronny; Huda, Fathul; Baniasih, Akbar I.; Farenia, Reni; Purba, Ambrosius
Indonesian Journal of Clinical Pharmacy Vol 2, No 1 (2013)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (625.104 KB)

Abstract

High intensity exercise (HI) induces oxidative stress. Running for 2400 meters is one of the simple exercise form which can be counted as HI. During HI, increase of oxygen consumption happened in muscle cell resulted in an increase of oxidant level. The aim of the study was to measure the effects of Indonesian green tea supplementation, before and after HI to the level of lipid peroxidation (TBARSMalonyldialdehyde (MDA)). The subjects of study were 42 male students from Faculty of Medicine, Universitas Padjadjaran (FMUP) and Faculty of Physical Exercise, Indonesia University of Education (FPOK-UPI). The subjects were divided into trained and untrained subject. Subjects were divided into groups using Astrand Harvard step test. The purpose of this test was measuring the level of VO2 max. Blood samples for MDA level were collected at 3 hours before and after high intensity aerobic  exercise. Oxidative stress was induced by 2400 meters run. The result showed that green tea supplement-ation was effective to decrease MDA plasma level especially after exercise. Green tea could serve as natural antioxidant resources, which potentially can be used as potential sport supplemental drink.Key words: Aerobic exercise, Malonyldialdehyde (MDA), pre and post exerciseStudi Pra dan Pasca Pemberian Suplemen Ekstrak Teh Hijauterhadap Kadar MDAHigh intensity exercise (HI) dapat menginduksi stres oksidatif. Berlari sejauh 2400 meter merupakan salah satu bentuk latihan sederhana yang dapat digolongkan sebagai HI. Selama HI, konsumsi oksigen pada sel otot meningkat yang dapat menyebabkan peningkatan kadar oksidan. Penelitian ini bertujuanuntuk mengukur efek dari suplemen teh hijau Indonesia sebelum dan setelah HI terhadap kadar lipid peroksida (TBARS-Malonyldialdehyde (MDA)). Subjek penelitian ini adalah 42 mahasiswa laki-laki dari Fakultas Kedokteran Universitas Padjadjaran dan Fakultas Pendidikan Olahraga dan Kesehatan,Universitas Pendidikan Indonesia. Subjek penelitian dibagi ke dalam kelompok terlatih dan tidak terlatih dengan menggunakan cara pengujian Astrand Harvard. Tes ini bertujuan untuk mengukur kadar VO2 max. Sampel darah untuk kadar MDA diambil 3 jam sebelum dan setelah high intensity aerobic exercise. Stres oksidatif diinduksi dengan berlari sejauh 2400 meter. Hasil penelitian menunjukkan bahwa suplemen teh hijau efektif dalam menurunkan kadar MDA dalam plasma khususnya setelah berlari. Teh hijau dapat menjadi sumber antioksidan alami yang berpotensi sebagai minuman suplemen olahraga.Kata kunci: Aerobic exercise, Malonyldialdehyde (MDA), sebelum dan setelah berlari
Early Detection of the Heavy Metals Pollution Effect on Citarum River Using Zebrafish Muscle Mitochondria Biomarkers Gene Expression Oktorina, Lenny; Goenawan, Hanna; Sylviana, Nova; Kirana, Kartika Hajar; Feriandi, Yudi; Lesmana, Ronny
Global Medical & Health Communication (GMHC) Vol 13, No 1 (2025)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i1.14110

Abstract

Citarum is the longest river in West Java and one of the most polluted rivers in Indonesia and the world. Heavy metals from agriculture, industry, and household waste pollute the Citarum river. Heavy metals enter humans and animals by consuming contaminated food and beverages. Several studies have identified mitochondria as a primary target for heavy metal poisoning, resulting in impaired mitochondrial energy production, induction of oxidative stress, apoptosis, and mitophagy. This study aims to investigate the impact of heavy metals from the upstream and downstream areas of the Citarum river on mitochondrial gene expression of cox4i1, sod2, baxa, mfn1b, and ppargc1a in the skeletal muscle of zebrafish (Danio rerio) using in vivo models for biological monitoring of early detection of environmental heavy metal pollution. This experimental study was conducted from December 2019 to March 2020. The study involved four treatment groups and one control group of zebrafish, which were exposed to river water and sediments collected from two sites in the Citarum river area in December 2019. The biomarker levels were analyzed using multivariate analysis. Although all heavy metal levels except mercury were below the WHO threshold in all samples, this study's results showed that the RT-PCR results indicated that the levels of cox4i1, baxa, and ppargc1a in all samples were generally higher than those in the control. There were significant differences (p<0.05) using multivariate analysis in sod2 in Cibeureum water compared to Cibeureum sediment and ppgarc1a compared to control and Balekambang sediment. In conclusion, heavy metals from the upstream and downstream areas of the Citarum river had an impact on mitochondrial gene expression of cox4i1, sod2, baxa, mfn1b, and ppargc1a in the skeletal muscle of zebrafish. Biomarkers pparc1gc and sod2 could be further studied to identify the most valid and reliable parameters for biological monitoring, which may aid in the early detection of environmental damage to humans and animals.
Edukasi Pencegahan Stroke pada Masyarakat Desa Cigugur Girang: Stroke Prevention Education in Cigugur Girang Village Goenawan, Hanna; Tarawan, Vita Murniati; Radhiyanti, Putri Teesa; Ramadhanti, Julia; Lesmana, Ronny
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 8 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i8.7058

Abstract

Stroke patients could get sequelae, and it will decrease the patient’s quality of life. Stroke could be caused by comorbid diseases such as hypertension, diabetes mellitus, and dyslipidemia. Thus, stroke could be prevented by reducing the comorbid diseases. The prevention of stroke is necessary to be done in order to reduce stroke cases, especially in Bandung’s rural area. Villagers have limited access to health information and health services. In this community service, the methods we used were to screen the two risk factors of stroke (blood pressure and blood glucose ad random measurement) in Cigugur Girang Village, West Bandung area. The aim of this community service is to find comorbid factors of stroke and give education to people who have one or more stroke risk factors. The results of the blood pressure measurement screening showed that more than 40% of the residents of Cigugur Girang village had blood pressure above normal, and 5% of the population had blood sugar levels higher than normal. The risk factor for stroke in residents of Cigugur Girang Village mainly is high blood pressure. In this community service, people with high blood pressure were educated on how to maintain normal blood pressure and how to change their lifestyle. On the other hand, some participant has high blood glucose level. High blood glucose levels will develop into diabetes mellitus. In this education program, we gave information about the complications of high blood glucose, including stroke. Thus, this education program could increase community awareness to prevent stroke.
Measurable training program to improve physical performance: literature review Fachrul Ihsan, Muhammad; Purba, Ambrosius; Goenawan, Hanna; Satia Graha, Ali; Womsiwor, Daniel
Jurnal SPORTIF : Jurnal Penelitian Pembelajaran Vol 7 No 2 (2021): Jurnal SPORTIF: Jurnal Penelitian Pembelajaran
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2964.307 KB) | DOI: 10.29407/js_unpgri.v7i2.16046

Abstract

This study aims to determine the appropriate training program and portion in order to improve the physical performance of athletes.This literature review inquiry was obtained from various PubMed and Google Scholar databases by entering keywords, namely: Sports, Yoga, Basic Physical Components, MDA and IL6. This inquiry reviewed 33 articles published in national and international online journals and have been accredited. The results literature review done on prior studies show basic physical components can be optimally improved through exercises based on the FITT formula, namely interval training, fartlek, weight training, circuit training, plyometrix, rope jump and PNF. In addition, showed that aerobic and anaerobic exercises decreased MDA levels. However, the control group experienced a very significant increase in MDA levels. High-intensity exercise was found able to trigger releasing inflammatory mediators such as TNF-ά and IL-6. Furthermore, some literature showed that long-term yoga practice can reduce MDA levels and IL-6 levels as it as it increases antioxidant levels and anti imflamatory levels. This literature review is expected to provide comprehensive explanation of good and measurable training programs for athletes, coaches and sports institutions. Thereby, athletes’ physical performance can be optimally improved and injuries can be avoided so that athletes get sports achievements.
The AKT Pathway and Satellite Cell Activation in Skeletal Muscle Mass Regulation Sofiyanti, Santi; Goenawan, Hanna; Lesmana, Ronny; Tarawan, Vita Murniati
Folia Medica Indonesiana Vol. 58, No. 1
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Highlight: • AKT or protein kinase B increase protein synthesis and control the degradation of proteins. • Satellite cells was provided remarkable ability to regenerate skeletal muscle. • Stimulation of protein synthesis is effective therapy to maintain muscle mass, prevent muscle wasting to reduce risk sarcopenia and improve quality of life in the elderly. Abstract: Muscles have an important role as a regulator of glucose and triglyceride metabolism. Some researches show the correlation between skeletal muscle mass and metabolic diseases, such as diabetes. Skeletal muscle mass decrease occurs due to chronic illness or physiological process of aging, thus increasing the risk of metabolic diseases as well as motion difficulty in the elderly. Skeletal muscle mass depends on balanced protein synthesis and degradation, controlled through a variety of signal transduction pathways including the AKT. AKT or protein kinase B increases protein synthesis through the mTOR and GSK3β and controls the degradation of proteins through FoxO transcription factors. Another factor that has an alleged role in the regulation of skeletal muscle is the satellite cells which provide remarkable ability to regenerate skeletal muscle. A comprehensive understanding of the biomolecular mechanism of muscle mass regulation is important to develop effective treatment or prevention of muscle atrophy in many cases, either caused by pathological conditions, such as chronic diseases, or the process of aging.
Effects of Moderate-Intensity Treadmill Training on Cardiac Mitochondrial Mitophagy and Dynamics in Young and Aged Wistar Rats Gunadi, Julia Windi; Ramadhan, Difa Hidayat; Safira, Bernike Tirsa; Ramadhan, Andra Alifya; Wahyudianingsih, Roro; Limyati, Yenni; Goenawan, Hanna; Lesmana, Ronny
Althea Medical Journal Vol 13, No 1 (2026)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v13n1.4553

Abstract

Background: Cardiac aging is closely associated with mitochondrial dysfunction and impaired quality control mechanism. Exercise has been shown to modulate mitochondrial homeostasis, however, its effects on cardiac mitophagy and mitochondrial dynamics during aging remain unclear. This study investigated the effects of moderate-intensity treadmill training on mitochondrial maintenance-related gene expression in the hearts of young and aged Wistar rats.Methods: Young and aged rats were divided into four groups: young control, young exercise, aged control, and aged exercise (n=6 per group). Exercise groups performed treadmill running at 20 m/min for 30 minutes/day, 5 days/week for 8 weeks. Cardiac gene expression levels of Pink1, Parkin, Mfn1, Mfn2, Opa1, Drp1, and Fis1 were analyzed using semi-quantitative polymerase chain reaction (PCR). Data were analyzed using one-way ANOVA or Kruskal–Wallis test followed by appropriate post hoc analyses.Results: Exercise significantly increased Mfn2 expression in aged exercise rats compared with aged controls (p=0.029), suggesting partial restoration of age-related decline. Expression of Mfn1 and Drp1 varied among groups but showed no significant pairwise differences. Expression levels of Opa1, Fis1, Pink1, and Parkin remained unchanged. These results indicate that moderate exercise selectively enhances mitochondrial fusion capacity while maintaining balanced fission and basal mitophagy activity.Conclusion: Moderate-intensity treadmill training promotes mitochondrial  fusion-related adaptation in aging cardiac tissue. Regular moderate exercise may represent a potential non-pharmacological strategy to support mitochondrial function and mitigate cardiovascular aging.  
Bentuk dan Intensitas Edukasi yang Diinginkan Penderita Hipertensi di Jatinangor Muhammad Rizki Fadil; Yulia Sofiatin; Hanna Goenawan
Quantum Wellness : Jurnal Ilmu Kesehatan Vol. 3 No. 1 (2026): Maret: Quantum Wellness : Jurnal Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/quwell.v3i1.2927

Abstract

Hypertension contributes to numerous complications such as heart disease, stroke, kidney failure, and is a risk factor of disability and death. Hypertension Prevalence in Jatinangor is 37.8%, that is higher than national rate. The control of hypertension is low and the education at the primary health facility is short. Therefore, another buffer system for education such as posbindu is needed. Activities that educate people with hypertension become very important, but need to be adjusted as needs. Aim of this study is to determine form and intensity of education preferred by hypertension patients Method: Qualitative descriptive with case study approach using focused group discussion (FGD) method, led by main moderator and assisted by a second moderator. Participants consisted of 15 people with hypertension chosen purposively with the inclusion criterias female and parallel to the research objective. The discussion used semi-structured questions. This study is conducted in two villages in Jatinangor, Desa Cipacing and Desa Cilayung from February to May 2017. Results: Participants wanted education in the form of traditional learning, game simulation, written notes, and video recording. The intensity of education preferred until patients understand, it tends to be performed more than once, and preferred place are performed within Posyandu (Integrated Health and Nutrition Post) with education frequency varies from once a week to once a month. Conclusion: Hypertension patients have variable preference of education forms and its intensity. Innovations in the development of methods in accordance with hypertension patients’ needs must be continued, so that interventions can become more effective for hypertension patients.
Co-Authors . SETIAWAN Abdul Hadi Hassan Adjat Setiadjati Rasjad Ahmad Kurniawan Ahmad Kurniawan Aldo, Mochammad Ali Satia Graha Ambrosius Purba Ambrosius Purba Ambrosius Purba Andi Wijaya Arto Yuwono Soeroto Astrid Feinisa Khairani Astrid, Stephanie Averina Octaxena Aslani Aziis Mardanarian Rosdianto Aziiz Mardanarian Rosdianto Aziiz Mardanarian Rosdianto Bahjah, Firda Hanan Baniasih, Akbar I. Baniasih, Akbar I. Bela Ita Karina Bertha Pangaribuan Daba, Mariel Daniel Womsiwor Darmayanti, Meita Decky Gunawan, Decky Diana Krisanti Jasaputra Dimpuulina Erna Mariati Edward J Hadi Elvine Gunawan Euis Julaeha Fachrul Ihsan, Muhammad Fani Rahma Yenita Felix Samuel Ferdyan Efza Fifi Veronica Fitri Fadhilah Genta Syaifrin Laudza Gilang Muhamad Nur Iqbal Gita Widya Pradini Goenadi, Julia Windi Gunadi, Julia Windi Herry Herman Hidayat, Shaffana Huda, Fathul Huda, Fathul Imam Megantara Irma Ruslina Defi Isa Mahendra Iwan Setiawan Iwan Setiawan Iwan Setiawan Jatnika, Danti Dja Julia Windi Gunadi Julia Windi Gunadi Juliati Juliati Kartika Hajar Kirana, Kartika Hajar Kastella, Faysal Lisda Amalia Mariel Daba Mas Rizky A.A. Syamsunarno Melisa I. Barliana Muhammad Rizki Fadil Muhtado, Azmi Raffi Mulyanaga, William Giovanni Nova Sylviana Nuroh Najmi Nurunnisa Sholeha Letto Oktorina, Lenny Prasetyo, Wibowo Budi Prayudi Santoso Qiantori, Adziqa Ammara Radhiyanti, Putri Teesa Rahdiyanti, Putri Teesa Ramadhan, Andra Alifya Ramadhan, Difa Hidayat Ramadhanti, Julia Ray, Hamidie Ronald Daniel Reni Farenia Reni Farenia Ronny Lesmana Roro Wahyudianingsih Roro Wahyudianingsih, Roro Rosdianto, Aziis Mardanarian Rosdianto, Aziiz Mardanarian Safira, Bernike Tirsa Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Siti Baitul Mukarromah Sofiyanti, Santi Sri A. Sumiwi sugianli, Adhi Sunarjati Sudigdoadi Supriatno Salam Susanti Husen Susianti Susianti Tarawan, Vita M. Taufik Hidayat Teddy Hidayat Teresa Lucretia, Teresa Tiodora Arimenda Br. Subekti Titing Nurhayati Trianing Tyas Kusuma Unang Supratman Upik Rahmi, Upik Vita Murniati Tarawan Vita Murniati Tarawan Lubis Wahyu Widowati Wuri, Rahmitiana Yenni Limyati Yudi Feriandi Yulia Sofiatin Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi, Yuni Susanti